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Articles 151 - 180 of 382
Full-Text Articles in Applied Mathematics
Non-Locality, Precognition & Spirit From The Physics Point Of View, Florentin Smarandache, Victor Christianto
Non-Locality, Precognition & Spirit From The Physics Point Of View, Florentin Smarandache, Victor Christianto
Branch Mathematics and Statistics Faculty and Staff Publications
There are various supernatural phenomena which can hardly be explained by the existing mainstream science, for instance non-local interactions (e.g. ESP) and also precognitive interdictions. And there are other problems such as how to include the Spirit in the framework of physics. For example, it has been known for long time that intuition plays significant role in many professions and human life, including entrepreneurship, government, and also in detective or law enforcement activities. Despite these examples, such a precognitive interdiction is hardly accepted in mainstream science. In this paper, we discuss non-local interactions and advanced solutions of Maxwell equations, and …
On Some Metaphysical Problems Of Many Worlds Interpretation Of Quantum Mechanics, Florentin Smarandache, Victor Christianto, Yunita Umniyati
On Some Metaphysical Problems Of Many Worlds Interpretation Of Quantum Mechanics, Florentin Smarandache, Victor Christianto, Yunita Umniyati
Branch Mathematics and Statistics Faculty and Staff Publications
Despite its enormous practical success, many physicists and philosophers alike agree that the quantum theory is full of contradictions and paradoxes which are difficult to solve consistently. Even after 90 years, the experts themselves still do not all agree what to make of it. The area of disagreement centers primarily around the problem of describing observations. Formally, the socalled quantum measurement problem can be defined as follows: the result of a measurement is a superposition of vectors, each representing the quantity being observed as having one of its possible values. The question that has to be answered is : how …
Ns-Cross Entropy-Based Magdm Under Single-Valued Neutrosophic Set Environment, Florentin Smarandache, Surapati Pramanik, Shyamal Dalapati, Shariful Alam, Tapan Kumar Roy
Ns-Cross Entropy-Based Magdm Under Single-Valued Neutrosophic Set Environment, Florentin Smarandache, Surapati Pramanik, Shyamal Dalapati, Shariful Alam, Tapan Kumar Roy
Branch Mathematics and Statistics Faculty and Staff Publications
A single-valued neutrosophic set has king power to express uncertainty characterized by indeterminacy, inconsistency and incompleteness. Most of the existing single-valued neutrosophic cross entropy bears an asymmetrical behavior and produces an undefined phenomenon in some situations. In order to deal with these disadvantages, we propose a new cross entropy measure under a single-valued neutrosophic set (SVNS) environment, namely NS-cross entropy, and prove its basic properties. Also we define weighted NS-cross entropy measure and investigate its basic properties. We develop a novel multi-attribute group decision-making (MAGDM) strategy that is free from the drawback of asymmetrical behavior and undefined phenomena. It is …
Summary Of The Special Issue “Neutrosophic Information Theory And Applications” At “Information” Journal, Florentin Smarandache, Jun Ye
Summary Of The Special Issue “Neutrosophic Information Theory And Applications” At “Information” Journal, Florentin Smarandache, Jun Ye
Branch Mathematics and Statistics Faculty and Staff Publications
