Computer Sciences Commons^™

Development And Testing Of An Unmanned Aircraft System For Environmental Science, Jerald James Brady

Open Access Theses & Dissertations

For some environmental science applications, Unmanned Aircraft Systems (UASs) are increasingly recognized for their capacity to collect remotely sensed data in a safer, more efficient and effective manner than is permitted with manned aircraft and satellite remote sensing platforms. To date, however, technological, human, and other challenges have constrained adoption of UASs in the environmental sciences. This study developed and tested a new UAS for an archetypical environmental science research group (stakeholder) composed of non-UAS experts. Specifically, this thesis: 1) Assessed the research and operational needs of the stakeholder to determine the optimum UAS platform; 2) Developed an Unmanned Aerial …

Bcc Skin Cancer Diagnosis Based On Texture Analysis Techniques, Shao-Hui Chuang, Xiaoyan Sun, Wen-Yu Chang, Gwo-Shing Chen, Adam Huang, Jiang Li, Frederic D. Mckenzie

Electrical & Computer Engineering Faculty Publications

In this paper, we present a texture analysis based method for diagnosing the Basal Cell Carcinoma (BCC) skin cancer using optical images taken from the suspicious skin regions. We first extracted the Run Length Matrix and Haralick texture features from the images and used a feature selection algorithm to identify the most effective feature set for the diagnosis. We then utilized a Multi-Layer Perceptron (MLP) classifier to classify the images to BCC or normal cases. Experiments showed that detecting BCC cancer based on optical images is feasible. The best sensitivity and specificity we achieved on our data set were 94% …

Using A Focus Measure To Automate The Location Of Biological Tissue Surfaces In Brightfield Microscopy, Daniel Toby Elozory

USF Tampa Graduate Theses and Dissertations

The study of microstructures in brightfield microscopy using unbiased stereology plays a large and growing role in bioscience research. Stereology enables objective quantitative analysis of biological structures within a tissue sample. A first step in the stereology process is to calculate the thickness of a tissue sample by locating the top and bottom surfaces of the sample. The aim of this project is to fully automate this location process by using the relative optical focus measure as an indicator of tissue surface boundary.

The current method for identification of focus bounding planes requires a trained user to manually select the …

Computational Network Analysis Of The Anatomical And Genetic Organizations In The Mouse Brain, Shuiwang Ji

Computer Science Faculty Publications

Motivation: The mammalian central nervous system (CNS) generates high-level behavior and cognitive functions. Elucidating the anatomical and genetic organizations in the CNS is a key step toward understanding the functional brain circuitry. The CNS contains an enormous number of cell types, each with unique gene expression patterns. Therefore, it is of central importance to capture the spatial expression patterns in the brain. Currently, genome-wide atlas of spatial expression patterns in the mouse brain has been made available, and the data are in the form of aligned 3D data arrays. The sheer volume and complexity of these data pose significant challenges …

Spatial Semantics For Better Interoperability And Analysis: Challenges And Experiences In Building Semantically Rich Applications In Web 3.0, Amit P. Sheth

Kno.e.sis Publications

No abstract provided.

Appearance Based Stage Recognition Of Drosophila Embryos, Gopi Chand Nutakki

Masters Theses & Specialist Projects

Stages in Drosophila development denote the time after fertilization at which certain specific events occur in the developmental cycle. Stage information of a host embryo, as well as spatial information of a gene expression region is indispensable input for the discovery of the pattern of gene-gene interaction. Manual labeling of stages is becoming a bottleneck under the circumstance of high throughput embryo images. Automatic recognition based on the appearances of embryos is becoming a more desirable scheme. This problem, however, is very challenging due to severe variations of illumination and gene expressions. In this research thesis, we propose an appearance …

A Microrna Target Prediction Algorithm, Rupinder Singh

Master's Projects

MicroRNA target prediction using the experimental methods is a challenging task. To accelerate the process of miRNA target validation, many computational methods are used. Computational methods yield many potential candidates for experimental validation. This project is about developing a new computational method using dynamic programming to predict miRNA targets with more accuracy. The project discusses the currently available computational methods and develops a new algorithm using the currently available knowledge about miRNA interactions.

Flexible Bootstrapping-Based Ontology Alignment, Prateek Jain, Pascal Hitzler, Amit P. Sheth

Kno.e.sis Publications

BLOOMS (Jain et al, ISWC2010) is an ontology alignment system which, in its core, utilizes the Wikipedia category hierarchy for establishing alignments. In this paper, we present a Plug-and-Play extension to BLOOMS, which allows to flexibly replace or complement the use of Wikipedia by other online or offline resources, including domain-specific ontologies or taxonomies. By making use of automated translation services and of Wikipedia in languages other than English, it makes it possible to apply BLOOMS to alignment tasks where the input ontologies are written in different languages.

