Applied Mathematics Commons^™

Adaptive Randomization Designs, Jenna Colavincenzo

Statistics

Adaptive design methodologies use prior information to develop a clinical trial design. The goal of an adaptive design is to maintain the integrity and validity of the study while giving the researcher flexibility in identifying the optimal treatment. An example of an adaptive design can be seen in a basic pharmaceutical trial. There are three phases of the overall trial to compare treatments and experimenters use the information from the previous phase to make changes to the subsequent phase before it begins.

Adaptive design methods have been in practice since the 1970s, but have become increasingly complex ever since. One …

Constructing Phylogenetic Trees Using Maximum Likelihood, Anna Cho

Scripps Senior Theses

Maximum likelihood methods are used to estimate the phylogenetic trees for a set of species. The probabilities of DNA base substitutions are modeled by continuous-time Markov chains. We use these probabilities to estimate which DNA bases would produce the data that we observe. The topology of the tree is also determined using base substitution probabilities and conditional likelihoods. Felsenstein [2] introduced this method of finding an estimate for the maximum likelihood phylogenetic tree. We will explore this method in detail in this paper.

A Bayesian Secondary Analysis In An Asthma Study, Samuel P. Wilcock, Vernon M. Chinchilli, Stephen P. Peters

ACMS Conference Proceedings 2011

A recent study published in the New England Journal of Medicine by the Asthma Clinical Research Network (ACRN) compared three different treatments for their effectiveness in treating adults with uncontrolled asthma. This paper will describe the study design and its results, then detail the beginnings of a secondary analysis using Bayesian methods to estimate the parameters of interest. The methods will be explained, and the preliminary estimates given and contextualized. The paper will conclude with a discussion of the next steps and the goals for further analysis of the data in this study.

Software Internationalization: A Framework Validated Against Industry Requirements For Computer Science And Software Engineering Programs, John Huân Vũ

Master's Theses

View John Huân Vũ's thesis presentation at http://youtu.be/y3bzNmkTr-c.

In 2001, the ACM and IEEE Computing Curriculum stated that it was necessary to address "the need to develop implementation models that are international in scope and could be practiced in universities around the world." With increasing connectivity through the internet, the move towards a global economy and growing use of technology places software internationalization as a more important concern for developers. However, there has been a "clear shortage in terms of numbers of trained persons applying for entry-level positions" in this area. Eric Brechner, Director of Microsoft Development Training, suggested …

Gauss' Method Of Least Squares: An Historically-Based Introduction, Belinda B. Brand

LSU Master's Theses

This work presents Gauss' justification of the method of least squares, following the treatment given by Gauss himself in "Theoria Combinationis Observationum Erroribus Minimis Obnoxiae," where the main idea is to show that the least squares estimate is the unbiased linear estimate of minimum variance. (Actually, we present Gauss' argument both in his terminology and translated into matrix terminology.) We show how this contrasts with Gauss' earlier justfication in "Theoria Motus Corporum Coelestium" which was based on the assumption of a normal distribution of errors, and yielded the estimate of maximum likelihood. We present as a background the development from …

A New Confidence Interval For The Mean Of A Normal Distribution, David Lee Wallace

All Master's Theses

A typical problem in statistical inference is the following: An experimenter is confronted with a density function f(x; ϴ) which describes the underlying population of measurements. The form of f may or may not be known, and ϴ is a parameter (possibly vector-valued) which describes the population. The statistician's job is to estimate or to test hypotheses about the unknown parameter ϴ. In this paper, we shall consider interval estimation of the mean of the normal density function.