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- Tanzania Journal of Engineering and Technology (TJET) (22)
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Articles 1 - 30 of 101
Full-Text Articles in Dynamic Systems
Voltage-Related Power Quality Issues And Impacts On Distribution Networks With Sensitive Loads - A Review, Godwin Elinazi Mnkeni, Jackson Justo, Aviti Thadei Mushi, Bakari M. M. Mwinyiwiwa
Voltage-Related Power Quality Issues And Impacts On Distribution Networks With Sensitive Loads - A Review, Godwin Elinazi Mnkeni, Jackson Justo, Aviti Thadei Mushi, Bakari M. M. Mwinyiwiwa
Tanzania Journal of Engineering and Technology (TJET)
Voltage disturbances are the most important power quality (PQ) complications that customers and power utilities face in this smart era. The growing adoption of sophisticated electronic equipment and integration of renewable energy sources (RES) into power grids has increased the susceptibility of power distribution networks (PDNs) to voltage sags, swells, interruptions, flicker, and voltage imbalance. These disturbances, mainly caused by upstream faults, switching operations, and RES integration, compromise voltage PQ and system reliability. Consequently, they accelerate equipment degradation, increase electronic waste (e-waste), raise reactive power demand and maintenance costs, increase power losses, and impose substantial economic losses on customers and …
Supply Chain Analysis: The Oregonator Autocatalytic Case Study, Abigail Butcher
Supply Chain Analysis: The Oregonator Autocatalytic Case Study, Abigail Butcher
Discovery Day - Daytona Beach
Understanding stability in complex supply chains remains a critical challenge due to nonlinear feedback, delayed responses, and sensitivity to parameter changes. This project presents a novel framework that applies bifurcation analysis to evaluate system stability, using the Oregonator autocatalytic chemical reaction model as an analog for supply chain dynamics. A parameter sweep of key model variables, particularly the stoichiometric factor f and the reaction rate constants k, is used to identify transitions between stable and oscillatory regimes. These transitions provide insight into how variations in feedback strength can drive instability in real-world systems. The framework will then be extended to …
Ai-Driven Scheduling Algorithms For Private Aviation, Tayan Benson, Jessica Buskey, Gabriel Camacho, Caitlyn A. Gabrinowitz
Ai-Driven Scheduling Algorithms For Private Aviation, Tayan Benson, Jessica Buskey, Gabriel Camacho, Caitlyn A. Gabrinowitz
Discovery Day - Daytona Beach
Private aviation scheduling is complex and dynamic, requiring frequent aircraft repositioning based on demand and operational constraints, unlike fixed commercial airline schedules. As fleets grow beyond 300 aircraft, traditional deterministic methods become too slow, leading to the use of approaches such as genetic algorithms, but neural network-based methods have not seen in-depth exploration. This project models aircraft scheduling as a network, where airports and flights form a graph. It explores advanced AI methods, including graph neural networks and spatio-temporal graph neural networks (STGNNs), to capture both network structure and time constraints. The goal is to generate efficient daily schedules from …
Physicochemical Properties And Chemical Compositions Of Cashew Nut Shell Liquid Extracted With Carbon Dioxide–Expanded Hexane, Neema Msuya, Joseph Yn Philip, Frank Jacob, Kando K. Janga
Physicochemical Properties And Chemical Compositions Of Cashew Nut Shell Liquid Extracted With Carbon Dioxide–Expanded Hexane, Neema Msuya, Joseph Yn Philip, Frank Jacob, Kando K. Janga
Tanzania Journal of Engineering and Technology (TJET)
Cashew nut shell liquid (CNSL) is a mixture of phenolic compounds that can effectively replace commercially available phenols in various applications. This study investigated the physicochemical properties and chemical composition of CNSL extracted using CO2–expanded hexane (CXH) and compared to the traditional Soxhlet extraction method. Steamed cashew nut shells (sCNS) were used in both cases. The CXH was carried under varying CO2-mole fractions (0.468-0.892) and temperatures (20-36 °C) whereas Soxhlet extraction was performed at atmospheric pressure and hexane boiling point. Response Surface Methodology (RSM) with Central Composite Face-Centred Design (CCFD) was employed to evaluate the effect …
