Chemistry Commons^™

Microwave Synthesis And Reactions Of Cpru(Dppe)Cl With Sulfur Containing Ligands, Srikanth Muthyala

Student Theses and Dissertations

The microwave synthesis of CpRu(dppe)Cl and CpRu(PPh3)(P(OMe)3)Cl were investigated. A new preparative method using microwave irradiation was found for CpRu(dppe)Cl and CpRu(PPh3)(P(OMe)3)Cl. Attempts to prepare CpRu(P(OMe)3)2Cl failed. Reactions of CpRu(dppe)Cl and CpRu(PPh3)(P(OMe)3)Cl with cyclothioether ligands were attempted. Pentamethylene sulfide (pms), tetrahydrothiophene (tht), and thietane (thie) were the ligands considered. The dppe-dithiooxamide complex {(µ-dtoxa)[CpRudppe]2}(BF4)2 was isolated and the structure was determined using X-ray diffraction techniques: space group P 21 21 21, a = 14.120 (7) Å, b = 16.099 Å, c = 30.917 Å. α = β = ϒ = 90O, V Å3 = 7028 (6), R(F), Rw (F) = 0.0531 …

Synthesis And Fading Of Eighteenth-Century Prussian Blue Pigments: A Combined Study By Spectroscopic And Diffractive Techniques Using Laboratory And Synchrotron Radiation Sources, Louise Samain, Fernande Grandjean, Gary J. Long, Pauline Martinetto, Pierre Bordet, Jana Sanyova, David Strivay

Chemistry Faculty Research & Creative Works

Prussian blue, a hydrated iron(III) hexacyanoferrate(II) complex, is a synthetic pigment discovered in Berlin in 1704. Because of both its highly intense color and its low cost, Prussian blue was widely used as a pigment in paintings until the 1970s. The early preparative methods were rapidly recognized as a contributory factor in the fading of the pigment, a fading already known by the mid-eighteenth century. Herein two typical eighteenth-century empirical recipes have been reproduced and the resulting pigment analyzed to better understand the reasons for this fading. X-ray absorption and Mössbauer spectroscopy indicated that the early syntheses lead to Prussian …

Improving Student Learning Of Organic Chemistry By The Use Of Case Comparisons., Divine-Favour Ekene Anene

College of Arts & Sciences Senior Theses

No abstract provided.

Ipads In The Science Laboratory: Experience In Designing And Implementing A Paperless Chemistry Laboratory Course, Tiffany Hesser, Pauline Schwartz

Chemistry and Chemical Engineering Faculty Publications

In the fall of 2012, 20 General Chemistry Honors students at the University of New Haven were issued the new iPad 3 to incorporate these devices both in the classroom and the laboratory. This paper will focus on the integration of the iPad into the laboratory curriculum while creating a paperless experience, an environment where no paper would enter or be used for the laboratory over the course of the year. Specific apps were chosen that would allow for an easy transition of course materials into an electronic format. After a transition period for the students and instructor, the overall …

Use Of Self-Assembled Monolayers To Tailor Surface Properties: From Lubrication To Neuronal Development, Natalie Ann Lafranzo

All Theses and Dissertations (ETDs)

The subsequent work describes advances in modifying the chemical properties of various substrates to tailor the surface properties for specific applications. This is achieved by making use of a molecular assembly known as self-assembled monolayers, or SAMs. SAMs are composed of tightly packed organic molecules that form a well-ordered structure on a substrate. Typically, the head group of the monomer is covalently anchored to the substrate, and monolayer order and self-assembly is achieved through van der Waals interactions between the long alkyl chains of the monomer's tail group. Monolayers containing head groups consisting of thiols, siloxanes, and phosphonates have been …

Integrating Art And Science In Undergraduate Education, Daniel Gurnon

Chemistry & Biochemistry Faculty Publications

The prevailing vision for undergraduate science education includes increased collaboration among teachers of science, technology, engineering and math (STEM) and an overhaul of introductory courses [1]–[4]. But by staying within the borders of STEM, are we overlooking connections between the arts and innovative science? Likewise, are we missing an important opportunity to inspire and inform nonscientists? Here we explore how weaving the visual arts into a science curriculum can both help develop scientific imagination and engage nonscientists. As an example, we describe a recent collaboration between artists and scientists to create a series of science-inspired sculptures.

