Computer Sciences Commons^™

Making Proteomics Accessible: Rokaixplorer For Interactive Analysis Of Phospho-Proteomic Data, Serhan Yılmaz, Filipa Blasco Tavares Pereira Lopes, Daniela Schlatzer, Marzieh Ayati, Mark R. Chance, Mehmet Koyutürk

Computer Science Faculty Publications

We present RokaiXplorer, an intuitive web tool designed to address the scarcity of user-friendly solutions for proteomics and phospho-proteomics data analysis and visualization. RokaiXplorer streamlines data processing, analysis, and visualization through an interactive online interface, making it accessible to researchers without specialized training in proteomics or data science. With its comprehensive suite of modules, RokaiXplorer facilitates phospho-proteomic analysis at the level of phosphosites, proteins, kinases, biological processes, and pathways. The tool offers functionalities such as data normalization, statistical testing, activity inference, pathway enrichment, subgroup analysis, automated report generation, and multiple visualizations, including volcano plots, bar plots, heat maps, and network …

Methionine Sulfoxide Speciation In Mouse Hippocampus Revealed By Global Proteomics Exhibits Age- And Alzheimer’S Disease-Dependent Changes Targeted To Mitochondrial And Glycolytic Pathways, Filipa Blasco Tavares Pereira Lopes, Daniela Schlatzer, Mengzhen Li, Serhan Yılmaz, Rihua Wang, Xin Qi, Marzieh Ayati, Mehmet Koyutürk, Mark R. Chance

Computer Science Faculty Publications

Methionine oxidation to the sulfoxide form (MSox) is a poorly understood post-translational modification of proteins associated with non-specific chemical oxidation from reactive oxygen species (ROS), whose chemistries are linked to various disease pathologies, including neurodegeneration. Emerging evidence shows MSox site occupancy is, in some cases, under enzymatic regulatory control, mediating cellular signaling, including phosphorylation and/or calcium signaling, and raising questions as to the speciation and functional nature of MSox across the proteome. The 5XFAD lineage of the C57BL/6 mouse has well-defined Alzheimer’s and aging states. Using this model, we analyzed age-, sex-, and disease-dependent MSox speciation in the mouse hippocampus. …

Methionine Sulfoxide Speciation In Mouse Hippocampus Revealed By Global Proteomics Exhibits Age- And Alzheimer’S Disease-Dependent Changes Targeted To Mitochondrial And Glycolytic Pathways, Filipa Blasco Tavares Pereira Lopes, Daniela Schlatzer, Mengzhen Li, Serhan Yılmaz, Rihua Wang, Xin Qi, Marzieh Ayati, Mehmet Koyutürk, Mark R. Chance

Computer Science Faculty Publications

Methionine oxidation to the sulfoxide form (MSox) is a poorly understood post-translational modification of proteins associated with non-specific chemical oxidation from reactive oxygen species (ROS), whose chemistries are linked to various disease pathologies, including neurodegeneration. Emerging evidence shows MSox site occupancy is, in some cases, under enzymatic regulatory control, mediating cellular signaling, including phosphorylation and/or calcium signaling, and raising questions as to the speciation and functional nature of MSox across the proteome. The 5XFAD lineage of the C57BL/6 mouse has well-defined Alzheimer’s and aging states. Using this model, we analyzed age-, sex-, and disease-dependent MSox speciation in the mouse hippocampus. …

Image De‑Photobombing Benchmark, Vatsa S. Patel, Kunal Agrawal, Samah Baraheem, Amira Yousif, Tam Nguyen

Computer Science Faculty Publications

Removing photobombing elements from images is a challenging task that requires sophisticated image inpainting techniques. Despite the availability of various methods, their effectiveness depends on the complexity of the image and the nature of the distracting element. To address this issue, we conducted a benchmark study to evaluate 10 state-of-the-art photobombing removal methods on a dataset of over 300 images. Our study focused on identifying the most effective image inpainting techniques for removing unwanted regions from images. We annotated the photobombed regions that require removal and evaluated the performance of each method using peak signal-to-noise ratio (PSNR), structural similarity index …

Visualizing Routes With Ai-Discovered Street-View Patterns, Tsung Heng Wu, Md Amiruzzaman, Ye Zhao, Deepshikha Bhati, Jing Yang

