Chemistry Commons^™

Determination Of Crystalline Content Gradients In Cold-Drawn Poly-L-Lactic Acid Films By Dsc, Anne O'Connor, A. Riga, John F. Turner Ii

Chemistry Faculty Publications

Poly-L-lactic acid (PLLA) is a semi-crystalline, optically active, biodegradable, and biocompatible polymer that has been utilized extensively in biomedical applications as an implantable artificial cell scaffold material. In its crystalline form, PLLA is piezoelectric and it has been implicated in the enhancement of electromechanically induced osteogenesis in vivo. In its amorphous state, however, PLLA does not exhibit piezoelectricity. By uniaxially cold-drawing the polymer, PLLA can be endowed with varying degrees of piezoelectricity. It is important to understand the crystalline architecture of drawn PLLA so that the osteogenic potential imparted by piezoelectricity, if any, can be differentiated from the effects of …

Comparison Studies Of The Mechanistic Formation Of Polyhalogentaed Dibenzo-P-Dioxins And Furans From The Thermal Degradation Of 2-Bromophenol And 2-Chlorophenol, Catherine Spearing Evans

LSU Doctoral Dissertations

Emissions of polychlorinated dibenzo-p-dioxins and furans (PCDD/Fs) and polybrominated dibenzo-p-dioxins and furans (PBDD/Fs) from hazardous waste incinerators, and many other sources for combustion have been considered environmentally hazardous and a major health threat. Recently, a growing number of materials containing brominated hydrocarbons, commonly used flame retardants, have been disposed in municipal and hazardous waste incinerators. This results in the increased potential for formation of PBDD/Fs and other hazardous combustion by-products. In contrast to chlorinated hydrocarbons, the reactions of brominated hydrocarbons have been studied only minimally. In fact, studies have shown that brominated phenols form higher yields of PBDD/Fs than the …

Dynamics Of Complex Polymer Solutions: Putting Diffusion To Work And Exploring Rigid Rod Diffusion, Garrett John Doucet

LSU Doctoral Dissertations

This dissertation is concerned with random coil and rodlike polymer diffusion in complex solutions. The development of fluorescence photobleaching recovery, FPR, as a technique to determine polymer molecular weight distributions by measuring the diffusion distribution and converting it to a molecular weight distribution using a calibration curve is first covered. Fluorescently tagged probes were individually dissolved in polymer solutions at negligible amounts and measured with FPR to construct the calibration curve of self-diffusion vs. molecular weight. Once calibration curves were constructed, bimodal distributions were separated using the matrices corresponding to the calibration curves. The diffusion of the probes and separation …

The Syntheses Of Novel Indicators And Materials For Chiral Separation, Rolanda Johnson

LSU Doctoral Dissertations

The colorimetric properties of resorcinarene solutions had not been fully investigated since von Baeyer's initial synthesis. We find that the solutions containing resorcinarene macrocycles develop color upon heating or standing. In the presence of saccharides, these solutions exhibit significant color changes which are readily observable by visual inspection. We determined that the solution color is due to macrocycle ring opening and oxidation. The optical responses to saccharides are due to complexation of the sugar with the acyclic chromophores. We have applied these mechanistic insights towards the challenging problems of the visual detection of saccharides and other important biologically analytes. In …

Applications Of The Titanium Catalyzed Cyclocarbonylation Towards Natural Product Syntheses, Jongtae Yang

LSU Doctoral Dissertations

Recently an efficient methodology, a hetero Pauson-Khand reaction, based on titanium-catalyzed cyclocarbonylation of tethered enals for the general preparation of ¥ã-butyrolactone rings, which are typically embedded in polycyclic systems of many natural products was reported. To demonstrate this new strategy, the total syntheses of the natural products asteriscanolide and ginkgolide were investigated. The first part of this work is dedicated to synthetic efforts toward the total synthesis of asteriscanolide. Approaches highlighted by the [2,3]-Wittig rearrangement, the thermal silyloxy-Cope rearrangement, and a titanium-catalyzed cyclocarbonylation, which is the pivotal step to afford the ¥ã-butyrolactone ring. This study firmly established the utility of …

Synthesis And Characterization Of Superparamagnetic Silica--Homopolypeptide Composite Particles, Sibel Turksen

