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Faculty Publications

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Articles 361 - 390 of 592

Full-Text Articles in Chemistry

Oriented Cell Growth On Self-Assembled Bacteriophage M13 Thin Films, Jianhua Rong, L. Andrew Lee, Kai Li, Brandon Harp, Charlene M. Mello, Zhongwei Niu, Qian Wang Sep 2008

Oriented Cell Growth On Self-Assembled Bacteriophage M13 Thin Films, Jianhua Rong, L. Andrew Lee, Kai Li, Brandon Harp, Charlene M. Mello, Zhongwei Niu, Qian Wang

Faculty Publications

Fibrillar M13 bacteriophages were used as basic building blocks to generate thin films with aligned nanogrooves, which, upon chemical grafting with RGD peptides, guide cell alignment and orient the cell outgrowth along defined directions.


Structure Of The Thioredoxin-Like Domain Of Yeast Glutaredoxin 3, Lydia M. Gibson, Nin N. Dingra, Caryn E. Outten, Lukasz Lebioda Aug 2008

Structure Of The Thioredoxin-Like Domain Of Yeast Glutaredoxin 3, Lydia M. Gibson, Nin N. Dingra, Caryn E. Outten, Lukasz Lebioda

Faculty Publications

Yeast glutaredoxin 3 (Grx3) is a cytosolic protein that regulates the activity of the iron-responsive transcriptional activator Aft1. This member of the monothiol glutaredoxin family contains a thioredoxin-like domain and a glutaredoxin-like domain, which both possess a monothiol active site. The crystal structure of the thioredoxin-like domain has been determined at 1.5 Å resolution and represents the first published structure of this domain for the monothiol glutaredoxin family. The loop containing the signature motif WAxxC is partially disordered, indicating a greater degree of flexibility in this region compared with classical dithiol thioredoxins with a WCGPC active-site motif.


Stable Long-Time Semiclassical Description Of Zero-Point Energy In High-Dimensional Molecular Systems, Sophya Garashchuk, Vitaly A. Rassolov Jul 2008

Stable Long-Time Semiclassical Description Of Zero-Point Energy In High-Dimensional Molecular Systems, Sophya Garashchuk, Vitaly A. Rassolov

Faculty Publications

Semiclassical implementation of the quantum trajectory formalism [J. Chem. Phys. 120, 1181 (2004)] is further developed to give a stable long-time description of zero-point energy in anharmonic systems of high dimensionality. The method is based on a numerically cheap linearized quantum force approach; stabilizing terms compensating for the linearization errors are added into the time-evolution equations for the classical and nonclassical components of the momentum operator. The wave function normalization and energy are rigorously conserved. Numerical tests are performed for model systems of up to 40 degrees of freedom.


The Role Of Upstream Sequences In Selecting The Reading Frame On Tmrna, Allen R. Buskirk, Mickey R. Miller, David W. Healey, Jonathan D. Dewey, Stephen G. Robison Jun 2008

The Role Of Upstream Sequences In Selecting The Reading Frame On Tmrna, Allen R. Buskirk, Mickey R. Miller, David W. Healey, Jonathan D. Dewey, Stephen G. Robison

Faculty Publications

tmRNA acts first as a tRNA and then as an mRNA to rescue stalled ribosomes in eubacteria. Two unanswered questions about tmRNA function remain: how does tmRNA, lacking an anticodon, bypass the decoding machinery and enter the ribosome? Secondly, how does the ribosome choose the proper codon to resume translation on tmRNA? According to the -1 triplet hypothesis, the answer to both questions lies in the unique properties of the three nucleotides upstream of the first tmRNA codon. These nucleotides assume an A-form conformation that mimics the codon-anticodon interaction, leading to recognition by the decoding center and choice of the …


Manipulating The Cavity Of A Porous Material Changes The Photoreactivity Of Included Guests, Mahender B. Dewal, Yuewen Xu, Jun Yang, Fiaz Mohammed, Mark D. Smith, Linda S. Shimizu Jun 2008

Manipulating The Cavity Of A Porous Material Changes The Photoreactivity Of Included Guests, Mahender B. Dewal, Yuewen Xu, Jun Yang, Fiaz Mohammed, Mark D. Smith, Linda S. Shimizu

Faculty Publications

Changing an ether to a ketone within the framework of a bis-urea macrocycle has little effect on the supramolecular assembly of this building block into porous crystals but introduces a triplet sensitizer into the framework that dramatically alters the photochemical reactions of included guests.


