Chemistry Commons^™

Solvation Of Organic Cations In The Gas Phase And Within Molecular Clusters, Ahmed Hamid

Theses and Dissertations

The role of the solvent in ionic and ion-molecule interactions is of fundamental importance in kinetics and thermodynamics of solution chemistry. However, the study of the ionic interactions in the presence of a large number of solvent molecules is very challenging. Therefore, the gas-phase is the appropriate medium to study such reactions on a molecular level where the ion-solvent interaction can be examined by studying ions surrounded with a cluster of solvent molecules in the complete absence of the any interference caused by the bulk of the solvent. In nature, organic ions can form hydrogen bonds with solvents. An insight …

Sorption Kinetic Study Of Selenite And Selenate Onto A High And Low Pressure Aged Iron Oxide Nanomaterial, Christina M. Gonzalez, Jeffrey Hernandez, Jose R. Peralta-Videa, Cristian E. Botez, Jason Parsons, Jorge L. Gardea-Torresdey

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

The sorption of selenite (SeO32−) and selenate (SeO42−) onto Fe3O4 nanomaterials produced by non microwave-assisted or microwave-assisted synthetic techniques was investigated through use of the batch technique. The phase of both synthetic nanomaterials was determined to be magnetite by X-ray diffraction. The average grain sizes of non microwave-assisted and microwave-assisted synthetic Fe3O4 were determined to be 27 and 25 nm, respectively through use of the Scherrer's equation. Sorption of selenite was pH independent in the pH range of 2-6, while sorption of selenate decreased at pH 5 and 6. The addition of Cl− had no significant effect on selenite or …

Stiefel And Grassmann Manifolds In Quantum Chemistry, Eduardo Chiumiento, Michael Melgaard

Articles

We establish geometric properties of Stiefel and Grassmann manifolds which arise in relation to Slatertype variational spaces in many-particle Hartree-Fock theory and beyond. In particular, we prove thatthey are analytic homogeneous spaces and submanifolds of the space of bounded operators on the single-particle Hilbert space. As a by-product we obtain that they are complete Finsler manifolds. These geometric properties underpin state-of-the-art results on existence of solutions to Hartree-Fock type equations.

Improved Synthesis Of The Longtailed Mealybug Pheromone, Johanna M. Bakonyi

Master's Theses

No abstract provided.

Dibenzo(B,F)(1,4)Diazocine-6,11(5h,12h)-Dione Dianion. The Chameleon Compound, Ruben Fernandez^, Sergio Villanueva, Tomas Espinosa, James Salvador*

COURI Symposium Abstracts, Spring 2012

No abstract provided.

Development Of Novel Non-Invasive Diagnostic Methods For Early Detection Of Prostate And Breast Cancer, Marisol Sanchez^, Olivia C. Jones, Wen-Yee Lee*

COURI Symposium Abstracts, Spring 2012

No abstract provided.

Photo-Friedel-Crafts Acylation With Sunlight, Fernando De Leon^, Shizue Mito*

COURI Symposium Abstracts, Spring 2012

No abstract provided.

Enantioselective Biotransformation Of Prochiral Ketone Via Daucus Carota, Ryan Smith, Charlie Knox, Elizabeth Davis

Undergraduate Research Conference

Biotransformations of prochiral ketones can be performed using plant cells. The benefits of using plant cells include low cost, environmentally sound procedures compared to conventional chemical processes, and the stereospecific nature of the reaction.1,2 Benzofuran-2-yl methyl ketone was reduced to (- )-benzofuran-2-yl-ethanol after incubation with carrots in water. The reaction was enantioselective in that it produced the S-isomer as indicated by optical activity. Currently, attempts to isolate the carrot enzyme and antimicrobial studies of the (-)-benzofuran-2-yl-ethanol product are underway.

Research In The Teaching Laboratory: Improving The Synthesis Of Lidocaine, Chris Taliaferro

Undergraduate Research Conference

The multi-step synthesis of Lidocaine is traditionally a low-yielding reaction mainly due to its second step, formation of a-chloro-2,6-dimethylacetanilide. Students often question the use of an acid (acetic acid) as the solvent for the reaction of a base (2,6-dimethylaniline, 1) with the acyl chloride (a-chloroacetyl chloride, 2), (Reaction Scheme) but they follow the procedure as directed.

