Open Access. Powered by Scholars. Published by Universities.®
Medicinal-Pharmaceutical Chemistry Commons™
Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Medicinal-Pharmaceutical Chemistry
Small Ring Analogs Of Acetylcholine. Synthesis And Absolute Configurations Of Cyclopropane Derivatives., Douglas Armstrong, Joseph G. Cannon
Small Ring Analogs Of Acetylcholine. Synthesis And Absolute Configurations Of Cyclopropane Derivatives., Douglas Armstrong, Joseph G. Cannon
Faculty Scholarship – Chemistry
Conformational rigidity has been conferred upon the OCCN portion of acetylcholine by incorporation of the C atoms into a cyclopropane ring. trans-2-Acetoxycyclopropyltrimethylammonium iodide has been prepared from an olefinic starting material, 2-vinyloxytetrahydropyran; assignment of the trans configuration to the 1,2-disubstituted cyclopropane systems was based upon literature precedent and upon nmr data, and was confirmed by X-ray crystallographic analysis. Resolution of one of the racemic intermediates in the reaction sequence was achieved, which permitted preparation of both enantiomers of the final product. X-Ray crystallographic analysis has demonstrated that the muscarinically active (+)-trans-2-acetoxycyclopropyltrimethylammonium iodide possesses the same absolute configuration …