Chemistry Commons^™

A New Paradigm For The Supramolecular Structure Of Laterally Offset Diarenes: Polymorphs Ii Of Para-Substituted Acetophenone Azines, Yp.Ph.(Me)C.N.N.C(Me).Ph.Yp (Y = Cl, Br, Ch3), Harmeet Bhoday, Kaidi Yang, Steven P. Kelley, Rainer Glaser

Chemistry Faculty Research & Creative Works

The crystal structures of polymorphs II of acetophenone azines Y_pPhRCNNCRPhY_p with R = CH₃ and Y = Cl (1M), Br (2M), and CH₃ (8M) are discussed. The azine molecules in polymorphs II are Ci-symmetric with trans-azine moieties and conrotatory phenyl twists. Polymorphs 1M-I and 2M-I contain C2-symmetric enantiomers with pronounced azine twists and disrotatory phenyl twists and allow for strong lateral double T-contacts. The three polymorphs II exemplify the new Paradigm IV for the supramolecular architectures of "laterally offset diarenes" and result in "shiplap/flat" idioteloamphiphile monolayers. Intralayer lateral attraction is provided by edge-to-face arene-arene contacts …

Multiscale Computational Chemistry Studies Of The Catalytic Mechanisms Of Non-Heme Fe(Ii)/2-Oxoglutarate-Dependent Oxygenases, Simahudeen Bathir Jaber Sathik Rifayee

Dissertations, Master's Theses and Master's Reports

Enzymes catalyze complex biological transformations. Non-heme Fe(II)/2-oxoglutarate (2OG)–dependent enzymes are highly versatile catalysts capable of selective C–H oxidation, enabling transformations such as hydroxylation, halogenation, desaturation, demethylation, ring rearrangements, epoxidation, and electrophilic aromatic substitution. These enzymes are involved in various biological processes, including fatty acid metabolism, hypoxic signaling, collagen maturation, and transcriptional regulation. Computational Modeling provides detailed knowledge of the enzymes including atomistic details of the important catalytic species, conformational and electronic effects, which are crucial to enzyme engineering and drug design efforts. This dissertation implements advanced multi-scale molecular modelling techniques including Molecular dynamics and Quantum Mechanic / Molecular Mechanics calculations …

New Psychoactive Substances Detected In Wastewater Samples Collected Along The Interstate Highway Rest Areas In Kentucky, Durga Prasad Kodati

Murray State Theses and Dissertations

The rapid emergence and proliferation of new psychoactive substances (NPS) pose significant challenges to public health and law enforcement. The potential for abuse and toxicity of these substances, which are intended to mimic the effects of controlled drugs, has been raising concerns as these compounds are designed to evade being regulated. There are traditional methods of tracking NPS, such as seizures and forensic toxicology, but they are delayed and seldom effective because these substances continue to evolve rapidly. Wastewater-based epidemiology (WBE) has emerged as a promising tool for real-time surveillance of drug consumption. The primary objective of this research was …

Synthesis Of Noval Hydroxy Chalcone And Study Of Fluorescent Properties, Margaret Hilliker

Williams Honors College, Honors Research Projects

Chalcones are a class of naturally occurring compounds found in plants, which have a general structure of Ar–CO–CH=CH–Ar’. They have shown significant potential as tunable organic fluorophores due to their extended π-conjugation and structural simplicity. In this study, a 2-hydroxy-substituted chalcone featuring a terminal dimethylamino group was synthesized via a pyrrolidine-catalyzed aldol condensation and characterized for its photophysical properties. The electron-donating and -accepting ends of the molecule establish an intramolecular charge transfer (ICT) pathway, while the hydroxyl group enables excited state intramolecular proton transfer (ESIPT), leading to complex emission behavior. Room temperature fluorescence analysis revealed broad, featureless emission, while low-temperature …

