Computer Sciences Commons^™

Rna Genome Annotation With A Focus On T. Brucei, Brett Bucci

Theses

The goal of this project is to identify untranslated regions (UTRs) and UTR-indicating patterns in the genome of T. brucei. T. brucei is an interesting organism, and as the cause of African sleeping sickness -- which infects 300,000-500,000 people and a significant number of cattle annually -- is currently the subject of considerable research. Using existing algorithms, several patterns have been found that may lead to more complete UTR annotations in the T. brucei genome. The most encouraging sequence is the 11-base sequence GAGGGIICG]TGGGG, which appears in five hypothetical genes near the tail. Discovery of several such sequences could guide …

Utr Prediction Programs For Trypanosoma Brucei, Maria Moutafis

Theses

In the past few years, the field of bioinformatics has seen a rapid increase in the need for use of various sequence analysis tools. As we advance in the fields of science and technology, new programs and software are constantly being developed in this field. Rapidly expanding gene sequence databases and rapidly evolving sequence analysis tools are providing researchers with ways to search for highly similar query sequences whether they are nucleotide, protein, or gene databases. This thesis will focus on sequence alignment tools, specifically concentrating on tools that help determine/predict non-coding regions of sequences also known as untranslated regions …

Changes In Poverty And Educational Attainment, 2000 To 2007 Poverty Rates Increasing For Those With College Education, Too, Mark Salling

All Maxine Goodman Levin School of Urban Affairs Publications

No abstract provided.

Hispanics And Asians Increase In Numbers In Cuyahoga County An Analysis Of 2007 County Population Estimates, Mark Salling

All Maxine Goodman Levin School of Urban Affairs Publications

No abstract provided.

The Cleveland-Akron-Elyria Region Doing Well: More Persons Attending College And Getting Degrees, 2000 To 2007, Mark Salling

All Maxine Goodman Levin School of Urban Affairs Publications

Discussions of economic development and job availability in northeast Ohio often lament the unavailability of a qualified workforce in some sectors. Workforce training and attracting more educated population to the region are sited as important, even critical, objectives for the region. While a more detailed study of the regions’ workforce by The Center for Community Solutions is nearing completion, the release of new data by the Census Bureau provides some enlightening observations about college enrollments and educational attainment in the region.

Ohio Continues To Lag In Population Growth And Comments On Prospects For The Future An Analysis Of 2007 State Population Estimates, Mark Salling

All Maxine Goodman Levin School of Urban Affairs Publications

No abstract provided.

Molecular Targets Of 2,3,7,8-Tetrachlorodibenzo-P-Dioxin (Tcdd) Within The Zebrafish Ovary: Insights Into Tcdd-Induced Endocrine Disruption And Reproductive Toxicity, Tisha C. King Heiden, Craig Struble, Matthew L. Rise, Martin J. Hessner, Reinhold J. Hutz, Michael J. Carvan Iii

Mathematics, Statistics and Computer Science Faculty Research and Publications

TCDD is a reproductive toxicant and endocrine disruptor, yet the mechanisms by which it causes these reproductive alterations are not fully understood. In order to provide additional insight into the molecular mechanisms that underlie TCDD's reproductive toxicity, we assessed TCDD-induced transcriptional changes in the ovary as they relate to previously described impacts on serum estradiol concentrations and altered follicular development in zebrafish. In silico computational approaches were used to correlate candidate regulatory motifs with observed changes in gene expression. Our data suggest that TCDD inhibits follicle maturation via attenuated gonadotropin responsiveness and/or depressed estradiol biosynthesis, and that interference of estrogen-regulated …

Pathos: Pervasive At Home Sleep Monitoring, Ian Obermiller, Sheikh Iqbal Ahamed

Mathematics, Statistics and Computer Science Faculty Research and Publications

Sleeping disorders affect a large percentage of the population, and many of them go undiagnosed each year because the method of diagnosis is to stay overnight at a sleep center. Because pervasive technologies have become so prevalent and affordable, sleep monitoring is no longer confined to a permanent installation, and can therefore be brought directly into the user home. We present a unique solution to the problem of home sleep monitoring that has the possibility to take the place of and expand on the data from a sleep center. PATHOS focuses not only on analyzing patterns during the night, but …