Co2 Fixation Kinetics Of Halothiobacillus Neapolitanus Mutant Carboxysomes Lacking Carbonic Anhydrase Suggest The Shell Acts As A Diffusional Barrier For Co2, Zhicheng Dou, Sabine Heinhorst, Eric B. Williams, C. Daniel Murin, Jessup M. Shively, Gordon C. Cannon Apr 2008

Co2 Fixation Kinetics Of Halothiobacillus Neapolitanus Mutant Carboxysomes Lacking Carbonic Anhydrase Suggest The Shell Acts As A Diffusional Barrier For Co2, Zhicheng Dou, Sabine Heinhorst, Eric B. Williams, C. Daniel Murin, Jessup M. Shively, Gordon C. Cannon

Faculty Publications

The widely accepted models for the role of carboxysomes in the carbon-concentrating mechanism of autotrophic bacteria predict the carboxysomal carbonic anhydrase to be a crucial component. The enzyme is thought to dehydrate abundant cytosolic bicarbonate and provide ribulose 1.5-bisphosphate carboxylase/oxygenase (RubisCO) sequestered within the carboxysome with sufficiently high concentrations of its substrate, CO2, to permit its efficient fixation onto ribulose 1,5-bisphosphate. In this study, structure and function of carboxysomes purified from wild type Halothiobacillus neapolitanus and from a high CO2-requiring mutant that is devoid of carboxysomal carbonic anhydrase were compared. The kinetic constants for the carbon …


Comment On “Contact Conditions For The Charge In The Theory Of The Electrical Double Layer”, Douglas Henderson, L. B. Bhuiyan Mar 2008

Comment On “Contact Conditions For The Charge In The Theory Of The Electrical Double Layer”, Douglas Henderson, L. B. Bhuiyan

Faculty Publications

Exact results in any field, including statistical mechanics, are both aesthetically pleasing and very valuable in assessing theoretical approximations.


Quenching Of Highly Vibrationally Excited Pyrimidine By Collisions With Co4, Jeremy A. Johnson, Andrew M. Duffin, Brian J. Hom, Karl E. Jackson, Eric T. Sevy Feb 2008

Quenching Of Highly Vibrationally Excited Pyrimidine By Collisions With Co4, Jeremy A. Johnson, Andrew M. Duffin, Brian J. Hom, Karl E. Jackson, Eric T. Sevy

Faculty Publications

Relaxation of highly vibrationally excited pyrimidine (C4N2H4) by collisions with carbon dioxide has been investigated using diode laser transient absorption spectroscopy. Vibrationally hot pyrimidine (E'=40,635 cm^-1) was prepared by 248-nm excimer laser excitation, followed by rapid radiationless relaxation to the ground electronic state. The nascent rotational population distribution (J=58–80) of the 0000 ground state of CO2 resulting from collisions with hot pyrimidine was probed at short times following the excimer laser pulse. Doppler spectroscopy was used to measure the CO2 recoil velocity distribution for J=58–80 of the 0000 state. Rate constants and probabilities for collisions populating these CO2 rotational states …


Ozone Exposure In A Mouse Model Induces Airway Hyperreactivity That Requires The Presence Of Natural Killer T Cells And Il-17, Paul B. Savage, Muriel Pichavant, Sho Goya, Everett H. Meyer, Richard A. Johnston, Hye Y. Kim, Ponpan Matangkasombut, Ming Zhu, Yoichiro Iwakura, Rosemarie H. Dekruyff, Stephanie A. Shore, Dale T. Umetsu Feb 2008

