Computer Sciences Commons^™

How Low Can You Go? Feature Selection For Drug Discovery, Derek Jones, Sally R. Ellingson, W. A. De Jong

Commonwealth Computational Summit

The cost of bringing a drug to market depends on how quickly a candidate drug can be “discovered” and evaluated to ensure safety and effectiveness. In this work we develop a method for predicting whether a given drug and protein compound will “bind.” Our aim is to select a set of features to predict drug-protein interactions.

This study focuses on kinases. Kinase inhibitors are the largest class of new cancer therapies. Selective inhibition is difficult due to high sequence similarity, leading to off-target interactions and side-effects. Pictured here human c-SRC.

Healthcare It In Skilled Nursing And Post-Acute Care Facilities: Reducing Hospital Admissions And Re-Admissions, Improving Reimbursement And Improving Clinical Operations, Scott L. Hopes

USF Tampa Graduate Theses and Dissertations

Health information technology (HIT), which includes electronic health record (EHR) systems and clinical data analytics, has become a major component of all health care delivery and care management. The adoption of HIT by physicians, hospitals, post-acute care organizations, pharmacies and other health care providers has been accepted as a necessary (and recently, a government required) step toward improved quality, care coordination and reduced costs: “Better coordination of care provides a path to improving communication, improving quality of care, and reducing unnecessary emergency room use and hospital readmissions. LTPAC providers play a critical role in achieving these goals” (HealthIT.gov, 2013).

Though …

A Stochastic Epidemiological Model Of The Response Of American Chestnut Populations To Fungal Blight, Kelsey Lieberman, Rebecca Rouleau, Anita Davelos Baines, Martin Allen

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Computational Modeling For Abnormal Brain Tissue Segmentation, Brain Tumor Tracking, And Grading, Syed Mohammad Shamin Reza

Electrical & Computer Engineering Theses & Dissertations

This dissertation proposes novel texture feature-based computational models for quantitative analysis of abnormal tissues in two neurological disorders: brain tumor and stroke. Brain tumors are the cells with uncontrolled growth in the brain tissues and one of the major causes of death due to cancer. On the other hand, brain strokes occur due to the sudden interruption of the blood supply which damages the normal brain tissues and frequently causes death or persistent disability. Clinical management of these brain tumors and stroke lesions critically depends on robust quantitative analysis using different imaging modalities including Magnetic Resonance (MR) and Digital Pathology …

An Evaluation Of The Effects Of Intensity And Duration On Outcomes Across Treatment Domains For Children With Autism Spectrum Disorder, Erik J. Linstead, D. R. Dixon, E. Hong, C. O. Burns, Ryan French, M. N. Novack, D. Granpeesheh

Mathematics, Physics, and Computer Science Faculty Articles and Research

Applied behavior analysis (ABA) is considered an effective treatment for individuals with autism spectrum disorder (ASD), and many researchers have further investigated factors associated with treatment outcomes. However, few studies have focused on whether treatment intensity and duration have differential influences on separate skills. The aim of the current study was to investigate how treatment intensity and duration impact learning across different treatment domains, including academic, adaptive, cognitive, executive function, language, motor, play, and social. Separate multiple linear regression analyses were used to evaluate these relationships. Participants included 1468 children with ASD, ages 18 months to 12 years old, M= …

Vcksm: Verifiable Conjunctive Keyword Search Over Mobile E-Health Cloud In Shared Multi-Owner Settings, Yinbin Miao, Jianfeng Ma, Ximeng Liu, Qi Jiang, Junwei Zhang, Limin Shen, Zhiquan Liu

Research Collection School Of Computing and Information Systems

Searchable encryption (SE) is a promising technique which enables cloud users to conduct search over encrypted cloud data in a privacy-preserving way, especially for the electronic health record (EHR) system that contains plenty of medical history, diagnosis, radiology images, etc. In this paper, we focus on a more practical scenario, also named as the shared multi-owner settings, where each e-health record is co-owned by a fixed number of parties. Although the existing SE schemes under the unshared multi-owner settings can be adapted to this shared scenario, these schemes have to build multiple indexes,which definitely incur higher computational overhead. To save …

Unobtrusive Monitoring To Detect Depression For Elderly With Chronic Illnesses, Jung-Yoon Kim, Na Liu, Hwee Xian Tan, Chao-Hsien Chu