LSU Doctoral Dissertations

Hierarchical construction and characterization of core-shell composite particles of interest are presented. The research described shows interest in new types of polymers that provide chirality and responsiveness which have been ignored for so long. The general synthetic design described in this document can be readily used as a model for other systems. Core-shell composite systems of interest consist of silica or silica-coated cobalt cores grafted with a homopolypeptide shell, mostly poly(epsilon-carbobenzyloxy-L-lysine) or poly(gamma-benzyl-L-glutamate). Core particles were decorated with amino groups through a silylation reaction. The amino groups initiated the polymerization (with attachment) of N-carboxyanhydride (NCA) monomers, resulting in a homopolypeptide …

The Synthesis And Characterisation Of Diiron And Triiron Carbonyl Cluster Compounds With Sulphur And Phosphine Ligands, Geraldine Gray

Theses

This work is primarily concerned with the synthesis and characterisation of di and triiron carbonyl cluster derivatives which contain sulphur and phosphine ligands.

The first chapter is a review of the literature of such complexes. Included are diiron carbonyl clusters which contain phosphine ligands, those which contain sulphur, and those that contain phosphine and sulphur ligands. Triiron carbonyl clusters which contain phosphine ligands, sulphur ligands and both are also discussed.

Chapter two describes the synthesis of compounds of the type [{Fe₂(SR)₂(CO)₅)₂Ph₂P (CH₂)_nPPh₂] (R = …

Synthesis, Separation And Reactivities Of Multidentate Phosphine Ligands And Investigation Into Dirhodium Hydroformylation And Hydrocarboxylation Catalysis, David Aubry

LSU Doctoral Dissertations

A dirhodium homogeneous hydroformylation catalyst based on a tetraphosphine ligand, rac-Et₂PCH₂CH₂P(Ph)CH₂P(Ph)CH₂CH₂PEt₂, rac-et,ph-P4, is under investigation. The ligand synthesis produces a racemic mixture and a facile and efficient method of separation of the racemic and meso diastereomers was achieved through reaction of et,ph-P4 with two equivalents of NiCl₂ in EtOH to yield an almost quantitatively isolable precipitate of meso-Ni₂Cl₄(et,ph-P4) and the soluble rac-Ni₂Cl₄(et,ph-P4). Subsequent cyanolysis of these complexes liberates the et,ph-P4 ligand, and the …

Lipid-Lowering Effects Of Ethyl 2-Phenacyl-3-Aryl-1h-Pyrrole- 4-Carboxylates In Rodents, Justin M. Holub, Kathy O'Toole-Colin, Adam Getzel, Anthony Argenti, Michael A. Evans, Daniel C. Smith, Gerard A. Dalglish, Shahzad Rifat, Donna L. Wilson, Brett M, Taylor, Ulander Miott, Josephine Glersaye, Kam Suet Lam, Bryan J. Mccranor, Joshua D. Berkowitz, Robert B. Miller, John R. Lukens, Keith Krumpe, John T. Gupton, Bruce S. Burnham

Chemistry Faculty Publications

A series of substituted 2-phenacyl-3-phenyl-1H-pyrrole-4-carboxylates were prepared from substituted acetophenones in 6 steps. The final condensations between a chloroenal and an aminoketone were carried out under neutral conditions in parallel to yield the series listed below. Selected pyrrole derivatives proved to be potent hypolipidemic agents lowering serum triglyceride concentrations in CF-1 male mice after 14 days of I.P. administration. One agent orally lowered serum cholesterol in Sprague-Dawley male rats at 2mg/kg/day after 14 days. The agents demonstrated a lowering of mouse serum LDL- cholesterol levels and selected compounds showed an elevation of serum HDL-cholesterol levels. The cholesterol concentrations in the …

Determination Of Calories In Food Via Adiabatic Bomb Calorimeter, Kenneth C. Mcgill, Michelle L. Yasechko, Wendy K. Nkari

The Corinthian

The adiabatic bomb calorimeter has been an effective tool in facilitating heat transfer between molecules via combustion reaction. Heat is released from the substance combusted and transferred into another, usually water. The heat transferred is measured and the enthalpy of combustion determined for the combusted material. One such classic experiment is the determination of combustion enthalpy of sucrose, obtaining the calorimeter constant with benzoic acid. The results of an adiabatic combustion experiment can be taken one step further to determine the combustion enthalpy in kcal/g by a simple conversion calculation. Since food nutrition labels report calories per grams of serving …