A Potentially Fruitful Path Toward A Cleaner And Safer Environment: Mxenes Uses In Environmental Remediation, Ali Mohammad Amani, Milad Abbasi, Atena Najdian, Farzaneh Mohamadpour, Seyed Reza Kasaee, Hesam Kamyab, Shreeshivadasan Chelliapan, Hanieh Ardeshiri, Lobat Tayebi, Ehsan Vafa, Sarah Mosleh-Shirazi, Alireza Jahanbin, Saravanan Rajendran, Daniel Simancas-Racines

Electrical & Computer Engineering Faculty Publications

The rapid industrialization of the world has resulted in severe environmental pollution, necessitating the development of new materials such as pollution remediation. Two-dimensional (2D) MXenes have emerged as a promising family of materials due to their unique physicochemical properties, making them ideal for environmental remediation. The article sheds light on the new opportunities of MXenes in the removal of organic and inorganic contaminants, including organic dyes, pharmaceuticals, heavy metals, radionuclides, and gas pollutants. MXenes also show excellent performance in photocatalytic degradation, adsorption, and microbial inactivation with environmental safety. Moreover, their application in recovering valuable elements from waste streams is also …

The Development Of A One Pot, Two Reaction Synthetic Preparation Of 1,2,4-Oxadiazole, And Synthesis Of Ataluren, A Novel Drug In The Fight Against Duchenne Muscular Dystrophy. Efforts Towards The Synthesis Of A Potential Protease Inhibitor Against The Main Protease (3clpro) Of Covid-19, Austin J. Carter

Theses and Dissertations

1,2,4-Oxadiazoles are five-membered heterocyclic structures first synthesized by Tiemann and Krüger in 1884. Recent discoveries suggest an array of useful biological properties.In preparation of 1,2,4-oxadiazoles, the most prevalent precursors are amidoximes, which can be created via the reaction of nitriles with hydroxylamine hydrochloride and a base. The amidoximes are reacted with an activated carboxylic acid to yield an acylated intermediate. This intermediate can be exposed to a base to cyclize into the 1,2,4-oxadiazole. This thesis describes the efforts in combining these three steps into a unified one-pot synthesis.

Currently, there are a significant number of commercially available FDA approved and …

Asymmetric Synthesis Of The Hiv Protease Inhibitor Tmc-126 And An Anti-Malarial Agent Via A Titanium Tetrachloride Mediated Asymmetric Glycolate Aldol Addition Reaction. Redefining The Curtius Rearrangement Reaction Via Dehomologation Of Carboxylic Acids Bearing Alpha-Leaving Groups, Kweku Amaning Affram

Theses and Dissertations

Acquired Immune Deficiency Syndrome (AIDS) and malaria are two devastating infectious diseases caused by HIV and Plasmodium parasites. AIDS is caused by HIV-1 and HIV-2, transmitted through sexual contact, blood transfusions, needle sharing, and perinatal routes. Malaria, caused by plasmodium parasites through mosquito bites. Today, millions of people around the world have been infected with HIV and malaria and much research has been done to treat it. However, despite advancements in therapeutic options, these diseases remain a significant global health threat, particularly in developing countries due to the emergence of drug-resistant strains for both HIV and malaria complicating eradication efforts. …

Site-Specific Modification Of Antibodies Utilizing Microbial Transglutaminase For Improved Immunoassay Performance, Emily Beitello

Theses and Dissertations

Immobilization strategies used for fixing antibodies to solid phase surfaces significantly contribute to the antigen capture capacity and influences the performance and sensitivity of immunoassays. Traditional methodologies result in the random orientation and/or the weak attachment of immobilized antibodies. Different formats of immunoassays scope in applicability to many fields of research and everyday use. Improving the efficiency of immobilizing antibodies in immunoassays is a beneficial endeavor to increase assay sensitivity. Here, we investigated the use of enzyme-mediated conjugation of antibodies to facilitate a highly oriented immobilization. Microbial transglutaminase (mTG) catalyzes the covalent bond formation between a plethora of primary amine …

Electrochemical Observation And Ph Dependence Of All Three Expected Redox Couples In An Extremophilic Bifurcating Electron Transfer Flavoprotein With Fused Subunits, Debarati Das, Wassim El Housseini, Monica Brachi, Shelley D. Minteer, Anne Frances Miller

