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Full-Text Articles in Inorganic Chemistry
High-Resolution Three-Dimensional Nmr Structure Of The Kras Proto-Oncogene Promoter Reveals Key Features Of A G-Quadruplex Involved In Transcriptional Regulation, A. Kerkour, J. Marquevielle, S. Ivashchenko, Liliya A. Yatsunyk, J.-L. Mergny, G. F. Salgado
High-Resolution Three-Dimensional Nmr Structure Of The Kras Proto-Oncogene Promoter Reveals Key Features Of A G-Quadruplex Involved In Transcriptional Regulation, A. Kerkour, J. Marquevielle, S. Ivashchenko, Liliya A. Yatsunyk, J.-L. Mergny, G. F. Salgado
Chemistry & Biochemistry Faculty Works
Non-canonical base pairing within guanine-rich DNA and RNA sequences can produce G-quartets, whose stacking leads to the formation of a G-quadruplex (G4). G4s can coexist with canonical duplex DNA in the human genome and have been suggested to suppress gene transcription, and much attention has therefore focused on studying G4s in promotor regions of disease-related genes. For example, the human KRAS proto-oncogene contains a nuclease-hypersensitive element located upstream of the major transcription start site. The KRAS nuclease-hypersensitive element (NHE) region contains a G-rich element (22RT; 5′-AGGGCGGTGTGGGAATAGGGAA-3′) and encompasses a Myc-associated zinc finger-binding site that regulates KRAS transcription. The NEH region …
Effect Of Zinc Cations On The Kinetics Of Supramolecular Assembly And The Chirality Of Porphyrin J-Aggregates, A. Romeo, M. A. Castriciano, R. Zagami, G. Pollicino, L Monsù Scolaro, Robert F. Pasternack
Effect Of Zinc Cations On The Kinetics Of Supramolecular Assembly And The Chirality Of Porphyrin J-Aggregates, A. Romeo, M. A. Castriciano, R. Zagami, G. Pollicino, L Monsù Scolaro, Robert F. Pasternack
Chemistry & Biochemistry Faculty Works
Dilute aqueous solutions of anionic meso-4-sulfonatophenyl-porphyrin (TPPS) extract zinc(ii) ions from glass or quartz surfaces at room temperature and efficiently form the corresponding metal complex (ZnTPPS). The partial or complete formation of ZnTPPS has been probed by UV/Vis spectroscopy and both static and time-resolved fluorescence. The source of zinc(ii) ions has been clearly identified through inductively coupled plasma optical emission spectrometry. The presence of increasing amounts of ZnTPPS slows down the rate of TPPS J-aggregate formation in acid solution. This influences the nucleation step and has a profound impact on the onset of chirality in these species. This evidence indicates …