The Enhancement Of Peroxide-Cured Fluoroelastomer Rubber To Metal Bonding, Richard Hunter Cooke Iii

Browse all Theses and Dissertations

A "combi-cured&" fluoroelastomer (FKM) rubber formulation was designed to yield 100% cohesive rubber failure when cured to cold-rolled steel with derivatives of polymeric silane adhesives. Three different categories of adhesives were tested: Unsaturated Polymeric Silane with Phosphonium Salt (UPSP-D), Unsaturated Polymeric Silane (UPS-L), and Saturated Polymeric Silane (SPS-L). Adhesion Inserts molded using ASTM Method D429 Method C all consistently yielded 100% cohesive rubber failure and showed adhesion strength in the range of 700 to 800 psi after being pulled at 2" per minute until break. After obtaining consistent 100% rubber failure, a design of experiment (DOE) was implemented to determine …

Organic Thin-Film Transistors And Tips-Pentacene, Zachary Stewart

Lewis Honors College Capstone Collection

TIPS-Pentacene, an organic semiconductor characterized by its good electronic properties, solubility, and stability, is used primarily in organic thin-film transistors (OTFT). This research seeks to create an OTFT by crafting a stencil, depositing the source and drain onto a substrate’s surface, and processing TIPS-Pentacene onto the channel between them. In addition, if time permits, the electronic properties of several OTFTs will be compared to determine how to optimize their production.

Development Of Quantitative Bioanalytical Methods For The Pharmacological Studies Of Anti-Cancer Drugs, Ye Feng

ETD Archive

In the anticancer drug discovery and therapy development, it is essential to understand the pharmacological properties of the drugs. Today, pharmaceutical analysis is employed throughout the whole drug discovery and development process. Pharmacokinetic-pharmacodynamic relationships are playing an increasingly important role in decisions on the rational development and use of new drugs and they can provide a detailed knowledge of the mechanism of the drug and a better understanding of the molecular targets on which they act. Due to the significance of pharmacological analysis, sensitive analytical methods are critically needed for pharmacological studies. Therefore, our long-term goal is to provide guidelines …

Optimization Of Gradient Chromatofocusing For The Protein Separation And Lc-Ms/Ms Determination Of Ngp1-01 In Mouse Serum, Brain, And Retina, Harini Jogiraju

ETD Archive

No abstract provided.

Gradient Chromatofocusing And Reversed Phase Hplc In Protein Analysis And Lc-Ms/Ms Determination Of Thiazolidinedione Nl-1 In Mouse Serum And Brain, Kiran K. Pedada

ETD Archive

No abstract provided.

Development Of Lc-Ms/Ms Methods For Quantitative Analysis Of Plant-Derived Anticancer Agent And Synthetic Estrogen In Complex Matrices, Simuli Lindah Wabuyele

ETD Archive

No abstract provided.

Drug Delivery Via Nanoparticles, Laura Ward

Natural Sciences Student Research Presentations

Much research is being conducted to investigate the potential use of nanoparticles as an efficient drug delivery system. Important characteristics of nanoparticles that affect how they interact with biological systems include size, composition ,surface characteristics and shape. One of the many potential medical uses of nanoparticles is targeted drug delivery; nanoparticles have the potential to deliver concentrated amounts of medication to select areas of the body, reducing toxic effects in healthy areas of the body.

Lyrica, Shannon Hayward

Natural Sciences Student Research Presentations

Illustrates the chemical components of Lyrica, a pain management medication.

