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Articles 1 - 5 of 5
Full-Text Articles in Inorganic Chemistry
Designing And Synthesizing A Warhead-Fragment Inhibitory Ligand For Ivyp1 Through Fragment-Based Drug Discovery, Samuel Moore
Designing And Synthesizing A Warhead-Fragment Inhibitory Ligand For Ivyp1 Through Fragment-Based Drug Discovery, Samuel Moore
Symposium of Student Scholars
Fragment-based drug discovery (FBDD) is a powerful tool for developing anticancer and antimicrobial agents. Within this, magnetic resonance spectroscopy (NMR) provides a comprehensive qualitative and quantitative approach to screening and validating weak and robust binders with targeted proteins, making NMR among the most attractive strategies in FBDD. Inhibitor of vertebrate lysozyme (Ivyp1) of P. aeruginosa serves as an excellent target because of its active cellular location and implications in clinical prognosis for cystic fibrosis and immunocompromised patients. This study uses current NMR and biophysical techniques to develop a covalent, fragment-linked warhead inhibitor for Ivyp1 through synthetic methods, warhead linking, and …
Bismuth Binding In Human Metallothionein, Emily M. Toswell
Bismuth Binding In Human Metallothionein, Emily M. Toswell
Undergraduate Student Research Internships Conference
Bismuth metal is one of the least toxic heavy metals for humans. It is used in a wide variety of applications including organic synthesis, cosmetics and pharmaceutical applications. In biomedicine, bismuth is a therapeutic metal used in metallodrugs such as Pepto Bismol for its antimicrobial and antibacterial properties. Metallothionein (MT) is a cysteine rich protein found in the liver, kidneys, brain and central nervous system. MT can bind a variety of metals including essential metals such as zinc and copper. This research investigates the binding pathway of Bi[EDTA]- with fully metallated Zn7MT by using mass-spectrometry and UV-vis absorption.
Extracting Lithium Using The Steric Bulk Of An Aminimide Functional Group, Jacob Parker, Martin Chin Ph.D.
Extracting Lithium Using The Steric Bulk Of An Aminimide Functional Group, Jacob Parker, Martin Chin Ph.D.
Summer Undergraduate Research Program (SURP) Symposium
An aminimide is a zwitterionic group containing a cationic nitrogen bonded to an anionic nitrogen. The goal of this project was to use the steric bulk and electronic properties of the aminimide to block other species in a brine solution such as potassium, and selectively pick up lithium. To test this, polymethacrylate beads which contain carboxyl groups were modified to the desired aminimide. Three different aminimide groups were tested, a trimethylaminimide, aminopyridiniumaminimide, and a triethylaminimide. The modified beads would be introduced to a solution containing lithium and the lithium concentration was measured before and after exposure to the beads using …
Using An Aminimide Polymer To Extract Lithium From A Brine Solution, Austin Heidbreder, Martin Chin Ph.D.
Using An Aminimide Polymer To Extract Lithium From A Brine Solution, Austin Heidbreder, Martin Chin Ph.D.
Summer Undergraduate Research Program (SURP) Symposium
Fast lithium isolation from water partly containing lithium ions would be an improvement over the current method of obtaining lithium in lithium mining water operations. The aminimide functional group can be used to selectively bind to lithium cations to extract lithium from brine. To characterize this uptake, the concentration of water containing lithium was measured with atomic absorption spectroscopy before and after the solution has been exposed to a polymer with the aminimide functional group. Three different polymers were used: trimethyl EGDM polymer, trimethyl TMPTA polymer, and the triethyl TMPTA polymer. Of the three, the trimethyl TMPTA polymer seemed to …
Corrosion Prevention Of Aluminum Alloy, Andrea Brenner
Corrosion Prevention Of Aluminum Alloy, Andrea Brenner
Symposium of Student Scholars
Aluminum alloy (Al-alloy) is a widely used metal in construction, aerospace, aviation, and other necessary fields due to its lightweight and tweakable properties. However, corrosion is inevitable on metals and alloys, and that causes millions of dollars of revenue loss every year. Therefore, we propose to research fabricating coating to prevent corrosion on Al-alloy. This study uses an iron-based metal-organic framework (MOF) and polyurethane (PU) based composite coating to prevent corrosion on the Al-alloy. The makeup of the composite material is changed by varying the percentage of MOF. In addition, a binder is also used to enhance the homogenization between …