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Full-Text Articles in Chemistry
One-Step Synthesis Of Hierarchical [B]-Zsm-5 Using Cetyltrimethylammonium Bromide As Mesoporogen, Büşra Karakaya Yalçin, Bahar İpek
One-Step Synthesis Of Hierarchical [B]-Zsm-5 Using Cetyltrimethylammonium Bromide As Mesoporogen, Büşra Karakaya Yalçin, Bahar İpek
Turkish Journal of Chemistry
One-step facile synthesis of boron containing ZSM-5 microspheres is developed using 1,6-diaminohexane as the structure-directing agent and cetyltrimethylammonium bromide as the mesoporogen. High boron incorporation up to Si/B ratio of 38 is achieved and evidenced by the stretching vibrations of B-O-Si at 667 cm$^{-1}$ and 917 cm$^{-1}$ using Fourier-transform infrared spectra. The morphology of the crystals resembles berry-like spheres with sizes approximately 15 μm, which is composed of aggregated nanocrystals having sizes around 450 nm, is observed using scanning electron microscopy. The textural properties, i.e. the surface areas and pore volumes are investigated using N$_{2}$ adsorption at -196 $^{\circ}$C. t-plot …
A Review: A Comparison Of Different Adsorbents For Removal Of Cr (Vi), Cd (Ii) And Ni (Ii), Anja Pfeifer, Mojca Skerget
A Review: A Comparison Of Different Adsorbents For Removal Of Cr (Vi), Cd (Ii) And Ni (Ii), Anja Pfeifer, Mojca Skerget
Turkish Journal of Chemistry
A review of the studies dealing with the removal of chromium, cadmium, and nickel ions with different adsorbents published in the literature between 2014 and 2018 is given in tabular form, along with the adsorption conditions, adsorption isotherm, and kinetic models applied by the authors to model the experimental data and adsorption capacities. The review focuses on the efficiency of ion removal.
Evaluation Of A Novel Nanocrystalline Hydroxyapatite Powder And A Solid Hydroxyapatite/Chitosan-Gelatin Bioceramic For Scaffold Preparation Used As A Bone Substitute Material, Sharmin Rahman, Kazi Hanium Maria, Mohammad Saif Ishtiaque, Arijun Nahar, Harinarayan Das, Sheikh Manjura Hoque
Evaluation Of A Novel Nanocrystalline Hydroxyapatite Powder And A Solid Hydroxyapatite/Chitosan-Gelatin Bioceramic For Scaffold Preparation Used As A Bone Substitute Material, Sharmin Rahman, Kazi Hanium Maria, Mohammad Saif Ishtiaque, Arijun Nahar, Harinarayan Das, Sheikh Manjura Hoque
Turkish Journal of Chemistry
Artificially fabricated hydroxyapatite (HAP) shows excellent biocompatibility with various kinds of cells and tissues which makes it an ideal candidate for a bone substitute material. In this study, hydroxyapatite nanoparticles have been prepared by using the wet chemical precipitation method using calcium nitrate tetra-hydrate [Ca(NO$_{3})_{2}$.4H$_{2}$O] and di-ammonium hydrogen phosphate [(NH$_{4})_{2}$HPO$_{4}$] as precursors. The composite scaffolds have been prepared by a freeze-drying method with hydroxyapatite, chitosan, and gelatin which form a 3D network of interconnected pores. Glutaraldehyde solution has been used in the scaffolds to crosslink the amino groups ($\vert $NH$_{2})$ of gelatin with the aldehyde groups ($\vert $CHO) of chitosan. …
The Use Of Water-Soluble Phthalocyanines As Textile Dyes In Nylon/Elastane Fabric: Fastness And Antibacterial Effectiveness, Armağan Günsel, Ayşe Usluoğlu, Ahmet Turgut Bi̇lgi̇çli̇, Büşra Tosun, Gülnur Arabaci, Meryem Ni̇lüfer Yaraşir
The Use Of Water-Soluble Phthalocyanines As Textile Dyes In Nylon/Elastane Fabric: Fastness And Antibacterial Effectiveness, Armağan Günsel, Ayşe Usluoğlu, Ahmet Turgut Bi̇lgi̇çli̇, Büşra Tosun, Gülnur Arabaci, Meryem Ni̇lüfer Yaraşir
Turkish Journal of Chemistry
This work reports on dyeing of nylon/elastane fabric with water-soluble phthalocyanines (1-4) bearing quinoline 5-sulfonic acid substituents on the peripheral or nonperipheral positions and determining the antibacterial efficiency of the phthalocyanine compounds and the dyed nylon/elastane fabrics. The light, washing, water, perspiration, and rubbing fastness properties of nylon/elastane fabrics dyed with phthalocyanines were also determined. The results showed that all dyed fabrics showed very good wet fastness values. The lightfastness value of the nylon/elastane fabric dyed with phthalocyanine dye (1) showed a much better value than the others. Also, the antibacterial efficiencies of the dyed nylon fabrics and the dye …