Computer Science Faculty Publications

Street-level visual appearances play an important role in studying social systems, such as understanding the built environment, driving routes, and associated social and economic factors. It has not been integrated into a typical geographical visualization interface (e.g., map services) for planning driving routes. In this article, we study this new visualization task with several new contributions. First, we experiment with a set of AI techniques and propose a solution of using semantic latent vectors for quantifying visual appearance features. Second, we calculate image similarities among a large set of street-view images and then discover spatial imagery patterns. Third, we integrate …

Ex-Vivo Hippocampus Segmentation Using Diffusion-Weighted Mri, Haoteng Tang, Siyuan Dai, Eric M. Zou, Guodong Liu, Ryan Ahearn, Ryan Krafty, Michel Modo, Liang Zhan

Computer Science Faculty Publications

The hippocampus is a crucial brain structure involved in memory formation, spatial navigation, emotional regulation, and learning. An accurate MRI image segmentation of the human hippocampus plays an important role in multiple neuro-imaging research and clinical practice, such as diagnosing neurological diseases and guiding surgical interventions. While most hippocampus segmentation studies focus on using T1-weighted or T2-weighted MRI scans, we explore the use of diffusion-weighted MRI (dMRI), which offers unique insights into the microstructural properties of the hippocampus. Particularly, we utilize various anisotropy measures derived from diffusion MRI (dMRI), including fractional anisotropy, mean diffusivity, axial diffusivity, and radial diffusivity, for …

Possible Role Of Correlation Coefficients And Network Analysis Of Multiple Intracellular Proteins In Blood Cells Of Patients With Bipolar Disorder In Studying The Mechanism Of Lithium Responsiveness: A Proof-Concept Study, Keming Gao, Marzieh Ayati, Nicholas M. Kaye, Mehmet Koyutürk, Joseph R. Calabrese, Eric Christian, Hillard M. Lazarus, David Kaplan

Computer Science Faculty Publications

Background: The mechanism of lithium treatment responsiveness in bipolar disorder (BD) remains unclear. The aim of this study was to explore the utility of correlation coefficients and protein-to-protein interaction (PPI) network analyses of intracellular proteins in monocytes and CD4+ lymphocytes of patients with BD in studying the potential mechanism of lithium treatment responsiveness. Methods: Patients with bipolar I or II disorder who were diagnosed with the MINI for DSM-5 and at any phase of the illness with at least mild symptom severity and received lithium (serum level ≥ 0.6 mEq/L) for 16 weeks were divided into two groups, responders (≥50% …

A Reliable Diabetic Retinopathy Grading Via Transfer Learning And Ensemble Learning With Quadratic Weighted Kappa Metric, Sai Venkatesh Chilukoti, Liqun Shan, Vijay Srinivas Tida, Anthony S. Maida, Xiali Hei

Computer Science Faculty Publications

The most common eye infection in people with diabetes is diabetic retinopathy (DR). It might cause blurred vision or even total blindness. Therefore, it is essential to promote early detection to prevent or alleviate the impact of DR. However, due to the possibility that symptoms may not be noticeable in the early stages of DR, it is difficult for doctors to identify them. Therefore, numerous predictive models based on machine learning (ML) and deep learning (DL) have been developed to determine all stages of DR. However, existing DR classification models cannot classify every DR stage or use a computationally heavy …

Locally Tight Programs, Jorge Fandinno, Vladimir Lifschitz, Nathan Temple

Computer Science Faculty Publications

Program completion is a translation from the language of logic programs into the language of first-order theories. Its original definition has been extended to programs that include integer arithmetic, accept input, and distinguish between output predicates and auxiliary predicates. For tight programs, that generalization of completion is known to match the stable model semantics, which is the basis of answer set programming. We show that the tightness condition in this theorem can be replaced by a less restrictive “local tightness” requirement. From this fact we conclude that the proof assistant ANTHEM-P2P can be used to verify equivalence between locally tight …

Locally Tight Programs, Jorge Fandinno, Vladimir Lifschitz, Nathan Temple

Computer Science Faculty Publications

Program completion is a translation from the language of logic programs into the language of first-order theories. Its original definition has been extended to programs that include integer arithmetic, accept input, and distinguish between output predicates and auxiliary predicates. For tight programs, that generalization of completion is known to match the stable model semantics, which is the basis of answer set programming. We show that the tightness condition in this theorem can be replaced by a less restrictive “local tightness” requirement. From this fact we conclude that the proof assistant ANTHEM-P2P can be used to verify equivalence between locally tight …

A Simple Proof That Ricochet Robots Is Pspace-Complete, Jose Balanza-Martinez, Angel A. Cantu, Robert Schweller, Tim Wylie

Computer Science Faculty Publications

In this paper, we seek to provide a simpler proof that the relocation problem in Ricochet Robots (Lunar Lockout with fixed geometry) is PSPACE-complete via a reduction from Finite Function Generation (FFG). Although this result was originally proven in 2003, we give a simpler reduction by utilizing the FFG problem, and put the result in context with recent publications showing that relocation is also PSPACE-complete in related models.

