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Articles 991 - 1020 of 1803

Full-Text Articles in Computer Sciences

The Killingly Mascot Case Study, Jordan Lumpkins Dec 2020

The Killingly Mascot Case Study, Jordan Lumpkins

School of Professional Studies

In the summer of 2019, in Killingly, Connecticut the local Board of Education voted to retire the "Redmen" mascot name it had used for nearly a century. This legislation was widely opposed and received extensive media coverage. Within a few months, the town experienced a massive political referendum where several local Board of Education members and Councilmen were replaced by single issue politicians promising to reinstate the "Redmen" name. Now holding a majority on the Board of Education, these Board members made Killingly the first school in U.S. history to reinstate a mascot after being deemed "derogatory."

It is the …


Higher Education Responses To Crisis: A Case Study Of Clark University And The Pandemic Of 2020, Lisa Gillingham Dec 2020

Higher Education Responses To Crisis: A Case Study Of Clark University And The Pandemic Of 2020, Lisa Gillingham

School of Professional Studies

The COVID-19 pandemic has delivered an existential challenge to universities and other academic institutions at a time when they are already grappling with other weighty issues that may alter the fabric of higher education. COVID-19 has forced these institutions to consider and employ new ways of conducting its work with a sense urgency that is unprecedented in the recent history of the academy. The rate of learning around these models is rapid, and Higher Education is ripe for change.

Clark University has addressed the pandemic with a plan to protect and pivot using strategies that support the continuation of its …


Envrment: Investigating Experience In A Virtual User-Composed Environment, Matthew Key Dec 2020

Envrment: Investigating Experience In A Virtual User-Composed Environment, Matthew Key

Master's Theses

Virtual Reality is a technology that has long held society's interest, but has only recently began to reach a critical mass of everyday consumers. The idea of modern VR can be traced back decades, but because of the limitations of the technology (both hardware and software), we are only now exploring its potential. At present, VR can be used for tele-surgery, PTSD therapy, social training, professional meetings, conferences, and much more. It is no longer just an expensive gimmick to go on a momentary field trip; it is a tool, and as with the automobile, personal computer, and smartphone, it …


Evaluating The Reproducibility Of Physiological Stress Detection Models, Varun Mishra, Sougata Sen, Grace Chen, Tian Hao, Jeffrey Rogers, Ching-Hua Chen, David Kotz Dec 2020

Evaluating The Reproducibility Of Physiological Stress Detection Models, Varun Mishra, Sougata Sen, Grace Chen, Tian Hao, Jeffrey Rogers, Ching-Hua Chen, David Kotz

Dartmouth Scholarship

Recent advances in wearable sensor technologies have led to a variety of approaches for detecting physiological stress. Even with over a decade of research in the domain, there still exist many significant challenges, including a near-total lack of reproducibility across studies. Researchers often use some physiological sensors (custom-made or off-the-shelf), conduct a study to collect data, and build machine-learning models to detect stress. There is little effort to test the applicability of the model with similar physiological data collected from different devices, or the efficacy of the model on data collected from different studies, populations, or demographics.

This paper takes …


Towards Development Of A Remote Charting System For Connected Healthcare, Alex Bodurka Dec 2020

Towards Development Of A Remote Charting System For Connected Healthcare, Alex Bodurka

Masters Theses

Health Care Providers play a crucial role in a patients well-being. While their primary role is to treat the patient, it is also vital to ensure that they can spend adequate time with the patient to create a unique treatment plan and build a personal relationship with their patients to help them feel comfortable during their treatment. Health Care Providers are frequently required to manually record patient data to track their healthcare progress during their hospital stay. However, with hospitals continuously trying to optimize their workflows, this crucial one-on-one time with the patient is often not practical.

As a solution, …


Implementation Of An Electronic Alert For Improving Adherence To Diabetic Foot Exam Screenings In Type 2 Diabetic Patients In Primary Care Clinics, Ruby Denson Dec 2020

Implementation Of An Electronic Alert For Improving Adherence To Diabetic Foot Exam Screenings In Type 2 Diabetic Patients In Primary Care Clinics, Ruby Denson

Student Scholarly Projects

Practice Problem: Patients with type 2 diabetes mellitus (T2DM) are at an increased risk of complications including foot ulcerations (Harris-Hayes et al., 2020). Preventive care is essential for the early detection of foot ulcers but despite the advantages of preventive screening, a limited number of primary care providers perform annual foot exams (Williams et al., 2018).

