Chemistry Commons^™

Carbon Dioxide-Mediated Synthesis Of Pyrroles In Water, Ram Naresh Yadav, Bimal K. Banik

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

A novel carbon dioxide-mediated synthesis of diverse pyrroles using 2,5- dimethoxytetrahydrofuran and primary amines has been achieved in excellent yield. Despite the importance of pyrroles, no study has been performed using carbon dioxide as a reagent to accomplish Paal-Knorr reaction.

Ammonium Chloride-Induced Synthesis Of Pyrroles Via Paalknorr Reaction, Debasish Bandyopadhyay, Bimal K. Banik

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

Reaction of commercially available 2,5-hexanedione and primary amino compounds in the presence of ammonium chloride produced N-substituted pyrroles in excellent yield. In contrast to other available methods, this current procedure for the preparation of pyrroles is exceedingly simple, efficient, and eco-friendly and therefore, may find numerous applications in this field.

พอลิแล็กทิกแอซิด/พอลิไวนิลแอลกอฮอล์/แกรฟีนนาโนคอมพอสิต, จาฬุพักต์ รัตนคช

Chulalongkorn University Theses and Dissertations (Chula ETD)

งานวิจัยนี้มีวัตถุประสงค์เพื่อพัฒนาวิธีการเตรียมพอลิแล็กทิกแอซิด/พอลิไวนิลแอลกอฮอล์/แกรฟีนนาโนคอมพอสิต รวมถึงศึกษาอิทธิพลของการเติมอนุภาคแกรฟีนต่อสัณฐานวิทยา สมบัติเชิงกล สมบัติทางความร้อน และสมบัติการนำไฟฟ้าของวัสดุนาโนคอมพอสิตที่เตรียมได้ โดยเริ่มด้วยการสังเคราะห์แกรฟีนจากแกรไฟต์ด้วยวิธีของฮัมเมอร์ และใช้กรดแอลแอสคอร์บิกเป็นตัวรีดิวซ์ พิสูจน์เอกลักษณ์ของอนุภาคแกรฟีนที่เตรียมได้ด้วยเทคนิคอินฟราเรดสเปกโทรสโกปีและเทคนิคเอกซเรย์ดิฟแฟรกชัน จากนั้นเตรียมของผสมระหว่างพอลิไวนิลแอลกอฮอล์กับแกรฟีนที่ปริมาณต่าง ๆ ด้วยวิธีแช่เยือกแข็ง แล้วนำไปผสมกับพอลิแล็กทิกแอซิดด้วยเครื่องอัดรีดสกรูคู่และขึ้นรูปเป็นชิ้นงานด้วยกระบวนการอัดแบบ ศึกษาสัณฐานวิทยาเพื่อวิเคราะห์อันตรกิริยาของผสมระหว่างพอลิไวนิลแอลกอฮอล์กับแกรฟีนด้วยกล้องจุลทรรศน์แบบคอนโฟคอล และวิเคราะห์ภาคตัดขวางของชิ้นงานคอมพอสิตด้วยกล้องจุลทรรศน์อิเล็กตรอนแบบส่องกราด ผลการทดสอบสมบัติเชิงกล สมบัติทางความร้อน และสมบัติการนำไฟฟ้าของวัสดุนาโนคอมพอสิตที่เตรียมได้ พบว่าปริมาณผลึกลดลงเมื่อปริมาณแกรฟีนเพิ่มขึ้น แต่ไม่ส่งผลต่ออุณหภูมิกลาสทรานสิชัน อุณหภูมิหลอมเหลวผลึก และอุณหภูมิการเกิดผลึก อีกทั้งการเติมแกรฟีนที่มีการใช้พอลิไวนิลแอลกอฮอล์เป็นตัวพาลงในพอลิเมอร์เมทริกซ์ ทำให้ความทนแรงดึง และความยืดสูงสุด ณ จุดขาด มีแนวโน้มลดลงด้วย อย่างไรก็ดีการเติมแกรฟีนในปริมาณน้อย ๆ สามารถช่วยเพิ่มความทนแรงดึงได้เมื่อเปรียบเทียบกับงานวิจัยก่อนหน้าที่ไม่มีการเติมตัวพาหรือตัวช่วยเพิ่มการกระจายตัว นอกจากนี้พบว่าปริมาณแกรฟีนที่เพิ่มขึ้น ทำให้ค่าการนำไฟฟ้าของคอมพอสิตเมื่อเทียบกับพอลิแล็กทิกแอซิดบริสุทธิ์เพิ่มขึ้น คอมพอสิตที่พัฒนาขึ้นสามารถนำไปประยุกต์ในงานที่ต้องการสมบัติการต้านทานไฟฟ้าสถิตย์ได้

