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Articles 1 - 30 of 179
Full-Text Articles in Astrophysics and Astronomy
X-Raying The Material Surrounding Active Supermassive Black Holes, Isaiah S. Cox
X-Raying The Material Surrounding Active Supermassive Black Holes, Isaiah S. Cox
All Dissertations
It is important to understand the nature of the gas and dust immediately surrounding the supermassive black hole (SMBH) in active galactic nuclei (AGN), because this material feeds the accretion disk and couples the activities going on at the AGN scale to the host galaxy. However, there remain large uncertainties on basic properties about this material such as its location and distribution. This is primarily due to the difficulties in resolving spatial information on these scales at extragalactic distances.
AGN emit a tremendous amount of radiation all across the electromagnetic spectrum, including X-rays. The X-rays come from a very small …
Numerical Calculations Of The Electromagnetic And Gravitational Wave Signatures Of Unequal Mass Black Hole Binary Inspirals, Madeline Clyburn
Numerical Calculations Of The Electromagnetic And Gravitational Wave Signatures Of Unequal Mass Black Hole Binary Inspirals, Madeline Clyburn
All Dissertations
In 2015, the Laser Interferometer Gravitational-Wave Observatory (LIGO) measured the first gravitational waves (GWs) from the coalescence of two stellar-mass black holes. This detection marked a historic milestone in astrophysics, confirming general relativity and establishing the existence of gravitationally bound black holes. Since then, researchers have extended the search to even more massive black hole mergers. Recently, the International Pulsar Timing Array (IPTA), including the North American Nanohertz Observatory for Gravitational Waves (NANOGrav), detected a nanohertz GW background from supermassive black hole binaries (SMBHBs), black holes with masses M ≃10^7−10^9 M⊙ orbiting throughout the universe. However, a single SMBHB has …
Cosmic Duets: A Search For Binary Supermassive Black Holes In Merging Galaxies, Sagar Adhikari
Cosmic Duets: A Search For Binary Supermassive Black Holes In Merging Galaxies, Sagar Adhikari
All Dissertations
Galaxies are vast cosmic islands of stars, dust, and gas. They come in various shapes and sizes. They might look static for the timescales we are used to, but they are dynamic and collisional systems that can merge with other galaxies to make bigger galaxies. Most galaxies, including the Milky Way, host a central supermassive black hole (SMBH) with a mass greater than a million (sometimes a billion) times the mass of the Sun. When galaxies merge, their SMBHs form a binary system before ultimately merging. These cosmic duets are of great interest to astronomers and astrophysicists as they are …
12co Ro-Vibrational Spectroscopy Of Protoplanetary Disks: Inferring Planet-Disk Interactions, Janus Kozdon
12co Ro-Vibrational Spectroscopy Of Protoplanetary Disks: Inferring Planet-Disk Interactions, Janus Kozdon
All Dissertations
Observing and studying planets around young stars during their initial formation stages is essential for understanding the physics of their formation. Protoplanetary disks are the host sites of planets, and they exhibit substructures that hint towards the planets' presence, but the planet itself has rarely been detected. Analysis of the substructures in protoplanetary disks, especially towards the inner regions where most planets seem to lie, will provide information that can be used to refine theories about planet-disk interactions and, ultimately, planet formation. To probe the high-velocity inner regions, this study utilizes high-resolution spectroscopy, which has increased sensitivity with increasing velocities. …
Chemical & Electromagnetic Signatures Of Binary Neutron Star Mergers, Benjamin Amend