Enhancing Community Engagement Through ‘Nitunze Kilombero’ Mobile App: Case Of Climate Land Use And Cover Management For Kilombero Basin, Ghanima Chanzi, Subira Munishi
Enhancing Community Engagement Through ‘Nitunze Kilombero’ Mobile App: Case Of Climate Land Use And Cover Management For Kilombero Basin, Ghanima Chanzi, Subira Munishi
Tanzania Journal of Engineering and Technology (TJET)
The Kilombero Basin in southeastern Tanzania faces significant challenges due to rapid land use and land cover (LULC) changes driven by climate change, population growth, and unsustainable farming practices. This study assessed the role of community engagement and digital reporting through the 'NITUNZE KILOMBERO', mobile application in supporting water resources management in the basin. The App facilitates real-time reporting of environmental issues, provides educational resources, and enables collaboration between local communities and authorities. A mixed-methods approach, including household surveys and key informant interviews, was employed to assess the app's effectiveness. Results indicate high community awareness of LULC impacts, with 85% …
Adaptive Intervention Strategies In Co-Evolving Multiplex Networks: A Reinforcement Learning Approach To Real-Time Misinformation Containment, Anjali Ashokrao Bhadre Dr., Harshvardhan Prabhakar Ghongade Dr.
Adaptive Intervention Strategies In Co-Evolving Multiplex Networks: A Reinforcement Learning Approach To Real-Time Misinformation Containment, Anjali Ashokrao Bhadre Dr., Harshvardhan Prabhakar Ghongade Dr.
Northeast Journal of Complex Systems (NEJCS)
The growing transmission of misinformation via social media creates serious challenges to public health, democracy and social cohesion. To date, methods used to contain misinformation rely upon static representations of networks and set rules for interventions. In contrast, this study presents the first Multiplex Adaptive Reinforcement Intervention Network (MARIN), a framework for real-time adaptive intervention in the context of dynamic misinformation transmission using co-evolving multiplex networks and deep reinforcement learning. Unlike past studies that have assumed static network structures, MARIN has the ability to allow for dynamic changes in network topology as a result of both misinformation transmission and intervention …
An Analytical Framework For Quantifying Urban And Community Resilience To Natural Hazards From Cell-Phone Gps-Location And Traffic-Flow Data, Georgios Chatzikyriakidis
An Analytical Framework For Quantifying Urban And Community Resilience To Natural Hazards From Cell-Phone Gps-Location And Traffic-Flow Data, Georgios Chatzikyriakidis
Civil and Environmental Engineering Theses and Dissertations
Urban areas are increasingly exposed to natural hazards while accommodating a growing share of the global population, yet a consistent science-based framework for quantifying urban and community resilience remains lacking. This dissertation develops a physics-based analytical framework grounded in statistical mechanics and the quantitative theory of Brownian motion. A city is conceptualized as a complex medium in which citizens move analogously to Brownian particles within a viscoelastic environment, influenced by socioeconomic interactions and infrastructure functionality.
A central premise is that urban resilience, interpreted as engineering resilience (an outcome), can be quantified through a single metric: the mean-square displacement MSD=⟨r²(t)⟩, of …
Adaptive Artificial Potential Field Guidance And Control For Autonomous Docking With Uncooperative And Unknown Spacecraft, Steven Holmberg
Adaptive Artificial Potential Field Guidance And Control For Autonomous Docking With Uncooperative And Unknown Spacecraft, Steven Holmberg
Theses and Dissertations
The increasing demand for on-orbit servicing (OOS), active debris removal (ADR), and space domain awareness (SDA) missions has increased the need for autonomous spacecraft rendezvous and proximity operations (RPO) with uncooperative and unknown targets. Traditional guidance and control methods are typically designed for cooperative systems with known geometry and state information. This work builds on previous research to develop and evaluate an artificial potential field (APF)-based control framework capable of autonomous operation with minimal prior target knowledge and applicability to both relatively static and tumbling spacecraft.
