Medicinal-Pharmaceutical Chemistry Commons^™

Effects Of Cisplatin Analog Size On The Reaction With Dna Bases, Swathi Nandala

Masters Theses & Specialist Projects

Cancer is the second leading cause of death in the United States. Cisplatin is one of the well-known anti-cancer agents used to treat testicular and ovarian cancers. It mainly binds to the DNA bases, which leads to cell death. The cytotoxic activity of the cisplatin analogs is due to the interaction of platinum with nucleotides like adenine at N₇ or N₁ position and guanine at N₇ position. Guanine is the primary target for cisplatin analogs whereas adenine is the secondary target. Cisplatin analogs, [Pt(Me₅dien)(D₂O)]²⁺[Me₅dien = N,N,N’,N’,N’’-pentamethyl diethylene triamine] and …