Ozone Exposure In A Mouse Model Induces Airway Hyperreactivity That Requires The Presence Of Natural Killer T Cells And Il-17, Paul B. Savage, Muriel Pichavant, Sho Goya, Everett H. Meyer, Richard A. Johnston, Hye Y. Kim, Ponpan Matangkasombut, Ming Zhu, Yoichiro Iwakura, Rosemarie H. Dekruyff, Stephanie A. Shore, Dale T. Umetsu

Faculty Publications

Exposure to ozone, which is a major component of air pollution, induces a form of asthma that occurs in the absence of adaptive immunity. Although ozone-induced asthma is characterized by airway neutrophilia, and not eosinophilia, it is nevertheless associated with airway hyperreactivity (AHR), which is a cardinal feature of asthma. Because AHR induced by allergens requires the presence of natural killer T (NKT) cells, we asked whether ozone-induced AHR had similar requirements. We found that repeated exposure of wild-type (WT) mice to ozone induced severe AHR associated with an increase in airway NKT cells, neutrophils, and macrophages. Surprisingly, NKT cell-deficient …


Singlet Oxygen Chemistry In Water. 2. Photoexcited Sensitizer Quenching By O2 At The Water−Porous Glass Interface, Jovan Giaimuccio, Matibur Zamadar, David Aebisher, Gerald J. Meyer, Alexander Greer Jan 2008

Singlet Oxygen Chemistry In Water. 2. Photoexcited Sensitizer Quenching By O2 At The Water−Porous Glass Interface, Jovan Giaimuccio, Matibur Zamadar, David Aebisher, Gerald J. Meyer, Alexander Greer

Faculty Publications

Insight into the O2 quenching mechanism of a photosensitizer (static or dynamic) would be useful for the design of heterogeneous systems to control the mode of generation of 1O2 in water. Here, we describe the use of a photosensitizer, meso-tetra(N-methyl-4-pyridyl)porphine (1), which was adsorbed onto porous Vycor glass (PVG). A maximum loading of 1.1 × 10−6 mol 1 per g PVG was achieved. Less than 1% of the PVG surface was covered with photosensitizer 1, and the penetration of 1 reaches a depth of 0.32 mm along all faces of the glass. Time-resolved measurements …


Singlet Oxygen Chemistry In Water:  A Porous Vycor Glasssupported Photosensitizer, David Aebisher, Nikolay S. Azar, Matibur Zamadar, Naveen Gandra, Harry D. Gafney, Roumei Gao, Alexander Greer Jan 2008

Singlet Oxygen Chemistry In Water:  A Porous Vycor Glasssupported Photosensitizer, David Aebisher, Nikolay S. Azar, Matibur Zamadar, Naveen Gandra, Harry D. Gafney, Roumei Gao, Alexander Greer

Faculty Publications

Singlet molecular oxygen [1O2 (1Δg)] is generated cleanly in aqueous solution upon irradiation of a heterogeneous complex, meso-tetra(N-methyl-4-pyridyl)porphine (1) adsorbed onto porous Vycor glass (PVG). The cationic photosensitizer 1 tightly binds onto PVG and gives a stable material, which does not dissociate 1 into the surrounding aqueous phase. The production of 1O2 was measured by monitoring the time-resolved 1O2 (1Δg) phosphorescence at 1270 nm. Indirect analysis of 1O2 generation was also carried out with the photooxidation oftrans-2-methyl-2-pentenoate anion, which afforded the corresponding hydroperoxide. Sensitizer-1-impregnated PVG gives rise to a new singlet …


Tetra-μ-Aqua-Octaaquabis(μ-4-Chloropyridine-2,6-Dicarboxylato(Bis(4-Chloro-Pyridine-2,6-Dicarboxylato)Tricobalt(Ii)-Disodium(I) Bis[Triaquabis(4-Chloro-Pyridine-2,6-Dicarboxylato)Cobalt(Ii)] Hexahydrate, Lamaryet Moody, Shawna Balof, Shanika Smith, Varma H. Rambaran, Don Vanderveer, Alvin A. Holder Jan 2008

