Applied Mathematics Commons^™

Tumour-Immune Dynamics With An Immune Checkpoint Inhibitor, Elpiniki Nikolopoulou

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

A Household Model Of German Cockroach Infestations And Their Effect On Symptoms Of Atopic Asthma, Karen Funderburk

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Modeling The Impact Of The Latent Period On The Spatial Spread Of Dengue Fever, Juan Melendez-Alvarez

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Identification Of Hostile Hemodynamics And Geometries Of Cerebral Aneurysms: A Case-Control Study, Bong Jae Chung, F. Mut, C. M. Putman, F. Hamzei-Sichani, W. Brinjikji, D. Kallmes, C. M. Jimenez, Juan R. Cebral

Department of Applied Mathematics and Statistics Faculty Scholarship and Creative Works

BACKGROUND AND PURPOSE: Hostile hemodynamic conditions and geometries are thought to predispose aneurysms for instability and rupture. This study compares stable, unstable, and ruptured aneurysms while controlling for location and patient characteristics. MATERIALS AND METHODS: The hemodynamics and geometries of 165 stable, 65 unstable, and 554 ruptured aneurysms were compared. Hemodynamics was modeled using image-based computational fluid dynamics. Case-control pairs were selected matching aneurysm location, patient age, and sex. Paired Wilcoxon tests were used to compare hemodynamic and geometric variables among different aneurysm groups. The pairing was repeated 100 times, and the combined P values were calculated and adjusted for …

Numerical Ruin Probability In The Dual Risk Model With Risk-Free Investments, Sooie-Hoe Loke, Enrique Thomann

Mathematics Faculty Scholarship

In this paper, a dual risk model under constant force of interest is considered. The ruin probability in this model is shown to satisfy an integro-differential equation, which can then be written as an integral equation. Using the collocation method, the ruin probability can be well approximated for any gain distributions. Examples involving exponential, uniform, Pareto and discrete gains are considered. Finally, the same numerical method is applied to the Laplace transform of the time of ruin.

Non-Locality, Precognition & Spirit From The Physics Point Of View, Florentin Smarandache, Victor Christianto

Branch Mathematics and Statistics Faculty and Staff Publications

There are various supernatural phenomena which can hardly be explained by the existing mainstream science, for instance non-local interactions (e.g. ESP) and also precognitive interdictions. And there are other problems such as how to include the Spirit in the framework of physics. For example, it has been known for long time that intuition plays significant role in many professions and human life, including entrepreneurship, government, and also in detective or law enforcement activities. Despite these examples, such a precognitive interdiction is hardly accepted in mainstream science. In this paper, we discuss non-local interactions and advanced solutions of Maxwell equations, and …

Boundary Homogenization And Capture Time Distributions Of Semipermeable Membranes With Periodic Patterns Of Reactive Sites, Andrew J. Bernoff, Daniel Schmidt, Alan E. Lindsay

All HMC Faculty Publications and Research

We consider the capture dynamics of a particle undergoing a random walk in a half- space bounded by a plane with a periodic pattern of absorbing pores. In particular, we numerically measure and asymptotically characterize the distribution of capture times. Numerically we develop a kinetic Monte Carlo (KMC) method that exploits exact solutions to create an efficient particle- based simulation of the capture time that deals with the infinite half-space exactly and has a run time that is independent of how far from the pores one begins. Past researchers have proposed homogenizing the surface boundary conditions, replacing the reflecting (Neumann) …

Minutes & Seconds: The Scientists, Patrick Aievoli

Zea E-Books Collection

Minutes & Seconds, is a captivating intelligible read for those who strive to understand where the “what if” moment has gone. Succeeding his other captivating books, Aievoli’s deep introspective lens dials his readers in to awaken the proverbial sleeping giant inside of our consciousness. He designs an insightful exciting romp through the surreal landscape of our society and illustrates how various pioneers have lead us to a crossroads. I’m truly impressed with Aievoli’s perspicacious comprehension of where digital has taken us through the hands of these select individuals. --Sequoyah Wharton