The Mycobacterium Tuberculosis Drugome And Its Polypharmacological Implications, Sarah L. Kinnings, Li Xie, Kingston H. Fung, Richard M. Jackson, Lei Xie, Phillip E. Bourne

Publications and Research

We report a computational approach that integrates structural bioinformatics, molecular modelling and systems biology to construct a drug-target network on a structural proteome-wide scale. The approach has been applied to the genome of Mycobacterium tuberculosis (M.tb), the causative agent of one of today’s most widely spread infectious diseases. The resulting drug-target interaction network for all structurally characterized approved drugs bound to putative M.tb receptors, we refer to as the ‘TB-drugome’. The TB-drugome reveals that approximately one-third of the drugs examined have the potential to be repositioned to treat tuberculosis and that many currently unexploited M.tb receptors may be chemically druggable …

Ontology Alignment For Linked Open Data, Prateek Jain, Pascal Hitzler, Amit P. Sheth, Kunal Verma, Peter Z. Yeh

Kno.e.sis Publications

The Web of Data currently coming into existence through the Linked Open Data (LOD) effort is a major milestone in realizing the Semantic Web vision. However, the development of applications based on LOD faces difficulties due to the fact that the different LOD datasets are rather loosely connected pieces of information. In particular, links between LOD datasets are almost exclusively on the level of instances, and schema-level information is being ignored. In this paper, we therefore present a system for finding schema-level links between LOD datasets in the sense of ontology alignment. Our system, called BLOOMS, is based on the …

(1e,3e)-1,4-Bis(4-Methoxyphenyl)Buta1,3-Diene, Gopinathan Narayan, Nigam Rath, Suresh Das

Chemistry & Biochemistry Faculty Works

The title compound, C18H18O2, which exhibits blue emission in the solid state, is an inter­mediate in the preparation of liquid crystals and polymers. The mol­ecule is located on an inversion centre. In the crystal, mol­ecules are arranged in a herringbone motif.

Impact Of Interdisciplinary Undergraduate Research In Mathematics And Biology On The Development Of A New Course Integrating Five Stem Disciplines, Lester Caudill, April L. Hill, Kathy Hoke, Ovidiu Z. Lipan

Biology Faculty Publications

Funded by innovative programs at the National Science Foundation and the Howard Hughes Medical Institute, University of Richmond faculty in biology, chemistry, mathematics, physics, and computer science teamed up to offer first- and second-year students the opportunity to contribute to vibrant, interdisciplinary research projects. The result was not only good science but also good science that motivated and informed course development. Here, we describe four recent undergraduate research projects involving students and faculty in biology, physics, mathematics, and computer science and how each contributed in significant ways to the conception and implementation of our new Integrated Quantitative Science course, a …

Impact Of Interdisciplinary Undergraduate Research In Mathematics And Biology On The Development Of A New Course Integrating Five Stem Disciplines, Lester Caudill, April L. Hill, Kathy Hoke, Ovidiu Z. Lipan

Department of Math & Statistics Faculty Publications

Funded by innovative programs at the National Science Foundation and the Howard Hughes Medical Institute, University of Richmond faculty in biology, chemistry, mathematics, physics, and computer science teamed up to offer first- and second-year students the opportunity to contribute to vibrant, interdisciplinary research projects. The result was not only good science but also good science that motivated and informed course development. Here, we describe four recent undergraduate research projects involving students and faculty in biology, physics, mathematics, and computer science and how each contributed in significant ways to the conception and implementation of our new Integrated Quantitative Science course, a …

Drug Off-Target Effects Predicted Using Structural Analysis In The Context Of A Metabolic Network Model, Roger L. Chang, Lei Xie, Philip E. Bourne, Bernhard O. Palsson

Publications and Research

Recent advances in structural bioinformatics have enabled the prediction of protein-drug off-targets based on their ligand binding sites. Concurrent developments in systems biology allow for prediction of the functional effects of system perturbations using large-scale network models. Integration of these two capabilities provides a framework for evaluating metabolic drug response phenotypes in silico. This combined approach was applied to investigate the hypertensive side effect of the cholesteryl ester transfer protein inhibitor torcetrapib in the context of human renal function. A metabolic kidney model was generated in which to simulate drug treatment. Causal drug off-targets were predicted that have previously been …

2,2′,5,5′-Tetra­Chloro­Benzidine, Onome Ugono, Marcel Douglas, Nigam Rath, Alicia Beatty

Chemistry & Biochemistry Faculty Works

In the crystal structure of the title compound, C12H8Cl4N2, mol­ecules lie on crystallographic twofold axes at the centre of the C-C bonds linking the benzene rings, such that the asymmetric unit consists of a half-mol­ecule. The individual mol­ecules participate in inter­molecular N-H...N, N-H...Cl, C-H...Cl and Cl...Cl [3.4503 (3) Å] inter­actions.

