Non-linear Dynamics Commons^™

Mathematical Analysis Of Eukaryotic Pericentromere, Puranjan Ghimire

Theses and Dissertations

The centromere is crucial for chromosomal stability and their proper segregation during cell division in eukaryotes. Surrounding the centromere are pericentromeres, made of repetitive DNA elements called pericentromeric repeats, varying from 10 in fission yeast to thousands in humans. These repeats form densely packed heterochromatin, where genes are usually silenced. The silencing mechanism across different pericentromeric repeats remains unclear.

Despite variations in sequence and length, pericentromeric repeats are conserved across eukaryotes, indicating their functional importance. This dissertation presents mathematical models to quantify gene silencing in fission yeast and humans. In fission yeast, my model predicts that silencing occurs only with …

Innovations In Drop Shape Analysis Using Deep Learning And Solving The Young-Laplace Equation For An Axisymmetric Pendant Drop, Andres P. Hyer

Theses and Dissertations

Axisymmetric Drop Shape Analysis (ADSA) is a technique commonly used to determine surface or interfacial tension. Applications of traditional ASDA methods to process analytical technologies are limited by computational speed and image quality. Here, we address these limitations using a novel machine learning approach to analysis. With a convolutional neural network (CNN), we were able to achieve an experimental fit precision of (+/-) 0.122 mN/m in predicting the surface tension of drop images at a rate of 1.5 ms^-1 versus 7.7 s^-1, which is more than 5,000 times faster than the traditional method. The results are validated on real images …

A Novel Method For Sensitivity Analysis Of Time-Averaged Chaotic System Solutions, Christian A. Spencer-Coker

Theses and Dissertations

The direct and adjoint methods are to linearize the time-averaged solution of bounded dynamical systems about one or more design parameters. Hence, such methods are one way to obtain the gradient necessary in locally optimizing a dynamical system’s time-averaged behavior over those design parameters. However, when analyzing nonlinear systems whose solutions exhibit chaos, standard direct and adjoint sensitivity methods yield meaningless results due to time-local instability of the system. The present work proposes a new method of solving the direct and adjoint linear systems in time, then tests that method’s ability to solve instances of the Lorenz system that exhibit …

Role Of Inhibition And Spiking Variability In Ortho- And Retronasal Olfactory Processing, Michelle F. Craft

Theses and Dissertations

Odor perception is the impetus for important animal behaviors, most pertinently for feeding, but also for mating and communication. There are two predominate modes of odor processing: odors pass through the front of nose (ortho) while inhaling and sniffing, or through the rear (retro) during exhalation and while eating and drinking. Despite the importance of olfaction for an animal’s well-being and specifically that ortho and retro naturally occur, it is unknown whether the modality (ortho versus retro) is transmitted to cortical brain regions, which could significantly instruct how odors are processed. Prior imaging studies show different …

Dynamic Parameter Estimation From Partial Observations Of The Lorenz System, Eunice Ng

Theses and Dissertations

Recent numerical work of Carlson-Hudson-Larios leverages a nudging-based algorithm for data assimilation to asymptotically recover viscosity in the 2D Navier-Stokes equations as partial observations on the velocity are received continuously-in-time. This "on-the-fly" algorithm is studied both analytically and numerically for the Lorenz equations in this thesis.

Modeling Nonlinear Heat Transfer For A Pin-On-Disc Sliding System, Brian A. Boardman

Theses and Dissertations

The objective of this research is to develop a numerical method to characterize heat transfer and wear rates for samples of Vascomax® 300, or Maraging 300, steel. A pin-on-disc experiment was conducted in which samples were exposed to a high-pressure, high-speed, sliding contact environment. This sliding contact generates frictional heating that influences the temperature distribution and wear characteristics of the test samples. A two-dimensional nonlinear heat transfer equation is discretized and solved via a second-order explicit finite difference scheme to predict the transient temperature distribution of the pin. This schematic is used to predict the removal of material from the …

The Analysis Of Neural Heterogeneity Through Mathematical And Statistical Methods, Kyle Wendling

Theses and Dissertations

Diversity of intrinsic neural attributes and network connections is known to exist in many areas of the brain and is thought to significantly affect neural coding. Recent theoretical and experimental work has argued that in uncoupled networks, coding is most accurate at intermediate levels of heterogeneity. I explore this phenomenon through two distinct approaches: a theoretical mathematical modeling approach and a data-driven statistical modeling approach.