นาโนคอมพอสิตของพอลิแล็กทิกแอซิด/เอทิลีนไวนิลแอซีเทตโคพอลิเมอร์เติมด้วยนาโนไฮบริด พอลิเมทิลเมทาคริเลต/ซิลิกา, จัสมิน พงค์เกษม

Chulalongkorn University Theses and Dissertations (Chula ETD)

นาโนคอมพอสิตของพอลิแล็กทิกแอซิด/เอทิลีนไวนิลแอซีเทตโคพอลิเมอร์ (อีวีเอ) ถูกเตรียมด้วยนาโนซิลิกาและนาโนไฮบริดของพอลิเมทิลเมทาคริเลต/นาโนซิลิกา (1, 3 และ 5 ส่วนโดยน้ำหนักต่อเรซินร้อยส่วน) ด้วยการผสมแบบหลอมเหลวในเครื่องผสมแบบปิดตามด้วยเครื่องอัดแบบ โดยนาโนเลเท็กซ์ของพอลิเมทิลเมทาคริเลต/นาโนซิลิกาถูกสังเคราะห์ด้วยกระบวนการเกิดพอลิเมอร์ ‘อิน ซิทู’ ดิฟเฟอเรนเชียลไมโครอิมัลชัน ซึ่งนาโนไฮบริดของพอลิเมทิลเมทาคริเลต/นาโนซิลิกาที่เตรียมได้มีร้อยละการกราฟต์เท่ากับร้อยละ 90.9 และมีขนาดอนุภาคเฉลี่ยและพื้นที่ผิวเท่ากับ 43.4 นาโนเมตร และ 71.3 ตารางเมตรต่อกรัม ตามลำดับ จากการศึกษาสัณฐานวิทยา พบว่า อนุภาคนาโนไฮบริดแสดงลักษณะโครงสร้างแบบแก่น-เปลือก ที่มีนาโนซิลิกาเป็นแก่นกลางและพอลิเมทิลเมทาคริเลตเป็นเปลือก ขั้นแรกพอลิเมอร์ผสมพอลิแล็กทิกแอซิด/อีวีเอที่อัตราส่วนต่างๆ (อีวีเอ ร้อยละ 10-30 โดยน้ำหนัก) ได้ถูกเตรียม และพบว่า ความทนแรงกระแทกและการยืดตัว ณ จุดขาดได้รับการปรับปรุง ขณะที่ยังส์มอดุลัสและเสถียรภาพทางความร้อนมีค่าลดลงเมื่อเติมอีวีเอลงในพอลิแล็กทิกแอซิด เนื่องด้วยพอลิเมอร์ผสม 90/10 พอลิแล็กทิกแอซิด/อีวีเอมีสมบัติเชิงกลที่เหมาะสม จึงถูกเลือกเพื่อเตรียมนาโนคอมพอสิตด้วยนาโนซิลิกาและนาโนไฮบริดของพอลิเมทิลเมทาคริเลต/นาโนซิลิกา จากผลการทดลอง พบว่าการเติมนาโนซิลิกาหรือนาโนไฮบริดของพอลิเมทิลเมทาคริเลต/นาโนซิลิกาในพอลิเมอร์ผสม 90/10 พอลิแล็กทิกแอซิด/อีวีเอ ได้ปรับปรุงความทนแรงกระแทกและเสถียรภาพทางความร้อน หากแต่การยืดตัว ณ จุดขาดมีค่าลดลง นอกจากนี้ การเติมนาโนซิลิกาส่งผลให้ความทนแรงดึงและยังส์มอดุลัสมีค่าลดลง ขณะที่ความทนแรงดึงและยังส์มอดุลัสของนาโนคอมพอสิตด้วยนาโนไฮบริดของพอลิเมทิลเมทาคริเลต/นาโนซิลิกา มีค่าเพิ่มขึ้น โดยสรุป พบว่านาโนไฮบริดของพอลิเมทิลเมทาคริเลต/นาโนซิลิกา แสดงประสิทธิภาพในการเสริมแรงได้ดีกว่านาโนซิลิกาที่ปริมาณการเติมสารตัวเติมที่เท่าๆ กัน เนื่องจากมีแรงยึดเหนี่ยวระหว่างพอลิเมอร์-สารตัวเติมที่มากกว่า