The proposed APF formulation incorporates established safety constructs from cooperative docking systems, including an …
Safe Control Design For Quadruped Locomotion In Unstructured Environments Using Linear Transfer Operators, Sriram Sundar Krishnamoorthy Shankara Narayanan
Safe Control Design For Quadruped Locomotion In Unstructured Environments Using Linear Transfer Operators, Sriram Sundar Krishnamoorthy Shankara Narayanan
All Dissertations
Deploying quadruped robots in unstructured, obstacle-rich environments requires control and planning methods that remain safe and reliable despite complex terrain geometry, limited sensing, and inevitable modeling errors. This thesis develops operator-theoretic tools for safe control design of robotic systems using linear transfer operators, with a focus on quadruped locomotion in unstructured environments. The central goal is to develop a unified operator-theoretic framework for safe control design based on the Perron–Frobenius (P–F) and Koopman operators. In particular, the thesis leverages \emph{density functions} to develop safe navigation frameworks in the dual space of densities. In the operator-theoretic perspective, the P–F operator governs …
The Digital Neuron: Neural Cellular Automata For Neural–Symbolic Translation, Nicole Assenza
The Digital Neuron: Neural Cellular Automata For Neural–Symbolic Translation, Nicole Assenza
SMU Data Science Review
A neural cellular automata (NCA) architecture, referred to as Pluto’s NCA, was developed to characterize bilateral communication and semantic reciprocity between symbolic representations and a spatially distributed update field. The architecture employs an encoder–automata–decoder pipeline that maps symbolic inputs into a multichannel state field and reconstructs them through agreement-driven attractor convergence within a stable semantic attractor landscape. System behavior was evaluated under controlled perturbations, including rhythmic desynchronization, graded ablations, correlated and independent noise, and percolation-based structural degradation. Quantities such as Agreement(t), internal coherence Aᵢ(t), the recovery time constant τ, and the critical percolation threshold pc were measured to assess stability, …
Markov-Modulated Queueing Network For Mobile Traffic Aggregation With Threshold-Controlled Buffers, Anton A. Esin, Elmira Yu. Kalimulina
Markov-Modulated Queueing Network For Mobile Traffic Aggregation With Threshold-Controlled Buffers, Anton A. Esin, Elmira Yu. Kalimulina
Mathematical Modelling and Numerical Simulation with Applications
We study the problem of data transmission from mobile platforms operating in high-speed transit between cellular base stations, under conditions of unstable and intermittent connectivity. Conventional queueing and connectivity models often fail to capture the combined effects of rapidly changing signal conditions, finite buffer capacity, and dynamic topology. We aim to develop a tractable yet expressive model that integrates stochastic link availability, queue dynamics, and buffer control. We propose a mathematical framework based on queues whose service intensities are modulated by a continuous-time Markov chain (CTMC) representing signal conditions along a high-speed trajectory. The core subsystem is a two-stage (aggregation …
Stability Analysis Of Thermohaline Convection With A Time-Varying Shear Flow Using The Lyapunov Method, Kalin Kochnev
Stability Analysis Of Thermohaline Convection With A Time-Varying Shear Flow Using The Lyapunov Method, Kalin Kochnev
Honors Scholar Theses
This work applies the Lyapunov method to identify instabilities and compute the growth rate of a linear time-varying system. The linear system studied describes cold fresh water on top of hot salty water with a periodically time-varying background shear flow. A time-dependent weighting matrix is employed to construct a Lyapunov function candidate. The resulting linear matrix inequalities are discretized in time using the forward Euler method. As the number of temporal discretization points increases, the growth rate predicted by the Lyapunov method or Floquet theory, used for comparison, will converge to the same value obtained from numerical simulations. Furthermore, the …
