Medicinal-Pharmaceutical Chemistry Commons^™

Molecular Basis Of Substrate Recognition In Bjai, An Ahl Synthase From Bradyrhizobium Japonicum, Nicole Cornell

Boise State University Theses and Dissertations

Resistance to antibiotics has become a major challenge in today’s society for treating bacterial infections. Inhibition of quorum sensing has a potential to be a non-antibiotic based therapeutic that could be used to fight these bacterial infections. Quorum sensing is a cell density dependent, intercellular communication mechanism that bacteria use to synchronize behavior such as virulence and resistance to antibiotics. If this switch from planktonic to communal behavior can be inhibited, the bacteria will be less virulent. One possible way to accomplish this is by inhibiting the enzymes that are responsible for making the quorum sensing signaling molecules in Gram-negative …