Dynamic Systems Commons^™

Frameworks For The Techno-Economic Assessment Of Membrane-Based Bioprocessing Platforms, Juan Jose Romero Conde

All Dissertations

This dissertation describes developing and implementing computational frameworks for simulating and optimizing purification processes in the biopharmaceutical industry. The framework performs techno-economic analyses to establish value propositions for new process alternatives, especially membrane technologies. Initially, the focus is developing a framework capable of simulating monoclonal antibody (mAb) capture using membrane and resin media in multi-column chromatography (MCC) platforms for continuous manufacturing. Subsequently, the impact of capture MCC is compared against other intensification strategies in established mAb manufacturing facilities. Finally, the framework application expands to simulate the purification of adeno-associated virus (AAV) vectors for gene therapy.

Chapter 2 details the framework …

Complete Neighbourhood Search Heuristic Algorithm For Portfolio Optimization, Collether John

Tanzania Journal of Engineering and Technology (TJET)

In portfolio optimization, the fundamental goal of an investor is to optimally allocate investments between different assets. Mean-variance optimization methods make unrealistic assumptions to solve the problem of optimal allocation. On the other hand, when realistic constraints like holding size and cardinality are introduced it leads to optimal asset allocation which differ from the mean variance optimization. The resulting optimization problem become quite complex as it exhibits multiple local extrema and discontinuities. Heuristic algorithms work well for the complex problem. Therefore, a heuristic algorithm is developed which is based on hill climbing complete (HC-C). It is utilized to solve the …

Target Control Of Networked Systems, Isaac S. Klickstein

Mechanical Engineering ETDs

The control of complex networks is an emerging field yet it has already garnered interest from across the scientific disciplines, from robotics to sociology. It has quickly been noticed that many of the classical techniques from controls engineering, while applicable, are not as illuminating as they were for single systems of relatively small dimension. Instead, properties borrowed from graph theory provide equivalent but more practical conditions to guarantee controllability, reachability, observability, and other typical properties of interest to the controls engineer when dealing with large networked systems. This manuscript covers three topics investigated in detail by the author: (i) the …

Optimization And Control Of An Array Of Wave Energy Converters, Jianyang Lyu

Dissertations, Master's Theses and Master's Reports

This study explored optimal configuration of both the array layout and the dimension of each WEC in the array. The array contains heaving buoys with full interaction and exact hydrodynamics. Optimization of dimension was done on each WEC in the array with a given optimal layout, and a higher q-factor was achieved. Both impedance matching optimal control and derivative control were employed, which provides both theoretical maximum energy and a more realistic case. Then the work was expanded to optimization of both the array layout and the dimension of each WEC in the array. An average of 39.21% higher q-factor …