Universal Systems Simulation Via Constraint Hypergraphs With Applications To Digital Twins, John Morris
Universal Systems Simulation Via Constraint Hypergraphs With Applications To Digital Twins, John Morris
All Dissertations
The characterization of systems encompasses a variety of modeling frameworks designed to capture specific behaviors and components of various system domains. Whatever the framework, the core elements of a system representation are the information of the system and a description of how that information is related. The relations in deterministic systems are functions, which, when composed to form executable processes, can be used to simulate system data. A declarative modeling framework is one that encodes mechanisms for preparing these simulations within the model structure, allowing an external agent to form the execution processes required for a given context. To date, …
Optimal Location And Sizing Of Facts Devices To Improve Voltage Profiles On A 132 Kv Mwanza-Musoma-Nyamongo Transmission Line, Peter Makolo
Optimal Location And Sizing Of Facts Devices To Improve Voltage Profiles On A 132 Kv Mwanza-Musoma-Nyamongo Transmission Line, Peter Makolo
Tanzania Journal of Engineering and Technology (TJET)
Recently, utility companies have desired to supply quality, stable and reliable power to customers, and ensure they meet the demand. Flexible AC Transmission Systems (FACTS) dynamic compensator devices such as Static Synchronous Compensator (STATCOM), Static VAr Compensator (SVC) and Unified Power Flow Controller (UPFC) are an impeccable choice, however, cost is one of the limiting factors following these technologies. In addition, using FACTS devices in the system requires a detailed steady state, dynamic and optimisation analysis to effectively meet the purpose and ensure reduced cost. This paper proposes using an optimised FACTS device to improve voltage profile, power transfer, system …
Fuzzy Logic-Based Decision Support System For Adoption Of Industry 4.0 Predictive Maintenance By Manufacturing Industries, Fred E. Peter
Fuzzy Logic-Based Decision Support System For Adoption Of Industry 4.0 Predictive Maintenance By Manufacturing Industries, Fred E. Peter
Tanzania Journal of Engineering and Technology (TJET)
In the context of Industry 4.0, predictive maintenance enhances operational efficiency by optimizing processes, minimizing downtime, and improving cost-effectiveness. However, implementing predictive maintenance requires a systematic approach due to its complexity. This study collected expert input from 15 food and beverage manufacturing industries located in Dar es Salaam, Tanzania, using a purposive sampling technique. Six representatives were selected from each industry, and their opinions were analyzed using MATLAB 7.6 through a fuzzy logic inference system. The analysis focused on key factors influencing Industry 4.0 technology adoption for predictive maintenance, including adoption intention (strategic decision, equipment data, perceived benefit) and perceived …
Assessment Of Maintenance Performance Level Of Selected Hydropower Plants In Tanzania, Mahamudu H. Mtebwa
Assessment Of Maintenance Performance Level Of Selected Hydropower Plants In Tanzania, Mahamudu H. Mtebwa
Tanzania Journal of Engineering and Technology (TJET)
Despite significant progress in increasing electricity access to over 78%, electricity reliability in Tanzania remains a concern, with frequent power outages reported. Maintenance issues in hydropower plants have been identified as a critical factor contributing to this problem. However, the specific maintenance performance levels have not been fully assessed. This study conducts a comprehensive evaluation of the maintenance performance of four key hydropower plants: Kidatu (204 MW), Kihansi (180 MW), Mtera (80 MW), and New Pangani Falls (68 MW). Data collected from staff surveys and maintenance records between 2018 and 2022 were used in the study. Although staff demonstrated a …
Design And Performance Analysis Of Fiber Bragg Grating Temperature Sensor For Industrial Processes Sensing Applications, Paul Stone Stone Brown Macheso S.B.
Design And Performance Analysis Of Fiber Bragg Grating Temperature Sensor For Industrial Processes Sensing Applications, Paul Stone Stone Brown Macheso S.B.