Sorption Studies Of Europium On Cerium Phosphate Using Box-Behnken Design, Süleyman İnan
Sorption Studies Of Europium On Cerium Phosphate Using Box-Behnken Design, Süleyman İnan
Turkish Journal of Chemistry
Amorphous cerium phosphate was prepared and characterized. Three-level Box-Behnken design (BBD) was employed to analyze the effect of process variables such as initial pH (2-6), contact time (60--180 min), and sorbent amount (0.05-0.15 g) on the sorption capacity of europium. Analysis of variance (ANOVA) revealed that the main effect of initial pH and sorbent amount has a substantial impact on the sorption of Eu(III). Probability F-value (F = 3 $\times $ 10$^{-3})$ and correlation coefficient (R$^{2}$ = 0.97) point out that the model is in good accordance with experimental data. The maximum sorption capacity of Eu(III) was found to be …
Effects Of Composition On Catalytic Activities Of Molybdenum Doped Platinum Nanoparticles, Aslihan Sümer
Effects Of Composition On Catalytic Activities Of Molybdenum Doped Platinum Nanoparticles, Aslihan Sümer
Turkish Journal of Chemistry
The physical and chemical properties of bimetallic nanoparticles can be optimized by tuning the particle composition. In this study, we identified CO adsorption and dissociation energetics on five Pt-Mo nanoparticles at different concentrations, the lowest energy Pt$_{7}$, Pt$_{6}$Mo, Pt$_{5}$Mo$_{2}$, Pt$_{4}$Mo$_{3}$, and Mo$_{7}$ clusters. We have shown that the CO adsorption and dissociation energies and preferred CO adsorption sites are largely dependent on the composition of the nanoparticles. As the Mo concentration increases, the strength of the C-O internal bond in the adsorption complex decreases, as indicated by a decrease in the C-O stretching frequency. Also, more Mo sites in the …
Effect Of Cnt Incorporation On Pan/Ppy Nanofibers Synthesized By Electrospinning Method, Ati̇ke İnce Yardimci, Meti̇n Tanoğlu, Selahatti̇n Yilmaz, Yusuf Selamet
Effect Of Cnt Incorporation On Pan/Ppy Nanofibers Synthesized By Electrospinning Method, Ati̇ke İnce Yardimci, Meti̇n Tanoğlu, Selahatti̇n Yilmaz, Yusuf Selamet
Turkish Journal of Chemistry
In this study, carbon nanotubes (CNTs) added polyacrylonitrile/polypyrrole (PAN/PPy) electrospun nanofibers were produced. Average diameters of the nanofibers were measured as 268 and 153 nm for 10 and 25 wt% of PPy contents, respectively. A relatively higher strain to failure values (23.3%) were observed for the low PPy content. When as-grown CNTs (1 and 4 wt%) were added into the PAN/PPy blends, disordered nanofibers were observed to form within the microstructure. To improve the interfacial properties of CNTs/PAN/PPy composites, CNTs were functionalized with H$_{2}$SO$_{4}$/HNO$_{3}$/HCl solution. The functionalized CNTs were well dispersed within the nanofibers and aligned along the direction of …
Photochromic And Fluorescence Properties Of Coumarin Fulgimides, Khamis Nassor Ally, Leyla Öztürk, Mahmut Köse
Photochromic And Fluorescence Properties Of Coumarin Fulgimides, Khamis Nassor Ally, Leyla Öztürk, Mahmut Köse
Turkish Journal of Chemistry
Four new fulgimides possessing a fluorescent coumarin unit were synthesized from the corresponding fulgides, and their photochromic as well as fluorescence properties were investigated. The open-ring forms of coumarin fulgimides were found to exhibit fluorescence in the visible region. Upon exposure to UV light, the fulgimides were transformed into the nonfluorescent closed-ring forms, which can be reverted to the initial fluorescent open-ring forms on exposure to visible light. The efficiency of quenching of fluorescence was as high as 95% at the photostationary state of UV irradiation.