Tetra-μ-Aqua-Octaaquabis(μ-4-Chloropyridine-2,6-Dicarboxylato(Bis(4-Chloro-Pyridine-2,6-Dicarboxylato)Tricobalt(Ii)-Disodium(I) Bis[Triaquabis(4-Chloro-Pyridine-2,6-Dicarboxylato)Cobalt(Ii)] Hexahydrate, Lamaryet Moody, Shawna Balof, Shanika Smith, Varma H. Rambaran, Don Vanderveer, Alvin A. Holder

Faculty Publications

The title compound, [Co3Na2(C72ClNO4)4(H2O)12][Co(C7H2ClNO4(H2O)3]2·6H2O, consists of a centrosymmetric dimer of [CoII(dipicCl)2]2- complex dianions [dipicCl is 4-chloro­pyridine-2,6-dicarboxyl­ate] bridged by an [Na2CoII(H2O)12]4+ tetra­cationic cluster, two independent [Co(dipicCl)(H2O)3] complexes, and six water mol­ecules of crystallization. The metals are all six-coordinate with distorted octahedral geometries. The [CoII(dipicCl)(H2O)3] complexes are neutral, with …


1,3,7,10,14,17,21,28,31,42,52,55-Dodeca­Kis(Trifluoro­Meth­Yl)- 1,3,7,10,14,17,21,28,31,42,52,55-Dodeca­Hydro­(C60-IH)[5,6]Fullerene, Natalia B. Shustova Prof. Dr., O.P. Anderson, O. V. Boltalina, S. H. Strauss, I. E. Kareev Nov 2007

1,3,7,10,14,17,21,28,31,42,52,55-Dodeca­Kis(Trifluoro­Meth­Yl)- 1,3,7,10,14,17,21,28,31,42,52,55-Dodeca­Hydro­(C60-IH)[5,6]Fullerene, Natalia B. Shustova Prof. Dr., O.P. Anderson, O. V. Boltalina, S. H. Strauss, I. E. Kareev

Faculty Publications

The title compound, C72F36, is one of four isomers of C60(CF3)12 for which crystal structures have been obtained. The fullerene mol­ecule has an idealized Ih C60 core with the 12 CF3 groups arranged in an asymmetric fashion on two ribbons of edge-sharing C6(CF3)2 hexa­gons, a parametaparaparaparametapara ribbon and a parametapara ribbon, giving an overall pmp 3 mp,pmp structure. There are no cage Csp 3 …


Rheology Of Tin Fluorophosphate Glass/Polyamide 12 Hybrids In The Low Concentration Regime, Kevin Urman, Thomas Schweizer, Joshua U. Otaigbe Nov 2007

Rheology Of Tin Fluorophosphate Glass/Polyamide 12 Hybrids In The Low Concentration Regime, Kevin Urman, Thomas Schweizer, Joshua U. Otaigbe

Faculty Publications

Phosphate glass (Pglass)/polymer hybrids are a unique material class that promises to help fulfill the growing need for new advanced materials. Rheological investigations into Pglass/polyamide 12 hybrids have shown a strong dependence on temperature and composition. Strong negative deviations from the log-additivity rule are also observed for these materials as well as a reduction in the activation energy for viscous flow. Hybrids containing < 2 vol. % Pglass are theologically simple fluids that display temperature independence in plots of storage modulus versus loss modulus. Hybrids containing >= 2 vol. % Pglass are rheologically complex and do not obey the time-temperature superposition principle. Through application of Han plots, we identified a structural change that occurs in hybrids containing >= 2 vol. % Pglass at …


Poly[(Nitrato-KO)Tris((Μ3-1h-1,2,4-Triazolato)Dizinc(Ii)]: A Three-Dimensional Coordination Polymer, Josephy M. Ellsworth, Mark D. Smith, Hans-Conrad Zur Loye Oct 2007

