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Full-Text Articles in Inorganic Chemistry
Investigation Of The Interactions Between Pt(Ii) And Pd(Ii) Derivatives Of 5,10,15,20-Tetrakis (N-Methyl-4-Pyridyl) Porphyrin And G-Quadruplex Dna, Navin C. Sabharwal , '14, O. Mendoza, John Michael Nicoludis , '12, Thomas Ruan , '16, J.-L. Mergny, Liliya A. Yatsunyk
Investigation Of The Interactions Between Pt(Ii) And Pd(Ii) Derivatives Of 5,10,15,20-Tetrakis (N-Methyl-4-Pyridyl) Porphyrin And G-Quadruplex Dna, Navin C. Sabharwal , '14, O. Mendoza, John Michael Nicoludis , '12, Thomas Ruan , '16, J.-L. Mergny, Liliya A. Yatsunyk
Chemistry & Biochemistry Faculty Works
G-quadruplexes are non-canonical DNA structures formed by guanine-rich DNA sequences that are implicated in cancer and aging. Understanding how small molecule ligands interact with quadruplexes is essential both to the development of novel anticancer therapeutics and to the design of new quadruplex-selective probes needed for elucidation of quadruplex biological functions. In this work, UV–visible, fluorescence, and circular dichroism spectroscopies, fluorescence resonance energy transfer (FRET) melting assays, and resonance light scattering were used to investigate how the Pt(II) and Pd(II) derivatives of the well-studied 5,10,15,20-tetrakis(N-methyl-4-pyridyl)porphyrin (TMPyP4) interact with quadruplexes formed by the human telomeric DNA, Tel22, and by the G-rich sequences …