Characterization Of Digraphs With Equal Domination Graphs And Underlying Graphs, Kim A. S. Factor, Larry J. Langley

Mathematics, Statistics and Computer Science Faculty Research and Publications

A domination graph of a digraph D , dom(D)dom(D), is created using the vertex set of D and edge {u,v}∈E[dom(D)]{u,v}∈E[dom(D)] whenever (u,z)∈A(D)(u,z)∈A(D) or (v,z)∈A(D)(v,z)∈A(D) for every other vertex z∈V(D)z∈V(D). The underlying graph of a digraph DD, UG(D)UG(D), is the graph for which D is a biorientation. We completely characterize digraphs whose underlying graphs are identical to their domination graphs, UG(D)=dom(D)UG(D)=dom(D). The maximum and minimum number of single arcs in these digraphs, and their characteristics, is given.

Empirical Bayes And Hierarchical Bayes Estimation Of Skew Normal Populations, Naveen K. Bansal, Mehdi Maadooliat, Xiaowei Wang

Mathematics, Statistics and Computer Science Faculty Research and Publications

We develop empirical and hierarchical Bayesian methodologies for the skew normal populations through the EM algorithm and the Gibbs sampler. A general concept of skewness to the normal distribution is considered throughout. Motivations are given for considering the skew normal population in applications, and an example is presented to demonstrate why the skew normal distribution is more applicable than the normal distribution for certain applications.

Unit Rectangle Visibility Graphs, Alice M. Dean, Joanna A. Ellis-Monaghan, Sarah J. Hamilton, Greta Pangborn

Mathematics, Statistics and Computer Science Faculty Research and Publications

Over the past twenty years, rectangle visibility graphs have generated consider- able interest, in part due to their applicability to VLSI chip design. Here we study unit rectangle visibility graphs, with fixed dimension restrictions more closely modeling the constrained dimensions of gates and other circuit components in computer chip applications. A graph G is a unit rectangle visibility graph (URVG) if its vertices can be represented by closed unit squares in the plane with sides parallel to the axes and pairwise disjoint interiors, in such a way that two vertices are adjacent if and only if there is a non-degenerate …

A Software-Based Trust Framework For Distributed Industrial Management Systems, Sheikh Iqbal Ahamed, Mohammad Zulkernine, Steve Wolfe

Mathematics, Statistics and Computer Science Faculty Research and Publications

One of the major problems in industrial security management is that most organizations or enterprises do not provide adequate guidelines or well-defined policy with respect to trust management, and trust is still an afterthought in most security engineering projects. With the increase of handheld devices, managers of business organizations tend to use handheld devices to access the information systems. However, the connection or access to an information system requires appropriate level of trust. In this paper, we present a flexible, manageable, and configurable software-based trust framework for the handheld devices of mangers to access distributed information systems. The presented framework …

Ets (Efficient, Transparent, And Secured) Self-Healing Service For Pervasive Computing Applications, Shameem Ahmed, Moushumi Sharmin, Sheikh Iqbal Ahamed

Mathematics, Statistics and Computer Science Faculty Research and Publications

To ensure smooth functioning of numerous handheld devices anywhere anytime, the importance of self-healing mechanism cannot be overlooked. Incorporation of efficient fault detection and recovery in device itself is the quest for long but there is no existing self-healing scheme for devices running in pervasive computing environments that can be claimed as the ultimate solution. Moreover, the highest degree of transparency, security and privacy attainability should also be maintained. ETS Self-healing service, an integral part of our developing middleware named MARKS (Middleware Adaptability for Resource discovery, Knowledge usability, and Self-healing), holds promise for offering all of those functionalities.

An Analysis Of Services Provided By Faith-Based Organizations To Cleveland’S Ward 17 Community, Mark Salling

All Maxine Goodman Levin School of Urban Affairs Publications

No abstract provided.

Brief Description And Analysis Of The Census Bureau's 2006 Population Estimates For Incorporated Places For Cleveland And Other Ohio Cities, Mark Salling

All Maxine Goodman Levin School of Urban Affairs Publications

No abstract provided.