Efficient Hierarchical Contrastive Self-Supervising Learning For Time Series Classification Via Importance-Aware Resolution Selection, Kevin Garcia, Juan M. Perez, Yifeng Gao

Computer Science Faculty Publications

Recently, there has been a significant advancement in designing Self-Supervised Learning (SSL) frameworks for time series data to reduce the dependency on data labels. Among these works, hierarchical contrastive learning-based SSL frameworks, which learn representations by contrasting data embeddings at multiple resolutions, have gained considerable attention. Due to their ability to gather more information, they exhibit better generalization in various downstream tasks. However, when the time series data length is significant long, the computational cost is often significantly higher than that of other SSL frameworks. In this paper, to address this challenge, we propose an efficient way to train hierarchical …

Predicting An Optimal Medication/Prescription Regimen For Patient Discordant Chronic Comorbidities Using Multi-Output Models, Ichchha Pradeep Sharma, Tam Nguyen, Shruti Ajay Singh, Tom Ongwere

Computer Science Faculty Publications

This paper focuses on addressing the complex healthcare needs of patients struggling with discordant chronic comorbidities (DCCs). Managing these patients within the current healthcare system often proves to be a challenging process, characterized by evolving treatment needs necessitating multiple medical appointments and coordination among different clinical specialists. This makes it difficult for both patients and healthcare providers to set and prioritize medications and understand potential drug interactions. The primary motivation of this research is the need to reduce medication conflict and optimize medication regimens for individuals with DCCs. To achieve this, we allowed patients to specify their health conditions and …

Efficient High-Resolution Time Series Classification Via Attention Kronecker Decomposition, Aosong Feng, Jialin Chen, Juan Garza, Brooklyn Berry, Francisco Salazar, Yifeng Gao, Rex Ying, Leandros Tassiulas

Computer Science Faculty Publications

The high-resolution time series classification problem is essential due to the increasing availability of detailed temporal data in various domains. To tackle this challenge effectively, it is imperative that the state-of-theart attention model is scalable to accommodate the growing sequence lengths typically encountered in highresolution time series data, while also demonstrating robustness in handling the inherent noise prevalent in such datasets. To address this, we propose to hierarchically encode the long time series into multiple levels based on the interaction ranges. By capturing relationships at different levels, we can build more robust, expressive, and efficient models that are capable of …

Self Pre-Training With Topology- And Spatiality-Aware Masked Autoencoders For 3d Medical Image Segmentation, Pengfei Gu, Yejia Zhang, Huimin Li, Chaoli Wang, Danny Z. Chen

Computer Science Faculty Publications

Masked Autoencoders (MAEs) have been shown to be effective in pre-training Vision Transformers (ViTs) for natural and medical image analysis problems. By reconstructing missing pixel/voxel information in visible patches, a ViT encoder can aggregate contextual information for downstream tasks. But, existing MAE pre-training methods, which were specifically developed with the ViT architecture, lack the ability to capture geometric shape and spatial information, which is critical for medical image segmentation tasks. In this paper, we propose a novel extension of known MAEs for self pre-training (i.e., models pre-trained on the same target dataset) for 3D medical image segmentation. (1) We propose …

Constrained Multiview Representation For Self-Supervised Contrastive Learning, Siyuan Dai, Kai Ye, Kun Zhao, Ge Cui, Haoteng Tang, Liang Zhan

Computer Science Faculty Publications

Representation learning constitutes a pivotal cornerstone in contemporary deep learning paradigms, offering a conduit to elucidate distinctive features within the latent space and interpret the deep models. Nevertheless, the inherent complexity of anatomical patterns and the random nature of lesion distribution in medical image segmentation pose significant challenges to the disentanglement of representations and the understanding of salient features. Methods guided by the maximization of mutual information, particularly within the framework of contrastive learning, have demonstrated remarkable success and superiority in decoupling densely intertwined representations. However, the effectiveness of contrastive learning highly depends on the quality of the positive and …

