Chemistry Commons^™

Phytotoxicity Of Silver Species To Egeria Densa And Applications To Phytoremediation, Leonard James Bernas

Theses and Dissertations

Silver species pose a significant threat to aquatic ecosystems because the use of silver nanoparticles (AgNps) for industrial applications is significantly increasing, as are discharges into waterways. The effects have only been studied on select fish and aquatic plants, so more research is needed to understand the risks associated with silver species in the environment. Egeria densa (E. densa, also known as Elodea densa), a common freshwater submerged macrophyte, was exposed to 0-1.25 ppm silver cations and 2 and 15 nm AgNps in an aqueous environment for 7 days. E. densa was chosen for this study because it is a …

Investigation Of Dynamic Biological Systems Using Direct Injection And Liquid Chromatography Mass Spectrometry, Adam Clayton Swensen

Theses and Dissertations

In biological systems, small changes can have significant impacts. It is, therefore, very important to be able to identify these changes in order to understand what is occurring in the organism. In many cases, this is not an easy task. Mass spectrometry has proven to be a very useful tool in elucidating biological changes even at a very small scale. Several different mass spectrometry based techniques have been developed to discover and investigate complex biological changes. Some of these techniques, such as proteomics, have been through years of development and have advanced to the point that anyone can complete complex …

A Pes Study Of Factors Influencing Metal Partitioning In Aquatic Systems: “Design Of Experiment As, Cd, Co, Cr, Cu, Pb, Ni, And Zn”, Eid A. Alkhatib, John Rapaglia, Leon Theim

Chemistry & Physics Faculty Publications

Mobility and bioavailability of heavy metals are related to their partitioning amongst suspended sediment and water. A Particle Entrainment Simulator (PES) is used to simulate sediment resuspention in natural surface water systems. The simulations were carried out under various conditions of water/suspended solids conditions. Five factors, each at various levels, are tested collectively: the pH of water at two levels (4 and 8), shear stress on bottom sediment at three levels (0.1, 0.3, and 0.5 N/m2 ) salinity of water at two levels (0.01 and 14.0 ppt), organic matter in sediment at three levels (0.50, 1.93, and 3.80%) and temperature …

Direct Attachment Of 4-Hydroxybenzoic Acid Polymers And Capture Agents To Flat Sheet And Microdialysis Membranes For Improved Mass Transport, Sarah Jane Phillips

Graduate Theses and Dissertations

Microdialysis (MD) sampling is a diffusion-based separation method which has the ability to sample any analyte that can diffuse across the semi-permeable membrane. However one challenge for MD is that for soluble proteins greater than 10 kDa, the relative recovery (RR) using a 100 kDa MD probe is between 1-5%.1 There are two major barriers that lead to these low recovery values - nonspecific adsorption (NSA) and poor solute mass transport. To overcome these two barriers, the modification of PES-based MD membranes has been initiated by laccase. Previous researchers have used laccase to modify PES flat sheet and hollow fiber …

Cucurbit[7]Uril-Tetramethylrhodamine Conjugate For Direct Sensing And Cellular Imaging, Andrew T. Bockus, Lauren C. Smith, Amy G. Grice, Omar A. Ali, Carolyn C. Young, William Mobley, Ashley Leek, James Lewis Roberts, Brittany Vinciguerra, Lyle D. Isaacs, Adam R. Urbach

Chemistry Faculty Research

This paper describes the design and synthesis of a conjugate (Q7R) comprising the synthetic host cucurbit[7]uril (Q7) linked to the fluorescent dye tetramethylrhodamine (TMR), and the characterization of its optical and guest-binding properties as well as its cellular uptake. Q7R was synthesized in two steps from monofunctionalized azidobutyl-Q7 and NHS-activated TMR. The fluorescence of Q7R is quenched upon guest binding, and this observable was used to determine equilibrium dissociation constant (K_d) values. Unexpectedly, the K_d values for guests binding to Q7R and to unmodified Q7 were essentially identical. Therefore, Q7R can directly report binding to Q7 without …