Through the mathematical approach, I examine firing rate heterogeneity in a feedforward network of stochastic neural oscillators utilizing a high-dimensional model. The firing rate heterogeneity stems from two sources: intrinsic (different individual cells) and network …

Quasi-Static Nonlinear Analysis Of A Celestial Icosahedron Shaped Vacuum Lighter Than Air Vehicle, Kyle D. Moore

Theses and Dissertations

Due to the many drawbacks associated with a traditional lighter than air vehicle (LTAV), there is a desire for a LTAV which generates lift from an internal vacuum. To date, two feasible designs (the icosahedron and the hexakis icosahedron) for this so called vacuum lighter than air vehicle (VLTAV) have been studied at the Air Force Institute of Technology (AFIT). This research looks to show the feasibility of a new design for a VLTAV, the celestial icosahedron. This research includes a boundary condition study which proves the symmetric nature of the celestial icosahedron's frame with laterally constrained and unconstrained vertices. …

A Study Of The Effect Of Harvesting On A Discrete System With Two Competing Species, Rebecca G. Clark

Theses and Dissertations

This is a study of the effect of harvesting on a system with two competing species. The system is a Ricker-type model that extends the work done by Luis, Elaydi, and Oliveira to include the effect of harvesting on the system. We look at the uniform bound of the system as well as the isoclines and perform a stability analysis of the equilibrium points. We also look at the effects of harvesting on the stability of the system by looking at the bifurcation of the system with respect to harvesting.

Discrete Nonlinear Planar Systems And Applications To Biological Population Models, Shushan Lazaryan, Nika Lazaryan, Nika Lazaryan

Theses and Dissertations

We study planar systems of difference equations and applications to biological models of species populations. Central to the analysis of this study is the idea of folding - the method of transforming systems of difference equations into higher order scalar difference equations. Two classes of second order equations are studied: quadratic fractional and exponential.

We investigate the boundedness and persistence of solutions, the global stability of the positive fixed point and the occurrence of periodic solutions of the quadratic rational equations. These results are applied to a class of linear/rational systems that can be transformed into a quadratic fractional equation …

Applications Of Stability Analysis To Nonlinear Discrete Dynamical Systems Modeling Interactions, Jonathan L. Hughes

Theses and Dissertations

Many of the phenomena studied in the natural and social sciences are governed by processes which are discrete and nonlinear in nature, while the most highly developed and commonly used mathematical models are linear and continuous. There are significant differences between the discrete and the continuous, the nonlinear and the linear cases, and the development of mathematical models which exhibit the discrete, nonlinear properties occurring in nature and society is critical to future scientific progress. This thesis presents the basic theory of discrete dynamical systems and stability analysis and explores several applications of this theory to nonlinear systems which model …

An Applied Mathematics Approach To Modeling Inflammation: Hematopoietic Bone Marrow Stem Cells, Systemic Estrogen And Wound Healing And Gas Exchange In The Lungs And Body, Racheal L. Cooper

Theses and Dissertations

Mathematical models apply to a multitude physiological processes and are used to make predictions and analyze outcomes of these processes. Specifically, in the medical field, a mathematical model uses a set of initial conditions that represents a physiological state as input and a set of parameter values are used to describe the interaction between variables being modeled. These models are used to analyze possible outcomes, and assist physicians in choosing the most appropriate treatment options for a particular situation. We aim to use mathematical modeling to analyze the dynamics of processes involved in the inflammatory process.

First, we create a …

Neural Extensions To Robust Parameter Design, Bernard Jacob Loeffelholz

Theses and Dissertations

Robust parameter design (RPD) is implemented in systems in which a user wants to minimize the variance of a system response caused by uncontrollable factors while obtaining a consistent and reliable system response over time. We propose the use of artificial neural networks to compensate for highly non-linear problems that quadratic regression fails to accurately model. RPD is conducted under the assumption that the relationship between system response and controllable and uncontrollable variables does not change over time. We propose a methodology to find a new set of settings that will be robust to moderate system degradation while remaining robust …