In creating Minutes & Seconds, Aievoli has assembled an interesting …

Inner Vectors For Toeplitz Operators, Raymond Cheng, Javad Mashreghi, William T. Ross

Department of Math & Statistics Faculty Publications

In this paper we survey and bring together several approaches to obtaining inner functions for Toeplitz operators. These approaches include the classical definition, the Wold decomposition, the operator-valued Poisson Integral, and Clark measures. We then extend these notions somewhat to inner functions on model spaces. Along the way we present some novel examples.

Parameter Sensitivity For In Vitro Anthrax Studies, Yareley Gonzalez, Maria Macias-Bedolla, Megan O. Powell

Spora: A Journal of Biomathematics

Studies done on interactions between spores and macrophages done in vitro show inconsistent results based on experimental protocol and inhibit meaningful extrapolation to in vivo. In this study, we perform a sensitivity analysis of a model representing in vitro studies of interactions between anthrax spores and macrophages to help address the effects of these inconsistencies. We perform both local and global analyses using Latin hypercube sampling and partial rank correlation coefficients. Our analysis indicates the amount of intracellular bacteria over time is most sensitive to the killing of intracellular bacteria by the macrophages and replication of the bacteria inside …

Galois Groups Of Differential Equations And Representing Algebraic Sets, Eli Amzallag

Dissertations, Theses, and Capstone Projects

The algebraic framework for capturing properties of solution sets of differential equations was formally introduced by Ritt and Kolchin. As a parallel to the classical Galois groups of polynomial equations, they devised the notion of a differential Galois group for a linear differential equation. Just as solvability of a polynomial equation by radicals is linked to the equation’s Galois group, so too is the ability to express the solution to a linear differential equation in "closed form" linked to the equation’s differential Galois group. It is thus useful even outside of mathematics to be able to compute and represent these …

The Philosophical Foundations Of Plen: A Protocol-Theoretic Logic Of Epistemic Norms, Ralph E. Jenkins

Dissertations, Theses, and Capstone Projects

In this dissertation, I defend the protocol-theoretic account of epistemic norms. The protocol-theoretic account amounts to three theses: (i) There are norms of epistemic rationality that are procedural; epistemic rationality is at least partially defined by rules that restrict the possible ways in which epistemic actions and processes can be sequenced, combined, or chosen among under varying conditions. (ii) Epistemic rationality is ineliminably defined by procedural norms; procedural restrictions provide an irreducible unifying structure for even apparently non-procedural prescriptions and normative expressions, and they are practically indispensable in our cognitive lives. (iii) These procedural epistemic norms are best analyzed in …

Accurate And Cost-Effective Traffic Information Acquisition Using Adaptive Sampling: Centralized And V2v Schemes, Shiau Hong Lim, Yeow Khiang Chia, Laura Wynter

Research Collection School Of Computing and Information Systems

The new generation of GPS-based tolling systems allow for a much higher degree of road sensing than has been available up to now. We propose an adaptive sampling scheme to collect accurate real-time traffic information from large-scale implementations of on-board GPS-based devices over a road network. The goal of the system is to minimize the transmission costs over all vehicles while satisfying requirements in the accuracy and timeliness of the traffic information obtained. The system is designed to make use of cellular communication as well as leveraging additional technologies such as roadside units equipped with WiFi and vehicle-to-vehicle (V2V) dedicated …

Predicting Impacts Of Chemicals From Organisms To Ecosystem Service Delivery: A Case Study Of Endocrine Disruptor Effects On Trout, Valery E. Forbes, Steve Railsback, Chiara Accolla, Bjorn Birnir, Randall J.F. Bruins, Virginie Ducrot, Nika Galic, Kristina Garber, Bret C. Harvey, Henriette I. Jager, Andrew Kanarek, Robert Pastorok, Richard Rebarber, Pernille Thorbek, Chris J. Salice