All In One Place: Ensuring Usable Access To Online Shopping Items For Blind Users, Yash Prakash, Akshay Kolgar Nayak, Mohan Sunkara, Sampath Jayarathna, Hae-Na Lee, Vikas Ashok

Computer Science Faculty Publications

Perusing web data items such as shopping products is a core online user activity. To prevent information overload, the content associated with data items is typically dispersed across multiple webpage sections over multiple web pages. However, such content distribution manifests an unintended side effect of significantly increasing the interaction burden for blind users, since navigating to-and-fro between different sections in different pages is tedious and cumbersome with their screen readers. While existing works have proposed methods for the context of a single webpage, solutions enabling usable access to content distributed across multiple webpages are few and far between. In this …

Runtime Support For Cpu-Gpu High-Performance Computing On Distributed Memory Platforms, Polykarpos Thomadakis, Nikos Chrisochoides

Computer Science Faculty Publications

Hardware heterogeneity is here to stay for high-performance computing. Large-scale systems are currently equipped with multiple GPU accelerators per compute node and are expected to incorporate more specialized hardware. This shift in the computing ecosystem offers many opportunities for performance improvement; however, it also increases the complexity of programming for such architectures. This work introduces a runtime framework that enables effortless programming for heterogeneous systems while efficiently utilizing hardware resources. The framework is integrated within a distributed and scalable runtime system to facilitate performance portability across heterogeneous nodes. Along with the design, this paper describes the implementation and optimizations performed, …

Can Large Language Models Discern Evidence For Scientific Hypotheses? Case Studies In The Social Sciences, Sai Koneru, Jian Wu, Sarah Rajtmajer

Computer Science Faculty Publications

Hypothesis formulation and testing are central to empirical research. A strong hypothesis is a best guess based on existing evidence and informed by a comprehensive view of relevant literature. However, with exponential increase in the number of scientific articles published annually, manual aggregation and synthesis of evidence related to a given hypothesis is a challenge. Our work explores the ability of current large language models (LLMs) to discern evidence in support or refute of specific hypotheses based on the text of scientific abstracts. We share a novel dataset for the task of scientific hypothesis evidencing using community-driven annotations of studies …

Identifying New Cancer Genes Based On The Integration Of Annotated Gene Sets Via Hypergraph Neural Networks, Chao Deng, Hong-Dong Li, Li-Shen Zhang, Yiwei Liu, Yaohang Li, Jianxin Wang

Computer Science Faculty Publications

Motivation

Identifying cancer genes remains a significant challenge in cancer genomics research. Annotated gene sets encode functional associations among multiple genes, and cancer genes have been shown to cluster in hallmark signaling pathways and biological processes. The knowledge of annotated gene sets is critical for discovering cancer genes but remains to be fully exploited.

Results

Here, we present the DIsease-Specific Hypergraph neural network (DISHyper), a hypergraph-based computational method that integrates the knowledge from multiple types of annotated gene sets to predict cancer genes. First, our benchmark results demonstrate that DISHyper outperforms the existing state-of-the-art methods and highlight the advantages of …

Artificial Intelligence For The Electron Ion Collider (Ai4eic), C. Allaire, R. Ammendola, E.-C. Aschenauer, M. Balandat, M. Battaglieri, J. Bernauer, M. Bondì, N. Branson, T. Britton, A. Butter, I. Chahrour, P. Chatagnon, E. Cisbani, E. W. Cline, S. Dash, C. Dean, W. Deconinck, A. Deshpande, M. Diefenthaler, R. Ent, C. Fanelli, M. Finger, M. Finger Jr., E. Fol, S. Furletov, Y. Gao, J. Giroux, N. C. Gunawardhana Waduge, O. Hassan, P. L. Hegde, R. J. Hernandez-Pinto, A. Hiller Blin, T. Horn, J. Huang, A. Jalotra, D. Jayakodige, B. Joo, M. Junaid, N. Kalantarians, P. Karande, B. Kriesten, R. Kunnawalkam Elayavalli, Y. Li, M. Lin, F. Liu, S. Liuti, G. Matousek, M. Mceneaney, D. Mcspadden, T. Menzo, T. Miceli, V. Mikuni, R. Montgomery, B. Nachman, R. R. Nair, J. Niestroy, S. A. Ochoa Oregon, J. Oleniacz, J. D. Osborn, C. Paudel, C. Pecar, C. Peng, G. N. Perdue, W. Phelps, M. L. Purschke, H. Rajendran, K. Rajput, Y. Ren, D. F. Renteria-Estrada, D. Richford, B. J. Roy, D. Roy, A. Saini, N. Sato, T. Satogata, G. Sborlini, M. Schram, D. Shih, J. Singh, R. Singh, A. Siodmok, J. Stevens, P. Stone, L. Suarez, K. Suresh, A. -N. Tawfik, F. Torales Acosta, N. Tran, R. Trotta, F. J. Twagirayezu, R. Tyson, S. Volkova, A. Vossen, E. Walter, D. Whiteson, M. Williams, S. Wu, N. Zachariou, P. Zurita