Students, if treated as scientists in training, should be able to form a hypothesis before an experiment, design experiments to test the given hypothesis, and evaluate the results. A typical laboratory class was assigned to synthesize a-chloro-2,6-dimethylacetanilide using …

Hydrophilic Polymers Of Poly (2-Hydroxy Ethyl Methacrylate) With Tunable Properties For Drug Release, Sequestration Of Blistering Agent, Preparation Of Ultra-Strong Hydrogels & Thermal Stability Of Various Organic Azides, Ramakanth Ananthoji

USF Tampa Graduate Theses and Dissertations

The design and synthesis of new finely tunable porous materials has spurred interest in developing novel uses in a variety of systems. Zeolites, inorganic materials with high thermal and mechanical stability, in particular, have been widely examined for use in applications such as catalysis, ion exchange and separation. A relatively new class of inorganic-organic hybrid materials known as metal-organic frameworks (MOFs) has recently surfaced, and many have exhibited their efficiency in potential applications such as ion exchange and drug delivery. A more recent development is the design and synthesis of a subclass of MOFs based on zeolite topologies (i.e. ZMOFs), …

Protein Profiling Of Adenine Nucleoside And Nucleotide Analogs Binding Proteins Using N6-Biotinylated-8-Azidoadenosine Analogs As Affinity Based Protein Profiling Probes, Shikha Mahajan

USF Tampa Graduate Theses and Dissertations

Identification of differential expressions of proteins in proteomic profiles of biological samples shows great potential as a valuable technique for the early diagnosis of various diseases. An important challenge in modern protein profiling approaches is to reduce the complexity of the samples by limiting the number of proteins that need to be evaluated for distinction in the expression between normal and deceased cells. In this research, an affinity based approach for the enrichment of nucleotide and nucleoside binding proteins from a complex cell proteome has been developed. To achieve this goal, new N6-biotinylated-8-azido-adenosine probes (AdoRs) have been designed and synthesized …

Extraction Politics: An Economic Analysis Of Rare Earth Elements, Aishwarya Subbaraman '12

Honor Scholar Theses

Rare earth elements (REE) have critical applications in high-technology industries such as defense and clean energy. China holds more than 90% of the current production capacity for these elements and in September, 2010 announced plans to cut its exports of the elements by 72%. Amid a rush to develop substitutes for the materials, in 2012 the USS. E.U., and Japan have filed a case against China in the WTO. This paper will analyze the extraction of rare earth clement (REE) extraction from the joint perspective of Economics and Political Science. After a brief backgrounder provided in Section 1, Section 2 …

Renewable Energy Sources: Fullerenes In Organic Solar Cells, Gustavo Hernandez^, Michael D. Irwin*

COURI Symposium Abstracts, Spring 2012

No abstract provided.

Zirconium Mediated One-Pot Synthesis Of Γ-Amino Acids From Carbon Dioxide, Diego A. Pedroza^, Shizue Mito*

COURI Symposium Abstracts, Spring 2012

No abstract provided.

Impact Of Cerium Oxide Nanoparticles On Cilantro (Coriandrum Sativum), Ana C. Barrios^, Maria I. Morales, Cyren M. Rico, Jose R. Peralta, Jorge L. Gardea-Torresdey

COURI Symposium Abstracts, Spring 2012

The impact of nanoparticles (NPs) on edible plants is currently a theme of great concern. Cerium oxide NPs (CeO₂ NPs) are widely used in biomedical applications, fuel additives, and other consumer products. Studies have shown that these NPs are associated with liver damage. In addition, studies from our research group have also shown that CeO₂ NPs are stored in plant tissues without modification. Thus, these NPs could be distributed in the food chain through edible plants, posing a threat for human health. Cilantro (Coriandrum sativum) is a very important culinary and medicinal plant worldwide. It is …

Towards The Synthesis Of An Α-L-Rhamnose And Α-D-Galactose Containing Trisaccharide Epitope Related To Trypanosoma Cruzi, Merieme Khamsi ^, Katja Michael *

COURI Symposium Abstracts, Spring 2012

No abstract provided.

Crystal Engineering Of Multi-Component Crystal Forms: The Opportunities And Challenges In Design, Heather Dawn Marie Clarke

USF Tampa Graduate Theses and Dissertations

There is heightened interest to diversify the range of crystal forms exhibited by active pharmaceutical ingredients (APIs) in the pharmaceutical industry. The crystal form can be regarded as the Achilles' heel in the development of an API as it directly impacts the physicochemical properties, performance and safety of the API. This is of critical importance since the crystal form is the preferred method of oral drug delivery by industry and regulatory bodies. The ability to rationally design materials is a lucrative avenue towards the synthesis of functional molecular solids with customized physicochemical properties such as solubility, bioavailability and stability. Pharmaceutical …

Synthesis, Structure, And Spectroscopic Properties Of Diphenyl Pyridine Amine Platinum (Ii) Complexes, Jacqueline Gamboa Varela^, Alejandro J. Metta-Magaña, Jose E. Núñez*

COURI Symposium Abstracts, Spring 2012

No abstract provided.

