Chemistry Commons^™

Rosalind Franklin And X-Ray Crystallography, Douglas Eddy

Natural Sciences Student Research Presentations

No abstract provided.

A.T.P. And Calories: The Chemistry Of The Body, Javed Hassan

Natural Sciences Student Research Presentations

No abstract provided.

Porcelain Veneers, Brittany Orr

Natural Sciences Student Research Presentations

No abstract provided.

Xylitol Vs. Aspartame, Melika Fini

Natural Sciences Student Research Presentations

No abstract provided.

The Chemistry Behind Beer, Anna Coates

Natural Sciences Student Research Presentations

No abstract provided.

Why Do Onions Make You Cry?, Richard Sumitro

Natural Sciences Student Research Presentations

No abstract provided.

The Side Effects Of Sleep Deprivation, Cameron Stuva

Natural Sciences Student Research Presentations

No abstract provided.

The Lithium-Ion Battery: The Electrochemistry Behind The World’S Most Popular Rechargeable Battery, William Samples

Natural Sciences Student Research Presentations

No abstract provided.

Baking Chemistry: Differences In Uses Among Chemical Leaveners, Diana Christopher

Natural Sciences Student Research Presentations

No abstract provided.

Biodiesel: Liquid Solar Energy, Leon Peters

Natural Sciences Student Research Presentations

No abstract provided.

Sickle Cell Anemia: Chemistry And Clinical Association, Nicole Lord

Natural Sciences Student Research Presentations

No abstract provided.

Virilon, Jenna Ault

Natural Sciences Student Research Presentations

No abstract provided.

Cyclopentadienone Conversions To Terephthalates And Cycloadditions Of Alkynes And Azides, Sarah E. Bragg

Browse all Theses and Dissertations

Cyclopentadienone derivatives can be converted via a Diels-Alder reaction to multifunctional terephthalate derivatives, which can then be converted to poly(phenylene vinylene) derivatives. It was demonstrated that terephthalate derivatives can be simply and reproducibly synthesized from 2,5-diethoxycarbonyl-3,4-diphenylcyclopentadienone with a variety of acetylenes, having yields ranging from 63% to quantitative yields. The terephthalate derivatives synthesized varied from oils to crystalline solids, but were readily isolated and generally had high rates of completion despite expected steric factors. Terephthalate derivatives with pendent acetylenes were formed in reactions with as low as a 3:1 ratio of diacetylene to cyclopentadienone. A terephthalate derivative with a pendent …

Novel Trisubstituted Arylidene Oxindoles With Potent Anti-Apoptotic Properties, Paul J. Repasky

Browse all Theses and Dissertations

Apoptosis is a highly complex, multi-step cellular pathway utilized to initiate cell suicide. The family of enzymes largely responsible for the process is the cystienyl aspartic acid proteases (caspases). This study details the design and synthesis of a new class of small molecule caspase inhibitors, namely arylidene oxindoles, which are comparable to the isatin family of inhibitors but which offer the advantage of incorporating three points of variability into the basic scaffold. Moreover, whereas the mode of action of isatins against caspases has been demonstrated to involve nucleophilic addition of the cysteine residue of the enzymes to the C-3 ketone …

The Impact Of Driving Conditions On Phev Battery Performance, Nathan Christensen, John Patten, Steven Srivastava, Gary P. Nola

Green Manufacturing Research Journal

The battery performance of a modified Prius with a 5 kWh plug-in battery was documented for a year to determine the impact of environmental conditions and user attributes on vehicle performance.  Both fuel economy and pure electrical efficiency were compared to ambient temperature.  The fuel economy has a positive relationship with ambient temperature until approximately 70˚F where the efficiency begins to drop.  Electrical performance has a positive linear relationship with ambient temperature.  With the emergence of electric vehicles (EVs) and PHEVs from a variety of automotive manufacturers, information on EV and PHEV performance for consumers will become more important.

Self-Assembly Of Amyloid Aggregates Simulated With Molecular Dynamics, Workalemahu Mikre Berhanu

Electronic Theses and Dissertations

Amyloids are highly ordered cross-β sheet aggregates that are associated with many diseases such as Alzheimer‟s, type II diabetes and prion diseases. Recently a progress has been made in structure elucidation, environmental effects and thermodynamic properties of amyloid aggregates. However, detailed understanding of how mutation, packing polymorphism and small organic molecules influence amyloid structure and dynamics is still lacking. Atomistic modeling of these phenomena with molecular dynamics (MD) simulations holds a great promise to bridge this gap. This Thesis describes the results of MD simulations, which provide insight into the effects of mutation, packing polymorphism and molecular inhibitors on amyloid …

Comparative Study Of Ethanol And Methanol Electro-Oxidation On A Platinum/Ceria Composite Electrode In Alkaline And Acid Solutions : Electro-Catalytic Performance And Reaction Kinetics, Carlos Humberto Hidalgo Martinez