Ftir And Ft-Raman Spectral Investigations On 4-Aminoquinaldine And 5-Aminoquinoline, N. Puviarasan, V. Arjunan, S. Mohan

Turkish Journal of Chemistry

The FTIR spectra of 4-aminoquinaldine and 5-aminoquinoline were recorded in solid phase on a Bruker IFS 66V spectrometer in the region 4000--400 cm^{-1}. The FT-Raman spectra of these compounds were also recorded in the same instrument with a FRA 106 Raman module. The molecules under investigation are considered to have a C_{S} point group by assuming the --NH_{2} and --CH_{3} groups as point masses. All the vibrations are both IR and Raman active. The simple general valance force field (SGVFF) is adopted for both inplane and out of plane vibrations. All the frequencies are assigned in terms of fundamentals, overtones …

Determination Of ^{90}Sr Accumulation In Human Teeth, Recep Acar, Orhan Acar

Turkish Journal of Chemistry

The accumulation of ^{90}Sr in decayed or exfoliated human teeth was investigated by ultra low level beta counting. Fuming nitric acid and the necessary carriers and reagents were used for dissolving the samples, and the separation and purification of ^{90}Sr. The Ca contents of samples were determined by flame atomic absorption spectrometry with Zeeman-effect background correction. A mixture of K and La used as a matrix modifier was found to be preferable for the determination of Ca in samples. The optimum concentration and concentration ratio of K and La on the absorbance of Ca in the NIST certified reference material, …

Synthesis And Antimicrobial Activity Of Some Pyridyl And Naphthyl Substituted 1,2,4-Triazole And 1,3,4-Thiadiazole Derivatives, Khosrow Zamani, Khalil Faghihi, Taraneh Tofighi, Mohammad Reza Shariatzadeh

Turkish Journal of Chemistry

Synthesis of new 1,2,4-tri and 1,3,4-thiadiazoles, bearing isomeric pyridyl and 1-naphthyl is reported using 1,4-disubstituted thiosemicarbazides in alkaline and acidic media, respectively. The methylthio and benzylthio derivatives of the synthesized triazoles are also reported. All of the synthesized compounds were characterized by their FT-IR, ^{1}H-NMR and mass spectral data. The antibacterial studies of some of the synthesized compounds against S. aureus} and E. coli} as MIC values are reported. None of them have important antibacterial activities.

Iridoid And Phenylethanoid Glycosides From Verbascum Lasianthum, Zeli̇ha Ş. Akdemi̇r, İ. İrem Tatli, Erdal Bedi̇r, Ikhlas A. Khan

Turkish Journal of Chemistry

Three iridoid glucosides, 8-O-acethylharpagide (1), harpagoside (2), and 6-O-vanilloylajugol (3), were isolated from the roots of Verbascum lasianthum Boiss. ex Bentham. In addition, 2 phenylethanoid glycosides, verbascoside {=acteoside, [\beta -(3,4-dihydroxyphenyl)-ethyl]-(3' -O-\alpha -L-rhamnopyranosyl)-(4' -O-caffeoyl)-\beta -D-glucopyranoside} (4) and poliumoside {= [\beta -(3,4-dihydroxyphenyl)-ethyl]-(3',6' -O-\alpha -L-dirhamnopyranosyl)-(4' -O-caffeoyl)-\beta -D-glucopyranoside} (5), were also isolated. The structures of all compounds were established by spectroscopic evidence (UV, IR, 1D and 2D NMR, LC-ESIMS). Compounds 2-5 demonstrated scavenging properties toward the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical in TLC autographic assays.

Chemically Crosslinked N-Vinyl-2-Pyrrolidone/2-Hydroxyethyl Methacrylate (Vp/Hema) Copolymer For The Controlled Release Of Cyclic Oligopeptide, Bashir Ahmad, Shumaila Bashir, Shams-Un Nisa, M. B. Huglin

Turkish Journal of Chemistry

Crosslinked copolymers of various compositions of N-vinyl-2-pyrrolidone (VP) and 2-hydroxyethyl methacrylate (HEMA) were prepared chemically in the presence of a crosslinking agent. The swelling mechanism was non-Fickian with about 86% conversion of feed composition to crosslinked copolymer. The reactivity ratios r_1 = 0.045 and r_2 = 3.07 for VP and HEMA indicate that HEMA is more reactive than VP in the reaction. Hydrophilicity, hydrophobicity and monomer composition in the copolymer controlled the drug release from the hydrogels.