Characterization, Mechanical, And Antibacterial Properties Of Nanofibers Derived From Olive Leaf, Fumitory, And Terebinth Extracts, Ni̇lşen Sünter Eroğlu, Suat Canoğlu, Meti̇n Yüksek
Characterization, Mechanical, And Antibacterial Properties Of Nanofibers Derived From Olive Leaf, Fumitory, And Terebinth Extracts, Ni̇lşen Sünter Eroğlu, Suat Canoğlu, Meti̇n Yüksek
Turkish Journal of Chemistry
In this study, nanofiber structures were obtained with convenient polymers (PVA [polyvinyl alcohol] and PCL [poly º-caprolactone]) derived from the herbal extracts of olive leaves, fumitory, and terebinth plants. Optimum nanofiber structures were identified by measuring viscosity and conductivity values and performing morphological analysis, characterization, and mechanical tests of the prepared solutions. The potential use for wound healing at the most efficient level was determined as a result of antibacterial analysis of the structures obtained. APT (PVA/terebinth) and BFO (PCL/fumitory) nanofibers had the thinnest diameter range and the highest strength values. In terms of the determination of antibacterial effects, nanofiber …
Synthesis And Bioactivities Of 1-(4-Hydroxyphenyl)-2-((Heteroaryl)Thio)Ethanones As Carbonic Anhydrase I, Ii And Acetylcholinesterase Inhibitors, Cem Yamali, Hali̇se İnci̇ Gül, Yeli̇z Demi̇r, Cavi̇t Kazaz, İlhami̇ Gülçi̇n
Synthesis And Bioactivities Of 1-(4-Hydroxyphenyl)-2-((Heteroaryl)Thio)Ethanones As Carbonic Anhydrase I, Ii And Acetylcholinesterase Inhibitors, Cem Yamali, Hali̇se İnci̇ Gül, Yeli̇z Demi̇r, Cavi̇t Kazaz, İlhami̇ Gülçi̇n
Turkish Journal of Chemistry
The discovery of enzyme targeting inhibitors is a popular area of drug research. Biological activities of the compounds bearing phenol and heteroaryl groups make them popular groups in drug design targeting important enzymes such as acetylcholinesterase (AChE, E.C.3.1.1.7) and carbonic anhydrases (CAs, EC 4.2.1.1). 1-(4-hydroxyphenyl)-2-((aryl)thio)ethanones as possible AChE and CAs inhibitors were synthesized, and their chemical structures were confirmed by IR, $^{1}$H NMR, $^{13}$C NMR, and HRMS. The compounds 2 and 4 were found potent AChE inhibitors with the Ki values of 22.13 ± 1.96 nM and 23.71 ± 2.95 nM, respectively, while the compounds 2 (Ki $=$ 8.61 ± …
In Silico Adme Predictions And In Vitro Antibacterial Evaluation Of 2-Hydroxy Benzothiazole-Based 1,3,4-Oxadiazole Derivatives, Afnan Ahmed Alghamdi, Mohammad Mahboob Alam, Syed Nazreen
In Silico Adme Predictions And In Vitro Antibacterial Evaluation Of 2-Hydroxy Benzothiazole-Based 1,3,4-Oxadiazole Derivatives, Afnan Ahmed Alghamdi, Mohammad Mahboob Alam, Syed Nazreen
Turkish Journal of Chemistry
In the present work, a library of fifteen 2-hydroxy benzothiazole-linked 1,3,4 -oxadiazole derivatives have been synthesized and confirmed using different analytical techniques. All of the synthesized compounds have been tested for antibacterial and in silico pharmacokinetic studies for the first time. From the ADME predictions, compound 4 showed the highest in silico absorption percentage (86.77%), while most of the compounds showed more than 70% absorption. All of the compounds comply with the Lipinski rule of 5, suggesting that the compounds possess good drug likeness properties upon administration. Furthermore, all of the compounds follow the Veber rule, indicating good bioavailability and …
Voltammetric Determination Of Itopride Using Carbon Paste Electrode Modified With Gd Doped Tio$_{2}$Nanotubes, Abdulaziz Nabil Amro, Khadijah Emran, Hessah Alanazi
Voltammetric Determination Of Itopride Using Carbon Paste Electrode Modified With Gd Doped Tio$_{2}$Nanotubes, Abdulaziz Nabil Amro, Khadijah Emran, Hessah Alanazi
Turkish Journal of Chemistry
In the present work TiO$_{2}$ nanotubes (TNT) have been synthesized by alkaline hydrothermal transformation. Then they have been doped with Gd element. Characterizations of doped and undoped TNT have been done with TEM and SEM. The chemical composition was analyzed by EDX, Raman and FTIR spectroscopy. The crystal structure was characterized by XRD. Carbon paste electrode has been fabricated and mixed with Gd doped and undoped TNT to form a nanocomposite working electrode. Comparison of bare carbon paste electrode and Gd doped and undoped TNT carbon paste electrode for 1.0 × 10$^{-3}$ M K$_{4\, }$[Fe(CN)$_{6}$] voltammetric analysis; it was observed …