The Maculoprotective Effect Of A Thiol Antioxidant In Retinal Degeneration Models, Hsiu-Jen Wang

Doctoral Dissertations

"Age-related macular degeneration (AMD) is a leading cause of irreversible blindness among adults, age 60 and older, in developed countries. While oxidative stress is implicated in the pathogenesis of AMD, clinical studies have shown that dietary antioxidants can delay progression of AMD. Currently, there is no FDA-approved treatment for AMD. Therefore, we hypothesized that N-acetylcysteine amide (NACA), a thiol antioxidant, would protect retinal pigment epithelium and impede the progression of retinal degeneration. The goal of this work was to evaluate the efficacy of NACA in preventing retinal pigment epithelial cell and photoreceptor death in AMD models. To achieve this, we …

Improvement Of Crystallization Behavior Of Polylactide Using Modified Chitin Whisker As Nucleating Agent, Nichaphat Passornraprasit

Chulalongkorn University Theses and Dissertations (Chula ETD)

This work focuses on the enhancement of crystallization behavior of polylactide (PLA). The small crystalline of polymer was used to induce nuclei for crystallization. The small crystalline of chitin whisker (CW) was prepared by acid hydrolysis. In order to enhance the compatibility between CW and PLA matrix, CW was grafted with acid terminated poly(D,L-lactic acid) (PDLLA) by coupling reaction to obtain PLA-g-CW. Then, the CW and PLA-g-CW were used as nucleating agents by compounding with PLA pellets at various contents from 0.1-0.3 phr by cast film extrusion. The SEM images of nanocomposites showed more agglomeration of whiskers with the increasing …

Separation Of Silver And Gold Ions/Nanoparticles In Water Using Chemically Modified-Silica For Spectrometric Detection, Pimpimon Anekthirakun

Chulalongkorn University Theses and Dissertations (Chula ETD)

The separation of gold and silver ions/nanoparticles in water using chemically-modified silica and unmodified silica was investigated by solid-phase extraction (SPE) followed by the determination via inductively coupled plasma-optical emission spectrometry (ICP-OES). 1-Carboxymethyl-3-methylimidazolium chloride ionic liquid [MimCM]Cl and humic acid (HA) immobilized onto aminopropyl silica (SiAP) sorbents were successfully prepared for the separation of metal species. Ionic liquid modified-SiAP (SiAP-IL) sorbent was chosen for the separation of gold ions/nanoparticles, while humic acids modified-SiAP (SiAP-HA) sorbent was selected for silver ions/nanoparticles. Based on this proposed method, the metal ions were preferentially adsorbed onto the solid sorbent over the metal nanoparticles, thus …

The Mechanism Of Inhibition Of Botulinum Neurotoxin Type A By Two Quinolinol Compounds, Yacoba Vroom Teschemaker Minnow