PICOT: The clinical question that guided this project was, “In adult patients with T2DM receiving care in a primary care setting, will the implementation of an electronic clinical reminder alert (ECR) increase provider adherence to performing an annual diabetic foot exam and risk …


Development Of Computational To Ols To Target Microrna, Luo Song Dec 2020

Development Of Computational To Ols To Target Microrna, Luo Song

Dissertations and Theses (Open Access)

MicroRNAs (a.k.a, miRNAs) play an important role in disease development. However, few of their structures have been determined and structure-based computational methods remain challenging in accurately predicting their interactions with small molecules. To address this issue, my thesis is to develop integrated approaches to screening for novel inhibitors by targeting specific structure motifs in miRNAs. The project starts with implementing a tool to find potential miRNA targets with desired motifs. I combined both sequence information of miRNAs and known RNA structure data from Protein Data Bank (PDB) to predict the miRNA structure and identify the motif to target, then I …


Eelgrass (Zostera Marina) Population Decline In Morro Bay, Ca: A Meta-Analysis Of Herbicide Application In San Luis Obispo County And Morro Bay Watershed, Tyler King Sinnott Dec 2020

Eelgrass (Zostera Marina) Population Decline In Morro Bay, Ca: A Meta-Analysis Of Herbicide Application In San Luis Obispo County And Morro Bay Watershed, Tyler King Sinnott

Master's Theses

The endemic eelgrass (Zostera marina) community of Morro Bay Estuary, located on the central coast of California, has experienced an estimated decline of 95% in occupied area (reduction of 344 acres to 20 acres) from 2008 to 2017 for reasons that are not yet definitively clear. One possible driver of degradation that has yet to be investigated is the role of herbicides from agricultural fields in the watershed that feeds into the estuary. Thus, the primary research goal of this project was to better understand temporal and spatial trends of herbicide use within the context of San Luis …


Identification Of Ecg Anomalies Through Deep Deterministic Learning, Uzair Iqbal Nov 2020

Identification Of Ecg Anomalies Through Deep Deterministic Learning, Uzair Iqbal

Student Works (2020-2029)

Electrocardiography (ECG) is a primary diagnostic tool for measuring the malfunctioning of the heart muscles in the context of morbidity of different cardiac diseases and arrhythmia. Different existing techniques and methods delivered accurate cardiac diseases myocardial infarction (heart stroke) and atrial fibrillation recognition. However, there are still some flaws in existing methods like recognition of special myocardial infarction situation flattened T wave in “Non-Specific ST-T Changes (nsst-t)” and reduction of computational cost in cardiac diseases recognition. Accurate recognition of cardiac diseases along with least computational complexity and feature analysis of flattened T wave in myocardial infarction remains an open job. …


Deep Learning With Physics Informed Neural Networks For The Airborne Spread Of Covid-19 In Enclosed Spaces, Udbhav Muthakana, Padmanabhan Seshaiyer, Maziar Raissi, Long Nguyen Nov 2020

Deep Learning With Physics Informed Neural Networks For The Airborne Spread Of Covid-19 In Enclosed Spaces, Udbhav Muthakana, Padmanabhan Seshaiyer, Maziar Raissi, Long Nguyen

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.


Coevolution, Dynamics And Allostery Conspire In Shaping Cooperative Binding And Signal Transmission Of The Sars-Cov-2 Spike Protein With Human Angiotensin-Converting Enzyme 2, Gennady M. Verkhivker Nov 2020

Coevolution, Dynamics And Allostery Conspire In Shaping Cooperative Binding And Signal Transmission Of The Sars-Cov-2 Spike Protein With Human Angiotensin-Converting Enzyme 2, Gennady M. Verkhivker

Mathematics, Physics, and Computer Science Faculty Articles and Research

Binding to the host receptor is a critical initial step for the coronavirus SARS-CoV-2 spike protein to enter into target cells and trigger virus transmission. A detailed dynamic and energetic view of the binding mechanisms underlying virus entry is not fully understood and the consensus around the molecular origins behind binding preferences of SARS-CoV-2 for binding with the angiotensin-converting enzyme 2 (ACE2) host receptor is yet to be established. In this work, we performed a comprehensive computational investigation in which sequence analysis and modeling of coevolutionary networks are combined with atomistic molecular simulations and comparative binding free energy analysis of …


Erica: Enabling Real-Time Mistake Detection And Corrective Feedback For Free-Weights Exercises, Meeralakshmi Radhakrishnan, Darshana Rathnayake, Koon Han Ong, Inseok Hwang, Archan Misra Nov 2020