Research Collection School Of Computing and Information Systems

Mental health related disorders are common diseases, especially among the elder. Among the various mental health diseases, one potential threat to ageing-in-place is the risk of depression. In this paper, we propose a simple unobtrusive sensing system using passive infra-red motion sensors to monitor the activities of daily living of elderly, who are living alone. A feature extraction module comprising of three layers-states, events, and activities, and the corresponding algorithms are proposed to extract features. Four popular classification models-neural network, C4.5 decision tree, Bayesian network, and support vector machine are then applied to detect the severity of depression. We implement …

Marketing Strategy Of School Of Professional Studies In China, Jiahui Liu, Jing Wang, Shuo An, Wengxing Wang, Yiwei Wang

School of Professional Studies

Chinese students are the most visible international presence at many universities across the United States, and the number continues to grow. Since 2010, The number of graduate students studying abroad has entered the period in which the increase has been declining. Under the circumstance of the weak global economy and high cost of education, the administration needs to attract the attention of Chinese students. In the process of competing for applicants, how to develop marketing strategies to attract students’ eyeballs has become an important means of trying to increase school income through Chinese students. The marketing strategy mentioned in this …

Predicting Potential Alzheimer Medical Condition In Elderly Using Iot Sensors - Case Study, Zhi Hao Kevin Chong, Yu Xuan Tee, Ling Jing Toh, Shi Jia Phang, Jie Ying Liew, Bertran Queck, Swapna Gottipati

Research Collection School Of Computing and Information Systems

Ageing population would cause profound problems and the impact is already being felt today in many developed countries such as Singapore. The main concern for the Government is to help the citizens with active ageing through home ownership and good healthcare. With Internet of Things (IoT) gaining traction globally, Singapore is set to take advantage of this technology and leverage it to extend its capabilities towards a graceful Ageing-In-Place for the elderly. This ties in nicely with the expertise of SHINE Seniors project by SMU-iCity Lab, which integrates IT with healthcare in ways that creates innovative IT health solutions that …

Secure Approximation Of Edit Distance On Genomic Data, Md Momin Al Aziz, Dima Alhadidi, Noman Mohammed

All Works

© 2017 The Author(s). Background: Edit distance is a well established metric to quantify how dissimilar two strings are by counting the minimum number of operations required to transform one string into the other. It is utilized in the domain of human genomic sequence similarity as it captures the requirements and leads to a better diagnosis of diseases. However, in addition to the computational complexity due to the large genomic sequence length, the privacy of these sequences are highly important. As these genomic sequences are unique and can identify an individual, these cannot be shared in a plaintext. Methods: In …

Mining Non-Lattice Subgraphs For Detecting Missing Hierarchical Relations And Concepts In Snomed Ct, Licong Cui, Wei Zhu, Shiqiang Tao, James T. Case, Olivier Bodenreider, Guo-Qiang Zhang

Computer Science Faculty Publications

Objective: Quality assurance of large ontological systems such as SNOMED CT is an indispensable part of the terminology management lifecycle. We introduce a hybrid structural-lexical method for scalable and systematic discovery of missing hierarchical relations and concepts in SNOMED CT.

Material and Methods: All non-lattice subgraphs (the structural part) in SNOMED CT are exhaustively extracted using a scalable MapReduce algorithm. Four lexical patterns (the lexical part) are identified among the extracted non-lattice subgraphs. Non-lattice subgraphs exhibiting such lexical patterns are often indicative of missing hierarchical relations or concepts. Each lexical pattern is associated with a potential specific type of error. …

Towards A Better Understanding Of On And Off Target Effects Of The Lymphocyte-Specific Kinase Lck For The Development Of Novel And Safer Pharmaceuticals, Xiaofei Zhang, Amir Kucharski, Wibe A. De Jong, Sally R. Ellingson

Markey Cancer Center Faculty Publications

In this work we have developed a multi-tiered computational platform to study protein-drug interactions. At the beginning of the workflow more efficient and less accurate methods are used to enable large libraries of proteins in many conformations and massive chemical libraries to be screened. At each subsequent step in the workflow a subset of input data is investigated with increased accuracy and more computationally expensive methods. We demonstrate the developed workflow with the investigation of the lymphocyte-specific kinase LCK, which is implicated as a drug target in many cancers and also known to have toxic effects when unintentionally targeted. Several …