A Rapid Spectrophotometric Method To Resolve A Binary Mixture Of Food Colorants (Riboflavine And Sunset Yellow), Mahmure Üstün Özgür

Turkish Journal of Chemistry

A very simple and rapid spectrophotometric method using measurements at zero-crossing wavelength is described for resolving binary mixtures of riboflavine (E-101) and sunset yellow (E-110) in a powder drink. The assay procedure for E-110 and E-101 involves the extraction of the colorants from the powder drink with pH 4.5 acetate buffer, filtration, appropriate dilution, and measurement of the first derivative absorbance values (denoted as ^1D). Calibration graphs are linear up to 25.0 \mu g.mL^{-1} for E-101 and 40.0 \mu g.mL^{-1} for E-110. The sensitivity and reproducibility of the method were determined by using the synthetic mixtures in different ratios prepared …

Defect Structure And Properties Of Sr-Doped La Cr O_{3-\Delta}, Mahmoud Omari, Ilhem Chadli, Salah Belaidi

Turkish Journal of Chemistry

A defect chemical model for the behavior of acceptor-doped LaCrO_3 as a function of oxygen pressure is proposed. This is considered within the regime that corresponds to oxygen deficit oxygen. The mathematical approach allows us to calculate the oxygen partial pressure dependant properties of La_{1-x} Sr_x Cr O_{3-\delta} in the range 0.10 \le x \le 0.30. The results show that the conductivity was independent of pO_2 and was proportional to the dopant concentration at high pO_2. Therefore, under reducing conditions, the conductivity decreased exponentially with decreasing pO_2 and asymptotically approached a pO_2^{1/4} relationship. Stability regimes and compensation mechanisms at various …

Electrorheological Properties Of Suspensions Prepared From Poly(Li-Tert-Butyl Methacrylate) Ionomer, Mustafa Yavuz, Hali̇l İbrahi̇m Ünal

Turkish Journal of Chemistry

The synthesis, characterisation and partial hydrolysis of poly(tert-butylmethacrylate), (PTBMA), and the electrorheological (ER) properties of its suspensions were investigated. The polymer was synthesised by radical polymerisation and partially hydrolysed by para-toluenesulphonic acid monohydrate (PTSA.H_2O), and then converted to a lithium salt (PTBMA-Li) by washing with a LiOH_{(aq)} solution. From particle size measurements, the average particle size of PTBMA-Li was determined to be 74 \mu m. Colloidal suspensions of ionomer were prepared in various insulating oils [silicone oil (SO), mineral oil (MO), threeoctylthreemellitate (TOTM) and dioctylphatalete (DOP)] at a series of concentrations (c = 5-33 m/m, %). The sedimentation stabilities of …

Study On The Solid Phase Extraction And Spectrophotometric Determination Of Cobalt With 2-(2-Quinolylazo)-5-Diethylaminoaniline, Qiufen Hu, Guangyu Yang, Xuechang Dong, Jiayuan Yin

Turkish Journal of Chemistry

A sensitive, selective and rapid method for the determination of cobalt based on the rapid reaction of cobalt(II) with QADEAA and the solid phase extraction of the Co(II)-QADEAA chelate with C_{18} membrane disks was developed. In the presence of pH = 5.5 buffer solution and cetyl trimethylammonium bromide (CTMAB) medium, QADEAA reacts with cobalt to form a violet complex with a molar ratio of 1:2 (cobalt to QADEAA). This chelate was enriched by the solid phase extraction with C_{18} membrane disks. An enrichment factor of 50 was obtained by elution of the chelate from the disks with a minimal amount …

The Crystal And Molecular Structure Of 1-(2-Chloro-Benzoyl)-3-P-Tolyl-Thiourea, Hakan Arslan, Ulrich Flörke, Nevzat Külcü

Turkish Journal of Chemistry

1-(2-Chloro-benzoyl)-3-p-tolyl-thiourea was synthesized and characterized by elemental analysis and IR spectroscopy. The crystal and molecular structure of the title compound was determined from single-crystal X-ray diffraction data. It crystalizes in the triclinic space group P-1, with a = 7.9942(9) Å, b = 9.531(1) Å, c = 11.075(1) Å, \alpha = 97.235(2) °, \beta = 111.099(2) °, and \gamma = 106.105(2) °.