Erica: Enabling Real-Time Mistake Detection And Corrective Feedback For Free-Weights Exercises, Meeralakshmi Radhakrishnan, Darshana Rathnayake, Koon Han Ong, Inseok Hwang, Archan Misra

Research Collection School Of Computing and Information Systems

We present ERICA, a digital personal trainer for users performing free weights exercises, with two key differentiators: (a) First, unlike prior approaches that either require multiple on-body wearables or specialized infrastructural sensing, ERICA uses a single in-ear "earable" device (piggybacking on a form factor routinely used by millions of gym-goers) and a simple inertial sensor mounted on each weight equipment; (b) Second, unlike prior work that focuses primarily on quantifying a workout, ERICA additionally identifies a variety of fine-grained exercising mistakes and delivers real-time, in-situ corrective instructions. To achieve this, we (a) design a robust approach for user-equipment association that …


Law Library Blog (November 2020): Legal Beagle's Blog Archive, Roger Williams University School Of Law Nov 2020

Law Library Blog (November 2020): Legal Beagle's Blog Archive, Roger Williams University School Of Law

Law Library Newsletters/Blog

No abstract provided.


Covid-19 Pandemic – Online Education In The New Normal And The Next Normal, X. Xie, Keng Siau, Fiona Fui-Hoon Nah Nov 2020

Covid-19 Pandemic – Online Education In The New Normal And The Next Normal, X. Xie, Keng Siau, Fiona Fui-Hoon Nah

Research Collection School Of Computing and Information Systems

The development and advancement of information technology provide a technical platform for education reform and opportunities for innovation in education. The global COVID-19 pandemic has created a new normal that further springboards such opportunities to large scale implementation of online education. Because online education has the advantages of flexibility, information accessibility, global reach, equity, innovation, and efficiency, a growing number of educational institutions are offering degree-granting distance and hybrid education programs. However, online education also has its shortcomings, which include technological constraints, the lack of a sense of belonging and connectedness, the presence of distractions, and a lack of engagement. …


A Hybrid Agent-Based And Equation Based Model For The Spread Of Infectious Diseases, Elizabeth Hunter, Brian Mac Namee, John D. Kelleher Oct 2020

A Hybrid Agent-Based And Equation Based Model For The Spread Of Infectious Diseases, Elizabeth Hunter, Brian Mac Namee, John D. Kelleher

Articles

Both agent-based models and equation-based models can be used to model the spread of an infectious disease. Equation-based models have been shown to capture the overall dynamics of a disease outbreak while agent-based models are able to capture heterogeneous characteristics of agents that drive the spread of an outbreak. However, agent-based models are computationally intensive. To capture the advantages of both the equation-based and agent-based models, we create a hybrid model where the disease component of the hybrid model switches between agent-based and equation-based. The switch is determined using the number of agents infected. We first test the model at …


Analysis Of Glutathione Supplementation Effects On Female Metabolic Syndrome Condition Using Classification Techniques, Nur Rasyidah Hasan Basri Oct 2020

Analysis Of Glutathione Supplementation Effects On Female Metabolic Syndrome Condition Using Classification Techniques, Nur Rasyidah Hasan Basri

Student Works (2020-2029)

Lesser known to the public that main antioxidants in our body, Glutathione are also said to influence the metabolic syndrome (MS) condition. Oral supplementation consisting of glutathione precursors and vitamin C introduced in the study was to improve glutathione (GSH) status of the consumer and the main objective of this study is to investigate GSH effects on selected MS condition. Several known studies had proven that oral supplementation improved GSH level of consumer. However, there is no definite proof on how it’s affecting MS parameters. Also, there is less study carried out on the relationship between glutathione levels and metabolic …


Gym Usage Behavior & Desired Digital Interventions: An Empirical Study, Meeralakshmi Radhakrishnan, Archan Misra, Rajesh Krishna Balan, Youngki Lee Oct 2020

Gym Usage Behavior & Desired Digital Interventions: An Empirical Study, Meeralakshmi Radhakrishnan, Archan Misra, Rajesh Krishna Balan, Youngki Lee

Research Collection School Of Computing and Information Systems

Understanding individual’s exercise motives, participation patterns in a gym and reasons for dropout are essential for designing strategies to help gym-goers with long-term exercise adherence. In this work, we derive insights on various exercise-related behaviors of gymgoers, including evidence of a significant number of individuals exhibiting early dropout and also describing their attitudes towards digital technologies for sustained gym participation. By utilizing gym visitation data logs of 6513 individuals over a longitudinal period of 16 months in a campus gym, we show the retention and dropout rates of gym-goers. Our data indicates that 32% of the people quit their gym …