Department of Mathematics: Faculty Publications

We demonstrate how mechanistic modeling can be used to predict whether and how biological responses to chemicals at (sub)organismal levels in model species (i.e., what we typically measure) translate into impacts on ecosystem service delivery (i.e., what we care about). We consider a hypothetical case study of two species of trout, brown trout (Salmo trutta; BT) and greenback cutthroat trout (Oncorhynchus clarkii stomias; GCT). These hypothetical populations live in a high-altitude river system and are exposed to human-derived estrogen (17α‑ethinyl estradiol, EE2), which is the bioactive estrogen in many contraceptives. We use the individual based model in STREAM …

Compressive Sampling For Phenotype Classification, Eric L. Brooks

Theses and Dissertations

Phenotype classification has become an increasingly important genomic research method for disease identification and treatment. Phenotype classification is the investigation into the genetic information concerned with locating biomarkers (features) in order to identify an observed effect. The primary challenge associated with phenotype classification is with analyzing the data due to the inherent high-dimensionality of DNA data. As a result, phenotype classification faces challenges with feature selection, and consequently, classification accuracy. This research developed a methodology to alleviate these challenges while improving classification performance. The methodology leverages concepts of compressive sampling, to arrive at a process that identifies features most relevant …

Yelp’S Review Filtering Algorithm, Yao Yao, Ivelin Angelov, Jack Rasmus-Vorrath, Mooyoung Lee, Daniel W. Engels

SMU Data Science Review

In this paper, we present an analysis of features influencing Yelp's proprietary review filtering algorithm. Classifying or misclassifying reviews as recommended or non-recommended affects average ratings, consumer decisions, and ultimately, business revenue. Our analysis involves systematically sampling and scraping Yelp restaurant reviews. Features are extracted from review metadata and engineered from metrics and scores generated using text classifiers and sentiment analysis. The coefficients of a multivariate logistic regression model were interpreted as quantifications of the relative importance of features in classifying reviews as recommended or non-recommended. The model classified review recommendations with an accuracy of 78%. We found that reviews …

Statistical Inference To Evaluate And Compare The Performance Of Correlated Multi-State Classification Systems, Beau A. Nunnally

Theses and Dissertations

The current emphasis on including correlation when comparing diagnostic test performance is quite important, however, there are cases in which correlation effects may be negligible with respect to inference. This proposed work examines the impact of including correlation between classification systems with continuous features by comparing the optimal performance of two diagnostic tests with multiple outcomes as well as providing inference for a sequence of tests. We define the optimal point using Bayes Cost, a metric that sums the weighted misclassifications within a diagnostic test using a cost/benefit structure. Through simulation, we quantify the impact of correlation on standard errors …

Numerical Simulation Of High Energy Laser Propagation, Dana F. Morrill

Theses and Dissertations

High energy lasers have many applications, such as in aerospace, weapons, wireless power transfer, and manufacturing. Fluid-laser interaction is important to predicting power at receiver, and other measures of laser beam quality. Typically the carrying medium of the laser is modeled statistically. This dissertation describes a novel method of coupling fluid dynamics to beam propagation in free space. The coupled laser-fluid solver captures dynamic interaction of fluid temperature and beam intensity. Ultimately, the model captures the effects of fluid convection in the laser intensity-field. Boundary conditions play an important role for fluid dynamics, more so than for beam dynamics. Simulation …

Robust Engineering Of Dynamic Structures In Complex Networks, Walter Botongo Bomela

McKelvey School of Engineering Graduate Student Theses & Dissertations

Populations of nearly identical dynamical systems are ubiquitous in natural and engineered systems, in which each unit plays a crucial role in determining the functioning of the ensemble. Robust and optimal control of such large collections of dynamical units remains a grand challenge, especially, when these units interact and form a complex network. Motivated by compelling practical problems in power systems, neural engineering and quantum control, where individual units often have to work in tandem to achieve a desired dynamic behavior, e.g., maintaining synchronization of generators in a power grid or conveying information in a neuronal network; in this dissertation, …