I, Synthesis Of Β-Sitosterol And Phytosterol Esters. Ii, New Methodology For Singlet Oxygen Generation From 1,1-Dihydroperoxides, Jiliang Hang

Department of Chemistry: Dissertations, Theses, and Student Research

Phytosterols are steroid compounds structurally similar with cholesterol and vary in the nature of carbon side chain. β-Sitosterol is commercially available in preparative amount only as mixtures with other phytosterols. New semipreparative synthesis of pure β-sitosterol and sidechain-modified phytosterols is discussed in this dissertation. This new synthesis is achieved via a temporary masking of the stigmasterol 5,6-alkene as an epoxide. Following performance of the desired modification, the alkene is regenerated through a mild deoxygenation. Preparation of phytosterol esters for cholesterol metabolism study is also discussed in this dissertation.

Singlet oxygen (¹O₂) is the lowest excited state …

Chemoselective Oxidation Of 6,13-Bis(Decylthio) Pentacene, Claire Eunhye Cho

Theses and Dissertations

Organic semiconductors present much potential for industrial use because of their possible low cost production, Pentacene and pentacene derivatives are promising candidates for organic semiconductor research since their ^-conjugated electronic structures possess small HOMO- LUMO gaps and high field effect mobility. Whereas there is much potential in devices made from pentacenes they do however undergo short lifetimes and poor processability due to photodegradation and poor solubility of pentacene. Previous research has shown that the pentacene lifetime and solubility can be enhanced by arylthio and alkylthio substituents placed on the pentacene backbone. For example 6,13-i?/s(decylthio)pentacene was one of the longest lived …

Synthesis And Theoretical Studies Of Pyridyl Fullerene Derivatives For Supramolecular Applications In Photovoltaic Systems, Robert Vina-Marrufo ^, Danisha M. Rivera-Nazario, Agustin Molina-Ontoria, Luis Echegoyen *

COURI Symposium Abstracts, Spring 2012

No abstract provided.

Initial Investigation Of The Wavelength Dependence Of Optical Properties Measured With A New Multi-Pass Aerosol Extinction Differential Optical Absorption Spectrometer (Ae-Doas), R. T. Chartier, Margaret E. Greenslade

Chemistry

Atmospheric aerosols directly affect climate by scattering and absorbing radiation. The magnitude of the impact is dependent upon the wavelength of light, but is often estimated near 550 nm. When light scattering and absorption by aerosols is approximated, the wavelength dependence of the refractive index for specific components is lost. As a result, climate models would have inherent uncertainties for aerosol contributions to radiative forcing when considering the entire solar spectrum. An aerosol extinction differential optical absorption spectrometer has been developed to directly measure aerosol extinction at mid-ultraviolet to near infrared wavelengths. The instrument consists of a spectrometer coupled to …

Chemistry & Biochemistry Newsletter, Department Of Chemistry & Biochemistry, South Dakota State University

Chemistry & Biochemistry Newsletter: 2002-2015

Inside:

Page 2 NSF Grant Challenges Traditional Teaching Strategies

Page 3 Economic Development Important CBC Research Outcome

Page 4 High-Tech Equipment Helps Department Study Molecules

Page 5 Chemistry Education Joins Western Regional Graduate Student Exchange; Alum Jared L. Anderson Joins LCGC’s Editorial Advisory board; Adam Hoppe Wins Berg Award for Research Excellence

Page 6 CBC Doctoral Candidate is SDSU’s Grad Student of the Year; The Robert and Katherine Burris Distinguished Lecture Series

Page 7 Universities & K-12 Schools Partner Up to Improve Math and Science; Recent Graduates

Page 8 Alum Update; Recent Grants; Another CBC Student Featured on SDSU’s Web …

Multiphoton Fluorescence Spectroscopy To Monitor The Folding/Unfolding Of The N-Terminal Domains 5-6 Of Wilson Disease Protein, Ibtesam Y. Alja'afreh, Ramakrishna Guda, David Huffman