A Taxonomy-Based Model For Expertise Extrapolation, Delroy H. Cameron, Boanerges Aleman-Meza, Ismailcem Budak Arpinar, Sheron L. Decker, Amit P. Sheth

Kno.e.sis Publications

While many ExpertFinder applications succeed in finding experts, their techniques are not always designed to capture the various levels at which expertise can be expressed. Indeed, expertise can be inferred from relationships between topics and subtopics in a taxonomy. The conventional wisdom is that expertise in subtopics is also indicative of expertise in higher level topics as well. The enrichment of Expertise Profiles for finding experts can therefore be facilitated by taking domain hierarchies into account. We present a novel semantics-based model for finding experts, expertise levels and collaboration levels in a peer review context, such as composing a Program …

Bioinformatics Across The Sciences, Nigel Yarlett

Cornerstone 3 Reports : Interdisciplinary Informatics

No abstract provided.

Ranking Documents Semantically Using Ontological Relationships, Boanerges Aleman-Meza, I. Budak Arpinar, Mustafa V. Nural, Amit P. Sheth

Kno.e.sis Publications

Although arguable success of today’s keyword based search engines in certain information retrieval tasks, ranking search results in a meaningful way remains an open problem. In this work, the goal is to use of semantic relationships for ranking documents without relying on the existence of any specific structure in a document or links between documents. Instead, real-world entities are identified and the relevance of documents is determined using relationships that are known to exist between the entities in a populated ontology. We introduce a measure of relevance that is based on traversal and the semantics of relationships that link entities …

Pattern Space Maintenance For Data Updates And Interactive Mining, Mengling Feng, Guozhu Dong, Jinyan Li, Yap-Peng Tan, Limsoon Wong

Kno.e.sis Publications

This article addresses the incremental and decremental maintenance of the frequent pattern space. We conduct an in-depth investigation on how the frequent pattern space evolves under both incremental and decremental updates. Based on the evolution analysis, a new data structure, Generator-Enumeration Tree (GE-tree), is developed to facilitate the maintenance of the frequent pattern space. With the concept of GE-tree, we propose two novel algorithms, Pattern Space Maintainer+ (PSM+) and Pattern Space Maintainer− (PSM−), for the incremental and decremental maintenance of frequent patterns. Experimental results demonstrate that the proposed algorithms, on average, outperform the representative state-of-the-art …

Cross-Market Model Adaptation With Pairwise Preference Data For Web Search Ranking, Jing Bai, Fernando Diaz, Yi Chang, Zhaohui Zheng, Keke Chen

Kno.e.sis Publications

Machine-learned ranking techniques automatically learn a complex document ranking function given training data. These techniques have demonstrated the effectiveness and flexibility required of a commercial web search. However, manually labeled training data (with multiple absolute grades) has become the bottleneck for training a quality ranking function, particularly for a new domain. In this paper, we explore the adaptation of machine-learned ranking models across a set of geographically diverse markets with the market-specific pairwise preference data, which can be easily obtained from clickthrough logs. We propose a novel adaptation algorithm, Pairwise-Trada, which is able to adapt ranking models that are trained …

2,4,6-Triphenyl­Aniline, Onome Ugono, Stephanie Cowin, Alicia Beatty

Chemistry & Biochemistry Faculty Works

Individual mol­ecules of the title compound, C24H19N, do not participate in hydrogen-bonding inter­actions due to the steric bulk of the phenyl rings ortho to the amine. The dihedral angles between the central ring and the pendant rings are 68.26 (10), 55.28 (10) and 30.61 (11)°.

10302 Summary - Learning Paradigms In Dynamic Environments, Barbara Hammer, Pascal Hitzler

Computer Science and Engineering Faculty Publications

The seminar centered around problems which arise in the context of machine learning in dynamic environments. Particular emphasis was put on a couple of specific questions in this context: how to represent and abstract knowledge appropriately to shape the problem of learning in a partially unknown and complex environment and how to combine statistical inference and abstract symbolic representations; how to infer from few data and how to deal with non i.i.d. data, model revision and life-long learning; how to come up with efficient strategies to control realistic environments for which exploration is costly, the dimensionality is high and data …

Trust Model For Semantic Sensor And Social Networks: A Preliminary Report, Pramod Anantharam, Cory Andrew Henson, Krishnaprasad Thirunarayan, Amit P. Sheth