Breakpoint Analysis Of Modis Vegetarian Cover Change In Southern California Deserts, Rebecca Baiman

STAR Program Research Presentations

This study applies time series breakpoint analysis to look at Moderate Resolution Imaging Spectroradiometer (MODIS) data of southern California. Past studies have looked at this desert land using Landsat data in order to analyze any changes the environment has gone through due to renewable energy development or other factors. This study develops a method for utilizing structural change models to study the DRECP land area. Focusing on breakpoints, this study found that most positive breakpoints represented years with high rainfall. Additionally, sandy washes with little vegetation did not yield any breakpoint between 2000 and 2018. This study can be used …

Development Of A Statistical Model For Discrimination Of Rupture Status In Posterior Communicating Artery Aneurysms, Felicitas J. Detmer, Bong Jae Chung, Fernando Mut, Michael Pritz, Martin Slawski, Farid Hamzei-Sichani, David Kallmes, Christopher Putman, Carlos Jimenez, Juan R. Cebral

Department of Applied Mathematics and Statistics Faculty Scholarship and Creative Works

Background: Intracranial aneurysms at the posterior communicating artery (PCOM) are known to have high rupture rates compared to other locations. We developed and internally validated a statistical model discriminating between ruptured and unruptured PCOM aneurysms based on hemodynamic and geometric parameters, angio-architectures, and patient age with the objective of its future use for aneurysm risk assessment. Methods: A total of 289 PCOM aneurysms in 272 patients modeled with image-based computational fluid dynamics (CFD) were used to construct statistical models using logistic group lasso regression. These models were evaluated with respect to discrimination power and goodness of fit using tenfold nested …

On The Well-Posedness And Global Boundary Controllability Of A Nonlinear Beam Model, Jessie Jamieson

Department of Mathematics: Dissertations, Theses, and Student Research

The theory of beams and plates has been long established due to works spanning many fields, and has been explored through many investigations of beam and plate mechanics, controls, stability, and the well-posedness of systems of equations governing the motions of plates and beams. Additionally, recent investigations of flutter phenomena by Dowell, Webster et al. have reignited interest into the mechanics and stability of nonlinear beams. In this thesis, we wish to revisit the seminal well-posedness results of Lagnese and Leugering for the one dimensional, nonlinear beam from their 1991 paper, "Uniform stabilization of a nonlinear beam by nonlinear boundary …

Closed Range Composition Operators On Bmoa, Kevser Erdem

Graduate Theses and Dissertations

Let φ be an analytic self-map of the unit disk D. The composition operator with symbol φ is denoted by Cφ. Reverse Carleson type conditions, counting functions and sampling sets are important tools to give a complete characterization of closed range composition operators on BMOA and on Qp for all p ∈ (0,∞).

Let B denote the Bloch space, let H2 denote the Hardy space. We show that if Cφ is closed range on B or on H2 then it is also closed range on BMOA. Closed range composition operators Cφ : B → BMOA are also characterized. Laitila found …

Dynamics Of Coupled Particles In A Time-Dependent, Double-Gyre Flow, Manuel Albrizzio

Theses, Dissertations and Culminating Projects

We consider a time-dependent, wind-driven, stochastic double-gyre flow, and investigate the interaction between the flow and coupled particles operating within the flow. It is known that noise can cause individual particles to escape from one gyre to another gyre. By computing the Lagrangian coherent structures (LCS) of the system, one can determine low and high probability regions of particle escape. We adjust the coupling between two particles, and study the effect on particle escape for a variety of initial conditions and noise intensities.