Poly[(Nitrato-KO)Tris((Μ3-1h-1,2,4-Triazolato)Dizinc(Ii)]: A Three-Dimensional Coordination Polymer, Josephy M. Ellsworth, Mark D. Smith, Hans-Conrad Zur Loye

Faculty Publications

In the title compound, [Zn2(C2H2N3)3(NO3)], there are two unique Zn atoms, both with site symmetry m. One forms a ZnN3O tetrahedron and the other a ZnN6 octahedron. One and a half 1H-1,2,4-triazolate ligands, with the half-ligand located on a mirror plane, and a disordered nitrate anion complete the asymmetric unit of the structure. The polymeric connectivity is three-dimensional.


Structural Characterization Using The Multiple Scattering Effects In Grazing-Incidence Small-Angle X-Ray Scattering, Byeongdu Lee, Chieh-Tsung Lo, P. Thiyagarajan, Dong R. Lee, Zhongwei Niu, Qian Wang Oct 2007

Structural Characterization Using The Multiple Scattering Effects In Grazing-Incidence Small-Angle X-Ray Scattering, Byeongdu Lee, Chieh-Tsung Lo, P. Thiyagarajan, Dong R. Lee, Zhongwei Niu, Qian Wang

Faculty Publications

The multiple scattering effects present in grazing-incidence small-angle X-ray scattering (GISAXS) data and interference between them are addressed theoretically as well as experimentally with measurement of a series of patterns at different incident angles, referred to as `incident-angle-resolved GISAXS' (IAR-GISAXS). X-ray reflectivity (XR), GISAXS and IAR-GISAXS of virus particles on Si-substrate supported-polystyrene films have been measured and all the data have been analyzed with appropriate formalisms. It was found that under certain conditions it is possible to extract the correct structural features of the materials from the GISAXS/IAR-GISAXS data using the kinematic SAXS formalisms, without the need to use the …


Instrumentation And Metrology For Single Rna Counting In Biological Complexes Or Nanoparticles By A Single-Molecule Dual-View System, Hui Zhang, Dan Shu, Faqing Huang, Peixuan Guo Oct 2007

Instrumentation And Metrology For Single Rna Counting In Biological Complexes Or Nanoparticles By A Single-Molecule Dual-View System, Hui Zhang, Dan Shu, Faqing Huang, Peixuan Guo

Faculty Publications

Limited by the spatial resolution of optical microscopy, direct detection or counting of single components in biological complexes or nanoparticles is challenging, especially for RNA, which is conformationally versatile and structurally flexible. We report here the assembly of a customized single-molecule dual-viewing total internal reflection fluorescence imaging system for direct counting of RNA building blocks. The RNA molecules were labeled with a single fluorophore by in vitro transcription in the presence of a fluorescent AMP. Precise calculation of identical or mixed pRNA building blocks of one, two, three, or six copies within the bacteriophage phi29 DNA packaging motor or other …


Inclusion Of Electrochemically Active Guests By Novel Oxacalixarene Hosts, Daniel Sobransingh, Mahender B. Dewal, Jacob Hiller, Mark D. Smith, Linda S. Shimizu Sep 2007

Inclusion Of Electrochemically Active Guests By Novel Oxacalixarene Hosts, Daniel Sobransingh, Mahender B. Dewal, Jacob Hiller, Mark D. Smith, Linda S. Shimizu

Faculty Publications

We demonstrate for the first time the utility of oxacalixarenes as hosts and investigate the forces that influence the thermodynamics of binding.