Fluorescent Sensing Platform For Low-Cost Detection Of Cu$^{\Mathbf{2+}}$ By Coumarin Derivative: Dft Calculation And Practical Application In Herbal And Black Tea Samples, Tahi̇r Savran, Abdurrahman Karagöz, Şükri̇ye Ni̇han Karuk Elmas, Duygu Aydin, Furkan Özen, Kenan Koran, Fatma Nur Arslan, Ahmet Orhan Görgülü, İbrahi̇m Yilmaz
Fluorescent Sensing Platform For Low-Cost Detection Of Cu$^{\Mathbf{2+}}$ By Coumarin Derivative: Dft Calculation And Practical Application In Herbal And Black Tea Samples, Tahi̇r Savran, Abdurrahman Karagöz, Şükri̇ye Ni̇han Karuk Elmas, Duygu Aydin, Furkan Özen, Kenan Koran, Fatma Nur Arslan, Ahmet Orhan Görgülü, İbrahi̇m Yilmaz
Turkish Journal of Chemistry
A fluorogenic probe based on a coumarin-derivative for Cu$^{2+}$ sensing in CH$_{3}$CN/H$_{2}$O media (v/v, 95/5, 5.0 \textmu M) was developed and applied in real samples. 3-(4-chlorophenyl)-6,7-dihydroxy-coumarin (MCPC) probe was obtained by synthetic methodologies and identified by spectral techniques. The probe MCPC showed remarkable changes with a ``turn-off'' fluorogenic sensing approach for the monitoring of Cu$^{2+}$ at 456 nm under an excitation wavelength of 366 nm. The response time of the probe MCPC was founded as only 1 min. The detection limit of the probe MCPC was recorded to be 1.47 nM. The binding constant and possible stoichiometric ratio (1:1) values …
Bis Benzothiophene Schiff Bases: Synthesis And In Silico-Guided Biological Activity Studies, Yasemi̇n Ünver, Di̇lek Ünlüer, Şahi̇n Di̇rekel, Serdar Durdaği
Bis Benzothiophene Schiff Bases: Synthesis And In Silico-Guided Biological Activity Studies, Yasemi̇n Ünver, Di̇lek Ünlüer, Şahi̇n Di̇rekel, Serdar Durdaği
Turkish Journal of Chemistry
Since benzo [$b$] thiophene scaffold is one of the privileged structures in drug discovery as this core exhibitsactivities for different biological problems, in this study bis (benzo[$b$]thiophene-2-yl) alkyl methanimine derivatives (1-9) were synthesized by reacting benzo[$b$]thiophene-2-carbaldehyde with diamines. All newly compounds were characterized by IR, $^{1}$H NMR and $^{13}$C NMR spectroscopic methods. Synthesized compounds were investigated using binary QSAR-based models on therapeutic activity prediction of synthesized compounds and they showed high predicted activities in following diseases: bacterial, angina, allergy, depression and obesity. Thus, they were then tested for their antimicrobial and antileishmanial activities as a result of this theoretical study. …
Synthesis, Biological Evaluation Of Antioxidant-Antibacterial Activities And Computational Studies Of Novel Anthracene- And Pyrene-Based Schiff Base Derivatives, Ayşegül Gümüş, Veysi̇ Okumuş, Selçuk Gümüş
Synthesis, Biological Evaluation Of Antioxidant-Antibacterial Activities And Computational Studies Of Novel Anthracene- And Pyrene-Based Schiff Base Derivatives, Ayşegül Gümüş, Veysi̇ Okumuş, Selçuk Gümüş
Turkish Journal of Chemistry
Schiff base derivatives with anthracene- and pyrene-based units, A1-A6 and P1-P6 were synthesized (89%-99% yields). Schiff base derivatives were designed to possess an heterocyclic moiety on one side to enhance the coordination ability towards metals. To investigate the biological assay of the newly synthesized compounds, their DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging, metal chelating, reducing power, antibacterial and DNA binding activities were tested. A6 (63.1%) showed the maximum free radical scavenging activity among all. However, compound P3 at concentration of 200 \textmu g/mL possessed the highest metal chelating (45.8%) activity and power of reduction. In addition, P3 and A6 showed antibacterial activity …
Effect Of Mg Doping On Morphology, Photocatalytic Activity And Related Biological Properties Of Zn$_{\Mathbf{1-X}}$ Mg$_{X}$ O Nanoparticles, Bestenur Yalçin, Doğan Akcan, İbrahi̇m Ertuğrul Yalçin, Mehmet Can Alphan, Kenan Şentürk, İbrahi̇m İlker Özyi̇ği̇t, Lütfi̇ Arda
Effect Of Mg Doping On Morphology, Photocatalytic Activity And Related Biological Properties Of Zn$_{\Mathbf{1-X}}$ Mg$_{X}$ O Nanoparticles, Bestenur Yalçin, Doğan Akcan, İbrahi̇m Ertuğrul Yalçin, Mehmet Can Alphan, Kenan Şentürk, İbrahi̇m İlker Özyi̇ği̇t, Lütfi̇ Arda
