Inorganic Chemistry Commons^™

Effect Of A Coordinating Pyridine Moiety On The Sap And Tsap Isomer Populations Of Bimodal Lanthanide (Iii) Complexes, Marisa Poveda, Osasere M. Evbuomwan

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Paramagnetic Chemical Exchange Saturation Transfer (PARACEST) agents are lanthanide complexes that generate contrast through the slow-to-intermediate exchange of paramagnetically-shifted protons or water molecules. Although PARACEST agents have shown promise as molecular imaging agents, in-vivostudies have been limited due to the masking of the CEST signal by spin-relaxation exchange (T_2ex) and Magnetization Transfer (MT) effects. The majority of PARACEST agents studied to date have been Ln(III)DOTA-tetraamides which can either adopt the square antiprismatic (SAP) or twisted square antiprismatic (TSAP) geometries in solution. The more compact nature of the SAP isomer, combined with its slower bound-water exchange kinetics, makes …