Theses, Dissertations and Culminating Projects

Quinolinol-based compounds are a promising starting point for discovery o f effective inhibitors o f the clostridial neurotoxin, botulinum neurotoxin type A light chain (BoNT/A LC). Insights into the mechanism o f inhibition by quinolinol compounds facilitate interpretation o f docking data and inhibitor optimization. In this study, a fluorogenic substrate o f BoNT/A, SNAPtide, was used to study the mechanism by which two new quinolinol compounds, MSU58 and MSU84, with IC₅₀ values of 3.3 uM and 5.8 uM, respectively, inhibit BoNT/A LC. Kinetic studies and model discrimination analysis showed both compounds to be competitive inhibitors o f BoNT/A …

Investigation Of Hsp90 Structure-Activity Relationships In Epigallocatechin Gallate, Arpita Patel

Theses, Dissertations and Culminating Projects

(-)-Epigallocatechin gallate (EGCG) is a polyphenolic natural product that inhibits the key chaperone protein Hsp90 by binding to the carboxy terminal portion of the protein. The natural product has modest activity as an Hsp90 inhibitor and there is little information in the literature on structure activity relationships for EGCG analogs. Previous studies from this laboratory provided initial data on the effect of a limited range of changes associated with functional groups, substituents and stereochemistry. The focus of this research is to explore these initial results in more detail with a focus on the synthesis of EGCG analogs with more drug …

Heterocycles Via The Pd-Catalyzed Heterofunctionalization Of Alkylidenecyclopropanes, Phillip Roman Lazzara

Dissertations

Natural compounds are often used as inspiration for novel chemical structures that provide medicinal benefits to human health. The unique 3-dimentional structures of these molecules make the majority of them synthetic challenges for organic chemists. While there is great diversity among these molecules, many of these carbon-based compounds exhibit similar key structural features. One of the most common features amongst biologically active molecules is a rigid carbon ring bearing nitrogen or oxygen atoms, which are known as heterocycles. The structural rigidity of heterocycles helps properly align key interactions of the molecule with those of a specific protein, which causes the …

A Miniaturized Spectrophotometric In Situ Ph Sensor For Seawater, Reuben C. Darlington

Graduate Student Theses, Dissertations, & Professional Papers

Since the Industrial Revolution, the world's oceans have absorbed increasing amounts of CO2 and the resultant changes to the marine carbonate chemical system have reduced the pH by > 0.1 units (~ 30%) in surface waters. This acidification of the oceans has many far reaching impacts on marine life and there is great need of quality instrumentation to assess and follow the changing carbonate system. This MIS project aims to develop a low cost pH sensor with high precision and accuracy for open sea measurements with special emphasis on reduced size and cost. Design effort is based on the commercially available …

Porphyrin-Based Catalysts For Electrochemical Reduction Of Carbon Dioxide, Piyawat Sangpittayatorn

Chulalongkorn University Theses and Dissertations (Chula ETD)

In this work, synthesis and investigation on catalytic activities for the electrochemical reduction (ECR) of carbon dioxide (CO2) of aminophenyl-substituted metalloporphyrin and metallobenzoporphyrin containing Zn(II) or Co(II) as a metal center and their polymers were described. Electropolymerization of the amino-functionalized monomers were performed on indium tin oxide (ITO)-coated glasses and carbon papers by means of cyclic voltammetry in dimethylformamide (DMF) containing a 0.1 M nBu4NPF6 supporting electrolyte by using a Pt plate as a counter electrode and a Ag/AgCl quasi-reference electrode (QRE). Due to low solubility of the Co-metallated monomers, homogeneous electrochemical reduction was studied in DMF containing 0.5 mM …

Structure-Reactivity Relationship Of Bio-Inspired Copper Complexes Containing Polypyridylamine Derivatives, Pattira Suktanarak

Chulalongkorn University Theses and Dissertations (Chula ETD)

In this dissertation, bio-inspired copper complexes were designed to study the influence from ligands, nuclearity, solvents and secondary coordination on reactivity toward small-molecule activation. This structure-reactivity relationship was examined in oxygen reduction reac­tions (ORR), and applied in detection of ascorbic acid (AsH2). First, copper(II) complexes containing polypyridyl-derivative ligands (i.e., Cu(dpa), Cu(adpa) and Cu2(addpa)) were synthesized and fully characterized by X-ray crystallography. The Cu(I) complexes which are active species for ORR were generated using AsH2 as a reducing agent. Redox states of the metal were examined by UV-Vis, NMR and EPR. It was found that copper complexes with various ligand topologies …

