Chemistry Commons^™

Intramolecular Reductive Heck Approach To Guaipyridine Alkaloids, Samantha Grosslight, Hope Spargo

Scholars Week

The guaipyridine alkaloids are a family of compounds that all share an unusual carbon structure, whose source plants have been used as a traditional medicine in Southeast Asia. Members of the guaipyridine family include cananodine and the rupestines. Cananodine has been isolated from the fruits of the Canaga odorata in Indonesia, Malaysia and the Philippines. Cananodine has been used of decades as a traditional medicine for the treatment of malaria, infections and fever. Studies of cananodine’s biological activity have reveled activity against Hep G2 and Hep 2,2,15 human hepatocarcinoma cell lines, the most common types of liver cancer. Due to …

Gold Catalyzed Lactonization Of Epoxide Esters, Carlos Enciso Lopez

Scholars Week

Lactones are cyclic esters of varying ring size that occur naturally in organic compounds. Organic structures such as these have various useful biological activities applicable to antibacterial drugs, potential anticancer drugs, and participants of metabolic processes. Gold catalysts Au(I) and Au(III) are shown in our experiments to be effective in inducing intramolecular lactonization of epoxide esters to form desired lactone products. In our experiments gold catalysts coordinated with epoxides to develop a positive charge on the carbon nearest to the carbonyl. The result is an intramolecular lactonization of the ester via nucleophilic attack of the carbonyl oxygen onto the positive …

2016-01-A3dsrinp-Csc-Sta-Cmb-522-Bps-542, Raymond Pulver, Neal Buxton, Xiaodong Wang, John Lucci, Jean Yves Hervé, Lenore Martin

Bioinformatics Software Design Projects

Cholesterol is carried and transported through bloodstream by lipoproteins. There are two types of lipoproteins: low density lipoprotein, or LDL, and high density lipoprotein, or HDL. LDL cholesterol is considered “bad” cholesterol because it can form plaque and hard deposit leading to arteries clog and make them less flexible. Heart attack or stroke will happen if the hard deposit blocks a narrowed artery. HDL cholesterol helps to remove LDL from the artery back to the liver.

Traditionally, particle counts of LDL and HDL plays an important role to understanding and prediction of heart disease risk. But recently research suggested that …

Titanium-Oxides As A Stabilizing Agent For Environmentally Persistent Free Radicals (Epfrs), Josef Baylis

Scholarly and Creative Works Conference (2015 - 2021)

The mechanism of formation for surface bound radicals were studied using ab initio quantum methods. The shift in electron density from transition metal surfaces to surface bound radical groups was studied to learn the mechanism for the binding. Results indicate an oxidation-reduction based mechanism of formation.

Studies Of The Solid-Phase Pauson-Khand Reaction Selective In-Situ Enone Reduction To 3-Azabicyclo[3.3.0]Oct-Anones, Daniel Becker, Daniel L. Flynn

Daniel P. Becker

The Smit-Caple DSAC Pauson-Khand cyclization of a series of N-protected allyl propargyl amines in the absence of oxygen gave rise to formation of the saturated azabicyclo[3.3.0]octanones in excellent yields. Standard cyclization in air gave mixtures of saturated and unsaturated ketones.

Synthesis Of N-Boc-3-Azabicyclo[3.3.0]Octan-7-One Via Reductive Pauson-Khand Cyclization And Subsequent Conversion To A Novel Diazatricyclic Ring System, Daniel Becker, Daniel L. Flynn

Daniel P. Becker

An intramolecular reductive Pauson-Khand reaction of the hexacarbonyldicobalt complex of N-(tert-butyloxycarbonyl)allylpropargylamine under dry-state adsorption conditions directly afforded the saturated N-BOC-3-azabicyclo[3.3.0]octan-7-one when the reaction was performed under an inert atmosphere. This bicyclic ketone was converted in several steps to the novel octahydro-1-azeto[2′,3′:3,4]cyclopenta[1,2-C]pyrrole ring system as confirmed by single crystal X-ray analysis.