Tanzania Journal of Engineering and Technology (TJET)
The Fiber Bragg Grating (FBG) sensor has become a widespread sensing device because of its small size, passive design, immunity to electromagnetic interference, and direct ability to measure physical properties like temperature and strain. Recently, femtosecond infrared laser processing and regeneration techniques have resulted in the development of stable high-temperature gratings, which are a powerful tool in smart factories, an aspect of the fourth Industrial Revolution (4IR), and show promise for application in harsh environments like high pressure, high temperature, or ionizing radiation. The development of stable high-temperature gratings that can withstand harsh environmental factors like high temperatures, pressures, and …
Meta-Clustering For Specialized Language Models: Enhancing Contextual Adaptation And Mitigating Hallucinations In Diverse Healthcare Environments, Joshit Mohanty, Vaishali Vaishali, Sandeep Kumar Nayak, Sumit Lahiri
Meta-Clustering For Specialized Language Models: Enhancing Contextual Adaptation And Mitigating Hallucinations In Diverse Healthcare Environments, Joshit Mohanty, Vaishali Vaishali, Sandeep Kumar Nayak, Sumit Lahiri
Graduate Student Government Association Research Conference
Large Language Models (LLMs) have significantly advanced conversational AI by enabling dialogic information-seeking and task execution across diverse domains. However, their extensive parameters and broad domain scope lead to “data hallucinations.” These shortcomings are particularly evident in dynamic and diverse environments like India’s healthcare sector, where myriad languages, regional practices, and cultural nuances demand specialized, localized expertise rather than one-size-fits-all generalist models. This paper introduces a meta-clustering framework that integrates Distilled Language Models (DLMs) and Small/Specialized Language Models (SLMs) with meta-learning principles to address these limitations. By drawing on evidence from works such as MedHalu and Med-HALT, the framework seeks …
Dual Quaternions For Gravity Recovery Missions, Ryan Kinzie
Dual Quaternions For Gravity Recovery Missions, Ryan Kinzie
Doctoral Dissertations and Master's Theses
A dual quaternion-based modeling, state estimation and control approach is introduced as a better alternative to the traditional methods which are currently utilized for gravity recovery missions. The proposed modeling and control approach was verified against and compared to the tangent bundle to Special Euclidean Group 3 through MATLAB simulations. The dual quaternion-based approach shows superior performance over traditional linearized and uncoupled methodologies, in both modeling accuracy of spacecraft translational position, and the ability to control the pose of a test mass relative to its host spacecraft. Utilizing data products from the Gravity Recovery and Climate Experiment Follow-On mission, a …
Analysis Of Systematic Trade-Offs Between Military And Healthcare Expenditure Alongside Gdp Growth Of Select Asian And Western Exporting Economies In The 21st Century, Rahul Balamurugan, Carlos Gershenson, Preethi Nanjundan, Hiroki Sayama
Analysis Of Systematic Trade-Offs Between Military And Healthcare Expenditure Alongside Gdp Growth Of Select Asian And Western Exporting Economies In The 21st Century, Rahul Balamurugan, Carlos Gershenson, Preethi Nanjundan, Hiroki Sayama
Northeast Journal of Complex Systems (NEJCS)
This study explores the complexity in the trade-offs between military expenditure, healthcare expenditure, and GDP growth across select Asian nations and major weapon-exporting countries, examining how nations allocate finite resources between national security and human well-being over the past two decades. Using a systems science approach, the research integrates Granger causality testing to analyze temporal and directional relationships among GDP growth, military expenditure, and healthcare expenditure, uncovering their dynamic interdependencies. The methodology includes trend and slope analysis, Granger causality testing, outlier detection, and clustering to identify heterogeneity in resource allocation strategies. Developed, weapon-exporting nations exhibit complementary trends, with strong causality …
Integrating Neural Networks For Predictive Torque Control And Obstacle Avoidance In Autonomous Robot, Viswanath Kodali, Harsha Vardhan Borra, Kiran P
Integrating Neural Networks For Predictive Torque Control And Obstacle Avoidance In Autonomous Robot, Viswanath Kodali, Harsha Vardhan Borra, Kiran P
Northeast Journal of Complex Systems (NEJCS)
In the field of robotics, precise motion control and accurate computation of joint forces are critical for ensuring optimal performance. Traditional methods, such as using the Jacobian matrix for joint angle determination and Euler-Lagrange equations for torque computation, are reliable but computationally intensive, making them less suitable for real-time applications. This paper presents an advanced approach to improving the productivity and efficiency of a 3-Degree of Freedom (DOF) robotic arm by utilizing Artificial Neural Network (ANN). The proposed system dynamically predicts joint angles and torque, enabling faster and more efficient motion control.