Structural Analysis Of Cell Signaling Complexes, Takuma Aoba

Theses and Dissertations

Bardet-Biedl syndrome (BBS) is a rare genetic disease that causes retinal degradation, obesity, kidney dysfunction, polydactyly, and other cilium-related disorders. To date, more than 20 BBS genes, whose mutants cause BBS phenotypes, have been identified, and eight of those (BBS1-2, 4-5, 7-9, and 18) are known to form the BBSome complex. Recent studies have revealed that the BBSome is closely involved in the trafficking of signaling proteins in the primary cilium. Mutations in BBS genes are highly pathogenic because trafficking in the primary cilium is not fully functional when BBS mutations impair assembly of the BBSome. However, the functional links …

Ijns Masthead

International Journal of Nuclear Security

No abstract provided.

Letter From The Editor - Choe, Kwan Kyoo Choe

International Journal of Nuclear Security

No abstract provided.

Table Of Contents

International Journal of Nuclear Security

No abstract provided.

Call For The Student Writing Competition

International Journal of Nuclear Security

No abstract provided.

Call For Submission

International Journal of Nuclear Security

No abstract provided.

Security Culture And Its Self-Assessment As Supplementary Tools For Nuclear Security Training, Igor Khripunov, Sara Z. Kutchesfahani, Khairul -. Khairul -

International Journal of Nuclear Security

Security Culture and its Self-Assessment as Supplementary Tools for Nuclear Security Training

Igor Khripunov, PhD

Center for International Trade and Security, University of Georgia (USA)

Sara Z. Kutchesfahani, PhD

Center for International Trade and Security, University of Georgia (USA)

Khairul Khairul

National Nuclear Energy Agency of Indonesia (BATAN)

Abstract

Nuclear security culture – an emerging and widely recognized practice – serves as a means to support and enhance nuclear security. In fact, many International Atomic Energy Agency (IAEA) publications and the Nuclear Security Summits have highlighted the vital role of nuclear security culture and raised its status to the same …

Letter From The Editor - Frahi-Amroun, Akila Frahi-Amroun

International Journal of Nuclear Security

No abstract provided.

Letter From The Editor - Hirst, Russel K. Hirst

International Journal of Nuclear Security

No abstract provided.

Conformationally Superarmed S-Ethyl Glycosyl Donors As Effective Building Blocks For Chemoselective Oligosaccharide Synthesis In One Pot, Mithila Bandara, Jagodige Yasomanee, Nigam Rath, Christian Pedersen, Mikael Bols, Alexei Demchenko

Chemistry & Biochemistry Faculty Works

A new series of superarmed glycosyl donors has been investigated. It was demonstrated that the S-ethyl leaving group allows for high reactivity, which is much higher than that of equally equipped S-phenyl glycosyl donors that were previously investigated by our groups. The superarmed S-ethyl glycosyl donors equipped with a 2-O-benzoyl group gave complete β-stereoselectivity. Utility of the new glycosyl donors has been demonstrated in a one-pot one-addition oligosaccharide synthesis with all of the reaction components present from the beginning.

Dihedral-Angle-Controlled Crossover From Static Hole Delocalization To Dynamic Hopping In Biaryl Cation Radicals, Marat R. Talipov, Tushar S. Navale, Mohammad M. Hossain, Ruchi Shukla, Maxim V. Ivanov, Rajendra Rathore

Chemistry Faculty Research and Publications

In cases of coherent charge-transfer mechanism in biaryl compounds the rates follow a squared cosine trend with varying dihedral angle. Herein we demonstrate using a series of biaryl cation radicals with varying dihedral angles that the hole stabilization shows two different regimes where the mechanism of the hole stabilization switches over from (static) delocalization over both aryl rings to (dynamic) hopping. The experimental data and DFT calculations of biaryls with different dihedral angles unequivocally support that a crossover from delocalization to hopping occurs at a unique dihedral angle where the electronic coupling (H_ab) is one half of …