Kno.e.sis Publications

Trust is an amorphous concept that is becoming Increasingly important in many domains, such as P2P networks, E-commerce, social networks, and sensor networks. While we all have an intuitive notion of trust, the literature is scattered with a wide assortment of differing definitions and descriptions; often these descriptions are highly dependent on a single domain or application of interest. In addition, they often discuss orthogonal aspects of trust while continuing to use the general term “trust”. In order to make sense of the situation, we have developed an ontology of trust that integrates and relates its various aspects into a …

Sit-To-Stand Detection Using Fuzzy Clustering Techniques, Tanvi Banerjee, James M. Keller, Marjorie Skubic, Carmen Abbott

Kno.e.sis Publications

The ability to rise from a chair is an important parameter to assess the balance deficits of a person. In particular, this can be an indication of risk for falling in elderly persons. Our goal is automated assessment of fall risk using video data. Towards this goal, we present a simple yet effective method of detecting transition, i.e. sit-to-stand and stand-to-sit, from image frames using fuzzy clustering methods on image moments. The technique described in this paper is shown to be robust even in the presence of noise and has been tested on several data sequences using different subjects yielding …

Biomedical Ontologies For Parasite Research, Vinh Nguyen, Satya S. Sahoo, Priti Parikh, Todd Minning, Brent Weatherly, Flora Logan, Amit P. Sheth, Rick Tarleton

Kno.e.sis Publications

Trypanosoma cruzi is a protozoan parasite that causes Chagas disease or American trypanosomiasis, which is the leading cause of death in Latin America. The primary objective of this study is to create an ontology-driven information infrastructure to support parasite researchers in identifying gene knockout, vaccination, or drug targets for T. cruzi. This involves querying across multiple datasets from diverse sources, such as proteome, pathway, internal lab data, etc. that are often represented in heterogeneous formats. To address this, a multi-ontology parasite knowledge repository (PKR) is being created with an intuitive graphical query interface called Cuebee. The PKR is underpinned by …

Cloud Based Scientific Workflow For Nmr Data Analysis, Ashwin Manjunatha, Paul E. Anderson, Satya S. Sahoo, Ajith Harshana Ranabahu, Michael L. Raymer, Amit P. Sheth

Kno.e.sis Publications

This work presents a service oriented scientific workflow approach to NMR-based metabolomics data analysis. We demonstrate the effectiveness of this approach by implementing several common spectral processing techniques in the cloud using a parallel map-reduce framework, Hadoop.

Computational Modeling Of Biological Neural Networks On Gpus: Strategies And Performance, Byron Galbraith

Master's Theses (2009 -)

Simulating biological neural networks is an important task for computational neuroscientists attempting to model and analyze brain activity and function. As these networks become larger and more complex, the computational power required grows significantly, often requiring the use of supercomputers or compute clusters. An emerging low-cost, highly accessible alternative to many of these resources is the Graphics Processing Unit (GPU) - specialized massively-parallel graphics hardware that has seen increasing use as a general purpose computational accelerator thanks largely due to NVIDIA's CUDA programming interface. We evaluated the relative benefits and limitations of GPU-based tools for large-scale neural network simulation and …

How To Make Linked Data More Than Data, Prateek Jain, Amit P. Sheth, Kunal Verma, Pascal Hitzler, Peter Z. Yeh

Kno.e.sis Publications

The LOD cloud has a potential for applicability in many AI-related tasks, such as open domain question answering, knowledge discovery, and the Semantic Web. An important prerequisite before the LOD cloud can enable these goals is allowing its users (and applications) to effectively pose queries to and retrieve answers from it. However, this prerequisite is still an open problem for the LOD cloud and has restricted it to 'merely more data.' To transform the LOD cloud from 'merely more data' to 'semantically linked data' there are plenty of open issues which should be addressed. We believe this transformation of the …

Semantically Annotated Restful Services For Large-Scale Metabolomics Data Analysis, Ashwin Manjunatha, Paul E. Anderson, Satya S. Sahoo, Ajith H. Ranabahu, Michael L. Raymer, Amit P. Sheth

Kno.e.sis Publications

No abstract provided.

Janus: From Workflows To Semantic Provenance And Linked Open Data, Paolo Missier, Satya S. Sahoo, Jun Zhao, Carole Goble, Amit P. Sheth

Kno.e.sis Publications

Data provenance graphs are form of metadata that can be used to establish a variety of properties of data products that undergo sequences of transformations, typically specified as workflows. Their usefulness for answering user provenance queries is limited, however, unless the graphs are enhanced with domain-specific annotations. In this paper we propose a model and architecture for semantic, domain-aware provenance, and demonstrate its usefulness in answering typical user queries. Furthermore, we discuss the additional benefits and the technical implications of publishing provenance graphs as a form of Linked Data. A prototype implementation of the model is available for data produced …