Research and Creative Activities Poster Day

Denaturation of the N-terminal domains 5-6 of Wilson Disease protein has been monitored through its mutant WLN5-6Cys51 by circular dichroism (CD), one and two-photon fluorescence spectroscopy after binding it to the thiolreactive dye 7-diethylamino-3-(4‘-maleimidylphenyl) -4-methylcoumarin (CPM). Far-UV CD measurements have shown that the mutations and the binding of the dye did not affect the secondary structure of the protein as the unfolding transition remained constant. The fluorescence maximum of the dye changed with the denaturant concentration and followed the trend obtained from CD and shown that one dye labeled protein can be used to monitor the unfolding of protein. Interestingly, …

Identification And Analysis Of Stereoselective Drug Interactions With Low Density Lipoprotein By High-Performance Affinity Chromatography, Matt Sobansky, David S. Hage

Department of Chemistry: Faculty Publications

Columns containing immobilized low density lipoprotein (LDL) were prepared for the analysis of drug interactions with this agent by high-performance affinity chromatography (HPAC). R/SPropranolol was used as a model drug for this study. The LDL columns gave reproducible binding to propranolol over 60 h of continuous use in the presence of pH 7.4, 0.067 M potassium phosphate buffer. Experiments conducted with this type of column through frontal analysis indicated that two types of interactions were occurring between R-propranolol and LDL, while only a single type of interaction was observed between S-propranolol and LDL. The first type …

Lead Memory In General Aviation Aircraft Engine Emissions, Randal Demik, Jason Keleher, Natalie Kasak, Julius Keller, Alessandro Mazza, Jordan Raess

Chemistry Department Faculty Articles

There is interest from environmental organizations and regulating agencies to eliminate lead and reduce pollutants emitted into the atmosphere from general aviation aircraft using 100LL aviation gasoline (Avgas). 100SF (Swift Fuel) is under development by Swift Enterprises as a lead free general aviation alternative fuel product. The purpose of this study is to determine the amount of time required for engines to be free of lead emissions when first introduced to operation using 100SF. This study also investigated the lead cleansing decay profiles of the aircraft engines under 100SF initial operations. Results of this study revealed that a mean engine …

The Impact Of Ligand Design On The Coordination Chemistry And Reactivity Of Metal Pincer Complexes, Sarath Wanniarachchi

Dissertations (1934 -)

Pincer ligands are uninegative tridentate metal-coordinating agents of the form [XZY]- where Z is the central, anchoring Lewis donor while X and Y are flanking Lewis donors. Ever since initial reports of transition metal pincer complexes were published in the late 1970's, there has been burgeoning interest in such complexes because of their desirable robust nature, generally simple syntheses, and the spectacular chemical transformations that they can mediate. In this research project, two new sets of pincer ligands with a diarylamido anchor and either two pyrazolyl nitrogenous flanking donors (NNN pincer) or one pyrazolyl and one diphenylphosphine donor (NNP pincer) …

Using Photoactive Nanoparticles As Photodynamic Antimicrobial Chemotherapeutic (Pact) Agent To Treat Chronic Wounds, Chaitanya Poola

All Capstone Projects

The purpose of this study is to use photoactive vitamin nanoparticles as photodynamic antimicrobial chemotherapeutic agent to treat patients with chronic wounds. Chronic wounds are considered as a pandemic health problem which affects millions of people and increases ~10 % annually. According to the American Academy of Dermatology, the expense of treating chronic wounds constitutes over half of the total cost for all skin diseases. The main cause of chronic wounds is due to the existence of biofilms. Biofilms are complex microbial communities containing and are reported to be major factor contributing to multiple chronic inflammatory diseases. Owing to bacterial …

Detection Of Folate Receptor From Fr+ Cells, Gopikrishna Pinnaka

All Capstone Projects

Targeted drug delivery is a newer and less explored arena that has potential scope in tumor targeting because the regular chemotherapy has lethal effects on the normal cells also. Our present Work was an attempt to specifically target receptors on cancerous cells, especially the Folate Receptor (FR). Folate is important for cells for DNA synthesis and the tissues that rapidly divide require folate, cancer cells are no exceptions for this. To cope with the increased demand for the folate the cancer cells express greater FR on the cell surface. This very fact was our basis for the construction of our …

Folate Nanoparticle Conjugates, Safwat A. Masood

All Capstone Projects

The folate receptor is overexpressed on the surface of numerous cancer cell types including those of the breast, lung, kidney, ovary, and brain. Recent interest has exploded in the use of folate to deliver payloads and imaging agents to folate receptor positive cancer cells based on several positive clinical trials including phase III trials of EC-145, which is poised to become the first folate targeted, FDA approved drug. Given the success of EC-145 and numerous other agents in the pharmaceutical pipeline, there remains a great interest in the exploitation of this technology in the delivery of nanoscale agents to folate …