Fluorescent Graphene For Cancer Cell Targeting And Detection, Rabab Nadeem Hamzah

Theses and Dissertations

The highest cause of death and illness around the world is cancer, and the range of cancers continues to increase. Breast cancer is the second leading cause of cancer death in women today, mainly in older women (over 40 years), younger women can also be affected, especially those with a genetic predisposition. Early detection of breast cancer is needed in order to limit the risk of this disease and make significant improvements in the rate of cure. Combining clinical trials with bionanotechnology for the diagnosis and treatment of cancer has received considerable attention in the last several years. Different nanomaterials …

Post-Polymerization Functionalization Of Poly (Ethylene Oxide)–Poly (Β-6-Heptenolactone) Diblock Copolymers To Tune Properties And Self-Assembly, Elizabeth Gillies, Brooke M. Raycraft, Jarret Macdonald

Chemistry Publications

Polyester-based amphiphilic block copolymers and their nanoassemblies are of significant interest for a wide range of applications due to the degradability of the polyester block. However, the commonly used polyesters lack functional groups on their backbones, limiting the possibilities to chemically modify these polymers. Described here are new poly(ethylene oxide) (PEO)–poly(β-6-heptenolactone) (PHEL) block copolymers having pendant alkenes at each repeat unit on the PHEL block. First, the self-assembly of these block copolymers in aqueous solution was studied and it was found that they formed solid nanoparticles and vesicles depending on the relative block lengths. Next the alkene moieties of the …

Building The Education And Training Pillar Of The University Of Tennessee’S Institute For Nuclear Security, Howard Lewis Hall

International Journal of Nuclear Security

The University of Tennessee (UT) developed its first formal and coordinated efforts in nuclear security education in 2008-2009 with its graduate certificate program in nuclear security in the Department of Nuclear Engineering. Building on this work, in 2011 UT established the UT Institute for Nuclear Security (INS) as a collaborative center at the university to expand its curricular impact as well as foster research and partnerships with nearby major governmental facilities engaged in nuclear security work. Oak Ridge National Laboratory (ORNL), the Y-12 National Security Complex (Y-12), and Oak Ridge Associated Universities (ORAU) have joined with UT as charter members …

Promoting Excellence And Demonstrated Competence For Nuclear Security Training, Daniel Johnson, Brunelle Battistella, Roger Howsley

International Journal of Nuclear Security

The international community has spent considerable time, money, and effort attempting to establish a series of national and regional Centres of Excellence (COEs), also known as Nuclear Security Training and Support Centres (NSSCs). These Centres tend to have a wide variety of objectives, structures, and methods of delivery. Unsurprisingly, no internationally accepted standard exists on how they should operate. The IAEA has produced some excellent guidance (TECDOC 1734), but by virtue of its role cannot provide standards for benchmarking success. Against this backdrop, the World Institute for Nuclear Security (WINS) launched the WINS Academy, an initiative to provide practitioners with …

Spray Printing Of Organic Semiconducting Single Crystals, Grigorios-Panagiotis Rigas, Marcia M. Payne, John E. Anthony, Peter N. Horton, Fernando A. Castro, Maxim Shkunov

Chemistry Faculty Publications

Single-crystal semiconductors have been at the forefront of scientific interest for more than 70 years, serving as the backbone of electronic devices. Inorganic single crystals are typically grown from a melt using time-consuming and energy-intensive processes. Organic semiconductor single crystals, however, can be grown using solution-based methods at room temperature in air, opening up the possibility of large-scale production of inexpensive electronics targeting applications ranging from field-effect transistors and light-emitting diodes to medical X-ray detectors. Here we demonstrate a low-cost, scalable spray-printing process to fabricate high-quality organic single crystals, based on various semiconducting small molecules on virtually any substrate by …

Nuclear Security Education At Pakistan Institute Of Engineering And Applied Sciences (Pieas): Current Status, Future Prospects And The Lessons Learnt, Tariq Majeed Dr.