Exposure Of Commercial Titanium Dioxide And Copper Hydroxide Nanomaterials On Basil (Ocimum Basilicum): A Life Cycle And Transgenerational Study, Wenjuan Tan

Open Access Theses & Dissertations

Although thousands of reports have shown that engineered nanomaterials (ENMs) can alter several agronomical, physiological, and biochemical parameters in plant and mammal systems, the effects of long-term exposure and varietal responses are scarce. Titanium dioxide nanoparticles (nano-TiO2) and copper hydroxide nanoparticles [nano-Cu(OH)2], which are widely used in agriculture, medicine, food industry, textile, among other areas, are among the ENMs with high production and consumption globally. Though reports indicate that these ENMs affected plant development and metabolism, their interactions with basil (Ocimum basilicum) are unknown. Basil is a popular culinary herb worldwide, featured in Asian and European cuisine and has more …

Methods For Producing Graphene From Petroleum By-Products, Eva M. Deemer

Open Access Theses & Dissertations

N/A

Kinetic Analysis And Mechanochemical Syntheses Of Palladium Complexes, Jonathon Zachary

Murray State Theses and Dissertations

Mechanochemical synthesis is a rapidly developing, more environmentally friendly alternative to traditional solution based syntheses. Mechanochemical methods often result in higher overall yields, minimize undesirable side reactions, and present cleaner more concise methods for compound preparation. This work will address the syntheses of three dialkyl 2,2′-bipyridyl-4,4′-dicarboxylate complexes of palladium(II) iodide and the kinetics of these reactions. Then, this work will address the improved synthesis and purification of 1,3-dimethyl-1H-benzimidazolium iodide and the synthesis of diiodo-bis(1,3-dimethyl benzimidazol-2-ylidene) palladium(II).

The successful synthesis of dialkyl 2,2′-bipyridyl-4,4′-dicarboxylate complexes of palladium(II) iodide was carried out under solvent free ball milling conditions and the kinetic analysis was …

A Quartz Crystal Microbalance Study Of Thiol:Ene Poly(Ionic Liquid) Polymerization And Gas Absorption, Yueming Wu

Murray State Theses and Dissertations

ABSTRACT

The polymerization process of, and gas absorption by, imidazolium-containing thiol:ene poly (ionic liquid)s (PILs), prepared from bisallylimidazolium bis(trifluoromethyl sulfonyl)imide [NTf₂^-] and pentaerythritoltetrakis(3 mercaptopropionate), was studied. The thiol:ene PILs examined were recently reported by groups at Murray State University. The advantage of thiol:ene PILs over other reported PILs is that thiol:ene polymers are made rapidly by UV exposure and exhibit high mechanical and thermal stability due to high cross-linking. The properties of interest for the thiol:ene PILs were studied using a quartz crystal microbalance (QCM). QCM techniques are based on the piezoelectric effect, where certain crystals (e.g., …

Identification And Characterization Of A Chemical Compound That Inhibits Methionyl-Trna Synthetase From Pseudomonas Aeruginosa, Sara Robles, Yanmei Hu, Tahyra Resto, Frank Dean, James M. Bullard

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

Background: Pseudomonas aeruginosa is an opportunistic pathogen problematic in causing nosocomial infections and is highly susceptible to development of resistance to multiple antibiotics. The gene encoding methionyl-tRNA synthetase (MetRS) from P. aeruginosa was cloned and the resulting protein characterized.

Methods: MetRS was kinetically evaluated and the KM for its three substrates, methionine, ATP and tRNAMet were determined to be 35, 515, and 29 μM, respectively. P. aeruginosaMetRS was used to screen two chemical compound libraries containing 1690 individual compounds.