Acylated Flavone Glycosides From Veronica Pectinata Var. Glandulosa And V. Persica, İclal Saracoğlu, Ü. Şebnem Harput, Yukio Ogihara

Turkish Journal of Chemistry

This study deals with the isolation of a new acylated 5,6,7,3',4'-pentahydroxy-flavone glycoside (1) and 3 known allose-containing acylated flavone glycosides (2-4) as well as a known flavone aglycone (5) from the aerial parts of Veronica pectinata var. glandulosa and V. persica. The structures of the isolated compounds were determined to be 3' -hydroxy-4'-O-methylscutellarein-7-O-[2''-O-\alpha -L-rhamnopyranosyl-3''-O-(6''''-O-acetyl-\beta -D-glucopyranosyl)]-\beta- D-glucopyranoside, named sarachoside (1), 4' -O-methylisoscutellarein-7-O-2''- O-(6''' -O-acetyl-\beta -D-allopyranosyl)-\beta -D-glucopyranoside (2), isos\-cutellarein-7-O-2''-O-(6'''-O-acetyl-\beta-D-allopyranosyl)-\beta- D-glucopyranoside (3), 3'-hydroxy-4'-O-methy\-lisoscutellarein-7-O-2'' -O-(6'''-O-acetyl-\beta -D-allopyranosyl)-\beta -D-glucopyranoside (4) and 5,4'-dihydroxy-6,7,3' -trimethoxyflavone, named circilineol (5) by extensive 1-D and 2D-NMR spectroscopy. Sarachoside (1) exhibited potent radical scavenging activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical.

2,4-Dinitrophenylhydrazones Of 2,4-Dihydroxybenzaldehyde, 2,4-Dihydroxyacetophenone And 2,4-Dihydroxybenzophenone, Russell G. Baughman, Kenneth L. Martin, Rajendra K. Singh, James O. Stoffer

Chemistry Faculty Research & Creative Works

In 2,4-dihydroxybenzaldehyde 2,4-dinitrophenylhydrazone N,N-dimethylformamide solvate (or 4-[(2,4-dinitrophenyl)-hydrazonomethyl]benzene-1,3-diol N,N-dimethylformamide solvate

Chemical Constituents Of Linaria Aucheri, Di̇lek Erci̇l, M. Koray Sakar, Esther Del Olmo, Arturo San Feliciano

Turkish Journal of Chemistry

From the petroleum ether and methanol extracts of the aerial parts of Linaria aucheri (Scrophulariaceae) 6 known compounds: \beta-amyrin (1), ergost-7-en-3\beta-ol (2), stigmasta-5,22- E-dien-3\beta -ol (3), stigmast-5-en, 24S-3\beta-ol (4), antirrinoside (5) and linariin (6), were isolated and identified. The structures of these compounds have been elucidated by spectroscopic methods (UV, IR, ^{1}H NMR, ^{13}C NMR, DEPT-135 and GC-MS).

Chalcogeno Ureas Derived From Bis(1,3-Diazepan-2-Ylidene), Yetki̇n Gök, Engi̇n Çeti̇nkaya

Turkish Journal of Chemistry

A series of new electron rich olefins (=\overset{ } CNR(CH_2)_4\overset{ }NR)_2, 3, (a; R = CH_2C_6H_5, b; R = CH_2C_6H_4-OMe-p, c; R = CH_2C_6H_4-NMe_2-p) was generated via the condensation of RNH(CH_2)_4NHR with Me_2NCH (OMe)_2. The C=C bond cleavage reactions of 3 with S_8 and Se provide a simple and straightforward method for the synthesis of 1,3-diazepan-2-chalcogenones 4 and 5, respectively.

Crystal Habit Modification Of Vitamin C (L-Ascorbic Acid) Due To Solvent Effects, Ali̇ Arslantaş, Walter C. Ermler, Rahmi̇ Yazici, Di̇lhan M. Kalyon

Turkish Journal of Chemistry

Crystal morphologies are predicted for vitamin C (L-ascorbic acid) using attachment energy methods. The significant differences between predicted and observed morphologies when vitamin C is grown from water, isopropyl alcohol, acetone-water solution, and isopropyl alcohol-methanol solution are attributed to the effect of solvent on the growth rate of the various crystal habit faces. This effect, particularly the role of hydrogen bonding between solvent and crystal surface, is examined. Molecular modeling is combined with the results of simple experiments charting the habit shift of vitamin C as a function of the hydrogen bonding tendency of the solvent or solvent mixture. Attachment …