Turkish Journal of Chemistry
The objective of this study is to synthesize ZnO and Mg doped ZnO (Zn$_{1-x}$Mg$_{x}$O) nanoparticles via the sol-gel method, and characterize their structures and to investigate their biological properties such as antibacterial activity and hemolytic potential.Nanoparticles (NPs) were synthesized by the sol-gel method using zinc acetate dihydrate (Zn(CH$_{3}$COO)$_{2}$.2H$_{2}$O) and magnesium acetate tetrahydrate (Mg(CH$_{3}$COO)$_{2}$.4H$_{2}$O) as precursors. Methanol and monoethanolamine were used as solvent and sol stabilizer, respectively. Structural and morphological characterizations of Zn$_{1-x}$Mg$_{x}$O nanoparticles were studied by using XRD and SEM-EDX, respectively. Photocatalytic activities of ZnO and selected Mg-doped ZnO (Zn$_{1-x}$Mg$_{x}$O) nanoparticles were investigated by degradation of methylene blue (MeB). Results …
A Novel Selective Fluorescent Chemosensor For Fe$^{3+}$ Ions Based On Phthalonitrile Dimer:Synthesis, Analysis, And Theoretical Studies, Shaya Al-Raqa, İpek Ömeroğlu, Doğan Erbahar, Mahmut Durmuş
A Novel Selective Fluorescent Chemosensor For Fe$^{3+}$ Ions Based On Phthalonitrile Dimer:Synthesis, Analysis, And Theoretical Studies, Shaya Al-Raqa, İpek Ömeroğlu, Doğan Erbahar, Mahmut Durmuş
Turkish Journal of Chemistry
Phenyl-4,4-di(3,6-dibutoxyphthalonitrile) (3) was synthesized by the reaction of 1,4-phenylenebisboronic acid (1) and 4-bromo-3,6-dibutoxyphthalonitrile (2), using Suzuki cross-coupling reaction. The newly synthesized compound (3) was characterized by FT-IR, MALDI-MS, ESI-MS, $^{1}$H-NMR, $^{13}$C-NMR, and $^{13}$C-DEPT-135-NMR. The fluorescence property of phenyl-4,4-di(3,6- dibutoxyphthalonitrile) (3) towards various metal ions was investigated by fluorescence spectroscopy, and it was observed thatthe compound (3) displayed a significantly `turn-off? response to Fe$^{3+}$, which was referred to 1:2 complex formation between ligand (3) and Fe$^{3+}$. The compound was also studied via density functional theory calculations revealing the interaction mechanism of the molecule with Fe$^{3+}$ ions.
A Novel Molecular Imprinting Polymer For The Selective Adsorptionof D-Arabinitol From Spiked Urine, Yuni Retnaningtyas, Ganden Supriyanto, Ni Nyoman Tri Puspaningsih, Roedi Irawan, Siswandono Siswodihardjo
A Novel Molecular Imprinting Polymer For The Selective Adsorptionof D-Arabinitol From Spiked Urine, Yuni Retnaningtyas, Ganden Supriyanto, Ni Nyoman Tri Puspaningsih, Roedi Irawan, Siswandono Siswodihardjo
Turkish Journal of Chemistry
In this research, molecular imprinting polymers (MIPs) for D-arabinitol were synthesized using a bulk polymerization method through a noncovalent approach. The MIPs were prepared by using D-arabinitol as a template, acrylamide as a functional monomer, ethylene glycol dimethacrylateas cross-linker, benzoyl peroxide as an initiator and dimethyl sulfoxideas a porogen. MIPS was synthesized in several formulas with a different molar ratio of template to functional monomers and cross-linker. Fourier-transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM) were used to characterize the MIPs produced. A batch rebinding assay was used to test the binding efficiency of each formula. Batch rebinding test …
L-Proline/Cholesterol And Diosgenin Based Thiourea Cooperative System For The Directasymmetric Aldol Reaction In The Presence Of Water, Serkan Eymur, Eni̇s Taşci, Arzu Uyanik, Mustafa Yilmaz
L-Proline/Cholesterol And Diosgenin Based Thiourea Cooperative System For The Directasymmetric Aldol Reaction In The Presence Of Water, Serkan Eymur, Eni̇s Taşci, Arzu Uyanik, Mustafa Yilmaz
Turkish Journal of Chemistry
A series of cholesterol and based hydrophobic urea and thiourea compounds were synthesized and successfully used as a cocatalyst for L-proline catalyzed aldol reactions in the presence of water. The anticonfigured products were obtained with good yields (up to 94%), high diastereoselectivities (up to 95:5), and high enantiomeric excesses (up to 93% ee). The successful results for catalytic efficiency of L-proline in the presence of water reveal the importance of the hydrophobic nature of cholesterol and diosgenin parts of thiourea on the reactivity and selectivity in the presence of water.
