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Articles 241 - 254 of 254
Full-Text Articles in Chemistry
Synthesis Of 2-Dos Mimic From Diacetone-D-Glucose, Susie Choi, Dr. Young Wan Ham
Synthesis Of 2-Dos Mimic From Diacetone-D-Glucose, Susie Choi, Dr. Young Wan Ham
Journal of Undergraduate Research
2-deoxystreptamine (2-DOS) mimic was to be synthesized in several steps from commercially available diacetone-D-glucose in an effort to prepare novel amino acid residues for antiviral therapeutic development. The method presented in this paper was given up due to unexpected problems occurring at three of the 10 steps. A new method, which uses xylitol as the starting material and takes fewer steps, is to be used.
Using Dip-Pen Nanolithography To Orient Dna Origami, Michael Lydiksen, Dr. Adam Woolley
Using Dip-Pen Nanolithography To Orient Dna Origami, Michael Lydiksen, Dr. Adam Woolley
Journal of Undergraduate Research
Imagine having the ability to control the placement of atoms with reasonable speed and accuracy. Having this capacity naturally brings with it incredible technological advancements in areas such as integrated circuits and biochemistry. An exciting process known as dip-pen nanolithography (DPN) that I have been actively perfecting over the past year gives researchers the ability to control the placement of individual atoms at a desired location on a substrate. I have presented some of my results last spring in BYU’s annual College of Physical and Mathematical Science Spring Research Conference.
Structure Of Octahedral Polyomavirus, Robert Swenson, Dr. David Belnap
Structure Of Octahedral Polyomavirus, Robert Swenson, Dr. David Belnap
Journal of Undergraduate Research
Polyomaviruses (PVs) are viruses that can cause tumors in mammals and fatal diseases in birds. Knowles et al. (2) estimated that over 90% of the human population is infected with a polyomavirus, but these infections are usually dormant, and only show symptoms in patients with compromised immune systems. PVs normally form a capsid with icosahedral symmetry whose structure is known (Figure 1). In this structure, the major capsid protein (VP1) forms a stable pentamer with the C-terminal arms of the proteins extending outwards. VP1 pentamers (filled pentagons, Figure 1) interact with five other pentamers on some vertices, and with six …
Englerin-A, Curtis Allred, Dr. Merritt Andrus
Englerin-A, Curtis Allred, Dr. Merritt Andrus
Journal of Undergraduate Research
My project has been to synthesize smaller, simpler analogs of a molecule that is effective against renal cancer, called englerin-A.
Modeling Of An Ion Exchange Reaction Involving Decamethylcucurbit[5]Uril In The Gas Phase, Jacob Hedelius, Dr. David Dearden
Modeling Of An Ion Exchange Reaction Involving Decamethylcucurbit[5]Uril In The Gas Phase, Jacob Hedelius, Dr. David Dearden
Journal of Undergraduate Research
Mathematical modeling is both common and increasingly expected in scientific research, to both predict and to explain results. Models are used in many disciplines, from describing cellular process in biology, weather patterns in planetary science, to galaxies in physics. As part of my studies with the Office of Research and Creative Activities (ORCA), I created a simple model for reactions of the molecule decamethylcucurbit[5]uril (mc5) in the gas phase.
How Tmrna/Smpb Rescue Complex Binds To Stalled Ribosomes, Matthew Mcdowell, Dr. Allen Buskirk
How Tmrna/Smpb Rescue Complex Binds To Stalled Ribosomes, Matthew Mcdowell, Dr. Allen Buskirk
Journal of Undergraduate Research
Ribosomes are large complexes made up of ribosomal RNA and proteins and are the site of protein synthesis. However, ribosomes occasionally run into problems during this process and will stall during translation. Fortunately, two molecules known as tmRNA and SmpB are made by cells in order to free stalled ribosomes. We sytematically mutated G517, C518, C519 and A520 in the ribosome to see if binding fidelity decreases, and to see if these bases affect the activity of tmRNA/SmpB in ribosomes during ribosome rescue. This assay however, gave us no informative results because we were only looking at endpoints of its …
The Tat Two Hybrid System, Joshua Browning, Dr. Allen Buskirk
The Tat Two Hybrid System, Joshua Browning, Dr. Allen Buskirk
Journal of Undergraduate Research
The TAT two hybrid system for discovering novel stalling peptides met with some immediate challenges that ultimately resulted in the abandonment of this project. The feasibility for using this method to discover new peptide sequences that would cause the stalling of translation within an elongating ribosome became unlikely.
