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Full-Text Articles in Inorganic Chemistry
Association Of G-Quadruplex Forming Sequences With Human Mtdna Deletion Breakpoints, D. W. Dong, F. Pereira, Steven Paul Barrett , '13, J. E. Kolesar, K. Cao, J. Damas, Liliya A. Yatsunyk, F. B. Johnson, B. A. Kaufman
Association Of G-Quadruplex Forming Sequences With Human Mtdna Deletion Breakpoints, D. W. Dong, F. Pereira, Steven Paul Barrett , '13, J. E. Kolesar, K. Cao, J. Damas, Liliya A. Yatsunyk, F. B. Johnson, B. A. Kaufman
Chemistry & Biochemistry Faculty Works
Background: Mitochondrial DNA (mtDNA) deletions cause disease and accumulate during aging, yet our understanding of the molecular mechanisms underlying their formation remains rudimentary. Guanine-quadruplex (GQ) DNA structures are associated with nuclear DNA instability in cancer; recent evidence indicates they can also form in mitochondrial nucleic acids, suggesting that these non-B DNA structures could be associated with mtDNA deletions. Currently, the multiple types of GQ sequences and their association with human mtDNA stability are unknown. Results: Here, we show an association between human mtDNA deletion breakpoint locations (sites where DNA ends rejoin after deletion of a section) and sequences with G-quadruplex …