Chemistry Faculty Research & Creative Works

Bifurcating enzymes employ energy from a favorable electron transfer to drive unfavorable transfer of a second electron, thereby generating a more reactive product. They are therefore highly desirable in catalytic systems, for example, to drive challenging reactions such as nitrogen fixation. While most bifurcating enzymes contain air-sensitive metal centers, bifurcating electron transfer flavoproteins (bETFs) employ flavins. However, they have not been successfully deployed on electrodes. Herein, we demonstrate immobilization and expected thermodynamic reactivity of a bETF from a hyperthermophilic archaeon, Sulfolobus acidocaldarius (SaETF). SaETF differs from previously biochemically characterized bETFs in being a single protein, representing a concatenation of the …

Scalable Fabrication Of High-Payload Dendrimer-Based Nanoparticles For Targeted Atherosclerosis Therapy, Huari Kou, Lin Qi, Da Huang, Jiandong Wu, Honglan Shi, Hu Yang

Chemistry Faculty Research & Creative Works

Nanoparticle-based therapeutics hold promise for the treatment of atherosclerosis, but challenges such as low drug-loading capacity and a lack of scalable, controllable production hinder their clinical translation. Flash nanoprecipitation, a continuous synthesis method, offers a potential solution for scalable and reproducible nanoparticle production. In this study, we employed a custom-designed multi-inlet vortex mixer to perform cross-linking reaction-enabled flash nanoprecipitation, facilitating controlled and scalable synthesis of cross-linked Poly amidoamine (PAMAM) dendrimer nanoparticles. Notably, this approach allows simultaneous nanoparticle cross-linking and drug loading in a single step. The mannose moiety enabled specific targeting of macrophages via mannose receptors, enhancing the localization of …

Enhanced Biofuel Cells Based On A Hybrid Enzymatic/Bimetallic Composite For Complete Lactate Catalytic Electrooxidation, Jefferson Honorio Franco, João Victor Bonaldo, Shelley D. Minteer, Adalgisa R. De Andrade

Chemistry Faculty Research & Creative Works

We describe complete lactate electrooxidation in an enzymatic biofuel cell that combines the catalytic action of the bimetallic composite Ru@Pt-CNT and the enzyme oxalate oxidase (OxOx). The Ru@Pt-CNT/OxOx hybrid electrode was 2.0-fold more catalytically active than the electrode containing the bimetallic composite only. During chronoamperometric experiments, the hybrid electrode achieved a 35% higher maximum current density (2.65 ± 0.15 mA cm^-2) than the Ru@Pt-CNT electrode. Electrochemical impedance spectroscopy showed that the hybrid electrode had lower charge transfer resistance than the Ru@Pt-CNT electrode, confirming that OxOx had a high affinity for lactate during the bioelectrocatalytic reaction on the electrode …

Microwave Assisted Syntheses And Characterizations Of Near-Infrared Ratiometric Probes For Mitochondrial Ph Detection And Monitoring, Ronald J. Schwandt

Dissertations, Master's Theses and Master's Reports

Within the field of biochemistry, there has been a significant development of ratiometric fluorescent probes designed for mitochondrial pH detection; however, many of these probes have emissions within the visible spectrum and require long synthesis times with low-yield reactions. However, in recent years, microwave-assisted syntheses of organic molecules have led to significant increases in reaction yields and quicker reaction times. In this work, two common reactions in probe synthesis, Heck coupling, and Knoevenagel condensations are investigated using microwave-assisted synthesis. It was found the low-concentration Heck coupling reactions using palladium (II) acetate led to extremely efficient Heck coupling. Also, a novel …

Towards Developing Glut2 Specific Probes For Biochemical And Biomedical Applications, Abdelrahman Ismail