Transmission Electron Microscope Imaging Of Lipid-Body Cox Localization, Andrew Broadbent, Dr. Daniel Simmons
Transmission Electron Microscope Imaging Of Lipid-Body Cox Localization, Andrew Broadbent, Dr. Daniel Simmons
Journal of Undergraduate Research
The laboratory of Dr. Daniel L. Simmons, my mentor, studies the cyclooxygenase (COX) enzyme. Dr. Simmons is one of the world’s foremost authorities on COX, he having discovered one of its two known types, COX-2. The COX enzyme, which exists in many organisms, including humans, is responsible for producing molecules that trigger inflammation. For this reason, understanding COX is important: for example, aspirin works by deactivating the enzyme, and COX could play a role in the inflammation linked to diseases like type-II diabetes and cancer. Thus, greater knowledge of its workings could aid those suffering from a variety of diseases.
Laser-Induced Fluorescence Of No2, Joseph Mosley, Dr. Jaron Hansen
Laser-Induced Fluorescence Of No2, Joseph Mosley, Dr. Jaron Hansen
Journal of Undergraduate Research
The effects of water vapor on the kinetics and product branching ratio of the reaction of organic peroxy radicals (RO2) with nitrous oxide are under investigation. Hyrdrocarbon combustion produces organic peroxy radicals which then react with NO to form NO2 or organic nitrates (RONO2). This reaction which branches is shown below:
Identification Of Novel Ribosome Stalling Peptides Using The Tat-Two Hybrid, Benjamin Van Leeuwen, Dr. Allen Buskirk
Identification Of Novel Ribosome Stalling Peptides Using The Tat-Two Hybrid, Benjamin Van Leeuwen, Dr. Allen Buskirk
Journal of Undergraduate Research
Dr. Buskirk discontinued my previous project on discovering novel ribosomal stalling sequences shortly after the start of the semester because of its lack of relevance to more current ribosomal research trends. While there are still an unknown number of stalling sequences that have yet to be discovered, the current research has moved away from that field into more novel ribosomal research. Therefore, I was not able to finish my project as planned and presented in my last application.
Development Of Low-Cost Point-Of-Care Channel Flow Constriction Immunoassays For The Developing World, Neil Anderson, Dr. Adam Woolley
Development Of Low-Cost Point-Of-Care Channel Flow Constriction Immunoassays For The Developing World, Neil Anderson, Dr. Adam Woolley
Journal of Undergraduate Research
Biomarkers have a tremendous capacity for use in screening for various diseases, including cancer, diabetes, and bacterial infections. Existing immunoassay methods can detect a broad spectrum of biomarkers. However, they are costly to perform for small numbers of samples and require bulky, expensive instrumentation, making these methods unfit for point-of-care use in the developing world. The focus of my research in the past 10 months has been to help develop a small microfluidic system capable of detecting and quantifying biomarker concentrations with simple, easy-to-read results and that requires little or no technical training before use. Our group has developed and …
Supramolecular Chemistry For Students, Dr. Roger Harrison, Dr. John Lamb, Dr. David Dearden
Supramolecular Chemistry For Students, Dr. Roger Harrison, Dr. John Lamb, Dr. David Dearden
Journal of Undergraduate Research
Students working in the mentoring environment synthesized compounds and worked with separation and mass analyzer instruments. They learned how to make new compounds by organic synthesis and characterize their compounds by NMR and mass spectrometry. They also had the opportunity to work with other students who were working to apply their new compounds to chemical separations. They applied reactions they had learned in their courses. They learned to solve problems by finding new ways to synthesize or characterize their compounds. They learned to run, fix, and change settings on multifaceted instruments. They learned to trouble-shoot problems to solve instrumental errors. …
Rational Design Of The Metabolite Mimics As Novel Antibiotics Targeting Sam-I/Ii Riboswitches, Dr. Young Wan Ham
Rational Design Of The Metabolite Mimics As Novel Antibiotics Targeting Sam-I/Ii Riboswitches, Dr. Young Wan Ham
Journal of Undergraduate Research
In our 2009 MEG application, we have proposed structure-based rational design of metabolite mimics based on S-adenosylmethionine (SAM) as novel antibiotics targeting SAM-I/II riboswitches and subsequent development of fluorescence assay to evaluate binding of the designed mimics to SAM-I/II riboswitches.
Student Electrochemical Research, Dr. Dean Wheeler
Student Electrochemical Research, Dr. Dean Wheeler
Journal of Undergraduate Research
The work allowed additional students to join in electrochemical engineering research here at BYU. The mentored students worked on one of several possible projects with the broad theme of understanding and mitigating internal resistances in fuel cells and lithium batteries. Additional work was done on statistical mechanics models of fluid properties. The students gained experience and confidence as they applied and augmented knowledge gained from their coursework. They strengthened their technical leadership and teamwork skills that are part of the expected student outcomes in the chemical engineering curriculum.