Chem 109: General Chemistry I—A Peer Review Of Teaching Project Benchmark Portfolio, Eric D. Dodds

UNL Faculty Course Portfolios

This portfolio has been developed for CHEM 109: General Chemistry I. The course is the first of a freshman level two semester sequence in General Chemistry taken by students with majors in a wide variety of technical and scientific disciplines. CHEM 109 is a high enrollment class, with class sizes for individual sections nearing 200 students. The development of this portfolio was conducted with the following objectives: 1. Clearly identify, justify, and codify the major learning objectives for this course, 2. Describe and rationalize the course structure and learning assessment methods, 3. Analyze and reflect on student achievement in the …

Membrane Surface Charges Attracted Protons Are Not Relevant To Proton Motive Force, James Weifu Lee

Chemistry & Biochemistry Faculty Publications

[First Paragraph] Only a half-century ago, British scientist Peter Mitchell proposed the conceptual scheme known as "chemiosmotic theory" that identified the role of proton coupling in the formation of ATP in cells [1,2]. Mitchell's delocalized proton-coupling chemiosmotic theory was initially quite controversial. But it would win for him the Nobel Prize in Chemistry in 1978. However, questions about Mitchell's chemiosmotic hypothesis have never gone away and a number of credible studies indicated the full extent of Mitchell's idea didn't always hold up to experience.

Raman Spectroscopy For The Identification Of Body Fluid Traces : Mixtures And Contaminations, Race And Gender Differentation, Aliaksandra Sikirzhytskaya

Legacy Theses & Dissertations (2009 - 2024)

Body fluid traces are an important type of forensic evidence, which play a significant role in the reconstruction of a violent crime and often help to identify a victim or suspect based on DNA analysis. Despite a great need, there is no a single method, which could identify multiple body fluids. In addition, majority of current methods are destructive for the evidence. For about eight years, our laboratory has been working on the development of a new nondestructive method for identification of body fluid traces based on Raman microspectroscopy combined with advanced statistics. High differentiation power of the method has …

Raman Spectroscopic Analysis Of Body Fluids : Species Differentiation And The Effect Of Substrate Interference And Laser Power, Gregory Keith Mclaughlin

Legacy Theses & Dissertations (2009 - 2024)

Several recent discoveries demonstrate that Raman spectroscopy has a unique capability to characterize body fluid traces in a forensic capacity. This approach has thus garnered interest in the forensic community since 2008, when a proof of concept experiment established that blood, semen, vaginal fluid, sweat and saliva are easily differentiable through their Raman spectra. Several possible methods of identification have been described in the literature, one approach uses chemometrical models, and another applies recently formulated multidimensional Raman signatures. The analytical sampling method and the identification procedure provide several desirable traits for the field of forensic science. In particular, Raman spectroscopy …

Theoretical Design Of Stable Small Aluminium-Magnesium Binary Clusters, Edison Osorio, Alejandro Vasquez, Elizabeth Florez, Fanor Mondragon, Kelling J. Donald, William Tiznado

Chemistry Faculty Publications

We explore in detail the potential energy surfaces of the Al_xMg_y (x, y = 1–4) systems as case studies to test the utility and limitations of simple rules based on electron counts and the phenomenological shell model (PSM) for bimetallic clusters. We find that it is feasible to design stable structures that are members of this set of small Al–Mg binary clusters, using simple electron count rules, including the classical 4n + 2 Hückel model, and the most recently proposed PSM. The thermodynamic stability of the title compounds has been evaluated using several different descriptors, including …

New Ruthenium And Osmium Carbonyl Cluster Complexes With Main Group Bridging Ligands Having Unusual Structures And Bonding, Yuwei Kan

Theses and Dissertations

The reaction of IrRu3(CO)13(µ-H), 2.1 with HSnPh3 in hexane solvent at reflux has provided the new mixed metal cluster compounds Ir2Ru2(CO)11(SnPh3)(µ-H)3, 2.2 and IrRu3(CO)11(SnPh3)3(µ-H)¬4, 2.3 containing SnPh3 ligands. Compound 2.2 which was obtained in low yield (3%) contains a closed cluster having two iridium and two ruthenium atoms, one SnPh3 ligand and three bridging hydride ligands. Compound 2.3 has a butterfly structure for the four metal atoms with three SnPh3 ligands and four bridging hydride ligands around the periphery of the cluster. When compound 2.3 was heated to 97 oC for 30min, IrRu3(CO)9(μ-η2-C6H5)(μ4-SnPh)2(μ-SnPh2), 2.4 was formed by cleavage of phenyl …