Dissertations, Master's Theses and Master's Reports

Facilitated Glucose transporters (GLUTs) are membrane proteins responsible for the uptake of simple sugars and other structurally similar metabolites in all mammalian cells. One of the hallmarks of cancer is dysfunctional sugar metabolism, known as the Warburg effect, and one of the manifestations of that effect is abnormal GLUT expression. There are 14 known GLUT proteins with different expression patterns in different tissues, and tumors tend to express certain GLUTs that are not present in surrounding healthy tissue. Therefore, selective targeting of GLUTs presents a potentially powerful tool for diagnostics and treatment of cancer and other diseases. This has been …

Near-Infrared Fluorescent Cyanine Probes For Monitoring Nad(P)H Dynamics In Living Cells And Drosophila Larvae, May Waters

Dissertations, Master's Theses and Master's Reports

Nicotinamide adenine dinucleotide (NAD+/NADH) plays a critical role in cellular metabolism, with abnormally elevated NADH levels linked to disrupted metabolic processes and cancer. In this study, we developed near-infrared fluorescent probes to selectively measure NADH concentrations. We present five cyanine-based probes, which were optimized by modifying the connection bridges to fine tune electronics. Two NAD(P)H-biosensing probes consisting of 1,3,3-trimethyl-3H-indolium and 3-quinolinium acceptors, linked by thiophene, A, and 3,4-ethylenedioxythiophene, B, bridges are detailed. They exhibit near-infrared fluorescence at 742.1 nm and 727.2 nm for probes A and B, respectively, and generate absorbance signals at 690.6 nm and 685.9 nm. Probe A …

Development Of Near-Infrared Probe For The Detection Of Nadh And Nad(P)H In Live Cells And D. Melanogaster Larvae, Sophia J. Jaeger

Dissertations, Master's Theses and Master's Reports

A near-infrared fluorescent probe, A, was designed by substituting the carbonyl group of the coumarin dye’s lactone with a 4-cyano-1-methylpyridinium methylene group and then attaching an electron-withdrawing NADH-sensing methylquinolinium acceptor via a vinyl bond linkage to the coumarin dye at the 4-position. The probe exhibits primary absorption maxima at 603, 428, and 361 nm, and fluoresces weakly at 703 nm. The addition of NAD(P)H results in a significant blue shift in the fluorescence peak from 703 to 670 nm, accompanied an increase in fluorescence intensity. This spectral shift is attributed to the transformation of A−π–A−π–D configuration to D−π–A−π–D pyridinium platform …

Metal-Free Photoredox Catalysis For The S-Trifluoromethylation Of Thiols And Investigation Of Ph-Dependent Decontamination Of Dimethyl Chlorophosphate, A Nerve Agent Simulant, Via Hydrolysis With Azoles, Raheemat Rafiu

Doctoral Dissertations

"Organofluorine chemistry plays a critical role in synthetic chemistry due to the unique properties of fluorine. However, the S-trifluoromethylation of thiols remains underexplored, with existing methods often relying on toxic and expensive organometallic catalysts. Given the advantages of S-trifluoromethylated compounds, including enhanced pharmacological activity and improved metabolic stability, we developed a green and cost-effective method for the synthesis of S-CF3 compounds using diacetyl as the organic catalyst and Langloi's reagent as the trifluoromethylating reagent. This reaction, which proceeds under mild conditions using visible light photoredox catalysis, works across various substrate scopes, including aromatic, heteroaromatic, and aliphatic thiols.

Chemical Warfare Agents …

Design And Synthesis Of Organocatalyts For Efficient Decontamination Of Organophosphate-Based Nerve Agents And Pesticides, Emmanuel Kingsley Darkwah

Doctoral Dissertations

Exposure to organophosphate-based nerve agents and pesticides poses significant health and security threats to civilians, soldiers, and first responders. Despite extensive efforts to develop chemical detoxification agents for use in topical applications on exposed skin surfaces and for intravenous injections, there remains an unmet need for effective, non-hazardous decontaminating agents. The current state-of-the-art decontaminating agent, Dekon-139 (2,3-butanedione oxime, potassium salt), exhibits adverse effects when applied to the skin.