Security In Pervasive Computing: Current Status And Open Issues, Munirul Haque, Sheikh Iqbal Ahamed

Mathematics, Statistics and Computer Science Faculty Research and Publications

Million of wireless device users are ever on the move, becoming more dependent on their PDAs, smart phones, and other handheld devices. With the advancement of pervasive computing, new and unique capabilities are available to aid mobile societies. The wireless nature of these devices has fostered a new era of mobility. Thousands of pervasive devices are able to arbitrarily join and leave a network, creating a nomadic environment known as a pervasive ad hoc network. However, mobile devices have vulnerabilities, and some are proving to be challenging. Security in pervasive computing is the most critical challenge. Security is needed to …

Chainability And Hemmingsen's Theorem, Paul Bankston

Mathematics, Statistics and Computer Science Faculty Research and Publications

On the surface, the definitions of chainability and Lebesgue covering dimension ⩽1 are quite similar as covering properties. Using the ultracoproduct construction for compact Hausdorff spaces, we explore the assertion that the similarity is only skin deep. In the case of dimension, there is a theorem of E. Hemmingsen that gives us a first-order lattice-theoretic characterization. We show that no such characterization is possible for chainability, by proving that if κ is any infinite cardinal and AA is a lattice base for a nondegenerate continuum, then AA is elementarily equivalent to a lattice base for a continuum Y …

Dimensionality Reduction Using Non-Linear Principal Components Analysis, Tara Singh

Electrical & Computer Engineering Theses & Dissertations

Advances in data collection and storage capabilities during the past decades have led to an information overload in most sciences. Traditional statistical methods break down partly because of the increase in the number of observations, but mostly because of the increase in the number of variables associated with each observation. While certain methods can construct predictive models with high accuracy from high-dimensional data, it is still of interest in many applications to reduce the dimension of the original data prior to any modeling of the data. Patterns in the data can be hard to find in data of high dimensionality, …

A Data Gathering Toolkit For Biological Information Integration, Munira Lokhandwala

Theses

SYSTERS is a biological information integration system containing protein sequences from many protein databases such as Swiss-Prot and TrEMBL and also protein sequences from complete genomes available at Ensembl, The Arabidopsis Information Resource, SGD and GeneDB. For some protein sequences their encoding nucleotide sequences can be found in their corresponding websites. However, for some protein sequences their encoding nucleotide sequences are missing.

The goal of this thesis is to. collect all nucleotide sequences for the protein sequences in SYSTERS and store them in a common database. There are two cases. The first case is that if the nucleotide sequences can …

Network Activity Arising From Optimal Diameters Of Neuronal Processes, Juliane Gansert

Theses

Electrical coupling provides an important pathway for signal transmission between neurons. In several regions of the mammalian brain electrical synapses have been detected, and their role in the synchronization of neural networks and the generation of oscillations has been studied theoretically. Recently, it has been found that the amplitude of the postsynaptic potential is maximized for a specific diameter of the postsynaptic fiber.

In this thesis, the impact of the fiber's diameter on the success or failure of the action potential initiation and propagation is studied theoretically. Systems of two coupled neurons, as well as small networks, are investigated. The …

Comparative Analysis Of Parametric, Nonparametric And Permutation Methods For Differential Expression, Rahul Patil

Theses

DNA microarrays permit us to study the expression of thousands of genes simultaneously. They are now used in many different contexts to compare mRNA levels between two or more samples of cells. Microarray experiments typically give us expression measurements on a large number of genes. Increasing popularity of microarray technology has resulted in a number of tests being proposed to detect differentials expression.

The purpose of study is to compare the parametric, non parametric and permutation tests when applied to microarray data for differential expression analysis. t test (parametric), Mann Whitney test (nonparametric) and Significance of analysis (permutation ) test …

Atomic Hardy Space Theory For Unbounded Singular Integrals, Ryan Berndt

Mathematics Faculty Scholarship

No abstract provided.

Foreign-Born Population In Selected Ohio Cities, 1870 To 2000 A Brief Descriptive Report, Mark Salling, Ellen Cyran

All Maxine Goodman Levin School of Urban Affairs Publications

No abstract provided.