Chemical & Electromagnetic Signatures Of Binary Neutron Star Mergers, Benjamin Amend
All Dissertations
Binary neutron star (BNS) mergers are some of the most energetic events in the universe, producing both short gamma-ray bursts (GRBs) and kilonovae. GRBs are brief, bright flashes of gamma rays, powered by ultra-relativistic jets launched during the merger. These jets produce a prompt burst of gamma rays, followed by a broadband afterglow generated by external shocks as the outflow interacts with the surrounding medium. Kilonovae are optical-infrared transients from the radioactive decay of heavy, neutron-rich nuclei formed through the rapid neutron capture process (r-process) in the merger ejecta. Together, GRBs and kilonovae provide unique laboratories for probing fundamental physics …
Discovering High-Redshift Bl Lacs And Localizing Grbs For Mev Missions, Yong Sheng
Discovering High-Redshift Bl Lacs And Localizing Grbs For Mev Missions, Yong Sheng
All Dissertations
Blazars are active galactic nuclei (AGNs) with their jets aligned towards Earth. Gamma-ray bursts (GRBs) can be classified into long and short types. Long GRBs are produced by the collapse of massive stars, while short GRBs are formed by binary mergers (neutron star - neutron star or neutron star - black hole mergers). Both objects are the key probes of extreme physics processes and cosmic evolution, providing us an unique window to understand the Universe. My research aims to measure the redshift of blazars and localize GRBs for proposed and upcoming gamma-ray telescopes. BL Lac objects (BL Lacs) are a …
Probing The 'Mev Gap': Discovery And Characterization Of Persistent And Transient Mev-Gev Gamma-Ray Sources With The Fermi Large Area Telescoope, Scott Joffre
All Dissertations
The MeV Gap is a moniker for the energy regime E~0.1-100 MeV that has lacked sensitive observations for the last 20 years. This is not out of scientific disinterest, but observational challenges. The only instrument currently available to make observations in the MeV Gap is the Fermi Large Area Telescope (LAT). For the first time ever, Fermi-LAT has been leveraged to push its observational capabilities to its absolute lower energy limit to end this 20-year observational gap. Observing the MeV sky is imperative for identifying some of the most luminous galaxies in the Universe known as blazars. The brightest blazars …
The Effect Of Nuclear Isomers On S-Process Nucleosynthesis, Jaad Tannous
The Effect Of Nuclear Isomers On S-Process Nucleosynthesis, Jaad Tannous
All Dissertations
s-Process nucleosynthesis is a process in which stars produce elements of mass range A = 57 to 210. Since the days of B2FH, immense work has gone into quantifying and computing s-process yields and pathways. We expand upon said work along two fronts. The first front sets up the framework for proper treatment of nuclear isomers in network calculations. We apply the framework to study 85Kr, which is a pivotal isotope in the s-process chain that affects the abundance yields of Strontium and Rubidium isotopes. In particular, we are interested in the ratio of 88Sr/86Sr and 87Rb which are important …
Equilibria And Effective Transition Rates In Linear Networks, Sayani Ghosh
Equilibria And Effective Transition Rates In Linear Networks, Sayani Ghosh
All Dissertations
Investigating equilibration in nucleosynthetic processes is crucial for understanding stellar chemical abundances in nuclear astrophysical scenarios. While current computational models are effective at predicting final species abundances at the end of these stellar processes, they fail to provide insights into the evolution of equilibrium. Without this deeper understanding, it is challenging to determine the impact of individual reaction rates on timescales and the resultant equilibrium.