In this study, we designed and synthesized pharmaceutically relevant aminoguanidine-derived aldimines that are relatively non-toxic and substantially more effective at decontaminating nerve agents and pesticides compared to existing agents, and they act …

Evaluation Of Practical Methods To Determine If A Karst Creek Is Gaining Or Losing: Case Study Of Leith Creek, Elizabeth Jones

Graduate Theses/Dissertations

Karst landscapes are abundant in Missouri, with features such as caves, springs, and sinkholes that form through the dissolution of limestone. Leith Creek is a small stream in Polk County, Missouri fed by two springs and the shallow unconfined Springfield Plateau aquifer, a highly karstified aquifer which is made up of limestone and minor interbedded shale-mudstone units. To determine if Leith Creek is gaining or losing, stream flow, water chemistry and temperature sensors were monitored. Stream flow results required multiple visits to take measurements while temperature sensors required two visits, one to install the dataloggers and another to remove the …

Surface Modifications Of Titanium Alloys For Biomedical Applications, Justynne Fabian

Doctoral

Hip implant failure remains a critical concern in healthcare, primarily driven by poor bone integration and bacterial infection. These issues contribute to a rising number of revision surgeries, posing significant challenges that must be addressed, particularly in light of an ageing global population. Titanium surface anodisation emerges as a promising solution for biomedical applications, offering a cost-effective, controllable, and efficient process. The anodisation technique results in the formation of titanium dioxide nanotubes (TiO2 NTs) on the metal surface. These nanostructures offer several advantages, including enhanced mechanical properties, and potential for surface modification through the incorporation of antibacterial and osteoinductive properties. …

Structural Optimization And Stability Enhancement Of Uba(2) And Ntl9 Using The Computational Tool: Emcast, Bahar Ghazi Esfahani

Graduate Student Theses, Dissertations, & Professional Papers

This study enhances protein stability prediction by refining EmCAST (Empirical C-Alpha Stability Tool), a computational tool used to identify stabilizing mutations in protein domains. We applied EmCAST to two model proteins: the α-helical ubiquitin-associated domain 2 (UBA(2)) and the α/β N-terminal domain of ribosomal protein L9 (NTL9). Protein stability is critical for proper function, and mutations can lead to misfolding and disease. To validate EmCAST’s predictions, guanidine hydrochloride-induced denaturation was monitored using circular dichroism (CD) spectroscopy for both wild-type and mutant variants. Results guided refinements to EmCAST’s algorithm, incorporating new experimental datasets to improve accuracy. Additionally, we examined the assumption …

Removal Of Antibiotics Under Visible Light By Using C,N-Tio2 Incorporated Into Magnetite Mesoporous Silica Composites, Dwita Widyawati

Chulalongkorn University Theses and Dissertations (Chula ETD)

Water contamination, particularly from antibiotics such as ciprofloxacin, is a significant environmental challenge necessitating the development of new remediation solutions. A promising technique for eliminating CIP from the environment is photocatalysis. The synthesis of C,N-doped TiO2 embedded within magnetite mesoporous silica (MSI) composites is prepared to serve as a promising semiconductor catalyst for photodegradation under visible illumination. Tetrabutyl titanate (TBOT), glucose, and urea are used as precursors in the sol-gel synthesis process, which controls elemental ratios to produce a unique mesoporous composite material intended to improve antibiotic photodegradation in the presence of visible light. Comparisons showed significant differences between capped …

Effect Of Single Screw Extrusion Process Parameters On Gel Formation And Properties In Polycaprolactone Films, Kitthanya Ritthichai

Chulalongkorn University Theses and Dissertations (Chula ETD)

This research focuses on the production of polycaprolactone (PCL) films using the commercial grade CAPA 6800 through a continuous single-screw extrusion process. This method serves as an alternative to conventional solution-based film fabrication that requires solvents and chemical reagents. The effects of processing temperature (80–120 °C), screw design (mixing screw and plain screw), and extruder-barrel cooling system (water-cooled and air-cooled) on film quality, gel formation, thermal properties, and mechanical properties of PCL films were investigated. Based on the processing of high-purity PCL pellets, the results indicate that the processing temperature, screw design, and barrel-cooling system did not affect the chemical …