International Journal of Nuclear Security

In this paper, the details of nuclear security education at Pakistan Institute of Engineering and Applied Sciences (PIEAS) have been discussed. Nuclear Security education was initiated at PIEAS as a sub-specialty of its MS Nuclear Engineering Program in October 2009. Two courses, Nuclear Security (NE-581) and Physical Protection Systems (NE-582) have been offered on regular basis in the 3^rd and 4^th semesters. To date, 72 students have been graduated with this sub-specialty. The most important lesson learnt is that introduction of nuclear security related courses in nuclear engineering program has opened up new venues of applications of nuclear …

Design, Synthesis, And Evaluation Of Dasatinib-Amino Acid And Dasatinib-Fatty Acid Conjugates As Protein Tyrosine Kinase Inhibitors, Rakesh Tiwari, Alex Brown, Neda Sadeghiani, Amir Nasrolahi Shirazi, Jared Bolton, Amanda Tse, Gennady M. Verkhivker, Keykavous Parang, Gongqin Sun

Pharmacy Faculty Articles and Research

Derivatives of dasatinib were synthesized via esterification with 25 carboxylic acids including amino acids and fatty acids by extending the inhibitor to interact with more diverse sites and to improve specificity. Dasatinib-L-arginine derivative (Das-R, 7) was the most potent of the inhibitors tested with IC50 values of 4.4 nM, <0.25 nM, and <0.45 nM against Csk, Src, and Abl kinases, respectively. The highest selectivity ratio obtained in our study, 91.4 Csk/Src belonged to compound 18 (Das-C10) with an IC50 of 3.2 μM for Csk compared to 35 nM for Src. Furthermore, many compounds displayed increased selectivity toward Src, as compared with Abl. Compounds 15 (Das-E) and 13 (Das-C) demonstrated the largest gains (10.2 and 10.3 Abl/Src IC50 ratios). Das-R (IC50 = 2.06 μM) was significantly more potent than Das (IC50 = 26.3 μM) against Panc-1 cells while they both showed an IC50 < 51.2 pM against BV-173 and K562 cells. Molecular modeling and binding free energy simulations revealed a good agreement with the experimental results and rationalized differences in selectivity of the studied compounds. Integration of experimental and computational approaches in the design and biochemical screening of dasatinib derivatives facilitated rational engineering and diversification of dasatinib scaffold, providing useful insights into mechanisms of kinase selectivity.

Nuclear Security And Hrd - Viet Nam’S Effort, Nu-Hoai-Vi Nguyen, Tan Huu Vuong

International Journal of Nuclear Security

Viet Nam is expanding its nuclear energy program for the application in various areas including industries, agriculture, healthcare, education and research. Recognizing the importance of the nineteen issues laid out in the IAEA document “Milestones in Development of a National Infrastructure for Nuclear Power” [1], Vietnam is considering how to address these issues. This paper describes the establishment of nuclear security infrastructure in Viet Nam and how Viet Nam has addressed one of the nineteen issues, that is human resource development in nuclear energy in general and in nuclear security in particular.

Challenges And Responses For Ensuring Sustainability Of Insa Training Programs, Jongsook Kim, Hyung-Kyung Lee, Jin-Young Lee

International Journal of Nuclear Security

Providing a systematic training is critical for a state or international perspective to reinforce nuclear security regime nationally or internationally. Korea government recognizes the importance of such challenge, and established the INSA under the KINAC as a Center of Excellence for fostering national nuclear security capacity and contributing international nuclear security governance. INSA started with the government policy that the establishment of sustainable education and training infrastructure and processes is fundamental to the capacity building strategy. After established, INSA has been designing and delivering the domestic and international/regional training programs for the purpose of fostering human resources development in nuclear …