Determination Of Blood Glucose Parameter From Human Blood Serum By Using A Quartzcrystal Microbalance Sensor Coated With Phthalocyanines Compounds, Evi̇n Şahi̇n Sadik, Hamdi̇ Meli̇h Saraoğlu, İlke Gürol, Mehmet Ali̇ Ebeoğlu, Fatma Emel Koçak
Determination Of Blood Glucose Parameter From Human Blood Serum By Using A Quartzcrystal Microbalance Sensor Coated With Phthalocyanines Compounds, Evi̇n Şahi̇n Sadik, Hamdi̇ Meli̇h Saraoğlu, İlke Gürol, Mehmet Ali̇ Ebeoğlu, Fatma Emel Koçak
Turkish Journal of Chemistry
Determining the blood glucose level is important for the prevention and treatment of diabetes mellitus. We developed a sensor system using Quartz Crystal Microbalance (QCM) to determine the blood glucose level from human blood serum. This study consists of two experimental stages: artificial glucose/pure water solution tests and human blood serum tests. In the first stage of the study, the QCM sensor with the highest performance was identified using artificial glucose solution concentrations. In the second stage of the study, human blood serum measurements were performed using QCM to determine blood glucose levels. QCM sensors were coated with phthalocyanines (Pcs) …
The Production Of Enantiomerically Pure 1-Phenylethanol By Enzymatic Kineticresolution Method Using Response Surface Methodology, Ayşe Bozan, Rahi̇me Songür, Ülkü Mehmetoğlu
The Production Of Enantiomerically Pure 1-Phenylethanol By Enzymatic Kineticresolution Method Using Response Surface Methodology, Ayşe Bozan, Rahi̇me Songür, Ülkü Mehmetoğlu
Turkish Journal of Chemistry
As the enantiomers of 1-phenylethanol are valuable intermediates in several industries, the lipase catalyzed kinetic resolution of (R,S) -1-phenylethanol is a relevant research topic. In this study, the goal was to determine the optimum reaction parameters to produce enantiomerically pure 1-phenylethanol by lipase (Novozyme 435) catalyzed kinetic resolution using response surface methodology (RSM). Reactions were performed with 40-400 mM (R,S)-1-phenylethanol, 120-1200 mM vinyl acetate and 2-22 mg/ mL biocatalyst concentrations (BC$_{L}$), at 20-60 °C and with a stirring rate of 50-400 rpm for 5-120 min. The samples were analyzed using high performance liquid chromatography (HPLC) with a Chiralcel OB column. …
Magnetite Nanoparticles-Based Hydroxyl Radical Scavenging Activity Assay Ofantioxidants Using N, N-Dimethyl-P-Phenylenediamine Probe, Zi̇ya Can, Büşra Keski̇n, Ayşem Arda, Erol Erçağ, Mustafa Reşat Apak
Magnetite Nanoparticles-Based Hydroxyl Radical Scavenging Activity Assay Ofantioxidants Using N, N-Dimethyl-P-Phenylenediamine Probe, Zi̇ya Can, Büşra Keski̇n, Ayşem Arda, Erol Erçağ, Mustafa Reşat Apak
Turkish Journal of Chemistry
Excessive amounts of reactive oxygen species (ROS), unless counterbalanced by antioxidants, can cause cellular damage under oxidative stress conditions; therefore, antioxidative defenses against ROS must be measured. With the development of nanotechnology, nanoparticles have found numerous applications in science, health, and industries. Magnetite nanoparticles (Fe$_{3}$O$_{4}$:MNPs) have attracted attention because of their peroxidase-like activity. In this study, hydroxyl radicals (?OH) generated by MNPs-catalyzed degradation of H$_{2}$O$_{2}$ converted the N,N-dimethyl-p-phenylenediamine (DMPD) probe into its colored DMPD$^{•+}$ radical cation, which gave an absorbance maximum at λ = 553 nm. In the presence of antioxidants, $^{•}$OH was partly scavenged by antioxidants and produced less …
Application Of Synthesized Copper Nanoparticles Using Aqueous Extract Ofziziphus Mauritiana L. Leaves As A Colorimetric Sensor For The Detection Of Ag$^{+}$, Roomia Memon, Ayaz Ali Memon, Syed Tufail Hussain Sherazi, Siraj Uddin, Aamna Balouch, Muhammad Raza Shah, Sarfaraz Ahmed Mahesar, Kauser Rajar, Muhammad Hassan Agheem
Application Of Synthesized Copper Nanoparticles Using Aqueous Extract Ofziziphus Mauritiana L. Leaves As A Colorimetric Sensor For The Detection Of Ag$^{+}$, Roomia Memon, Ayaz Ali Memon, Syed Tufail Hussain Sherazi, Siraj Uddin, Aamna Balouch, Muhammad Raza Shah, Sarfaraz Ahmed Mahesar, Kauser Rajar, Muhammad Hassan Agheem
Turkish Journal of Chemistry