Over a period of seven months (August 2017–February 2018), the Special Issue dedicated to “Neutrosophic Information Theory and Applications” by the “Information” journal (ISSN 2078-2489), located in Basel, Switzerland, was a success. The Guest Editors, Prof. Dr. Florentin Smarandache from the University of New Mexico (USA) and Prof. Dr. Jun Ye from the Shaoxing University (China), were happy to select—helped by a team of neutrosophic reviewers from around the world, and by the “Information” journal editors themselves—and publish twelve important neutrosophic papers, authored by 27 authors and coauthors. There were a variety of neutrosophic topics studied and used by the …
Neutrosophic Soft Rough Graphs With Application, Florentin Smarandache, Muhammad Akram, Hafsa M. Malik, Sundas Shahzadi
Neutrosophic Soft Rough Graphs With Application, Florentin Smarandache, Muhammad Akram, Hafsa M. Malik, Sundas Shahzadi
Branch Mathematics and Statistics Faculty and Staff Publications
Neutrosophic sets (NSs) handle uncertain information while fuzzy sets (FSs) and intuitionistic fuzzy sets (IFs) fail to handle indeterminate information. Soft set theory, neutrosophic set theory, and rough set theory are different mathematical models for handling uncertainties and they are mutually related. The neutrosophic soft rough set (NSRS) model is a hybrid model by combining neutrosophic soft sets with rough sets. We apply neutrosophic soft rough sets to graphs. In this research paper, we introduce the idea of neutrosophic soft rough graphs (NSRGs) and describe different methods of their construction. We consider the application of NSRG in decision-making problems. In …
Nn-Harmonic Mean Aggregation Operators-Based Mcgdm Strategy In A Neutrosophic Number Environment, Florentin Smarandache, Kalyan Mondal, Surapati Pramanik, Bibhas C. Giri
Nn-Harmonic Mean Aggregation Operators-Based Mcgdm Strategy In A Neutrosophic Number Environment, Florentin Smarandache, Kalyan Mondal, Surapati Pramanik, Bibhas C. Giri
Branch Mathematics and Statistics Faculty and Staff Publications
A neutrosophic number (a + bI) is a significant mathematical tool to deal with indeterminate and incomplete information which exists generally in real-world problems, where a and bI denote the determinate component and indeterminate component, respectively. We define score functions and accuracy functions for ranking neutrosophic numbers. We then define a cosine function to determine the unknown weight of the criteria. We define the neutrosophic number harmonic mean operators and prove their basic properties. Then, we develop two novel multi-criteria group decision-making (MCGDM) strategies using the proposed aggregation operators. We solve a numerical example to demonstrate the feasibility, applicability, and …
Mental Models And Neutrosophic Cognitive Maps (Modelos Mentales Y Mapas Cognitivos Neutrosóficos), Maykel Leyva-Vazquez, Rebeca Escobar-Jara, Florentin Smarandache
Mental Models And Neutrosophic Cognitive Maps (Modelos Mentales Y Mapas Cognitivos Neutrosóficos), Maykel Leyva-Vazquez, Rebeca Escobar-Jara, Florentin Smarandache
Branch Mathematics and Statistics Faculty and Staff Publications
In this work, elements related to mental models elicitation and analysis are addressed through causal models. Issues related to the need to include indeterminacy in causal relationships through neutrophic cognitive maps are discussed. A proposal for static analysis in neutrosophic cognitive maps is presented. The following activities are included in the proposal: Calculate, measures of centrality, Classify nodes, De-neutrosification, and Ranking nodes. As future works, the incorporation of new metrics of centrality in neutrosophic cognitive maps is proposed. The inclusion of scenario analysis to the proposal is another area of future work.