To address the challenge of obstacle avoidance in …
Quantized Average Agreement Algorithms With Error Correction For Digraphs, Shuaib A. Mughal
Quantized Average Agreement Algorithms With Error Correction For Digraphs, Shuaib A. Mughal
Honors Undergraduate Theses
Multi-agent systems have become more and more prevalent as technology increasingly gets integrated into our daily lives. Some of these technological systems are large in size; for example, the smart grid where multiple devices are used to monitor and control different aspects of the energy grid. Another example is a team of autonomous systems deployed for a specific task. When these systems are spatially distributed, an important component of distributed algorithms is the ability for the agents to reach consensus on the global state of the system. Reaching agreement enables the spatially distributed agent make decisions or determine the next …
Safety And Optimality Monitors For Learning-Enabled Systems Using Conformal Prediction, Jackson Cox
Safety And Optimality Monitors For Learning-Enabled Systems Using Conformal Prediction, Jackson Cox
McKelvey School of Engineering Graduate Student Theses & Dissertations
The use of machine learning to create data-driven plant models and controllers has led to an increased need for safety and optimality monitors for model-based systems. System plant models are subject to uncertainty due to learning constraints such as unseen data and overfitting or physical constraints such as unknown dynamics and noise. This uncertainty is detrimental to safety-critical systems and must be properly regulated. To curb this uncertainty, we create prediction sets using the guarantees provided by Conformal Prediction. With a user-specified high probability, these prediction sets contain the true plant system states for an entire prediction horizon, which we …
Theory And Algorithms To Learn, Propagate, And Exploit Uncertainty For Stochastic Optimal Control Of Dynamical Systems, Vignesh Sivaramakrishnan
Theory And Algorithms To Learn, Propagate, And Exploit Uncertainty For Stochastic Optimal Control Of Dynamical Systems, Vignesh Sivaramakrishnan
Electrical and Computer Engineering ETDs
Non-Gaussian uncertainty frequently arises in learning and control problems involving stochastic dynamical systems, particularly in autonomous vehicles, UAVs, satellites, and robotics. In this dissertation, we propose a new framework that leverages characteristic functions that provides a frequency-domain representation of random variables. The dissertation is structured into three key areas. First, we address model-based stochastic optimal control for linear systems with non-Gaussian noise, demonstrating that characteristic functions can be used to enforce chance constraints and control systems toward desired distributions. Second, we explore data-driven stochastic control, utilizing empirical characteristic functions to handle systems with unknown disturbances. In addition, we derive several …
Hitch Cart “Landing Gear”, Rebekah White, Jose Raygoza, Randy Hernandez, Brandon Leon
Hitch Cart “Landing Gear”, Rebekah White, Jose Raygoza, Randy Hernandez, Brandon Leon
Mechanical Engineering
This report aims to allow our sponsor, to review our design process of the Hitch Cart Landing Gear Prototype. In the design overview section of this report, we discuss the primary design modifications we made to the wheel mechanism of the existing hitch cart prototype, including the addition of the ACME screws and the folding brackets. This allows our sponsor to see the intended improvements made to the past prototype and understand the primary goal of our project. Then, in the implementation section, we cover the entire manufacturing process to allow our sponsor to understand what manufacturing steps must be …
Development And Testing Of Small-Scale Flash Dryer For Maize Bran, Eden Ngowi
Development And Testing Of Small-Scale Flash Dryer For Maize Bran, Eden Ngowi
Tanzania Journal of Engineering and Technology (TJET)
Sun drying is the most common technique used to dry various food products due to its economic convenience. However, it is not effective owing to its unreliable nature leading to microbial deterioration and aflatoxin contamination of food. In Tanzania, about 1.3 million tonnes of maize bran are at risk of deterioration annually due to improper drying. The aim of this study was to design, fabricate and test an efficient small-scale flash dryer for maize bran. Using principles of material and energy balance, a small-scale flash dryer with a throughput of 500 kg of dry product per hour was designed resulting …
