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Full-Text Articles in Inorganic Chemistry
Electrochemical Characterization Of Self-Assembled Monolayers On Gold Substrates Derived From Thermal Decomposition Of Monolayer-Protected Cluster Films, Michael C. Leopold, Tran T. Doan, Melissa J. Mullaney, Andrew F. Loftus, Christopher M. Kidd
Electrochemical Characterization Of Self-Assembled Monolayers On Gold Substrates Derived From Thermal Decomposition Of Monolayer-Protected Cluster Films, Michael C. Leopold, Tran T. Doan, Melissa J. Mullaney, Andrew F. Loftus, Christopher M. Kidd
Chemistry Faculty Publications
Networked films of monolayer-protected clusters (MPCs), alkanethiolate-stabilized gold nanoparticles, can be thermally decomposed to form stable gold on glass substrates that are subsequently modified with self-assembled monolayers (SAMs) for use as modified electrodes. Electrochemical assessment of these SAM-modified gold substrates, including double-layer capacitance measurements, linear sweep desorption of the alkanethiolates, and diffusional redox probing, all show that SAMs formed on gold supports formed from thermolysis of MPC films possess substantially higher defect density compared to SAMs formed on traditional evaporated gold. The density of defects in the SAMs on thermolyzed gold is directly related to the strategies used to assemble …
Structure-Function Relationships Affecting The Sensing Mechanism Of Monolayer-Protected Cluster Doped Xerogel Amperometric Glucose Biosensors, Luke T. Dipasquale, Nicholas G. Poulos, Jackson R. Hall, Aastha Minocha, Tram Anh Bui, Michael C. Leopold
Structure-Function Relationships Affecting The Sensing Mechanism Of Monolayer-Protected Cluster Doped Xerogel Amperometric Glucose Biosensors, Luke T. Dipasquale, Nicholas G. Poulos, Jackson R. Hall, Aastha Minocha, Tram Anh Bui, Michael C. Leopold
Chemistry Faculty Publications
A systematic study of the structure–function relationships critical to understanding the sensing mechanism of 1st generation amperometric glucose biosensors with an embedded nanoparticle (NP) network is presented. Xerogel-based films featuring embedded glucose oxidase enzyme and doped with alkanethiolate-protected gold NPs, known as monolayer protected clusters (MPCs), exhibit significantly enhanced performance compared to analogous systems without NPs including higher sensitivity, faster response time, and extended linear/dynamic ranges. The proposed mechanism involves diffusion of the glucose to glucose oxidase within the xerogel, enzymatic reaction production of H2O2 with subsequent diffusion to the embedded network of MPCs where it is oxidized, an event …
Quantitative Analysis Of Heavy Metals In Children’S Toys And Jewelry: A Multi-Instrument, Multi-Technique Exercise In Analytical Chemistry And Public Health, Lauren E. Finch, Margot M. Hillyer, Michael C. Leopold
Quantitative Analysis Of Heavy Metals In Children’S Toys And Jewelry: A Multi-Instrument, Multi-Technique Exercise In Analytical Chemistry And Public Health, Lauren E. Finch, Margot M. Hillyer, Michael C. Leopold
Chemistry Faculty Publications
For most chemistry curricula, laboratory-based activities in quantitative and instrumental analysis continue to be an important aspect of student development/training, one that can be more effective if conceptual understanding is delivered through an inquiry-based process relating the material to relevant issues of public interest and student career trajectories. Laboratory experiences that actively engage students in this manner can be difficult to identify and execute. A special topics, project-based laboratory module is presented here that utilizes multiple techniques and instruments to investigate toxic metal content (lead, cadmium, and arsenic) in children’s toys and toy jewelry. The module effectively illustrates a considerable …
Functional Layer-By-Layer Design Of Xerogel-Based 1st Generation Amperometric Glucose Biosensors, Nicholas G. Poulos, Jackson R. Hall, Michael C. Leopold
Functional Layer-By-Layer Design Of Xerogel-Based 1st Generation Amperometric Glucose Biosensors, Nicholas G. Poulos, Jackson R. Hall, Michael C. Leopold
Chemistry Faculty Publications
Xerogel-based first-generation amperometric glucose biosensors, constructed through specific layer-by-layer assembly of films featuring glucose oxidase doped xerogel, a diffusion-limiting xerogel layer, and capped with both electropolymerized polyphenol and blended polyurethane semipermeable membranes, are presented. The specific combination of xerogels formed from specific silane precursors, including propyl-trimethoxysilane, isobutyl-trimethoxysilane, octyl-trimethoxysilane, and hydroxymethyl-triethoxysilane, exhibit impressive dynamic and linear ranges of detection (e.g., ≥24–28 mM glucose) and low response times, as well as significant discrimination against common interferent species such as acetaminophen, ascorbic acid, sodium nitrite, oxalic acid, and uric acid as determined by selectivity coefficients. Additionally, systematic electrochemical and contact angle studies of …