In this work, we model nucleosynthetic processes as directed graphs. We develop theorems that allow us to express the mass fractions of species as spanning arborescences of these graphs. By obtaining eigenvalues in terms of …
To The Torus And Beyond: An X-Ray Study Of Agn Tori Morphology, Andrealuna Pizzetti
To The Torus And Beyond: An X-Ray Study Of Agn Tori Morphology, Andrealuna Pizzetti
All Dissertations
Active Galactic Nuclei (AGN) are among the Universe's most energetic and powerful objects, fueled by an accreting supermassive black hole (SMBH) at the host galaxy's center, surrounded by a toroidal structure of dusty gas. Ultraviolet photons arising from the accretion disk get up-scattered to X-rays via inverse Compton scattering by hot electrons close to the accretion disk. Being produced in the very center of the AGN, X-ray photons are powerful messengers that probe the physics of the accretion system and the matter in the surroundings. The torus, formerly considered homogeneous, appears to be a more complex structure of clouds with …
A Deeper Understanding Of The R Process, Mengke Li
A Deeper Understanding Of The R Process, Mengke Li
All Dissertations
The overarching aim of my PhD research is to deepen our understanding of r-process nu- cleosynthesis. The initial phase of my work involved developing a Machine Learning-based nuclear mass model, specifically tailored to predict nuclear masses crucial for r-process nucleosynthesis. This model was then applied to simulate the r-process, focusing on neutron-rich nuclei significant to nucleosynthesis. The simulations yielded r-process abundance patterns, extending up to thorium and uranium, that align qualitatively with the observed solar system abundance patterns, with the characteristic peaks well positioned. Advancing our study further, we introduced a novel graph-based methodology named GrRproc for calculating r-process abundances. …
An Investigation Of The Accretion Processes In T Tauri And Herbig Ae/Be Systems Using High Resolution Optical And Near-Infrared Spectroscopy, Joshua Kern
All Dissertations
Star and planet formation is intimately tied to the accretion of material from the environments in which they form. During the formation process, disks of gas and dust develop in young stellar objects through which material is facilitated to the star and forming planets. Theoretical models of these accretion processes invoke viscous spreading via hydrodynamics, as well as more complex interactions with magnetic fields be it from the stellar component or the formation environment in order to catalyze these mass flows. These accretion models predict various scenarios including magnetospheric accretion as well as supersonic accretion flows in the disk atmosphere …
Spectroscopy Of Highly Charged Ions For Astrophysical And Laboratory Plasma Diagnostics, Yang Yang
Spectroscopy Of Highly Charged Ions For Astrophysical And Laboratory Plasma Diagnostics, Yang Yang
All Dissertations
Electron beam ion traps (EBITs) are small-scale laboratory devices that create and trap highly charged ions (HCI) for spectroscopic studies. These devices create plasma conditions resembling astrophysical environments like stellar winds and supernova remnants, providing valuable insights into astrophysical plasma. Theoretical models for such systems require incorporating relativistic and quantum electrodynamics effects, making experimental studies of HCIs essential for benchmarking these theories.
Spectral analysis of astrophysical and laboratory plasma requires understanding the ionization balance. Accurate atomic data, including excitation, ionization, and recombination cross sections, along with precise knowledge of operating conditions such as electron beam density, electron beam energy, and …
Simulating The Eccentricity Evolution Of Accreting Equal-Mass Binaries: Numerical Sensitivity To The Computational Domain Size And Grid Resolution, Zhongtian Hu
All Theses
With high resolution hydrodynamics simulations, we show that the optimal values of domain radius and grid resolution for the software Sailfish when simulating time-based eccentricity evolution of equal mass, non-circular accreting binaries in a circumbinary disk to be $r_{\rm out} \leq 15a$ and $\delta x / a \le 0.01 $. These values provide a useful guideline for optimizing the performance of simulation runs while maintaining scientific accuracy. Each artificial parameter is probed with 15 runs of 2000 orbits each.