Surface Studies Of Organic Thin Films Using Scanning Probe Microscopy And Nanofabrication, Venetia Denae Lyles

LSU Doctoral Dissertations

Porphyrins and metalloporphyrins have unique chemical and electronic properties and thus provide useful model structures for nanoscale studies of the role of chemical structure for electronic properties. Porphyrins have been proposed as viable materials for molecular-based information-storage devices, gas sensors, photovoltaic cells, organic light-emitting diodes and molecular wires. The function and efficiency of porphyrins in devices is largely attributable to molecular architecture and how the molecules are self-organized. Modifications of the porphyrin macrocycle, peripheral groups or bound metal ions can generate a range of electrical, photoelectrical or magnetic properties. The conductive properties are greatly influenced at the molecular level by …

Libraries From Libraries Approach To The Synthesis Of Arylidene Oxindoles, Kyle James Knisley

Browse all Theses and Dissertations

A libraries from libraries combinatorial chemistry approach was employed to synthesize fluorinated derivatives of both oxindoles and isatins as potential pharmaceuticals or targeting agents for imaging purposes related to cancer or Alzheimer's disease. Synthesis for these fluorinated derivatives are described by routes involving, either: a) N-alkylation of 5-substituted isatins followed by Wolff-Kishner reduction to the corresponding oxindoles and final Knoevenagel condensation with aryl aldehydes, or; b) Wolff-Kishner reduction of the isatins followed by condensation and finishing with the N-alkylation of the aldol products. In specific cases, a click reaction followed the N-alkylation of the aldol products to form the isatin …

Programmable Polymers Preparation Optimization And Applications On Solute Templates, Yinyan He

Theses and Dissertations

Programmable polymer is a type of stimuli-responsive polymer which can keep their induced properties after removal of the stimulu, as well as programmable polymers maintain the general properties as stimuli-responsive polymers, such as recognize and respond to the stimulus. The previous reported solvent Caryl-Nimide bonds based programmable polymers (SPP-1) can freely rotate and change the carboxylic acid recognition group orientation in response to templates. Solvent templates were used in the SPP-1. One potential application for SPPs is using their recognition and memory properties for the identification and separation of mixture solutions of various analytes. In my first project, I wanted …

Investigations Of The Non-Covalent Ch-Π Interactions Using Molecular Torsional Balances, Chen Zhao

Theses and Dissertations

Several bicycle N-arylimide based molecular balances were designed to study aliphatic CH-pi interactions and aromatic CH-pi interactions (edge-to-face arene-arene interactions). In each case, the geometries of the interactions were characterized in the solid-state via X-ray analysis, and the strengths of interactions were characterized in solution by their folded/unfolded ratios, as measured by integration of their 1H NMR spectra.

The balances are very sensitive to variations in the strengths of weak non-covalent interactions. Several different aspects of the CH-pi interactions were studied, such as sterics, conformational entropy, cooperativity, deuterium isotope effect, substitution effects, and solvent effects. It showed that due to …

Application Of Glycyrrhiza Glabra Root As A Novel Adsorbent In The Removal Of Toluene Vapors: Equilibrium, Kinetic, And Thermodynamic Study, Fazel Mohammadi-Moghadam, Mohammad Mehdi Amin,, Mehdi Khiadani, Fariborz Momenbeik, Heshmatollah Nourmoradi, Mohammad Sadegh Hatamipour