Results: A natural product compound (BM01C11) was identified that inhibited the aminoacylation function. The compound inhibited P. aeruginosa MetRS with an …

Improved Protein Characterizations Using Ionic Liquids: Page And Maldi-Ms, Punprabhashi Vidanapathirana

LSU Doctoral Dissertations

Protein separation by polyacrylamide gel electrophoresis (PAGE) and identification by matrix assisted laser desorption ionization-mass spectrometry (MALDI-MS) are primary tools of protein analysis. In these techniques, surfactants are used in protein sample preparation in order to enhance the protein solubility. Conventional surfactants have shown limitations in protein analysis due to the structural complexity of proteomes, resulting in low resolution. The research goal of this dissertation is to address some of these limitations by applying novel cationic ionic liquid surfactants (ILS), N-alkyl-4-methyl pyridinium bromide (CnPBr where n=4, 8, 11). The ILS would be suitable candidates to be used in PAGE protein …

Nanoscale Studies Of Proteins And Thin Films Using Scanning Probe Microscopy, Zachary Lane Highland

LSU Doctoral Dissertations

Nanostructures of organosilanes, thin metal films, and protein nanopatterns were prepared and analyzed with atomic force microscopy (AFM). Organosilanes with designed functional groups were used to selectively pattern green fluorescent protein at the nanoscale using protocols developed with particle lithography. Mesospheres are deposited onto a substrate to produce a surface mask. Organosilanes are deposited to form a matrix film surrounding nanopores for depositing proteins. The nanopatterns were characterized using AFM, after steps of particle lithography for directly visualizing surface changes. Studies with AFM also provide a compelling tool for teaching undergraduates to introduce concepts of nanoscience. An undergraduate laboratory was …

Chemical Synthesis: New Methods For O-Glycosylation And The Preparation Of Organic Thin Films, Rashanique Deondria Quarels

LSU Doctoral Dissertations

This dissertation focuses on the diverse use of chemical synthesis. Herein, I will discuss the use of synthetic organic chemistry for the modification surfaces and the synthesis of small molecules. Chapter One is an introduction to the realm of surface chemistry. I have highlighted some key methods for surface modification. Additionally, methods to characterize the as-formed thin films are also outlined. In Chapter Two, I discuss the use of visible-light photoredox catalysis in the nanoscale lithography of Au(111) surfaces. Blue LED irradiation of solutions of NBDT in the presence of Ru(bpy)32+ results in the formation of p-nitrophenyl radicals that graft …

Design, Synthesis, And Evaluation Of Innovative Bodipy-Peptidic Conjugates For Biological Application, Tyrslai Menyaee Williams

LSU Doctoral Dissertations

Abstract Chapter 1 provides a brief introduction to colorectal cancer (CRC), methods of detection, photodynamic therapy (PDT), and EGFR as an attractive targeting strategy for imaging CRC. Chapter 2 details the synthesis of ten peptide sequences for targeting EGFR receptors at the site of CRC, as a collaborative work with Dr. Seetharama Jois. This chapter also investigates the efficacy of these peptides for EGFR. Chapter 3 offers the first synthetic strategy for developing BODIPY-peptide conjugates via amide linkages. All conjugates were optimized for the best reaction conditions and good yields were observed. Each conjugate was subjected to photophysical, SPR, and …

Effect Of Metal Speciation In Fly Ash On Environmentally Persistent Free Radical Formation, Elisabeth Eileen Cook

LSU Doctoral Dissertations

Waste incineration and Superfund sites lead to the formation of pollutants harmful to both the environment and human health. Environmentally Persistent Free Radicals (EPFRs) are a class of newly discovered radical pollutants known to form on combustion by-products such as fly ash and particulate matter. EPFRs are rapidly gaining attention for their harmful effects on the environment and human health. Previous research has shown the formation of EPFRs through surface-mediated reactions with transition metal-oxides on particulates. The work presented in this dissertation explores the relationship between fly ash composition and EPFR formation. Fly ash production occurs from combustion systems, namely …

Design, Synthesis, Characterization And Evaluation Of Near Infrared Bodipy Dyes For Various Applications, Qianli Meng