Novel Perturbation Approach For The Structure Factor Of The Attractive Hard-Core Yukawa Fluid, Andrij Trokhymchuk, Roman Melnyk, Filip Moucka, Ivo Nezbeda Sep 2007

Novel Perturbation Approach For The Structure Factor Of The Attractive Hard-Core Yukawa Fluid, Andrij Trokhymchuk, Roman Melnyk, Filip Moucka, Ivo Nezbeda

Faculty Publications

A novel perturbation approach for the structure factor S(k) of the Lennard-Jones-type Yukawa fluid with z=1.8 is presented. An approach is based on a new reference system, that is, the short-range Yukawa model with z0 > z=1.8. By choosing for the reference system the value z0=6, it is shown that (i) the proposed approach for S(k) performs much better than the traditional hard-sphere reference perturbation method does; (ii) the use of an approximate mean spherical (MSA) description of the reference structure factor provides the results for S(k) that are more accurate as those obtained from the direct MSA computations; and (iii) …


Snell's Law Of Refraction Observed In Thermal Frontal Polymerization, John A. Pojman, Veronika Viner, Burcu Binici, Shanna Lavergne, Melanie Winsper, Dmitry Golovaty, Laura Gross Sep 2007

Snell's Law Of Refraction Observed In Thermal Frontal Polymerization, John A. Pojman, Veronika Viner, Burcu Binici, Shanna Lavergne, Melanie Winsper, Dmitry Golovaty, Laura Gross

Faculty Publications

We demonstrate that Snell’s law of refraction can be applied to thermal fronts propagating through a boundary between regions that support distinct frontal velocities. We use the free-radical frontal polymerization of a triacrylate with clay filler that allows for two domains containing two different concentrations of a peroxide initiator to be molded together. Because the polymerization reaction rates depend on the initiator concentration, the propagation speed is different in each domain. We study fronts propagating in two parallel strips in which the incident angle is 90°. Our data fit Snell’s law vr/vi = sin θr/sin …


Synthesis, Characterization, And Cyclopolymerization Of A Functional Non-Symmetric Divinyl Monomer, Bekir Dizman, Lon J. Mathias Aug 2007

Synthesis, Characterization, And Cyclopolymerization Of A Functional Non-Symmetric Divinyl Monomer, Bekir Dizman, Lon J. Mathias

Faculty Publications

A non-symmetric divinyl monomer with terminal carboxylic acid functionality was readily synthesized from the reaction of ethyl α-hydroxymethylacrylate (EHMA) with maleic anhydride. The new monomer (EHMA–MA) was homopolymerized in both bulk and ethyl acetate using AIBN as an initiator to give cyclopolymers. The synthesis of the monomer and cyclopolymers were followed by 13C NMR, 1H NMR, and FTIR. 1H NMR was also utilized to obtain the degree of cyclization of the polymers, which were found to be 95% or higher in all cases. The molecular weights of the cyclopolymers were around 40–60,000 g/mol as estimated by SEC. …


Poly[Μ2-Nitrato-(Μ4-Pyrazine-2-Carboxylato)Disilver(I)], Kathryn L. Seward, Joseph M. Ellsworth, Zeeshan M. Khaliq, Hans-Conrad Zur Loye Aug 2007

Poly[Μ2-Nitrato-(Μ4-Pyrazine-2-Carboxylato)Disilver(I)], Kathryn L. Seward, Joseph M. Ellsworth, Zeeshan M. Khaliq, Hans-Conrad Zur Loye

Faculty Publications

The title compound, [Ag2(C5H3N2O2)(NO3)]n, is a three-dimensional coordination polymer containing two-dimensional slabs held together by bridging nitrate groups. AgNO4 and AgNO5 silver coordination polyhedra arise. Weak argentophilic interactions [AgAg = 3.0686 (7) Å] occur in the crystal structure.