The presented work demonstrates the preparation of copper nanoparticles (CuNPs) via aqueous leaves extract of Ziziphus mauritiana L. (Zm) using hydrazine as a reducing agent. Various parameters such as volume of extract, concentration of hydrazine hydrate, concentration of copper chloride, and pH of the solution were optimized to obtain Ziziphus mauritiana L. leaves extract derived copper nanoparticles (Zm-CuNPs). Brownish red color was initial indication of the formation of Zm-CuNPs while it was confirmed by surface plasmon resonance (SPR) band at wavelength of 584 nm using ultraviolet-visible (UV-vis) spectroscopy. Synthesized Zm-CuNPs were characterized by Fourier transform infrared spectroscopy (FT-IR), scanning electron …
An Efficient Approach For The Synthesis Of Novel Methyl Sulfones In Acetic Acid Mediumand Evaluation Of Antimicrobial Activity, Gollapudi Ravi Kumar, Chandra Rao Dasireddy, Ravi Varala, Vijay Kotra, Hari Babu Bollikolla
An Efficient Approach For The Synthesis Of Novel Methyl Sulfones In Acetic Acid Mediumand Evaluation Of Antimicrobial Activity, Gollapudi Ravi Kumar, Chandra Rao Dasireddy, Ravi Varala, Vijay Kotra, Hari Babu Bollikolla
Turkish Journal of Chemistry
A series of nine methyl sulphones (3a-3i) starting from the aldehydes (1a-1i) were synthesized in two consecutive steps. In the first step, preparation of allyl alcohols (2a-2i) from their corresponding aldehydes by the reaction of sodium borohydride in methanol at room temperature is reported. Finally, methyl sulphones are synthesized by condensing sodium methyl sulfinates with allyl alcohols in the presence of BF$_{3}$.Et$_{2}$O in acetic acid medium at room temperature for about 2-3 h. The reaction conditions are simple, yields are high (85%-95%), and the products were obtained with good purity. All the synthesized compounds were characterized by their $^{1}$H, $^{13}$C …
Synthesis, Characterization And Evaluation Of Antidengue Activity Of Enantiomeric Schiffbases Derived From S-Substituted Dithiocarbazate, Maqsood Maryam, Sang Loon Tan, Karen Ann Crouse, Mohamed Ibrahim Mohamed Tahir, Hui Yee Chee
Synthesis, Characterization And Evaluation Of Antidengue Activity Of Enantiomeric Schiffbases Derived From S-Substituted Dithiocarbazate, Maqsood Maryam, Sang Loon Tan, Karen Ann Crouse, Mohamed Ibrahim Mohamed Tahir, Hui Yee Chee
Turkish Journal of Chemistry
A series of Schiff bases have been successfully synthesized through the acid-catalyzed condensation of S-substituted dithiocarbazates and three enantiomerically pure monoterpenes, (1R)-(+)-camphor, (1S)-(-)-camphor, (1R)-(-)-camphorquinone, (1S)- (+)-camphorquinone, (R)-(-)-carvone and (S)-(+)-carvone. Spectroscopic results revealed that the Schiff bases containing camphor or carvone likely adopted an E-configuration along the characteristic imine bond while those containing camphorquinone assumed a Z-configuration. The antidengue potential of these compounds was evaluated based on DENV 2 caused cytopathic effect (CPE) reduction-based in vitro evaluation. The compounds were validated through secondary foci forming unit reduction assay (FFURA). Compounds were also tested for their cytotoxicity against Vero cells. The compounds …
Design, Synthesis, And Spasmolytic Activity Of Thiophene-Based Derivatives Via Suzukicross-Coupling Reaction Of 5-Bromothiophene-2-Carboxylic Acid: Their Structural Andcomputational Studies, Nasir Rasool, Hafiz Mansoor Ikram, Ammara Rashid, Nazia Afzal, Muhammad Ali Hashmi, Muhammad Naeem Khan, Ayesha Khan, Imran Imran, Hafiz Muhammad Abdur Rahman, Syed Adnan Ali Shah
Design, Synthesis, And Spasmolytic Activity Of Thiophene-Based Derivatives Via Suzukicross-Coupling Reaction Of 5-Bromothiophene-2-Carboxylic Acid: Their Structural Andcomputational Studies, Nasir Rasool, Hafiz Mansoor Ikram, Ammara Rashid, Nazia Afzal, Muhammad Ali Hashmi, Muhammad Naeem Khan, Ayesha Khan, Imran Imran, Hafiz Muhammad Abdur Rahman, Syed Adnan Ali Shah
Turkish Journal of Chemistry
In the current research work, a facile synthesis of a series of novel thiophene-based derivatives of 5-bromothiophene-2- carboxylic acid (1) have been synthesized. All analogs (5a-5e, 10a-10f) were obtained from the coupling reaction of 5-bromothiophene- 2-carboxylic acid (1) and different arylboronic acids with moderate-to-good yields under controlled and optimal conditions. The structures of the newly synthesized compounds were characterized through spectral analysis and their spasmolytic activity, and most of the compounds exhibited potentially good spasmolytic effect. Among the synthesized analogs, compound phenethyl 5-(3,4-dichlorophenyl)thiophene-2-carboxylate (10d) particular showed an excellent spasmolytic effect with an EC$_{50}$ value of 1.26. All of the compounds …