Integrated Multiparametric Radiomics And Informatics System For Characterizing Breast Tumor Characteristics With The Oncotypedx Gene Assay, Michael A. Jacobs, Christopher B. Umbricht, Vishwa S. Parekh, Riham H. El Khouli, Leslie Cope, Katarzyna J. Macura, Susan Harvey, Antonio C. Wolff Sep 2020

Integrated Multiparametric Radiomics And Informatics System For Characterizing Breast Tumor Characteristics With The Oncotypedx Gene Assay, Michael A. Jacobs, Christopher B. Umbricht, Vishwa S. Parekh, Riham H. El Khouli, Leslie Cope, Katarzyna J. Macura, Susan Harvey, Antonio C. Wolff

Radiology Faculty Publications

Optimal use of multiparametric magnetic resonance imaging (mpMRI) can identify key MRI parameters and provide unique tissue signatures defining phenotypes of breast cancer. We have developed and implemented a new machine-learning informatic system, termed Informatics Radiomics Integration System (IRIS) that integrates clinical variables, derived from imaging and electronic medical health records (EHR) with multiparametric radiomics (mpRad) for identifying potential risk of local or systemic recurrence in breast cancer patients. We tested the model in patients (n = 80) who had Estrogen Receptor positive disease and underwent OncotypeDX gene testing, radiomic analysis, and breast mpMRI. The IRIS method was trained …


Dictionary-Based Diabetes Distress Detection Mechanism Using Facebook Reactions, Marian Cynthia Martin Sep 2020

Dictionary-Based Diabetes Distress Detection Mechanism Using Facebook Reactions, Marian Cynthia Martin

Student Works (2020-2029)

Over the last decade, the internet has paved the way for Facebook to become the digital hub for social networking transforming the ways of sharing information carrying rich and valuable information of users’ perspectives. Facebook support groups compromised of online diabetes communities facilitates users to connect to different people with similar conditions and share information wrapped in their own sentiments and emotions. Diabetes being a major life threatening health issue, results in diabetes distress among the online diabetes community. However, the detection of diabetes distress had been carried out manually using surveys and questionnaires, accentuating the lack of studies in …


Exploring The Eating Disorder Examination Questionnaire, Clinical Impairment Assessment, And Autism Quotient To Identify Eating Disorder Vulnerability: A Cluster Analysis, Natalia Stewart Rosenfield, Erik Linstead Sep 2020

Exploring The Eating Disorder Examination Questionnaire, Clinical Impairment Assessment, And Autism Quotient To Identify Eating Disorder Vulnerability: A Cluster Analysis, Natalia Stewart Rosenfield, Erik Linstead

Engineering Faculty Articles and Research

Eating disorders are very complicated and many factors play a role in their manifestation. Furthermore, due to the variability in diagnosis and symptoms, treatment for an eating disorder is unique to the individual. As a result, there are numerous assessment tools available, which range from brief survey questionnaires to in-depth interviews conducted by a professional. One of the many benefits to using machine learning is that it offers new insight into datasets that researchers may not previously have, particularly when compared to traditional statistical methods. The aim of this paper was to employ k-means clustering to explore the Eating Disorder …


Barriers And Facilitators In Implementing A Pilot, Pragmatic, Telemedicine-Delivered Healthy Lifestyle Program For Obesity Management In A Rural, Academic Obesity Clinic, John A. Batsis, Auden C. Mcclure, Aaron B. Weintraub, Diane Sette, Sivan Rotenberg, Courtney J. Stevens, Diane Gilbert-Diamond, David Kotz, Stephen Bartels, Summer B. Cook, Richard I. Rothstein Sep 2020

Barriers And Facilitators In Implementing A Pilot, Pragmatic, Telemedicine-Delivered Healthy Lifestyle Program For Obesity Management In A Rural, Academic Obesity Clinic, John A. Batsis, Auden C. Mcclure, Aaron B. Weintraub, Diane Sette, Sivan Rotenberg, Courtney J. Stevens, Diane Gilbert-Diamond, David Kotz, Stephen Bartels, Summer B. Cook, Richard I. Rothstein

Dartmouth Scholarship

Few evidence-based strategies are specifically tailored for disparity populations such as rural adults. Two-way video-conferencing using telemedicine can potentially surmount geographic barriers that impede participation in high-intensity treatment programs offering frequent visits to clinic facilities. We aimed to understand barriers and facilitators of implementing a telemedicine-delivered tertiary-care, rural academic weight-loss program for the management of obesity.