Cosmic Diffuse Neutrino And Gamma-Ray Backgrounds In The Mev Regime, Ilukpitiye Samalka Anandagoda
Cosmic Diffuse Neutrino And Gamma-Ray Backgrounds In The Mev Regime, Ilukpitiye Samalka Anandagoda
All Dissertations
Cosmic Multi-Messenger backgrounds include relic diffuse components created in the early Universe and contributions from individual sources. In this dissertation, I present the work done in Anandagoda (2019); Anandagoda et al. (2020, 2023) where type Ia (SNe Ia) and core-collapse supernovae (CCSNe) contributions to the diffuse neutrino and gamma-ray backgrounds in the MeV regime are studied. These backgrounds are referred to as DSNB and DSGB respectively. Based on this work, the diffuse SN Ia background is ~106 times lower (for electron antineutrinos) than the CCSN background making it negligible. The predicted DSNB electron antineutrino flux at earth in the …
The Search For Heavily Obscured Active Galactic Nuclei In The Local Universe, Ross Silver
The Search For Heavily Obscured Active Galactic Nuclei In The Local Universe, Ross Silver
All Dissertations
Active galactic nuclei (AGN) are supermassive black holes (SMBHs) in the center of galaxies that accrete surrounding gas and emit across the entire electromagnetic spectrum. They are the most energetic persistent emitters in the Universe, capable of outshining their host galaxies despite their emission originating from a region smaller than our Solar System. AGN were some of the first sources discovered that helped teach us that there were galaxies outside of our own, and they proved the existence of black holes. Moreover, AGN can give us valuable insights into other branches of astrophysics. For example, they can be used to …
The Pursuit For Gamma-Ray Emitting Pulsar Wind Nebulae With The Fermi-Large Area Telescope, Jordan Eagle
The Pursuit For Gamma-Ray Emitting Pulsar Wind Nebulae With The Fermi-Large Area Telescope, Jordan Eagle
All Dissertations
Pulsar wind nebulae are highly magnetized particle winds, descending from core collapse supernovae (CC SNe), and each powered by an energetic, rapidly rotating neutron star. There are at least 125 Galactic pulsar wind nebulae (PWNe) that have been discovered from radio wavelengths to TeV gamma-rays, the majority of which were first identified in radio or X-ray surveys. An increasing number of PWNe are being identified in the TeV band by ground-based air Cherenkov Telescopes such as HESS, MAGIC, and VERITAS such that they constitute the dominant source class of Galactic TeV emitters. High-energy sources like PWNe may be responsible for …
Co Molecular Spectroscopy And Spectro-Astrometry Of Protoplanetary Disks, Stanley Jensen
Co Molecular Spectroscopy And Spectro-Astrometry Of Protoplanetary Disks, Stanley Jensen
All Dissertations
Until relatively recently, the only known planets were those in our own solar system (Mayor & Queloz, 1995). However modern instruments and techniques have revealed that planets are ubiquitous around main sequence stars over the last three decades. From this we have obtained a multitude of insights into planetary populations. For instance, while the terrestrial and gas giant planet types are both well accounted for in extra-solar systems, the arrangement of our own system with inner terrestrial planets and outer gas giants is not clearly the typical organization (van der Marel & Mulders, 2021). In fact we see that in …
Exploring The Glow Of The Universe In Gamma-Rays And Hunting Distant Agn, Changam Meenakshi Rajagopal
Exploring The Glow Of The Universe In Gamma-Rays And Hunting Distant Agn, Changam Meenakshi Rajagopal
All Dissertations
The entirety of the γ-ray radiation permeating our Universe is encoded in the extragalactic γ-ray background. This is a superposition of resolved sources, mostly powerful relativistic jets powered by supermassive black holes, i.e., blazars, and an unresolved isotropic component, aka, the diffuse isotropic gamma-ray background (IGRB). Studying the IGRB can help unveil its composition, as well as unearth multi-messenger relationships between the intensities of PeV neutrinos, ultra high energy cosmic rays (> 1018 eV), and sub-TeV γ-rays. The comparable energy budgets of these three phenomena (neutrinos, UHECR, and γ-rays) indicates a physical connection or a common source amongst them. On …