Towards Unobtrusive Mental Well-Being Monitoring For Independent-Living Elderly, Sinh Huynh, Hwee-Pink Tan, Youngki Lee

Research Collection School Of Computing and Information Systems

It is essential to proactively detect mental health problems such as loneliness and depression in the independently-living elderly for timely intervention by caregivers. In this paper, we introduce an unobtrusive sensor-enabled monitoring system that has been deployed to 50 government housing ats with the independent-living elderly for two years. Then, we also present our initial findings from the 6-month sensor data between August 2015 and April 2016 as well as the survey data to measure the subjective well-being indicator. Our study showed the promising results that "room-level movements within a house" and "going out" behavior captured by our simple sensor …

The Acquisition And Analysis Of Electroencephalogram Data For The Classification Of Benign Partial Epilepsy Of Childhood With Centrotemporal Spikes, Jessica A. Scarborough

Master's Theses

In this thesis, I will expand upon each step in the process of acquiring and analyzing electroencephalogram (EEG) for the classification of benign childhood epilepsy with centrotemporal spikes. Despite huge advancements in the field of health informatics—natural language processing, machine learning, predictive modeling—there are significant barriers to the access of clinical data. These barriers include information blocking, privacy policy concerns, and a lack of stakeholder support. We will see that these roadblocks are all responsible for stunting biomedical research in some way, including my own experiences in acquiring the data for the second chapter of this thesis.

This second chapter …

We Are Alfred: Empathy Learned Through A Medical Education Virtual Reality Project, Barbara Swartzlander, Elizabeth Dyer, Marilyn R. Gugliucci

Library Services Faculty Posters

Poster describing project collaboration among University of New England (UNE) librarians and College of Osteopathic Medicine (COM) faculty, whose goal was to adopt technology which will teach UNECOM students to be empathic with older adults and familiarize medical students with information resources from the NIH/NLM related to older adult health. Technology tested was the Alfred Lab developed by Embodied Labs. First year medical students were required to complete the ‘We Are Alfred’ virtual reality module and a pre and post assessment. Descriptive statistics were applied to finite questions on pre and post assessments, and content analysis on open ended answers. …

Umass Memorial Healthcare Information System Job Ladder, Matthew Simoncini, Vamsi Kavuru, Antariksh Nanda, Tahaseen Mahaboob Basha, Vikram Patil

School of Professional Studies

The capstone project report emphasizes the importance of a job ladder and the need of an hour to implement it at UMASS Memorial health care. The scope of this project is to create a well-established job ladder at UMASS with pre-defined standards on job levels related to Information Technology department that would facilitate in hiring, developing and promoting employees at various stages.

A Learning Framework For The Ywca Central Massachusetts, Dayna Ankermann, Manjushree Burdekar, Priyanka Joshi, Ying Song, Yumeng Chen, Xing Xie

School of Professional Studies

After meeting with the Director of Wellness and Health Equity at the YWCA Central Massachusetts (which will be referred to as the YWCA from here on out), we learned that as a non-profit gym and health center, it is heavily underfunded. The main focus of the project was to determine how to upkeep the facility while bringing in new customers with limited resources and budget. Due to the needs of the YWCA, our group focused on six aspects: revenue stream, donor retention, increasing membership, customer experience, social media marketing, and membership fee structure. After completing extensive research, we were able …

Human Services Management (Hsm) Certificate Program Expansion To Western Massachusetts Feasibility Study, Paul Campbell, Patrick Deschenes, Maria Pacheco, Bradley Paul, Elizabeth Vittum, Jing Zhang

School of Professional Studies

One of the most popular cost-savings programs that the Providers’ Council currently offers its members is a Certificate in Nonprofit Human Service Management (HSM) provided in partnership with Clark University and Suffolk University. As human services providers are struggling to hire and retain qualified staff, the need to provide professional development opportunities to help grow and expand a skilled health and human services workforce is a critical issue facing nonprofit organizations and communities in Massachusetts. This feasibility study examines the viability of Providers’ Council and Clark University expanding its HSM Certificate Program to organizations and staff located in western Massachusetts. …

Somali National University, Sharmarke Abdulla, Nikala Pieroni, Jenna Caskie, Sergii Odnodvorets, Tanyue Gong, Lahari Dasari

School of Professional Studies

The executive summary presents an overview of the principal conclusions and recommendations for Somali National University Faculty of Education (FoEd) regarding the following concerns: Difficulty with recruiting high quality prospects to the FoEd; Ineffective and counterintuitive use of social media as a tool to improve brand equity, as well as as a tool to attract and communicate with prospective and current students; Unbalanced gender ratio of current student body; Absence of student services and student supports; Low student retention rate; Limited resources for academic advising; This document is the result of a Clark University School of Professional Studies Capstone Project.