Using The Census Bureau's Public Use Microdata For Migration Analysis, Mark Salling, Ellen Cyran

All Maxine Goodman Levin School of Urban Affairs Publications

Using the Census Bureau's Public Use Microdata for Migration Analysis, Proceedings of the annual conference of the Urban and Regional Information Systems Association, Vancouver, BC, Canada, September 2006, pp.336-348.

Specific Antibodies To Recombinant Allergens Of Aspergillus Fumigatus In Cystic Fibrosis Patients With Abpa, Viswanath P. Kurup, Alan P. Knutsen, Richard B. Moss, Naveen K. Bansal

Mathematics, Statistics and Computer Science Faculty Research and Publications

Background

Aspergillus fumigatus, a widely distributed fungus, has been implicated in causing life threatening infections as well as severe asthma and allergic diseases in man. Allergic affliction like allergic bronchopulmonary aspergillosis (ABPA) is a disabling lung disease frequently seen in patients with asthma and cystic fibrosis. Immunodiagnosis of the former is comparatively easier due to the availability of purified antigens and sensitive methods. However, this is not true with cystic fibrosis patients where the prevalence of ABPA is fairly high and the morbidity and mortality are significant.

Methods

In the present study, we have evaluated purified recombinant allergens from …

The Chang-Los-Suszko Theorem In A Topological Setting, Paul Bankston

Mathematics, Statistics and Computer Science Faculty Research and Publications

The Chang-Łoś-Suszko theorem of first-order model theory characterizes universal-existential classes of models as just those elementary classes that are closed under unions of chains. This theorem can then be used to equate two model-theoretic closure conditions for elementary classes; namely unions of chains and existential substructures. In the present paper we prove a topological analogue and indicate some applications.

Foreign Migration To The Cleveland-Akron-Lorain Metropolitan Area From 1995 To 2000, Mark Salling, Ellen Cyran

All Maxine Goodman Levin School of Urban Affairs Publications

This report is one of a series on migration to and from the region using the five percent Public Use Microdata Sample (PUMS) of the 2000 Census of Population and Housing and provides a description of foreign migrants moving to the Cleveland-Akron-Lorain (CAL) Consolidated Metropolitan Area (CMSA) from 1995 to 2000.* The report identifies the countries of origin of migrants and compares the demographic, socioeconomic, and housing characteristics of the foreign migrants to the CAL with other groups, including foreign migrants to Ohio and the nation, and, at times, to domestic migrants to and from the CAL.

The Stochastic Dance Of Early Hiv Infection, Stephen J. Merrill

Mathematics, Statistics and Computer Science Faculty Research and Publications

The stochastic nature of early HIV infection is described in a series of models, each of which captures aspects of the dance of HIV during the early stages of infection. It is to this highly variable target that the immune response must respond. The adaptability of the various components of the immune response is an important aspect of the system's operation, as the nature of the pathogens that the response will be required to respond to and the order in which those responses must be made cannot be known beforehand. As HIV infection has direct influence over cells responsible for …

A Survey On Intrusion Detection Approaches, A Murali M. Rao

International Conference on Information and Communication Technologies

Intrusion detection plays one of the key roles in computer security techniques and is one of the prime areas of research. Usages of computer network services are tremendously increasing day by day and at the same time intruders are also playing a major role to deny network services, compromising the crucial services for Email, FTP and Web. Realizing the importance of the problem due to intrusions, many researchers have taken up research in this area and have proposed several solutions. It has come to a stage to take a stock of the research results and project a comprehensive view so …

Specific Ige Response To Purified And Recombinant Allergens In Latex Allergy, Viswanath P. Kurup, Gordon L. Sussman, Hoong Y. Yeang, Nancy Elms, Heimo Breiteneder, Siti Am Arif, Kevin J. Kelly, Naveen K. Bansal, Jordan N. Fink

Mathematics, Statistics and Computer Science Faculty Research and Publications

Background

In recent years, allergy to natural rubber latex has emerged as a major allergy among certain occupational groups and patients with underlying diseases. The sensitization and development of latex allergy has been attributed to exposure to products containing residual latex proteins. Although improved manufacturing procedures resulted in a considerable reduction of new cases, the potential risk for some patient groups is still great. In addition the prevalent cross-reactivity of latex proteins with other food allergens poses a major concern. A number of purified allergens and a few commercial kits are currently available, but no concerted effort was undertaken to …