Structural Analysis Of Csos1a And The Protein Shell Of The Halothiobacillus Neapolitanus Carboxysome, Yingssu Tsai, Michael R. Sawaya, Gordon C. Cannon, Fei Cai, Eric B. Williams, Sabine Heinhorst, Cheryl A. Kerfeld, Todd O. Yeates Jun 2007

Structural Analysis Of Csos1a And The Protein Shell Of The Halothiobacillus Neapolitanus Carboxysome, Yingssu Tsai, Michael R. Sawaya, Gordon C. Cannon, Fei Cai, Eric B. Williams, Sabine Heinhorst, Cheryl A. Kerfeld, Todd O. Yeates

Faculty Publications

The carboxysome is a bacterial organelle that functions to enhance the efficiency of CO2 fixation by encapsulating the enzymes ribulose bisphosphate carboxylase/ oxygenase (RuBisCO) and carbonic anhydrase. The outer shell of the carboxysome is reminiscent of a viral capsid, being constructed from many copies of a few small proteins. Here we describe the structure of the shell protein CsoS1A from the chemoautotrophic bacterium Halothiobacillus neapolitanus. The CsoS1A protein forms hexameric units that pack tightly together to form a molecular layer, which is perforated by narrow pores. Sulfate ions, soaked into crystals of CsoS1A, are observed in the pores of the …


Computation Of Correlation Functions And Wave Function Projections In The Context Of Quantum Trajectory Dynamics, Sophya Garashchuk Apr 2007

Computation Of Correlation Functions And Wave Function Projections In The Context Of Quantum Trajectory Dynamics, Sophya Garashchuk

Faculty Publications

The de Broglie-Bohm formulation of the Schrödinger equation implies conservation of the wave function probability density associated with each quantum trajectory in closed systems. This conservation property greatly simplifies numerical implementations of the quantum trajectory dynamics and increases its accuracy. The reconstruction of a wave function, however, becomes expensive or inaccurate as it requires fitting or interpolation procedures. In this paper we present a method of computing wave packet correlation functions and wave function projections, which typically contain all the desired information about dynamics, without the full knowledge of the wave function by making quadratic expansions of the wave function …


Accumulation Of Pathological Tau Species And Memory Loss In A Conditional Model Of Tauopathy, Zdenek Berger, Hanno Roder, Amanda Hanna, Vijayaraghavan Rangachari, Mei Yue, Zbigniew Wszolek, Karen Ashe, Joshua Knight, Dennis Dickson, Cathy Andorfer, Terrone L. Rosenberry, Jada Lewis, Mike Hutton, Christopher Janus Apr 2007

Accumulation Of Pathological Tau Species And Memory Loss In A Conditional Model Of Tauopathy, Zdenek Berger, Hanno Roder, Amanda Hanna, Vijayaraghavan Rangachari, Mei Yue, Zbigniew Wszolek, Karen Ashe, Joshua Knight, Dennis Dickson, Cathy Andorfer, Terrone L. Rosenberry, Jada Lewis, Mike Hutton, Christopher Janus

Faculty Publications

Neurofibrillary tangles (NFTs) are a pathological hallmark of Alzheimer's disease and other tauopathies, but recent studies in a conditional mouse model of tauopathy (rTg4510) have suggested that NFT formation can be dissociated from memory loss and neurodegeneration. This suggests that NFTs are not the major neurotoxic tau species, at least during the early stages of pathogenesis. To identify other neurotoxic tau protein species, we performed biochemical analyses on brain tissues from the rTg4510 mouse model and then correlated the levels of these tau proteins with memory loss. We describe the identification and characterization of two forms of tau multimers (140 …


The Niemann-Pick Type C2 Protein Loads Isoglobotrihexosylceramide Onto Cd1d Molecules And Contributes To The Thymic Selection Of Nkt Cells, Paul B. Savage, Nicolas Schrantz, Yuval Sagiv, Yang Liu, Albert Bendelac, Luc Teyton Mar 2007

The Niemann-Pick Type C2 Protein Loads Isoglobotrihexosylceramide Onto Cd1d Molecules And Contributes To The Thymic Selection Of Nkt Cells, Paul B. Savage, Nicolas Schrantz, Yuval Sagiv, Yang Liu, Albert Bendelac, Luc Teyton