E-Hooks Provide Guidance And A Soft Landing For The Microtubule Binding Domain Of Dynein, Nayere Tajielyato, Lin Li, Yunhui Peng, Joshua Alper, Emil Alexov
E-Hooks Provide Guidance And A Soft Landing For The Microtubule Binding Domain Of Dynein, Nayere Tajielyato, Lin Li, Yunhui Peng, Joshua Alper, Emil Alexov
Publications
Macromolecular binding is a complex process that involves sensing and approaching the binding partner, adopting the proper orientation, and performing the physical binding. We computationally investigated the role of E-hooks, which are intrinsically disordered regions (IDRs) at the C-terminus of tubulin, on dynein microtubule binding domain (MTBD) binding to the microtubule as a function of the distance between the MTBD and its binding site on the microtubule. Our results demonstrated that the contacts between E-hooks and the MTBD are dynamical; multiple negatively charted patches of amino acids on the E-hooks grab and release the same positively charged patches on the …
Identifying Weak Interdomain Interactions That Stabilize The Supertertiary Structure Of The N-Terminal Tandem Pdz Domains Of Psd-95, Inna S. Yanez Orozco, Frank A. Mindlin, Junyan Ma, Bo Wang, Brie Levesque, Matheu Spencer, Soheila Rezaei Adariani, George Hamilton, Feng Ding, Mark E. Bowen, Hugo Sanabria
Identifying Weak Interdomain Interactions That Stabilize The Supertertiary Structure Of The N-Terminal Tandem Pdz Domains Of Psd-95, Inna S. Yanez Orozco, Frank A. Mindlin, Junyan Ma, Bo Wang, Brie Levesque, Matheu Spencer, Soheila Rezaei Adariani, George Hamilton, Feng Ding, Mark E. Bowen, Hugo Sanabria
Publications
Previous studies of the N-terminal PDZ tandem from PSD-95 produced divergent models and failed to identify interdomain contacts stabilizing the structure. We used ensemble and single-molecule FRET along with replica-exchange molecular dynamics to fully characterize the energy landscape. Simulations and experiments identified two conformations: an open-like conformation with a small contact interface stabilized by salt bridges, and a closed-like conformation with a larger contact interface stabilized by surface-exposed hydrophobic residues. Both interfaces were confirmed experimentally. Proximity of interdomain contacts to the binding pockets may explain the observed coupling between conformation and binding. The low-energy barrier between conformations allows submillisecond dynamics, …
A Versatile Carbon Nanotube-Based Scalable Approach For Improving Interfaces In Li-Ion Battery Electrodes, Lakshman K. Ventrapragada, Jingyi Zhu, Stephen E. Creager, Apparao M. Rao, Ramakrishna Podila
A Versatile Carbon Nanotube-Based Scalable Approach For Improving Interfaces In Li-Ion Battery Electrodes, Lakshman K. Ventrapragada, Jingyi Zhu, Stephen E. Creager, Apparao M. Rao, Ramakrishna Podila
Publications
Resistive interfaces within the electrodes limit the energy and power densities of a battery, for example, a Li-ion battery (LIB). Typically, active materials are mixed with conductive additives in organic solvents to form a slurry, which is then coated on current collectors (e.g., bare or carbon-coated Al foils) to reduce the inherent resistance of the active material. Although many approaches using nanomaterials to either replace Al foils or improve conductivity within the active materials have been previously demonstrated, the resistance at the current collector active material interface (CCAMI), a key factor for enhancing the energy and power densities, remains unaddressed. …
Metallic Mxenes: A New Family Of Materials For Flexible Triboelectric Nanogenerators, Yongchang Dong, Sai Sunil Kumar Mallineni, Kathleen Maleski, Herbert Behlow, Vadym N. Mochalin, Apparao M. Rao, Yury Gogosti, Ramakrishna Podila