Gel Based Sensing Platforms For Ammonia Detection, Patita Salee

Chulalongkorn University Theses and Dissertations (Chula ETD)

This research focuses on the development of two biopolymer-based colorimetric platforms for ammonia detection in environmental water and gaseous samples. To detect ammonia in water samples, an agarose hydrogel membrane containing salicylate, hypochlorite, and sodium nitroprusside was incorporated into a flow analysis system to perform the Berthelot reaction within the gel. Ammonium in the sample was converted to monochloramine in an alkaline reagent stream, and its subsequent interaction with the sensing membrane yielded an indosalicylate blue chromophore, causing the gel to change from pale yellow to green–blue as the ammonia concentration increased. Under the optimal operating conditions, the method provided …

Functional Design Of Dissymmetric Ligands For Coordination Systems, Kaitlyn R. Brown

Theses and Dissertations (Comprehensive)

Herein, the functional design of dissymmetric ligands for coordination systems is explored with a focus on their synthesis and structural characterization. The design strategy of these ligands incorporates the ability to coordinate both metal cations and anions along with a ligand site for other functionalization. Their synthesis, structural and other characterization, Hirshfeld surface analysis, and some metal-coordinated complexes are discussed. Chapter 1 introduces supramolecular and coordination chemistry, along with relevant literature that supports this research and outlines the thesis objective. Chapter 2 investigates the hydrogen bonding of a dissymmetric pyrimidine thioether ligand in its neutral form, water solvate, protonated nitrate …

Investigating The Thermal Stratification Patterns Of A Shallow Polymictic Boreal Shield Lake And The Effectiveness Of Models In Predicting Shallow Lake Thermal Profiles, Matthew Roberts

Theses and Dissertations (Comprehensive)

Thermal stratification is a core process of lakes which plays a critical role in shaping the ecological dynamics of lakes, influencing major processes like nutrient cycling and oxygen availability. For shallow polymictic lakes, thermal stratification patterns present some unique differences due to the complex and variable nature of these lakes. In this thesis, I examined thermal stratification in a shallow polymictic lake in northwestern Ontario during the ice-free season of 2019 to investigate the frequency, duration, and driving factors of thermal stratification. The lake underwent 146 separate stratification events, with a median duration of 2 hours per event, with a …

Development Of Cyan And Blue Thermostable Fluorescent Proteins: Characterization And Structural Analysis, Acacia J. Jurkowski

Graduate Theses/Dissertations

Fluorescent proteins are commonly used as cell markers in living organisms. Modifications by mutation can be used to improve the qualities of these proteins including fluorescence, thermostability, pH stability, and chemical stability. The goal of this project is to use mutagenesis to improve the fluorescence of thermostable cyan and blue proteins derived from the thermal green protein (TGP). The first cyan protein developed by the DeVore lab (CTP 0.0) shifted the fluorescence to cyan but decreased the quantum yield (Φ_F) to 0.056. Further mutations were incorporated to increase the quantum yield through incorporating hydrogen bonding interactions to the …

Production Of Graphene From Graphite Via Flash Joule Heating Process, Siranut Sirathanutworakan

Chulalongkorn University Theses and Dissertations (Chula ETD)

Graphene is a material with unique properties and high potential. Due to its outstanding characteristics in strength, electrical and thermal conductivity, and flexibility, graphene is considered one of the materials of the future that can be used to enhance the efficiency of various emerging technologies. This research focuses on the synthesis of graphene using the Flash Joule Heating (FJH) process, during which an extremely high temperature occurs within milliseconds. The carbon precursor is rapidly exposed to intense heat, resulting in the dissociation of all chemical bonds in its structure and the reorganization of carbon atoms into a new graphene structure. …