LSU Doctoral Dissertations

4,4-Difluoro-4-bora-3a,4a-diaza-5-indacene (BODIPY) have drawn a large number of research attention, for its numerous useful application in the fields of material and biology. Small modification of this well-known fluophore has been shown to optimize its photophysical and chemical properties. This work mainly focuses on functionalization of BODIPY cores with halogenated atoms, particularly iodine, and their subsequent post-functionalization reactions, mainly cross-coupling reaction and substitutions, for various further applications. Chapter 1 of this dissertation gives a general overview of BODIPYs including their synthetic strategies, post-functionalization, and how BODIPYs are utilized in many biological applications. Chapter 2 mainly focuses on the synthesis and characterization …

Fluorescent Probe Interrogation Of A Cytoprotective Cancer-Linked Oxidoreductase In Two-Dimensional Human Cell Cultures And Solid Tumor Mimics, Bijeta Prasai

LSU Doctoral Dissertations

Fluorescence molecular imaging is an emerging field with potential to aid in optically guided surgery for cancer treatment. To overcome the drawbacks of always-on fluorescent probes, such as indocyanine green, activatable fluorescent probes are being developed that allow high signal-to-background imaging for better discrimination of cancerous cells from normal cells. For activation, turn-on fluorescent probes rely on the presence of biomarkers such as antibodies, cell-surface receptors or enzymes that are highly specific to tumor cells. hNQO1 (human NAD(P)H: quinone oxidoreductase isoenzyme 1) is considered as one of such cancer-associated biomarkers that are present intracellularly in cancers of multiple origins. It …

Microwave-Induced Paal-Knorr Reaction With Ammonium Chloride: Synthesis Of Pyrroles, Debasish Bandyopadhyay, Bimal K. Banik

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

An expeditious microwave-induced synthesis of pyrroles using commercially available 2,5- dimethoxytetrahydrofuran and primary amines in the presence of ammonium chloride has been achieved in excellent yield.

Microwave-Induced Bismuth Triiodide-Catalyzed Facile Synthesis Of Octahydroxanthenes, Ashlee Chavez, Jessica Cruz, Alexdra Munoz, Ram Naresh Yadav, Debasish Bandyopadhyay, Bimal K. Banik

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

Microwave-induced reaction of 1,3-cyclohexanedione with numerous aldehydes using bismuth iodide is performed successfully toward the synthesis of important octahydroxanthenes. A most probable mechanism is suggested to explain the formation of products.

Carbon Dioxide-Mediated Preparation Of Pyrroles In Water Following Paal Knorr Method, Ram Naresh Yadav, Bimal K. Banik

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

Carbon dioxide-mediated new reaction of 2,5-hexanedione and primary amino compounds in water-THF produced N-substituted pyrroles in excellent yield. This method for the preparation of pyrroles is novel, simple, and efficient.

Non-Traditional Examination: A Study To Improve Academic And Research Performance Of Undergraduate Organic Chemistry Students#, Bimal K. Banik, Ram Naresh Yadav, Sunena Chandra

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

An investigation of conducting a presentation examination instead of a classical written examination method on academic and research performance of undergraduate chemistry students was performed at the University of Texas-Pan American. The results suggest that chemistry students do much better in the presentation examination compared to the written examination at the advanced organic chemistry course. But, the performances of the students in the lower level courses are mixed. However, students do much better in research work when presentation examination was conducted.

Dihydropyridines As Calcium Channel Blockers: An Overview, Thelma Salazar, Andres Gonzalez, Debasish Bandyopadhyay

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

Cardiovascular disease remains one of the leading causes of death in the United States. It is estimated that 1 in every 3 American adults suffer from high blood pressure. Hypertension, a precursor to most cardiovascular diseases, continues to grow at an alarming rate and is seldom managed carefully. Attempts have been made to manage hypertension and reduce the morbidity and mortality of the cardiovascular organ through methods including diets, increased amount of exercise, and medications. Many commercial drugs have been derived from dihydropyridine due to its antihypertensive property. Dihydropyridine derivatives work by acting as calcium channel blockers blocking the intake …