Metallic Mxenes: A New Family Of Materials For Flexible Triboelectric Nanogenerators, Yongchang Dong, Sai Sunil Kumar Mallineni, Kathleen Maleski, Herbert Behlow, Vadym N. Mochalin, Apparao M. Rao, Yury Gogosti, Ramakrishna Podila
Publications
Wearable and flexible electronics warrant the development of self-powered devices to circumvent the limitations imposed by traditional energy storage devices. Triboelectric nanogenerators (TENGs) that convert waste mechanical energy from human motion into electric power offer a solution. Highly electronegative and conducting TENG materials that support the generation of both large potential differences and high currents are imperative for effectively harvesting electric power from human muscle movements. Here, we demonstrate that two-dimensional MXenes (e.g., titanium carbide Ti3C2Tx, where Tx stands for surface functional groups such as -O, -OH, and -F) are a family of electrically conducting materials that are triboelectrically more …
Gamma-Ray-Emitting Narrow-Line Seyfert 1 Galaxies In The Sloan Digital Sky Survey, Vaidehi S. Paliya, M. Ajello, A. Mandal, C. S. Stalin, A. Kaur, D. Hartmann
Gamma-Ray-Emitting Narrow-Line Seyfert 1 Galaxies In The Sloan Digital Sky Survey, Vaidehi S. Paliya, M. Ajello, A. Mandal, C. S. Stalin, A. Kaur, D. Hartmann
Publications
The detection of significant γ-ray emission from radio-loud narrow-line Seyfert 1 (NLSy1s) galaxies enables us to study jets in environments different than those in blazars. However, due to the small number of known γ-ray-emitting NLSy1 (γ-NLSy1) galaxies, a comprehensive study could not be performed. Here, we report the first detection of significant γ-ray emission from four active galactic nuclei (AGNs), recently classified as NLSy1 from their Sloan Digital Sky Survey (SDSS) optical spectrum. Three flat-spectrum radio quasars (FSRQs) present in the third Large Area Telescope AGN catalog (3LAC) are also found as γ-NLSy1 galaxies. …
A Micro-Raman Study Of Exfoliated Few-Layered N-Type Bi2 Te2.7 Se0.3, Liu Fengjiao, Karakaya Mehmet, Pooja Puneet, Rahul Rao, Podila Ramakrishna, Sriparna Bhattacharya, Apparao M. Rao
A Micro-Raman Study Of Exfoliated Few-Layered N-Type Bi2 Te2.7 Se0.3, Liu Fengjiao, Karakaya Mehmet, Pooja Puneet, Rahul Rao, Podila Ramakrishna, Sriparna Bhattacharya, Apparao M. Rao
Publications
Previously we showed that the thermoelectric (TE) performance of bulk n-type Bi2Te2.7Se0.3 can be enhanced by subjecting it to a combined process of chemical or mechanical exfoliation (C/ME) followed by a rapid densification and restacking of the exfoliated layers via the spark-plasma-sintering technique (SPS). Here, we present a systematic micro-Raman study of two-dimensional flakes of n-type Bi2Te2.7Se0.3 produced by the C/ME process, as a function of the flake thickness. We found Raman evidence for flakes with: (i) integer number of quintuples which exhibited a strong electron-phonon coupling, and …
A Micro-Raman Study Of Exfoliated Few-Layered N-Type Bi2 Te2.7Se0.3, Fengjiao Liu, Longyu Hu, Mehmet Karakaya, Pooja Puneet, Rahul Rao, Ramakrishna Podila, Sriparna Bhattacharya, Apparao M. Rao
A Micro-Raman Study Of Exfoliated Few-Layered N-Type Bi2 Te2.7Se0.3, Fengjiao Liu, Longyu Hu, Mehmet Karakaya, Pooja Puneet, Rahul Rao, Ramakrishna Podila, Sriparna Bhattacharya, Apparao M. Rao
Publications
Previously we showed that the thermoelectric (TE) performance of bulk n-type Bi2Te.27Se0.3 can be enhanced by subjecting it to a combined process of chemical or mechanical exfoliation (C/ME) followed by a rapid densification and restacking of the exfoliated layers via the spark-plasma-sintering technique (SPS). Here, we present a systematic micro-Raman study of two-dimensional flakes of n-type Bi2Te2.7Se0.3 produced by the C/ME process, as a function of the flake thickness. We found Raman evidence for flakes with: (i) integer number of quintuples which exhibited a strong electron-phonon coupling, and …
The Nustar Extragalactic Survey: Average Broadband X-Ray Spectral Properties Of The Nustar-Detected Agns, A. Delmoro, D. M. Alexander, J. A. Bauer, F. Civano, J. R. Mullaney, D. R. Ballantyne, W. N. Brandt, A. Comastri, P. Gandhi, F. A. Harrison, G. B. Lansbury, L. Lanz, B. Luo, S. Marchesi, S. Puccetti, C. Ricci, C. Saez, D. Stern, E. Treister, L. Zappacosta