Mathematical Modeling Of A Continuous-Flow Packed-Bed Reactor With Immobilizedlipase For Kinetic Resolution Of (R,S)-2-Pentanol, Asli Soyer Malyemez, Abdulwahap Giwa, Emi̇ne Bayraktar, Ülkü Mehmetoğlu
Mathematical Modeling Of A Continuous-Flow Packed-Bed Reactor With Immobilizedlipase For Kinetic Resolution Of (R,S)-2-Pentanol, Asli Soyer Malyemez, Abdulwahap Giwa, Emi̇ne Bayraktar, Ülkü Mehmetoğlu
Turkish Journal of Chemistry
In this study, the kinetic resolution of (R,S)-2-pentanol via transesterification to achieve S-2-pentanol, a key intermediate required in the synthesis of anti-Alzheimer drugs, was investigated in continuous-flow packed-bed reactors. The effects of residence time, substrate concentration, and operation time of the enzyme were investigated. Under steady state conditions, 50% conversion and enantiomeric excess of the substrate (ee$_{S}$)>99% were achieved at a residence time of 0.04 min. Productivity of the continuous-flow process (1.341 mmol/min/g)was about 4 times higher than that of the corresponding batch process (0.363 mmol/min/g). In addition, the mathematical modeling of the packed-bed reactor was conductedusing an axial …
Innovational Combination Of Hetero-Bifunctional N-Peg Quinoline Scaffolds Derivatives With Improved Anticancer Activity Against Breast And Colon Cancer Cell Lines And P-Glycoprotein, Cytochrome P450 Enzyme Activity Prediction, Mahesh Gaidhane, Ajay Ghatole, Kushal Lanjewar, Kishor Hatzade
Innovational Combination Of Hetero-Bifunctional N-Peg Quinoline Scaffolds Derivatives With Improved Anticancer Activity Against Breast And Colon Cancer Cell Lines And P-Glycoprotein, Cytochrome P450 Enzyme Activity Prediction, Mahesh Gaidhane, Ajay Ghatole, Kushal Lanjewar, Kishor Hatzade
Turkish Journal of Chemistry
Polyethylene glycol (PEG) is a polymer that is widely used as a carrier for drug delivery systems (DDS). A library of N-PEGylated quinoline derivatives of PEG molecular weight 200 was prepared rapidly after the activation of PEGs using maleic anhydride. Quinoline with a polymer backbone is essential as new material. PEG is a water-soluble nonionic polymer approved by food and drug organizations for medicine applications. Because of its nontoxic grapheme, it is widely utilized in numerous biochemical, cosmetic, pharmaceutical, and industrialized applications. The modern SwissADME is a web tool that stretches free admittance to a pool of hasty, yet solid, …
Catalytic Activity Of Novel Thermoplastic/Cellulose-Au Nanocomposites Prepared By Cryomilling, Joanna Kwiczak Yigitbasi
Catalytic Activity Of Novel Thermoplastic/Cellulose-Au Nanocomposites Prepared By Cryomilling, Joanna Kwiczak Yigitbasi
Turkish Journal of Chemistry
Due to environmental concerns, increasing attention has been focused on the application and preparation of biobased polymers and their blends. In this study, cellulose, the most spread biopolymer on Earth, was used in the preparation of novel cotton/polypropylene- Au and cotton/polyethylene-Au nanocomposites via a green mechanochemical approach. First, mechanoradicals were generated by ball milling of the cotton and thermoplastics under cryo conditions, and then, these radicals were used in the reduction of Au ions to Au nanoparticles (Au NPs). Nanocomposites were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS). The application of mechanochemistry in …
Effective Synthesis Of Bicyclodienes Via Palladium-Catalyzed Asymmetric Allylic Alkylationand Ruthenium-Catalyzed Cycloisomerization, Ni̇zam Havare
Effective Synthesis Of Bicyclodienes Via Palladium-Catalyzed Asymmetric Allylic Alkylationand Ruthenium-Catalyzed Cycloisomerization, Ni̇zam Havare
Turkish Journal of Chemistry
[n.3.0]Bicycles (n = 3-6) can be synthesized using palladium-catalyzed asymmetric allylic alkylation followed by rutheniumcatalyzed cycloisomerization. New types of triarylphosphino-1,2-diaminooxazoline ligands show the same high levels of enantioselectivity observed with Trost ligand when employed in Pd-catalyzed allylic alkylation reactions. The enyne products of these allylic alkylation reactions were further elaborated using a Ru-catalyzed redox isomerization process, for which a mechanism is proposed.