Electronic Theses and Dissertations

A comparative study of the electro-oxidation of ethanol and methanol was carried out on a Pt/ceria composite electrode prepared by electro-deposition. Modification of the Pt electrode was realized by co-deposition from a 1.0 mM K₂PtCl₆ solution that also contained a 20 mM suspension of ceria. The electro-catalytic activities and stabilities of the Pt/ceria catalyst towards ethanol electro-oxidation reactions (EOR) and methanol electro-oxidation reactions (MOR) were investigated by potentiodynamic and potentiostatic methods in 0.5 M sulfuric acid and 1.0 M sodium hydroxide solutions at various concentrations of ethanol and methanol. The kinetics of ethanol and methanol on a Pt/ceria composite electrode …

High Resolution Hybrid Mass Spectrometry For The Determination Of Marine Biotoxins, Azaspiracids, And Their Biotransformation Products., Zuzana Skrabakova

Theses

Azaspiracids (AZAs), polyether marine toxins, are produced by marine microalgae and accumulate in filter-feeding bivalve molluscs, such as mussels, clams, oysters and scallops, while grazing on phytoplankton, from which they derive nutrition. Although being discovered quite recently, AZAs have caused several human intoxication events and thus became a problem for health authorities and shellfish industries. The rapid development of highly sensitive liquid chromatography multiple tandem mass spectrometry (LC-MS/MS, LC-MS") methods enabled the identification of numerous AZA analogues and added to the control of shellfish contamination. Tandem mass spectrometry techniques, while being highly selective and sensitive for determination of AZAs in …

Novel Lc-Ms Methods For The Determination Of Environmental And Food Contaminants Incorporating Analyte Confirmation Using High Resolution Ms, Michael George Cahill

Theses

The contamination of the aquatic environment with pesticides has become an emerging environmental issue because of the potential risk to human health and wildlife. Effluent from wastewater treatment plants (WWTPs) have been identified as an important source of micro­organic contaminants in the environment. The EC have implemented several directives for the control of pesticides in the environment including the 98/83/EEC directive establishing the concentration of pesticide allowed for human consumption, the 2000/60/EC directive set up to monitor priority pollutants that are hazardous substances in the environment and REACH ensuring these substances are registered, controlled, therefore ensuring that the industry is …

Enhanced Photorefractivity In A Polymeric Composite Photosensitized With Carbon Nanotubes Grafted To A Photoconductive Polymer, Naveen Kumar Lingam, Sonali Kalghatgi, Jeffrey G. Winiarz

Chemistry Faculty Research & Creative Works

We report on the photosensitization of photorefractive (PR) polymeric composites through the inclusion of multiwalled and singlewalled carbon nanotubes (CNTs), respectively, having poly(N -vinyl carbazole) (PVK) grafted to their surfaces. The PR nature of the holographic gratings was confirmed via the asymmetric exchange of energy in a two-beam-coupling (TBC) geometry, yielding TBC gain coefficients approaching 80 cm^-1. In addition, in degenerate-four-wave- mixing experiments the prepared composites exhibited diffraction efficiencies as high as 60% and overmodulation voltages as low as ∼40 V/μm. These notable figures of merit indicate that the grafting of the PVK polymer to the various CNTs …

Redox-Active Liposome Delivery Agents With Highly Controllable Stimuli-Responsive Behavior, Nicole Hollabaugh Carrier

LSU Doctoral Dissertations

Over the last few decades, liposomes have generated a lot of interest as drug delivery vehicles to address the need for providing both increased therapeutic efficacy and decreased systemic exposure, simultaneously. The challenge of increasing drug accumulation at diseased sites, without compromising the integrity and stability of the liposomal carrier during circulation, has been met with two possible solutions: (1) active targeting and (2) active triggering. To achieve selective and site-specific delivery of drugs to tumors, active triggering methods have been developed wherein a responsive element is incorporated into the liposomal bilayer, which causes destabilization of the liposome upon exposure …

Synthesis, Biological And Photophysical Studies Of Novel Compounds For Cancer Therapy, Edith Khavwajira Amuhaya

LSU Doctoral Dissertations

Cancer remains the second most common cause of death in the United States. It is therefore imperative that a lot of effort be put into finding a cure for this dreadful disease that shows no discrimination, and virtually anybody is at risk of developing the disease. Chapter 1 introduces basic facts about cancer and the available treatments, including PDT and BNCT. Our focus will be on these two bimodal therapies, which form the basis of my research work, which involves the synthesis of potential sensitizers to be used either in PDT or BNCT or both. In Chapter 2, I discuss …

Surface-Initiated Polymerization As A Novel Strategy Towards Preparation Of Organic Semiconducting Polymer Thin Films, Euiyong Hwang

LSU Doctoral Dissertations

Organic semiconducting polymer thin films are core materials for organic electronics that are conventionally prepared by solution processing techniques. Despite having the advantage of easy and fast thin film manufacturing, solution techniques have intrinsic drawbacks, such as disordered and poor molecular organization in the film (often resulting in poor device performance), as well as insufficient stabilities of the films and resulting devices. To improve this situation, we designed a novel “bottom-up” fabrication of surface-immobilized organic semiconducting thin films through in situ polymerization. This new strategy will allow high degree of control over molecular organization which therefore results in improved free …