Data-Driven Predictive Model For Various Shapes Of Gold Nanoparticle Synthesis Based On Self-Organizing Maps, Thanapol Khamhla

Chulalongkorn University Theses and Dissertations (Chula ETD)

This work presents a machine learning framework that simultaneously classifies the shape and predicts the localised surface plasmon resonance (LSPR) wavelength of gold nanoparticles (AuNPs) purely from synthesis conditions. The dataset used to train the model consist of synthesis conditions and the corresponding AuNPs characteristics, including spherical, star, plate, and rod shapes with their measured LSPR wavelengths, were compiled from existing literatures. Our model first classifies synthesis conditions into clusters according to their resulting shape and then builds local regression models for each shape, enabling both classification and quantitative prediction within a single framework. The proposed model integrates the clustering …

การสังเคราะห์แกรฟีนควอนตัมดอตฐานกรดฮิวมิกและการประยุกต์เป็นสารเคลือบเซนเซอร์ตรวจจับความเครียด, ปริตตา จูฑาภักติ

Chulalongkorn University Theses and Dissertations (Chula ETD)

แกรฟีนควอนตัมดอต (GQDs) ถูกสังเคราะห์จากกรดฮิวมิก (HA) ที่เป็นสารตั้งต้นด้วยการใช้หม้อทอดไฟฟ้าด้วยวิธีไฮโดรเทอร์มอล ซึ่งในงานวิจัยนี้มุ่งเน้นการศึกษาตัวแปรที่เกี่ยวข้องกับกระบวนการสังเคราะห์ GQDs ด้วยการเปลี่ยนแปลงอัตราส่วนของกรดฮิวมิกที่ใช้สังเคราะห์และศึกษาผลของตัวโดป จากผลการศึกษาพบว่าตัวโดปที่ใช้ในการะบวนการสังเคราะห์ GQDs ที่เหมาะสมคือ เอทิลีนไดเอมีน (EDA) และจากผลการทดลองแสดงให้เห็นว่า GQDs ที่ใช้ EDA มีความเข้มแสงฟลูออเรสเซนต์สูงสุดที่ 66 หน่วยที่ความยาวคลื่น 467 นาโนเมตร (ช่วงแสงเขียวอมฟ้า) เมื่ออัตราส่วนกรดฮิวมิกต่อเอทิลีนไดอะมีนเท่ากับ 10 : 0.5 (มิลลิกรัม : มิลลิลิตร) ขนาดเฉลี่ยของอนุภาคอยู่ที่ 6.68 นาโนเมตร ซึ่งถูกวิเคราะห์โดยกล้องจุลทรรศน์อิเล็กตรอนแบบส่องผ่าน และการวัดขนาดอนุภาค เทคนิคสเปกตรัมฟลูออเรสเซนซ์ และการดูดกลืนรังสี ตามลำดับ โครงสร้างกราฟิติกของ GQDs ถูกยืนยันด้วยสเปกโทรสโกปีรามาน ดังนั้นในงานวิจัยนี้จึงสนใจที่จะนำ GQDs ที่ใช้ EDA เป็นตัวโดปไปประยุกต์ใช้งานเป็นสารเคลือบเรืองแสงที่นำไปเคลือบลงบนยางซิลิโคนเพื่อนำไปประยุกต์ใช้เป็นสารเคลือบเซนเซอร์ตรวจจับความเครียด พบว่า ความเข้มของแสงฟลูออเรสเซนต์ของสารเคลือบเรืองแสง GQDs มีแนวโน้มลดลงเมื่อเวลาเวลาผ่านไป แต่สามารถหดกลับคืนใกล้เคียงสภาพเดิมเมื่อปล่อยการให้แรง และเมื่อเทียบค่าความเข้มของแสงฟลูออเรสเซนต์ของแต่ละอัตราส่วน พบว่า ที่อัตราส่วนกรดฮิวมิกต่อเอทิลีนไดอะมีนเท่ากับ 50 : 0.5 (มิลลิกรัม : มิลลิลิตร) มีค่าเข้มแสงของแสงฟลูออเรสเซนต์สูงที่สุด