Computer Science Faculty Publications

The Electron-Ion Collider (EIC), a state-of-the-art facility for studying the strong force, is expected to begin commissioning its first experiments in 2028. This is an opportune time for artificial intelligence (AI) to be included from the start at this facility and in all phases that lead up to the experiments. The second annual workshop organized by the AI4EIC working group, which recently took place, centered on exploring all current and prospective application areas of AI for the EIC. This workshop is not only beneficial for the EIC, but also provides valuable insights for the newly established ePIC collaboration at EIC. …

Short: Can Citations Tell Us About A Paper's Reproducibility? A Case Study Of Machine Learning Papers, Rochana R. Obadage, Sarah M. Rajtmajer, Jian Wu

Computer Science Faculty Publications

The iterative character of work in machine learning (ML) and artificial intelligence (AI) and reliance on comparisons against benchmark datasets emphasize the importance of reproducibility in that literature. Yet, resource constraints and inadequate documentation can make running replications particularly challenging. Our work explores the potential of using downstream citation contexts as a signal of reproducibility. We introduce a sentiment analysis framework applied to citation contexts from papers involved in Machine Learning Reproducibility Challenges in order to interpret the positive or negative outcomes of reproduction attempts. Our contributions include training classifiers for reproducibility-related contexts and sentiment analysis, and exploring correlations between …

Enhancing Research Productivity: Seamless Integration Of Personal Devices And Hpc Resources With The Cybershuttle Notebook Gateway, Yasith Jayawardana, Dimuthu Wannipurage, Eroma Abeysinghe, Suresh Marru

Computer Science Faculty Publications

Scientists often utilize personal laptops and workstations for initial research stages and turn to high-performance computing (HPC) supercomputers for compute-intensive tasks. However, seamless transitions between these environments are vital for enhancing productivity and accelerating research progress. Our paper presents the Cybershuttle Notebook Gateway, an open-source framework crafted to streamline this transition, optimize resource utilization, and reduce time-to-science for researchers. Leveraging JupyterLab, the framework extends kernel mechanics for seamless provisioning and connection to remote HPC cluster kernels. We delve into its architecture, which separates user authentication, kernel provisioning, and remote file system access. Additionally, we highlight practical capabilities like analyzing network …

Developing A Framework For Personalized Video-Based Quantum Information Science Education, Nikos Chrisochoides, Norou Diawara, Michail Giannakos

Computer Science Faculty Publications

This is a white paper on Workforce Development for Quantum Information Sciences (QIS) led by the Center for Real-Time Computing at Old Dominion University (ODU). We plan to investigate the potential of video lectures in supporting QIS. Specifically, we focus on following four objectives: (a) design a two-course series for both Master-level and PhD students; b) an upgrade of Experimental Lecture System (ELeSy) to test new, innovative, and transformative approaches for inclusive QIS education; c) design and implementation of a mixed-method systematic empirical study on the effects of video learning styles (in-person flipped classroom and voluntary video use) on graduate …

Hite: A Fast And Accurate Dynamic Boundary Adjustment Approach For Full-Length Transposable Element Detection And Annotation, Kang Hu, Peng Ning, Minghua Xu, You Zou, Jianye Chang, Xin Gao, Yaohang Li, Jue Ruan, Bin Hu, Jianxin Wang

Computer Science Faculty Publications

Recent advancements in genome assembly have greatly improved the prospects for comprehensive annotation of Transposable Elements (TEs). However, existing methods for TE annotation using genome assemblies suffer from limited accuracy and robustness, requiring extensive manual editing. In addition, the currently available gold-standard TE databases are not comprehensive, even for extensively studied species, highlighting the critical need for an automated TE detection method to supplement existing repositories. In this study, we introduce HiTE, a fast and accurate dynamic boundary adjustment approach designed to detect full-length TEs. The experimental results demonstrate that HiTE outperforms RepeatModeler2, the state-of-the-art tool, across various species. Furthermore, …

