Applied Mathematics Commons^™

A Mathematical Model For Treatment-Resistant Mutations Of Hiv, Helen Moore, Weiqing Gu

All HMC Faculty Publications and Research

In this paper, we propose and analyze a mathematical model, in the form of a system of ordinary differential equations, governing mutated strains of human immunodeficiency virus (HIV) and their interactions with the immune system and treatments. Our model incorporates two types of resistant mutations: strains that are not responsive to protease inhibitors, and strains that are not responsive to reverse transcriptase inhibitors. It also includes strains that do not have either of these two types of resistance (wild-type virus) and strains that have both types. We perform our analysis by changing the system of ordinary differential equations (ODEs) to …

Error Analysis Of Variable Degree Mixed Methods For Elliptic Problems Via Hybridization, Bernardo Cockburn, Jay Gopalakrishnan

Mathematics and Statistics Faculty Publications and Presentations

A new approach to error analysis of hybridized mixed methods is proposed and applied to study a new hybridized variable degree Raviart-Thomas method for second order elliptic problems. The approach gives error estimates for the Lagrange multipliers without using error estimates for the other variables. Error estimates for the primal and flux variables then follow from those for the Lagrange multipliers. In contrast, traditional error analyses obtain error estimates for the flux and primal variables first and then use it to get error estimates for the Lagrange multipliers. The new approach not only gives new error estimates for the new …

Nédélec Spaces In Affine Coordinates, Jay Gopalakrishnan, Luis E. García-Castillo, Leszek Demkowicz

Mathematics and Statistics Faculty Publications and Presentations

In this note, we provide a conveniently implementable basis for simplicial Nédélec spaces of any order in any space dimension. The main feature of the basis is that it is expressed solely in terms of the barycentric coordinates of the simplex.

A Schwarz Preconditioner For A Hybridized Mixed Method, Jay Gopalakrishnan

Mathematics and Statistics Faculty Publications and Presentations

In this paper, we provide a Schwarz preconditioner for the hybridized versions of the Raviart-Thomas and Brezzi-Douglas-Marini mixed methods. The preconditioner is for the linear equation for Lagrange multipliers arrived at by eliminating the ux as well as the primal variable. We also prove a condition number estimate for this equation when no preconditioner is used. Although preconditioners for the lowest order case of the Raviart-Thomas method have been constructed previously by exploiting its connection with a nonconforming method, our approach is different, in that we use a new variational characterization of the Lagrange multiplier equation. This allows us to …

Finite Extinction Time For Non-Linear Absorption-Diffusion Equations, Jacob B. Goldberg

Theses and Dissertations

In this thesis, we develop a numerical method in order to approximate the solutions of one-dimensional, non-linear absorption-diffusion equations. We test our method for accuracy against a linear diffusion equation with a solution that can be written in closed form. We then test various types of diffusion and absorption terms to determine which ones produce extinction in finite time. We also develop a numerical method to computationally solve diffusion-free equations. We compare the numerical solutions of the one-dimensional, non-linear absorption-diffusion equation and the diffusion-free equation and we find that for the cases tested, the numerical absorption-diffusion solutions are always less …

Hopf Bifurcation In Models For Pertussis Epidemiology, Herbert W. Hethcote, Yi Li, Zhujun Jing

Mathematics and Statistics Faculty Publications

Pertussis (whooping cough) incidence in the United States has oscillated with a period of about four years since data was first collected in 1922. An infection with pertussis confers immunity for several years, but then the immunity wanes, so that reinfection is possible. A pertussis reinfection is mild after partial loss of immunity, but the reinfection can be severe after complete loss of immunity. Three pertussis transmission models with waning of immunity are examined for periodic solutions. Equilibria and their stability are determined. Hopf bifurcation of periodic solutions around the endemic equilibrium can occur for some parameter values in two …

Calibrated Probabilistic Quantitative Precipitation Forecasts Based On The Mrf Ensemble, Frederick Anthony Eckel

Theses and Dissertations

Probabilistic quantitative precipitation forecasts (PQPF) based on the medium range forecast (MRF) ensemble are currently in operational use below their full potential quality (i.e., accuracy and reliability). This unfulfilled potential is due to the MRF ensemble being adversely affected by systematic errors which arise from an imperfect model and less than ideal ensemble initial perturbations. This thesis sought to construct a calibration to account for these systematic errors and thus produce higher quality PQPF. Systematic errors were explored with the use of the verification rank histogram, which tracks the performance of the ensemble. The information in these histograms was then …

Mathematical Models Of Chemotherapy, John Carl Panetta

Mathematics & Statistics Theses & Dissertations

Several mathematical models are developed to describe the effects of chemotherapy on both cancerous and normal tissue. Each model is defined by either a single homogeneous equation or a system of heterogeneous equations which describe the states of the normal and/or cancer cells. Periodic terms are added to model the effects of the chemotherapy. What we obtain are regions, in parameter space (dose and period), of acceptable drug regimens.

The models take into account various aspects of chemotherapy. These include, interactions between the cancer and normal tissue, cell specific chemotherapeutic drug, the use of non-constant parameters to aid in modeling …

Series Solutions, Factorials, And The Gamma Function, Steven J. Wilson

Topics in Mathematics

Using a power series to solve an ordinary differential equation will often result in a solution whose general term involves a product of terms from an arithmetic sequence. This paper explores how factorials and the gamma function can be used to rewrite such general terms in a closed form.

The Flow Approach To Swept Volume, Haitao Jiang

Theses

In this thesis, a method for representing swept volume based on the sweep differential equation and sweep vector field flow is developed. This method can be used to determine the boundary representation of a swept volume generated by any polygonal object undergoing a general smooth 2-D sweep. For any given sweep and object, a. set of candidate boundary points is computed using a selection criterion based on vector field behavior. The set of candidate boundary points is then trimmed in order to obtain the true boundary of the swept volume. This trimming procedure is based on some simple topological principles …

An Evolution Operator Solution For A Nonlinear Beam Equation, Carl E. Crockett

Theses and Dissertations

A nonlinear partial differential equation, motivated by the transverse vibration of a beam, is shown to have a unique solution. The existence theory, which is in the setting of semigroups and evolution operators, is a composite and synthesis of theorems of Kato. The formulation of the problem and the verification that the formulation leads to a solution are new. The introductory chapter provides background on the topic generally. Chapter 2 provides detailed formulations for the constant coefficient case. Chapter 3 describes nonautonomous cases. The general theorem is presented here. In Chapter 4, a more general case is considered. Namely, Kelvin …

The Fokker-Planck And Related Equations In Theoretical Population Dynamics, George Derise

Mathematics & Statistics Theses & Dissertations

The population growth of a single species is modeled by a differential equation with initial condition(s) so that the number of organisms in the population is derived using some mechanism of growth, i.e. a growth rate function. However, such deterministic models are often highly unrealistic in population dynamics because population growth is basically a random event. There are a large number of chance factors influencing growth that might not be taken into account by deterministic models. The effect of other species (for example, in the chance meeting of a predator), population fluctuations due to weather changes that would alter food …

Bending Vibrations Of A Cantilever Beam On An Eccentric Rotating Disc, Yousry S. Aboelnaga

Theses

The differential equation of motion for the C.G. line of a vibrating cantilever beam which is mounted on an eccentric rotating disc is derived. Exact solutions in terms of hypergeometric functions of this fourth order differential equation with variable coefficients are obtained by making several mild assumptions. These solutions include a large class of vibrational modes.

The primary idea leading to the exact solutions is the factorization of the fourth order differential operator into a pair of commuting second order operators.