Assessing The Importance Of Air-Decking Blasting In Controlling Bigv At An Open Pit Gold Mine In Tanzania Using Ann Model, Karim R. Baruti
Assessing The Importance Of Air-Decking Blasting In Controlling Bigv At An Open Pit Gold Mine In Tanzania Using Ann Model, Karim R. Baruti
Tanzania Journal of Engineering and Technology (TJET)
Air-decking blasting technique is used to control blast induced ground vibration (BIGV) in several mines including open-pit gold mines located in Tanzania. While the importance of air-deck to control BIGV is practically evident, theoretical models such as BIGV prediction models cannot be used to assess the importance of air-decking. The main objective of this study was to assess the importance of the air-decking blasting technique to control BIGV using the artificial neural network (ANN)Model. To achieve this objective, ANNs were modeled and trained to learn the pattern of data using Multilayer Perception with Back Propagation to predict BIGV. The main …
Perona-Malik Diffusion-Driven Regularization For Image Resolution Enhancement In Electrical Capacitance Tomography, Nassor Ally
Perona-Malik Diffusion-Driven Regularization For Image Resolution Enhancement In Electrical Capacitance Tomography, Nassor Ally
Tanzania Journal of Engineering and Technology (TJET)
Electrical Capacitance Tomography (ECT) is a non-invasive promising method for monitoring industrial processes, such as oil-gas flow in pipelines and solid-gas flow in pneumatic systems. Despite its potential benefits, ECT generates poor-quality images, often used only for qualitative analysis. A non-linear relationship between measured capacitances and permittivity distribution and the ill-posedness of the sensitivity matrix elements causes this limitation. This hinders the applicability of ECT in monitoring online industrial process applications. This work proposes a reconstruction method based on a nonlinear diffusion function to generate high-quality images from the measured capacitance data from the ECT system. The diffusion regularization functional …
Frameworks For The Techno-Economic Assessment Of Membrane-Based Bioprocessing Platforms, Juan Jose Romero Conde
Frameworks For The Techno-Economic Assessment Of Membrane-Based Bioprocessing Platforms, Juan Jose Romero Conde
All Dissertations
This dissertation describes developing and implementing computational frameworks for simulating and optimizing purification processes in the biopharmaceutical industry. The framework performs techno-economic analyses to establish value propositions for new process alternatives, especially membrane technologies. Initially, the focus is developing a framework capable of simulating monoclonal antibody (mAb) capture using membrane and resin media in multi-column chromatography (MCC) platforms for continuous manufacturing. Subsequently, the impact of capture MCC is compared against other intensification strategies in established mAb manufacturing facilities. Finally, the framework application expands to simulate the purification of adeno-associated virus (AAV) vectors for gene therapy.
Chapter 2 details the framework …
Duality Of Ensemble Systems Through Moment Representations, Vignesh Narayanan, Wei Zhang, Jr-Shin Li
Duality Of Ensemble Systems Through Moment Representations, Vignesh Narayanan, Wei Zhang, Jr-Shin Li
Publications
Controlling large-scale dynamic population systems, known as ensemble control, is a pervasive and essential task in many emerging applications from diverse scientific domains. Previous focuses in the area of ensemble control have been placed on seeking open-loop control strategies due to unavailability of state feedback information for each individual system in the ensemble. In this paper, we develop a foundational framework for analysis and control of ensemble systems with closed feedback control loops. We introduce the notion of ensemble moments and construct moment systems associated with the ensemble systems. By extending the classical moment problem in mathematical analysis and statistics, …