Research outputs 2013

The aim of this paper is to investigate the removal of toluene from gaseous solution through Glycyrrhiza glabra root (GGR) as a waste material. The batch adsorption experiments were conducted at various conditions including contact time, adsorbate concentration, humidity, and temperature. The adsorption capacity was increased by raising the sorbent humidity up to 50 percent. The adsorption of toluene was also increased over contact time by 12 h when the sorbent was saturated. The pseudo-second-order kinetic model and Freundlich model fitted the adsorption data better than other kinetic and isotherm models, respectively. The Dubinin-Radushkevich (D-R) isotherm also showed that the …

Controlling Nanoparticle Dispersion For Nanoscopic Self-Assembly, Nathan S. Starkweather

Master's Theses

Nanotechnology is the manipulation of matter and devices on the nanometer scale. Below the critical dimension length of 100nm, materials begin to display vastly different properties than their macro- or micro- scale counterparts. The exotic properties of nanomaterials may trigger the start of a new technological revolution, similar to the electronics revolution of the late 20^th century. Current applications of nanotechnology primarily make use of nanoparticles in bulk, often being made into composites or mixtures. While these materials have fantastic properties, organization of nano and microstructures of nanoparticles may allow the development of novel devices with many unique properties. …

A Cucurbit[8]Uril Sponge, Vijayakumar Ramalingam, Sharon K. Kwee, Lisa M. Ryno, Adam R. Urbach

Chemistry Faculty Research

This paper describes a convenient approach to quantitative removal of the synthetic host cucurbit[8]uril (Q8) from aqueous mixtures using a sepharose resin coated in memantine groups to selectively sequester Q8 in the presence of competing hosts and guests. The “Q8 sponge” can separate Q8 from Q6 and reverse the Q8-mediated dimerization of peptides.

Spectroscopy And Dynamics Of The Predissociated, Quasi-Linear S₂ State Of Chlorocarbene, Chong Tao, Craig A. Richmond, Calvin Mukarakate, Scott H. Kable, George B. Bacskay, Eric C. Brown, Richard Dawes, Phalgun Lolur, Scott A. Reid

Chemistry Faculty Research & Creative Works

In this work, we report on the spectroscopy and dynamics of the quasi-linear S₂ state of chlorocarbene, CHCl, and its deuterated isotopologue using optical-optical double resonance (OODR) spectroscopy through selected rovibronic levels of the S₁ state. This study, which represents the first observation of the S₂ state in CHCl, builds upon our recent examination of the corresponding state in CHF, where pronounced mode specificity was observed in the dynamics, with predissociation rates larger for levels containing bending excitation. In the present work, a total of 14 S₂ state vibrational levels with angular momentum 1 were observed …

Covalent Modification That Enhances Protein Properties And Functions And Folds Random Coil Into Alpha-Helix, Deepali Prashar

Chemistry - Dissertations

Understanding the fundamental science of aggregation and surface adsorption of proteins is critical for developing protein-based drugs, understanding aggregation-induced diseases and for preventing biofouling that impacts a wide range of industries. In spite of the advances in sensitive and high-throughput analytical methods, the commercialization of protein drugs has been impeded by poor solubility, inevitable aggregation, and difficulty in purification. The primary aim of this dissertation is to modify proteins covalently to induce folding in random coil sequences, prevent aggregation, surface adsorption and for increasing the thermal stability against aggregation of proteins.

The first chapter describes the chemistry for modifying the …

Synthesis Of 1,1-Dialkyhydrazines And Their Hydroxyl Radical Degradation In Aqueous Environments, Benjamin F. Strong

Masters Theses

Determination of hydroxyl radical rate constants are essential to ensure adequate degradation of contaminants in wastewater. Hydrazines are an important class of organic contaminants and are the focus of this research. Ten 1,1-dialkylhydrazines are synthesized by the zinc reduction of the corresponding N-nitrosamines. Their hydroxyl radical rate constants are determined using the linear accelerator at the Notre Dame Radiation Laboratory at pH 4, 7, and 10.

Their rate constants are found to depend on the protonation state of the molecule. At pH 4 the molecules are fully protonated and hydrogen atom abstraction is favored from the alkyl chains. At …