Anodic Stripping Voltammetric Determination Of Gold On A Polyvinylferrocene Coated Glassy Carbon Electrode, Muammer Kavanoz, Handan Gülce, Atti̇la Yildiz

Turkish Journal of Chemistry

The anodic stripping voltammetric determination of gold was accomplished on a chemically modified glassy carbon electrode in a solution containing chloride ions. A modifying polymer, polyvinylferrocene, was coated by immersing the glassy carbon surface in its solution in methylene chloride followed by solvent evaporation. Tetrahalo complexes of gold, tetrachloroaurate(III) and tetrabromoaurate(III) ions, were found to be reduced to metallic gold by chemical reduction during immersion of the polymer coated electrode into the solution containing aurate(III) ions. This reaction was utilized as means of preconcentration without the need for cathodic electrolysis prior to the anodic stripping of metallic gold. The effects …

A Convenient Synthesis Of 3,6-Disubstituted-1,4-Dihydro-[1,2,4,5]Tetrazines And Preparation Of New Acetic Acid Derivatives Containing 5-Oxo-4-Phenylamino- 4,5-Dihydro-[1,2,4]Triazole, Ahmet Demi̇rbaş

Turkish Journal of Chemistry

A series of compounds 8a-e, was synthesized by condensation of compounds 7a-e with ethyl bromoacetate. The treatment of compounds 8a-e with hydrazine hydrate afforded the corresponding hydrazide derivatives (9a-e). Subsequently, compounds 9a-e were converted to alkylidene hydrazides (10a-e). Moreover, upon heating in the presence of carboxylic acids, compounds 9a-e unexpectedly gave 1,4-dihydro-[1,2,4,5]tetrazine derivatives (11a-e).

Diffusion Effect On The Anodic Reactions Of Tungsten, Mustafa Anik, Tuba Cansizoğlu, Si̇nem Çevi̇k

Turkish Journal of Chemistry

Potentiodynamic and potentiostatic polarizations, and a rotating disk electrode technique were used to study the influence of diffusion on the anodic reactions of tungsten (W) in a broad pH range (\sim 0.3--13.5) in H_3PO_4 buffered solutions. The anodic current was controlled totally by the kinetics of H^+ -assisted dissolution below pH 1 (Region A). At around pH 2.5 (Region B), in addition to the kinetics of H_2O-assisted dissolution, specimen rotation had an effect on the current. This observation was attributed mainly to the physical damage to an oxide phase by hydrodynamic effects and partly to the diffusion of surface H_2WO_4(aq) …

Naphthoquinones From The Roots Of Onosma Argentatum Hub.-Mor. (Boraginaceae), Ufuk Özgen, Maksut Coşkun, Cavi̇t Kazaz, Hasan Seçen

Turkish Journal of Chemistry

Onosma argentatum Hub.-Mor. is an endemic species growing in Turkey. In this study, the roots of O. argentatum were extracted with n-hexane-dichloromethane (1:1). The extract was separated on a silica gel column eluting with n-hexane-ethyl acetate by gradient elution. New naphthoquinone compounds (3 known and 1 new) were isolated and their structures were elucidated by spectroscopic methods as deoxyshikonin, acetyl shikonin, 3-hydroxy-isovaleryl shikonin, and 5,8-O-dimethyl acetyl shikonin.

Synthesis And Antinociceptive Activity Of 2-[(2-Oxobenzothiazolin-3-Yl)Methyl]- 5-Aminoalkyl/Aryl-1,3,4-Thiadiazole, Ti̇jen Önkol, Bi̇lge Çakir, M. Fethi̇ Şahi̇n, Engi̇n Yildirim, Kevser Erol

Turkish Journal of Chemistry

Ten 2-[(2-oxobenzothiazolin-3-yl)methyl]-5-aminoalkyl/aryl-1,3,4-thiadiazole derivatives were synthesized. The chemical structures of these compounds were elucidated by their FT-IR and ^1H-NMR spectral data, as well as their elemental analyses. The compounds were tested for antinociceptive activity. Among these compounds, 2-[(2-oxobenzothiazolin-3-yl)methyl]-5-aminomethyl-1,3,4-thiadiazole (5a) was found to be significantly more active than the others and the standards in all the tests.