Archiving Digital Marketing: Examining Preservation Of Dynamic Content On The Web Through The Lens Of Online Advertisements, Christopher Rauch, Alex H. Poole, Travis Reid, Michele C. Weigle, Michael L. Nelson, Faryaneh Poursardar, Mat Kelly

Computer Science Faculty Publications

The transition to digital marketing has revolutionized advertising, reflecting and shaping societal norms and trends. The “Saving Ads” project addresses the challenges of preserving these ephemeral digital artifacts, essential for understanding the evolution of advertising and its socio-cultural impact. The initiative focuses on technical solutions for archiving dynamic online ads and enhancing access to these critical resources for future scholarship. By examining the preservation of online advertisements and suggesting improved approaches for archiving dynamic online content, this project contributes to the documentation of digital history.

Image-To-Mesh Conversion Method For Multi-Tissue Medical Image Computing Simulations, Fotis Drakopoulos, Yixun Liu, Kevin Garner, Nikos Chrisochoides

Computer Science Faculty Publications

Converting a three-dimensional medical image into a 3D mesh that satisfies both the quality and fidelity constraints of predictive simulations and image-guided surgical procedures remains a critical problem. Presented is an image-to-mesh conversion method called CBC3D. It first discretizes a segmented image by generating an adaptive Body-Centered Cubic mesh of high-quality elements. Next, the tetrahedral mesh is converted into a mixed element mesh of tetrahedra, pentahedra, and hexahedra to decrease element count while maintaining quality. Finally, the mesh surfaces are deformed to their corresponding physical image boundaries, improving the mesh’s fidelity. The deformation scheme builds upon the ITK open-source library …

Enhancing Heart Disease Prediction With Reinforcement Learning And Data Augmentation, Gayathri R., Sangeetha S. K. B., Sandeep Kumar Mathivanan, Hariharan Rajadurai, Benjula Anbu Malar Mb, Saurav Mallik, Hong Qin

Computer Science Faculty Publications

The study presents a novel method to improve the prediction accuracy of cardiac disease by combining data augmentation techniques with reinforcement learning. The complex nature of cardiac data frequently presents challenges for traditional machine learning models, which results in subpar performance. In response, our fusion methodology improves predictive capabilities by augmenting data and utilizing reinforcement learning's skill at sequential decision-making. Our method predicts cardiac disease with an astounding 94 % accuracy rate, which is an outstanding result. This significant improvement outperforms existing techniques and shows a deeper comprehension of intricate data relationships. The amalgamation of reinforcement learning and data augmentation …

Forecasting Crude Oil Price Using Multiple Factors, Hind Aldabagh, Xianrong Zheng, Mohammad Najand, Ravi Mukkamala

Computer Science Faculty Publications

In this paper, we predict crude oil price using various factors that may influence its price. The factors considered are physical market, financial, and trading market factors, including seven key factors and the dollar index. Firstly, we select the main factors that may greatly influence the prices. Then, we develop a hybrid model based on a convolutional neural network (CNN) and long short-term memory (LSTM) network to predict the prices. Lastly, we compare the CNN–LSTM model with other models, namely gradient boosting (GB), decision trees (DTs), random forests (RFs), neural networks (NNs), CNN, LSTM, and bidirectional LSTM (Bi–LSTM). The empirical …

Bayesian Neural Netwok Variational Autoencoder Inverse Mapper (Bnn-Vaim) And Its Application In Compton Form Factors Extraction, Md Fayaz Bin Hossen, Tareq Alghamdi, Manal Almaeen, Yaohang Li

Computer Science Faculty Publications

We extend the Variational Autoencoder Inverse Mapper (VAIM) framework for the inverse problem of extracting Compton Form Factors (CFFs) from deeply virtual exclusive reactions, such as the unpolarized Deeply virtual exclusive scattering (DVCS) cross section. VAIM is an end-to-end deep learning framework to address the solution ambiguity issue in ill-posed inverse problems, which comprises of a forward mapper and a backward mapper to simulate the forward and inverse processes, respectively. In particular, we incorporate Bayesian Neural Network (BNN) into the VAIM architecture (BNN-VAIM) for uncertainty quantification. By sampling the weights and biases distributions of the BNN in the backward mapper …