Synthesis, X-Ray Structures, Electronic Properties, And O2/No Reactivities Of Thiol Dioxygenase Active-Site Models, Anne A. Fischer, Nuru Stracey, Sergey V. Lindeman, Thomas C. Brunold, Adam T. Fiedler

Chemistry Faculty Research and Publications

Mononuclear non-heme iron complexes that serve as structural and functional mimics of the thiol dioxygenases (TDOs), cysteine dioxygenase (CDO) and cysteamine dioxygenase (ADO), have been prepared and characterized with crystallographic, spectroscopic, kinetic, and computational methods. The high-spin Fe(II) complexes feature the facially coordinating tris(4,5-diphenyl-1-methylimidazol-2-yl)phosphine (^Ph2TIP) ligand that replicates the three histidine (3His) triad of the TDO active sites. Further coordination with bidentate l-cysteine ethyl ester (CysOEt) or cysteamine (CysAm) anions yielded five-coordinate (5C) complexes that resemble the substrate-bound forms of CDO and ADO, respectively. Detailed electronic-structure descriptions of the [Fe(^Ph2TIP)(L_S,N)]BPh₄ complexes, where L …

‘A Novel Kaposi’S Sarcoma Therapy:’ Plasmonic Nanoparticles For Light-Mediated Drug Delivery, Blake Peter Kruger

Honors Capstones

No abstract provided.

Inhibition Of The Flavin-Dependent Monooxygenase Siderophore A (Sida) Blocks Siderophore Biosynthesis And Aspergillus Fumigatus Growth, Julia S. Martín Del Campo, Nancy Vogelaar, Karishma Tolani, Karina Kizjakina, Kim Harich, Pablo Sobrado

Chemistry Faculty Research & Creative Works

Aspergillus fumigatus is an opportunistic fungal pathogen and the most common causative agent of fatal invasive mycoses. The flavin-dependent monooxygenase siderophore A (SidA) catalyzes the oxygen and NADPH dependent hydroxylation of l-ornithine (l-Orn) to N5-l-hydroxyornithine in the biosynthetic pathway of hydroxamate-containing siderophores in A. fumigatus. Deletion of the gene that codes for SidA has shown that it is essential in establishing infection in mice models. Here, a fluorescence polarization high-throughput assay was used to screen a 2320 compound library for inhibitors of SidA. Celastrol, a natural quinone methide, was identified as a noncompetitive inhibitor of SidA with a MIC value …

Photocatalytic Reduction Of Co2 With Tunable Bandgap And Bandedge Materials, Thuhuong T. Ngo

USF Tampa Graduate Theses and Dissertations

Solar energy is a sustainable resource which has substantial potential to meet the increasing demand for renewable energy. Though there has been some success in harvesting solar energy for electricity production, converting solar energy to chemical energy as fuels is still a challenge due to low efficiency.

Since the discovery of TiO₂ photocatalysts for splitting water (4) and reducing CO₂ (5) to form useful chemical feedstock such as H₂, CO and CH₄, much research has been done to increase the efficiency of photocatalysts. However, the current conversion efficiency of photocatalysts remains low (~5%) (6, …

Graphene Quantum Dots Electrochemistry And Development Of Sensitive Electrochemical Biosensor [Hybrid Poster 1-B], Tyler Smith, Alexander Banaszak

Posters-at-the-Capitol

Graphene quantum dots (GQDs) are zero-dimensional material derived from graphene derivatives with characteristics from the structure of graphene with quantum confinement and edge effects possessing unique properties. Intense research activity in GQDs is attributed to their novel physical-chemical phenomena arising from the sp²-bonded carbon core surrounded with edge functional moieties. In this work, GQDs of optimal 5-7 nm size are investigated for their fundamental electrochemical properties and use in electrochemical sensing including enzyme-based glucose biosensor. Glucose oxidase (GO_x) was immobilized on GQDs modified glassy carbon (GC) and the UV-Vis absorption and fluorescence spectroscopy, electron microscopy, cyclic …