The Nustar Extragalactic Survey: Average Broadband X-Ray Spectral Properties Of The Nustar-Detected Agns, A. Delmoro, D. M. Alexander, J. A. Bauer, F. Civano, J. R. Mullaney, D. R. Ballantyne, W. N. Brandt, A. Comastri, P. Gandhi, F. A. Harrison, G. B. Lansbury, L. Lanz, B. Luo, S. Marchesi, S. Puccetti, C. Ricci, C. Saez, D. Stern, E. Treister, L. Zappacosta
Publications
We present a study of the average X-ray spectral properties of the sources detected by the NuSTAR extragalactic survey, comprising observations of the Extended Chandra Deep Field South (E-CDFS), Extended Groth Strip (EGS), and the Cosmic Evolution Survey (COSMOS). The sample includes 182 NuSTAR sources (64 detected at 8–24 keV), with 3–24 keV fluxes ranging between and 6 × 10−13 erg cm−2 s−1 ( erg cm−2 s−1) and redshifts in the range of . We produce composite spectra from the Chandra + NuSTAR data (, rest frame) for all the sources with redshift identifications …
Electromagnetic Radio Frequency Heating In The Pulsed Electric Current Sintering (Pecs) Process, Yufei Liu, D. H. Liebenberg
Electromagnetic Radio Frequency Heating In The Pulsed Electric Current Sintering (Pecs) Process, Yufei Liu, D. H. Liebenberg
Publications
Pulsed electric current sintering offers rapid sintering of many materials compared with hot press sintering. Earlier studies had demonstrated that neither sparks nor plasma formation occur in a typical apparatus such as Dr. Sinter™. Hitchcock et al. showed that electromagnetic radio frequency (rf) emission occurred during the pulsing current and suggested this emission was a relevant augmentation to the hot press sintering in addition to the current flow in the specimen. In this report the importance of rf emission in the sintering process is demonstrated and opportunities to further exploit this approach to improve the sintering process are suggested.
Effects Of Protein Corona On Iapp Amyloid Aggregation, Fibril Remodelling, And Cytotoxicity, Emily H. Pilkington, Yanting Xing, Bo Wang, Aleksandr Kakinen, Miaoyi Wang, Thomas P. Davis, Feng Ding, Pu Chen Ke
Effects Of Protein Corona On Iapp Amyloid Aggregation, Fibril Remodelling, And Cytotoxicity, Emily H. Pilkington, Yanting Xing, Bo Wang, Aleksandr Kakinen, Miaoyi Wang, Thomas P. Davis, Feng Ding, Pu Chen Ke
Publications
Aggregation of islet amyloid polypeptide (IAPP), a peptide hormone co-synthesized and co-stored with insulin in pancreatic cells and also co-secreted to the circulation, is associated with beta-cell death in type-2 diabetes (T2D). In T2D patients IAPP is found aggregating in the extracellular space of the islets of Langerhans. Although the physiological environments of these intra- and extra-cellular compartments and vascular systems significantly differ, the presence of proteins is ubiquitous but the effects of protein binding on IAPP aggregation are largely unknown. Here we examined the binding of freshly-dissolved IAPP as well as pre-formed fibrils with two homologous proteins, namely cationic …
Cytoplasmic Dynein Binding, Run Length, And Velocity Are Guided By Long-Range Electrostatic Interactions, Lin Li, Joshua Alper, Emil Alexov
Cytoplasmic Dynein Binding, Run Length, And Velocity Are Guided By Long-Range Electrostatic Interactions, Lin Li, Joshua Alper, Emil Alexov
Publications
Dyneins are important molecular motors involved in many essential biological processes, including cargo transport along microtubules, mitosis, and in cilia. Dynein motility involves the coupling of microtubule binding and unbinding to a change in the configuration of the linker domain induced by ATP hydrolysis, which occur some 25 nm apart. This leaves the accuracy of dynein stepping relatively inaccurate and susceptible to thermal noise. Using multi-scale modeling with a computational focusing technique, we demonstrate that the microtubule forms an electrostatic funnel that guides the dynein’s microtubule binding domain (MTBD) as it finally docks to the precise, keyed binding location on …