Coronavirus: Pandemics, Artificial Intelligence And Personal Data: How To Manage Pandemics Using Ai And What That Means For Personal Data Protection, Warren B. Chik Sep 2020

Coronavirus: Pandemics, Artificial Intelligence And Personal Data: How To Manage Pandemics Using Ai And What That Means For Personal Data Protection, Warren B. Chik

Research Collection Yong Pung How School Of Law

This chapter discusses the hearing of essential and urgent court matters in the Singapore courts during the COVID-19 pandemic. On 27 march 2020, the Singapore judiciary notified courst users that remote hearings were to be implemented for certain types of hearings by means of video and telephone conferencing facilities. Court users were also provided with indicative lists of matters which might be considered essential and urgent.


The Impact Of Herbal Infusion Consumption On Oxidative Stress And Cancer: The Good, The Bad, The Misunderstood, Wamidh H. Talib, Israa A. Al-Ataby, Asma Ismail Mahmod, Sajidah Jawarneh, Lina T. Al Kury, Intisar Hadi Al-Yasari Sep 2020

The Impact Of Herbal Infusion Consumption On Oxidative Stress And Cancer: The Good, The Bad, The Misunderstood, Wamidh H. Talib, Israa A. Al-Ataby, Asma Ismail Mahmod, Sajidah Jawarneh, Lina T. Al Kury, Intisar Hadi Al-Yasari

All Works

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. The release of reactive oxygen species (ROS) and oxidative stress is associated with the development of many ailments, including cardiovascular diseases, diabetes and cancer. The causal link between oxidative stress and cancer is well established and antioxidants are suggested as a protective mechanism against cancer development. Recently, an increase in the consumption of antioxidant supplements was observed globally. The main sources of these antioxidants include fruits, vegetables, and beverage. Herbal infusions are highly popular beverages consumed daily for different reasons. Studies showed the potent antioxidant effects of plants used in the …


Resveratrol And Tumor Microenvironment: Mechanistic Basis And Therapeutic Targets, Wamidh H. Talib, Ahmad Riyad Alsayed, Faten Farhan, Lina T. Al Kury Sep 2020

Resveratrol And Tumor Microenvironment: Mechanistic Basis And Therapeutic Targets, Wamidh H. Talib, Ahmad Riyad Alsayed, Faten Farhan, Lina T. Al Kury

All Works

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Resveratrol (3,40,5 trihydroxystilbene) is a naturally occurring non-flavonoid polyphenol. It has various pharmacological effects including antioxidant, anti-diabetic, anti-inflammatory and anti-cancer. Many studies have given special attention to different aspects of resveratrol anti-cancer properties and proved its high efficiency in targeting multiple cancer hallmarks. Tumor microenvironment has a critical role in cancer development and progression. Tumor cells coordinate with a cast of normal cells to aid the malignant behavior of cancer. Many cancer supporting players were detected in tumor microenvironment. These players include blood and lymphatic vessels, infiltrating immune cells, stromal fibroblasts …


Coronavirus: Pandemics, Artificial Intelligence And Personal Data: How To Manage Pandemics Using Ai And What That Means For Personal Data Protection, Warren B. Chik Sep 2020

Coronavirus: Pandemics, Artificial Intelligence And Personal Data: How To Manage Pandemics Using Ai And What That Means For Personal Data Protection, Warren B. Chik

Research Collection Yong Pung How School Of Law

This chapter discusses the hearing of essential and urgent court matters in the Singapore courts during the COVID-19 pandemic. On 27 march 2020, the Singapore judiciary notified courst users that remote hearings were to be implemented for certain types of hearings by means of video and telephone conferencing facilities. Court users were also provided with indicative lists of matters which might be considered essential and urgent.