Semiconducting Polymers And Block Copolymers Prepared By Chain-Growth Living Polymerization, Jinwoo Choi

LSU Doctoral Dissertations

Organic semiconducting polymers are the unique materials that considered a basis for the next generation of electronic and optoelectronic applications. However, high device performance of semiconducting polymers strongly depends on their molecular structure and nanoscale organization. Therefore, it is an essential task to develop robust and versatile synthetic approaches to build such well-defined semiconducting polymer materials. This Ph.D. study aimed at design of state-of-the-art synthetic approaches towards organic semiconducting polymers via chain-growth living polymerization as well as development of polymer architectures which can self-organize into supramolecular nanoassemblies or allow external control of the polymer’s properties. First, we prepared a series …

A Multifaceted Phenomenon Of Hydrophobic Effects: Insights Learned From Nucleation Algorithm Based Computer Simulation Approach, Hyunmi Kim

LSU Doctoral Dissertations

We have applied our new approach, a combination of the AVUS-HR nucleation algorithm and a thermodynamic cycle, to the studies of hydrophobicity-related researches. Due to the multifaceted characteristics of hydrophobicity, it is essential to acquire knowledge in various environments where hydrophobic relevant events occur for comprehensive understanding of this process. In this regards, we have chosen two relatively unstudied hydrophobic subjects for application of our new methodology. For the first subject, hydrophobic association behaviors of a methane pair confined into a nanometer sized hydrophobic cavity have been investigated. Our new approach demonstrates that the association behavior between two methane molecules …

Investigating The Effects Of The Plasticizers Bisphenol A And Di (2-Ethylhexyl) Phthalate On Dopaminergic Neurons In A C. Elegans Parkinson's Disease, Amanda Valera

Undergraduate Honors Theses

Parkinson's disease (PD) is a neurodegenerative disorder characterized by loss of dopamine (DA) containing neurons in the substantia nigra of the brain. Though the cellular pathways that lead to PD are varied and not well understood, elevated levels of reactive oxygen species (ROS) and inhibition of the mitochondrial electron transport chain enzyme complex I have been associated with PD pathogenesis. Environmental factors such as the plasticizers bisphenol A (BPA) and di(2-ethylhexyl) phthalate (DEHP) may also be involved in PD pathogenesis. In this research, three strains of the nematode Caenorhabditis elegans (C. elegans), a wild-type N2 strain, a ROS-sensitive nnt …

2,2,2-Tris(Pyrazol-1-Yl)Ethanol, Craig C. Mclauchlan, Brigette L. Smith, Reyhana S. Pippins, Brandon M. Nelson

Faculty Publications – Chemistry

The title compound TPE, C11H12N6O, was prepared by slow evaporation from diethyl ether. In the crystal, there is a hydrogen bond between the alcohol H atom and an N in the pyrazole ring of a neighboring mol­ecule.

Characterizing Potential Sustainable Energy Feedstocks, Jesse George Thompson

Dissertations

Trap grease offers a promising and less expensive alternative to food grade vegetable oils for biodiesel production, but its commercial marketability could be affected by its intense and offensive odor. Identification, quantitation and eventual elimination of the odorant compounds are vital challenges that need to be addressed before commercialization can be achieved. A rapid method using HS-SPME and GC/MS was developed in this study to identify and quantify the major volatile odorant compounds present in trap grease. The main odorant compounds were identified as short chain free fatty acids (SC-FFA) from C₄ - C₁₀.

Sensory evaluations by …

Glucosamine-Induced Insulin Resistance In Primary Rat Hepatocytes And The Role Of Selenium As An Insulin Mimetic, Sandhya N. Adiyodi Veetil

Dissertations

Type 2 diabetes is mediated by insulin resistance, the inability of insulin to elicit a normal biological response in insulin responsive tissues. Several cellular models have been utilized to determine the mechanism of induction of insulin resistance but questions remain unanswered. One model, implicates the products of the Hexosamine Biosynthetic Pathway (HBP) in the induction of insulin resistance under hyperglycemia. The major end product of HBP, UDP-GlcNAc, is the substrate for O-GlcNAc transferase, an enzyme that catalyzes the O-GlcNAcylation of numerous proteins. This modification may play a role in induction of insulin resistance and thus needs to be evaluated in …

The Affect Of Surface Hydrophobicity On Wind Erosion Probed By Atomic Force Microscopy, Bradley Eric Frost

Masters Theses

Several field and laboratory studies have shown indirectly the effects of atmospheric humidity on soil particle adhesion through reduced resistance to movement by wind as the humidity decreases. Similar studies have also shown that increased hydrophobicity has the same effect on susceptibility of soil particles to movement by wind as reduced humidity. Theoretical models of idealized soil particle cohesion by water menisci in equilibrium with the atmospheric humidity have been used to explain these results. However the interpretation of these phenomenological results has never been tested by direct measurement of soil inter-particle cohesion as a function of humidity and hydrophobicity. …