Faculty Publications

The Niemann-Pick type C2 (NPC2) protein is a small, soluble, lysosomal protein important for cholesterol and sphingolipid transport in the lysosome. The immunological phenotype of NPC2-deficient mice was limited to an impaired thymic selection of Valpha 14 natural killer T cells (NKT cells) and a subsequent reduction of NKT cells in the periphery. The remaining NKT cells failed to produce measurable quantities of interferon-gamma in vivo and in vitro after activation with alpha-galactosylceramide. In addition, thymocytes and splenocytes from NPC2-deficient mice were poor presenters of endogenous and exogenous lipids to CD1d-restricted Valpha 14 hybridoma cells. Importantly, we determined that similar …


Precision In Imaging Multivariate Optical Computing, Michael N. Simcock, Michael L. Myrick Mar 2007

Precision In Imaging Multivariate Optical Computing, Michael N. Simcock, Michael L. Myrick

Faculty Publications

Multivariate optical computing (MOC) is a method of performing chemical analysis using a multilayer thin-film structure known as a multivariate optical element (MOE). Recently we have been advancing MOC for imaging problems by using an imaging MOE (IMOE) in a normal-incidence geometry and employing normalization by the 1-norm. There are several important differences between the previously described 45° and the normal-incidence imaging, one of which is the measurement precision due to photon counting. We compare this precision to 45° MOC. We also discuss how MOE models with similar values of standard errors of calibration and prediction and similar gain values …


Trisodium Dicalcium Bismuth Hexaoxide, Irina V. Puzdrjakova, Rene B. Macquart, Mark D. Smith, Hans-Conrad Zur Loye Feb 2007

Trisodium Dicalcium Bismuth Hexaoxide, Irina V. Puzdrjakova, Rene B. Macquart, Mark D. Smith, Hans-Conrad Zur Loye

Faculty Publications

Single crystals of the title compound, Na3Ca2BiO6, were grown from a high-temperature reactive flux solution of Na2CO3. Na3Ca2BiO6 crystallizes as an ordered rock-salt structure (space group Fddd), in which the octahedral holes in the oxide array are filled by an ordered 3:2:1 arrangement of Na+, Ca2+ and Bi5+ cations. All atoms except for one O atom lie on special positions; site symmetries are as follows: Bi 222, Ca 2, Na 222 and 2, O 2.


A Coarse Grain Model For Dna, Thomas A. Knotts Iv, Nitin Rathore, David C. Schwartz, Juan J. De Pablo Feb 2007

A Coarse Grain Model For Dna, Thomas A. Knotts Iv, Nitin Rathore, David C. Schwartz, Juan J. De Pablo

Faculty Publications

Understanding the behavior of DNA at the molecular level is of considerable fundamental and engineering importance. While adequate representations of DNA exist at the atomic and continuum level, there is a relative lack of models capable of describing the behavior of DNA at mesoscopic length scales. We present a mesoscale model of DNA that reduces the complexity of a nucleotide to three interactions sites, one each for the phosphate, sugar, and base, thereby rendering the investigation of DNA up to a few microns in length computationally tractable. The charges on these sites are considered explicitly. The model is parametrized using …


Poly[Diaqua(Μ4-3-Fluorophthalato-Κ4O:O:O':O'')Cadmium(Ii)], Diana Rishmawi, Katie Lewis, Mark D. Smith, Leroy Peterson Jr., Hans-Conrad Zur Loye Feb 2007

Poly[Diaqua(Μ4-3-Fluorophthalato-Κ4O:O:O':O'')Cadmium(Ii)], Diana Rishmawi, Katie Lewis, Mark D. Smith, Leroy Peterson Jr., Hans-Conrad Zur Loye

Faculty Publications

The crystal structure of the title compound, [Cd(C8H3FO4)(H2O)2]n, consists of polymeric sheets formed by the bridging of octahedrally coordinated CdII by carboxylate O atoms of the 3-fluorophthalate (3-fpt2-) ligand. The layers exhibit hydrogen bonding between each of two coordinated water molecules and two O atoms of the ligand. Adjacent sheets are connected through - interactions.