Understanding The Flow Structure Of Low Reynolds Number Flows, Albert Jarvis

Theses, Dissertations and Culminating Projects

Ocean flows and the mechanisms by which their contents are organized has been a longstanding area of interest in applied mathematics. In recent years, a new theory has been developed to identify the structures responsible for the organization of fluid particles within complex geophysical flows. This theory is known as the theory of Lagrangian Coherent Structures (LCS) and details which structures are responsible for the organization of the flow and how to identify them. Being able to identify these LCS in real time has far reaching implications ranging from developing strategies for search and rescue missions to identifying the best …

Information Theoretic Thresholding Techniques Based On Particle Swarm Optimization., Surina Surina

Electronic Theses and Dissertations

In this dissertation, we discuss multi-level image thresholding techniques based on information theoretic entropies. In order to apply the correlation information of neighboring pixels of an image to obtain better segmentation results, we propose several multi-level thresholding models by using Gray-Level & Local-Average histogram (GLLA) and Gray-Level & Local-Variance histogram (GLLV). Firstly, a RGB color image thresholding model based on GLLA histogram and Tsallis-Havrda-Charv'at entropy is discussed. We validate the multi-level thresholding criterion function by using mathematical induction. For each component image, we assign the mean value from each thresholded class to obtain three segmented component images independently. Then we …

Evaluation Of Drug-Loaded Gold Nanoparticle Cytotoxicity As A Function Of Tumor Tissue Heterogeneity., Hunter Allan Miller

Electronic Theses and Dissertations

The inherent heterogeneity of tumor tissue presents a major challenge to nanoparticle-medicated drug delivery. This heterogeneity spans from the molecular to the cellular (cell types) and to the tissue (vasculature, extra-cellular matrix) scales. Here we employ computational modeling to evaluate therapeutic response as a function of vascular-induced tumor tissue heterogeneity. Using data with three-layered gold nanoparticles loaded with cisplatin, nanotherapy is simulated with different levels of tissue heterogeneity, and the treatment response is measured in terms of tumor regression. The results show that tumor vascular density non-trivially influences the nanoparticle uptake and washout, and the associated tissue response. The drug …

Developments In Multivariate Post Quantum Cryptography., Jeremy Robert Vates

Electronic Theses and Dissertations

Ever since Shor's algorithm was introduced in 1994, cryptographers have been working to develop cryptosystems that can resist known quantum computer attacks. This push for quantum attack resistant schemes is known as post quantum cryptography. Specifically, my contributions to post quantum cryptography has been to the family of schemes known as Multivariate Public Key Cryptography (MPKC), which is a very attractive candidate for digital signature standardization in the post quantum collective for a wide variety of applications. In this document I will be providing all necessary background to fully understand MPKC and post quantum cryptography as a whole. Then, I …

On Some Metaphysical Problems Of Many Worlds Interpretation Of Quantum Mechanics, Florentin Smarandache, Victor Christianto, Yunita Umniyati

Branch Mathematics and Statistics Faculty and Staff Publications

Despite its enormous practical success, many physicists and philosophers alike agree that the quantum theory is full of contradictions and paradoxes which are difficult to solve consistently. Even after 90 years, the experts themselves still do not all agree what to make of it. The area of disagreement centers primarily around the problem of describing observations. Formally, the socalled quantum measurement problem can be defined as follows: the result of a measurement is a superposition of vectors, each representing the quantity being observed as having one of its possible values. The question that has to be answered is : how …

Adaptive Meshfree Methods For Partial Differential Equations, Jaeyoun Oh

Dissertations

There are many types of adaptive methods that have been developed with different algorithm schemes and definitions for solving Partial Differential Equations (PDE). Adaptive methods have been developed in mesh-based methods, and in recent years, they have been extended by using meshfree methods, such as the Radial Basis Function (RBF) collocation method and the Method of Fundamental Solutions (MFS). The purpose of this dissertation is to introduce an adaptive algorithm with a residual type of error estimator which has not been found in the literature for the adaptive MFS. Some modifications have been made in developing the algorithm schemes depending …