Comparison Of Machine Learning Models: Gesture Recognition Using A Multimodal Wrist Orthosis For Tetraplegics, Charlie Martin Aug 2020

Comparison Of Machine Learning Models: Gesture Recognition Using A Multimodal Wrist Orthosis For Tetraplegics, Charlie Martin

The Journal of Purdue Undergraduate Research

Many tetraplegics must wear wrist braces to support paralyzed wrists and hands. However, current wrist orthoses have limited functionality to assist a person’s ability to perform typical activities of daily living other than a small pocket to hold utensils. To enhance the functionality of wrist orthoses, gesture recognition technology can be applied to control mechatronic tools attached to a novel fabricated wrist brace. Gesture recognition is a growing technology for providing touchless human-computer interaction that can be particularly useful for tetraplegics with limited upper-extremity mobility. In this study, three gesture recognition models were compared—two dynamic time-warping models and a hidden …


A Multicenter Mixed-Effects Model For Inference And Prediction Of 72-H Return Visits To The Emergency Department For Adult Patients With Trauma-Related Diagnoses, Ehsan Yaghmaei, Louis Ehwerhemuepha, William Feaster, David Gibbs, Cyril Rakovski Aug 2020

A Multicenter Mixed-Effects Model For Inference And Prediction Of 72-H Return Visits To The Emergency Department For Adult Patients With Trauma-Related Diagnoses, Ehsan Yaghmaei, Louis Ehwerhemuepha, William Feaster, David Gibbs, Cyril Rakovski

Mathematics, Physics, and Computer Science Faculty Articles and Research

Objective

Emergency department (ED) return visits within 72 h may be a sign of poor quality of care and entail unnecessary use of healthcare resources. In this study, we compare the performance of two leading statistical and machine learning classification algorithms, and we use the best performing approach to identify novel risk factors of ED return visits.

Methods

We analyzed 3.2 million ED encounters with at least one diagnosis under “injury, poisoning and certain other consequences of external causes” and “external causes of morbidity.” These encounters included patients 18 years or older from across 128 emergency room facilities in the …


Using Natural Language Processing And Sentiment Analysis To Augment Traditional User-Centered Design: Development And Usability Study, Curtis L. Petersen, Ryan Halter, David Kotz, Lorie Loeb, Summer B. Cook, Dawna M. Pidgeon, Brock Christensen, John A. Batsis Aug 2020

Using Natural Language Processing And Sentiment Analysis To Augment Traditional User-Centered Design: Development And Usability Study, Curtis L. Petersen, Ryan Halter, David Kotz, Lorie Loeb, Summer B. Cook, Dawna M. Pidgeon, Brock Christensen, John A. Batsis

Dartmouth Scholarship

Background: Sarcopenia, defined as the age-associated loss of muscle mass and strength, can be effectively mitigated through resistance-based physical activity. With compliance at approximately 40% for home-based exercise prescriptions, implementing a remote sensing system would help patients and clinicians to better understand treatment progress and increase compliance. The inclusion of end users in the development of mobile apps for remote-sensing systems can ensure that they are both user friendly and facilitate compliance. With advancements in natural language processing (NLP), there is potential for these methods to be used with data collected through the user-centered design process.

Objective: This study aims …


Hypergraph Analysis Of Structure Models, Cliff A. Joslyn, Teresa D. Schmidt, Martin Zwick Jul 2020

Hypergraph Analysis Of Structure Models, Cliff A. Joslyn, Teresa D. Schmidt, Martin Zwick

Complex Systems Faculty Publications and Presentations

Theoretical discussion on the analysis of hypergraph networks; application of analysis methods to hypergraph networks derived by applying Reconstructability Analysis to health care data (the PhD dissertation work of Teresa Schmidt).


Computational And Pharmacological Evaluation Of Carveol For Antidiabetic Potential, Muhammad Shabir Ahmed, Arif Ullah Khan, Lina Tariq Al Kury, Fawad Ali Shah Jul 2020

Computational And Pharmacological Evaluation Of Carveol For Antidiabetic Potential, Muhammad Shabir Ahmed, Arif Ullah Khan, Lina Tariq Al Kury, Fawad Ali Shah

All Works

© Copyright © 2020 Ahmed, Khan, Kury and Shah. Background: Carveol is a natural drug product present in the essential oils of orange peel, dill, and caraway seeds. The seed oil of Carum Carvi has been reported to be antioxidant, anti-inflammatory, anti-hyperlipidemic, antidiabetic, and hepatoprotective. Methods: The antidiabetic potential of carveol was investigated by employing in-vitro, in-vivo, and in-silico approaches. Moreover, alpha-amylase inhibitory assay and an alloxan-induced diabetes model were used for in-vitro and in-vivo analysis, respectively. Results: Carveol showed its maximum energy values (≥ -7 Kcal/mol) against sodium-glucose co-transporter, aldose reductase, and sucrose-isomaltase intestinal, whereas it exhibited intermediate energy …