การเตรียมคาร์บอนแบคทีเรียเซลลูโลสและควอนตัมดอตจากน้ำหมึกของหมึกกระดองสำหรับใช้งานตกแต่งสำเร็จสิ่งทอ, มณฑิชา สันติภาพมณฑล

Chulalongkorn University Theses and Dissertations (Chula ETD)

การพัฒนาวัสดุนาโนคาร์บอนและควอนตัมดอต เพื่อประยุกต์ใช้เป็นสารตกแต่งสำเร็จสิ่งทอเพื่อเพิ่มคุณสมบัติพิเศษ คาร์บอนนาโนไฟเบอร์และคาร์บอนควอนตัมดอตเป็นวัสดุนาโนที่มีสมบัติเด่นด้านความแข็งแรง การนำไฟฟ้า และการเรืองแสง ขอบเขตของงานวิจัยนี้ประกอบด้วยการเตรียม คาร์บอนนาโนไฟเบอร์จากแบคทีเรียเซลลูโลส (BC-CNF) และการสังเคราะห์ควอนตัมดอต (QDs) จากน้ำหมึกของหมึกกระดอง ซึ่งเป็นการสังเคราะห์ทางชีวภาพ ในส่วนของการเตรียม BC-CNF ได้มีการดัดแปรงโครงสร้างด้วยปฏิกิริยาซัลโฟเนต เพื่อให้ได้สาร BC-CNF-SO3- ซึ่งผลการวิเคราะห์ยืนยันการเกิดหมู่ฟังก์ชันซัลโฟเนต และอนุภาคในระดับซับไมครอน โดยมีขนาดอนุภาคเฉลี่ย 1.6218 ไมโครเมตร และสามารถกระจายตัวในน้ำได้ดี เมื่อนำ BC-CNF-SO3- มาตกแต่งสำเร็จบนผ้าพอลิเอสเทอร์ พบว่าความสามารถในการดูดซึมน้ำของผ้าเพิ่มขึ้น โดยผ้าที่ใช้ความเข้มข้นร้อยละ 3 ให้ประสิทธิภาพดีที่สุด ด้วยเวลาดูดซึมน้ำเฉลี่ยเพียง 2 วินาทีหลังการซัก ซึ่งแสดงถึงความคงทนต่อการซักที่ดี ในส่วนของการสังเคราะห์ QDs จากน้ำหมึกของหมึกกระดอง พบว่าอนุภาคมีขนาดอยู่ในช่วง 4-6 นาโนเมตร และแสดงความสามารถในการเรืองแสงภายใต้แสงอัลตราไวโอเลต โดยการเติมเอทิลีนไดเอมีน (EDA) ในปริมาณ 2 มิลลิลิตร ให้ค่าความเข้มของการเรืองแสงสูงสุด เมื่อนำ สารละลายควอนตัมดอตจากน้ำหมึกที่สังเคราะห์โดยเติมเอทิลีนไดเอมีน 2 มิลลิลิตร (EDA 2) ที่สังเคราะห์มาตกแต่งสำเร็จบนผ้าไนลอน พบว่าปริมาณ สารละลายควอนตัมดอตจากน้ำหมึกของหมึกกระดองที่สังเคราะห์โดยเติมเอทิลีนไดเอมีน 2 มิลลิลิตร (EDA 2) โดยใช้สารละลายปริมาตร 1 มิลลิลิตร ให้ความเข้มการเรืองแสงสูงสุด โดยก่อนซัก ค่าโดยประมาณ 180–190 a.u. และหลังซัก ค่าโดยประมาณ 110–120 a.u. โดยมีความคงทนต่อการซักดี ผลการวิจัยสรุปได้ว่า การประยุกต์ใช้ในการตกแต่งสำเร็จสิ่งทอ สามารถเพิ่มความสามารถในการดูดซึมน้ำของผ้าพอลิเอสเทอร์ และความสามารถในการเรืองแสงบนผ้าไนลอน