Network Exploration Of Correlated Multivariate Protein Data For Alzheimer's Disease Association, Matthew J. Lane

Theses

Alzheimer Disease (AD) is difficult to diagnose by using genetic testing or other traditional methods. Unlike diseases with simple genetic risk components, there exists no single marker determining as to whether someone will develop AD. Furthermore, AD is highly heterogeneous and different subgroups of individuals develop the disease due to differing factors. Traditional diagnostic methods using perceivable cognitive deficiencies are often too little too late due to the brain having suffered damage from decades of disease progression. In order to observe AD at early stages prior to the observation of cognitive deficiencies, biomarkers with greater accuracy are required. By using …

Granting Personhood For Sentient Non-Human Animals And Sentient Artificial Intelligences: A Demonstrative Argument, Jeremiah Meadows

Virginias Collegiate Honors Council Conference

While the subject of personhood has been exhaustively debated regarding the unborn, personhood for sentient animals and artificial intelligences is a concept that is rarely deliberated. Humanity has learned that there are multiple animal species which are very similar to humans in their self-awareness, emotional capacity, and free will. These traits have been partially developed for artificial intelligences as well, and those characteristics will evolve alongside human and technological development. As stratified societies emerged, there have been multiple occurrences where individuals were deemed lesser but then later acquired equal standing. Dr. Daniel Wilson, roboticist, wrote in his novel Robopocalypse, “It …

Predoctoral Dental Students’ Perceptions Of Dental Implant Training: Effect Of Preclinical Simulation And Clinical Experience, Soni Prasad, Naveen K. Bansal

School of Dentistry Faculty Research and Publications

The aims of this study were to assess 1) differences in perceptions of dental implant training between dental students who received didactic training alone (control group) and those who received didactic plus simulation training (test group); 2) differences in response between students with and without clinical experience in implant dentistry; and 3) the interaction effect of simulation training and clinical experience on students’ satisfaction. A survey was distributed to the control group in 2014 and to the test group in 2015; both groups were at the same U.S. dental school. Data were collected on confidence levels with various implant restorative …

An Online Educational Program Improves Pediatric Oncology Nurses’ Knowledge, Attitudes, And Spiritual Care Competence, Cheryl L. Petersen, Margaret Callahan, Donna O. Mccarthy, Ronda G. Hughes, Rosemary White-Traut, Naveen K. Bansal

Mathematics, Statistics and Computer Science Faculty Research and Publications

This study evaluated the potential impact of an online spiritual care educational program on pediatric nurses’ attitudes toward and knowledge of spiritual care and their competence to provide spiritual care to children with cancer at the end of life. It was hypothesized that the intervention would increase nurses’ positive attitudes toward and knowledge of spiritual care and increase nurses’ level of perceived spiritual care competence. A positive correlation was expected between change in nurses’ perceived attitudes toward and knowledge of spiritual care and change in nurses’ perceived spiritual care competence. A prospective, longitudinal design was employed, and analyses included one-way …

Toward A Collaborative Ai Framework For Assistive Dementia Care, Tze-Yun Leong

Research Collection School Of Computing and Information Systems

We envision an integrated framework for supporting the development and deployment of human-aware, general artificial intelligence (AI) that needs to collaborate in uncertain, changing environments. We examine the technology and system requirements of building assistive care agents for dementia or cognitive impaired patients through the continuum of care. We summarize the new AI capabilities and show examples of how an evolving, adaptive development approach would be able to support the basic functionalities and applications in a sound, practical, and scalable manner. We highlight the challenges and the opportunities involved in realizing the proposed framework, and call for future research and …

Computational Analysis Of Residue Interaction Networks And Coevolutionary Relationships In The Hsp70 Chaperones: A Community- Hopping Model Of Allosteric Regulation And Communication, Gabrielle Stetz, Gennady M. Verkhivker

Mathematics, Physics, and Computer Science Faculty Articles and Research

Allosteric interactions in the Hsp70 proteins are linked with their regulatory mechanisms and cellular functions. Despite significant progress in structural and functional characterization of the Hsp70 proteins fundamental questions concerning modularity of the allosteric interaction networks and hierarchy of signaling pathways in the Hsp70 chaperones remained largely unexplored and poorly understood. In this work, we proposed an integrated computational strategy that combined atomistic and coarse-grained simulations with coevolutionary analysis and network modeling of the residue interactions. A novel aspect of this work is the incorporation of dynamic residue correlations and coevolutionary residue dependencies in the construction of allosteric interaction networks …

Older Adult Health: National Library Of Medicine Resources For Health Care Providers And For Patients And Families, Elizabeth Dyer, Barbara Swartzlander, Marilyn R. Gugliucci, Laura Taylor

Library Services Faculty Publications

This list of resources was designed to complement a project funded by the National Network of Libraries of Medicine (NN/LM) New England Region (NER) entitled “Empathy Learned Through an Extended Medical Education Virtual Reality Project." The project used a virtual reality (VR) experience for 1st year medical students developed by Embodied Labs. The interactive “Alfred Lab” immerses users in the story of a 74-year-old patient who has macular degeneration and hearing loss, allowing users to experience these conditions from the patient’s perspective as he interacts with his family and doctor.

A System To Monitor Cognitive Workload In Naturalistic High-Motion Environments, Bethany K. Bracken, Seth Elkin-Frankston, Noa Palmon, Michael Farry, Blaise De B Frederick

H-Workload 2017: Models and Applications (Works in Progress)

Across many careers, individuals face alternating periods of high and low attention and cognitive workload can impair cognitive function and undermine job performance. We have designed and are developing an unobtrusive system to Monitor, Extract, and Decode Indicators of Cognitive Workload (MEDIC) in naturalistic, high-motion environments. MEDIC is designed to warn individuals, teammates, or supervisors when steps should be taken to augment cognitive readiness. We first designed and manufactured a forehead sensor device that includes a custom fNIRS sensor and a three-axis accelerometer designed to be mounted on the inside of a baseball cap or headband, or standard issue gear …

Towards A Not Obtrusive Low Cost Biosystem To Assess Risk Perception In Workplace Through Stress Detection, Emanuele Bellini, Serena Benevenuti, Chiara Batistini

H-Workload 2017: Models and Applications (Works in Progress)

The main aim of the article is to build a method to assess risk perception in real time in order to early detect and prevent risk behaviors and possible human errors. To this end, the relation between mental workload and stress as critical factors affecting risk perception has been investigated. In particular the mental-physical activation generated by an increment of the workload has the effect of reducing the resources needed to perceive risk increasing the worker vulnerability. The complexity of the stress phenomenon suggested the adoption of an integrated view. The Functional Model has been adopted to for its holistic …

Reducing Peak Workload In The Cockpit: A Human In The Loop Simulation Evaluating New Runway Selection Tool, Tanja Bos, Rolf Zon, Wilfred Rouwhorst

H-Workload 2017: Models and Applications (Works in Progress)

In efforts to increase safety and reduce peak workload situations in the cockpit, a tool with a different interaction style was developed for use in case of a runway change instructed by Air Traffic Control during approach. In an experiment a workload comparison was made between the new tool and the conventional cockpit. Workload was measured by means of a self-rating after each experiment run, as well as eye blink frequency during each run. Results show that the self-rated workload decreases with the new tool for one of the two crew members and the blink frequency suggests a workload decrease …

How Leaders Market And Commercialize Healthcare Technology Innovation, Roxie Mooney, Rocky J. Dwyer Dr.

Walden Faculty and Staff Publications

This study investigates what strategies technology development marketing leaders utilized to commercialize a new product innovation in the healthcare market. Analysis of data generated 3 major themes: strategies implemented during the prelaunch phase, strategies implemented during the pilot customer phase, and strategies implemented in the broader market launch phase of the CoI process. Findings from this study may contribute to maximizing commercial success and the diffusion of new product innovations in healthcare, which might lead to better patient outcomes and enhanced ways of practicing medicine.