Neutrosophic Operational Research - Vol. 3., Florentin Smarandache, Mohamed Abdel Basset, Victor Chang
Neutrosophic Operational Research - Vol. 3., Florentin Smarandache, Mohamed Abdel Basset, Victor Chang
Branch Mathematics and Statistics Faculty and Staff Publications
Foreword John R. Edwards This book is an excellent exposition of the use of Data Envelopment Analysis (DEA) to generate data analytic insights to make evidence-based decisions, to improve productivity, and to manage cost-risk and benefitopportunity in public and private sectors. The design and the content of the book make it an up-to-date and timely reference for professionals, academics, students, and employees, in particular those involved in strategic and operational decisionmaking processes to evaluate and prioritize alternatives to boost productivity growth, to optimize the efficiency of resource utilization, and to maximize the effectiveness of outputs and impacts to stakeholders. It …
Special Subset Vertex Subgraphs For Social Networks, Florentin Smarandache, W. B. Vasantha Kandasamy, Ilanthenral K
Special Subset Vertex Subgraphs For Social Networks, Florentin Smarandache, W. B. Vasantha Kandasamy, Ilanthenral K
Branch Mathematics and Statistics Faculty and Staff Publications
In this book authors for the first time introduce the new notion of special subset vertex subgraph of subset vertex graphs introduced recently in [46]. These subset vertex graphs takes the vertex set values from the power set P(X) of any set X. The main speciality of these subset vertex graphs is that once a set of subsets from P(X) is given, the edges of the graph are fixed in a unique way, so for a given collection of subset vertices the graph is always unique [46]. The special subset vertex subgraphs of G are the ones, which have the …
New Trends In Neutrosophic Theory And Applications Volume Ii, Florentin Smarandache, Surapati Pramanik
New Trends In Neutrosophic Theory And Applications Volume Ii, Florentin Smarandache, Surapati Pramanik
Branch Mathematics and Statistics Faculty and Staff Publications
Neutrosophic set has been derived from a new branch of philosophy, namely Neutrosophy. Neutrosophic set is capable of dealing with uncertainty, indeterminacy and inconsistent information. Neutrosophic set approaches are suitable to modeling problems with uncertainty, indeterminacy and inconsistent information in which human knowledge is necessary, and human evaluation is needed. Neutrosophic set theory was proposed in 1998 by Florentin Smarandache, who also developed the concept of single valued neutrosophic set, oriented towards real world scientific and engineering applications. Since then, the single valued neutrosophic set theory has been extensively studied in books and monographs introducing neutrosophic sets and its applications, …
Fuzzy And Neutrosophic Sets In Semigroups, Florentin Smarandache, Young Bae Jun, Madad Khan
Fuzzy And Neutrosophic Sets In Semigroups, Florentin Smarandache, Young Bae Jun, Madad Khan
Branch Mathematics and Statistics Faculty and Staff Publications
The first chapter, Characterizations of regular and duo semigroups based on int-soft set theory, investigates the relations among int-soft semigroup, int-soft (generalized) bi-ideal, int-soft quasi-ideal and int-soft interior ideal. Using int-soft left (right) ideal, an int-soft quasi-ideal is constructed. We show that every int-soft quasi-ideal can be represented as the soft intersection of an int-soft left ideal and an int-soft right ideal. Using int-soft quasiideal, an int-soft bi-ideal is established. Conditions for a semigroup to be regular are displayed.
Special Issue : Neutrosophic Multi-Criteria Decision Making, Florentin Smarandache, Jun Ye, Yan Hui Guo
Special Issue : Neutrosophic Multi-Criteria Decision Making, Florentin Smarandache, Jun Ye, Yan Hui Guo
Branch Mathematics and Statistics Faculty and Staff Publications
The notion of a neutrosophic quadruple BCK/BCI-number is considered in the first article (“Neutrosophic Quadruple BCK/BCI-Algebras”, by Young Bae Jun, Seok-Zun Song, Florentin Smarandache, and Hashem Bordbar), and a neutrosophic quadruple BCK/BCI-algebra, which consists of neutrosophic quadruple BCK/BCI-numbers, is constructed. Several properties are investigated, and a (positive implicative) ideal in a neutrosophic quadruple BCK-algebra and a closed ideal in a neutrosophic quadruple BCI-algebra are studied. Given subsets A and B of a BCK/BCI-algebra, the set NQ(A,B), which consists of neutrosophic quadruple BCK/BCInumbers with a condition, is established. Conditions for the set NQ(A,B) to be a (positive implicative) ideal of a …
Spanning Tree Problem With Neutrosophic Edge Weights, Florentin Smarandache, Said Broumi, Assia Bakali, Mohamed Talea, Arindam Dey, Le Hoang Son
Spanning Tree Problem With Neutrosophic Edge Weights, Florentin Smarandache, Said Broumi, Assia Bakali, Mohamed Talea, Arindam Dey, Le Hoang Son
Branch Mathematics and Statistics Faculty and Staff Publications
Neutrosophic set and neutrosophic logic theory are renowned theories to deal with complex, not clearly explained and uncertain real life problems, in which classical fuzzy sets/models may fail to model properly. This paper introduces an algorithm for finding minimum spanning tree (MST) of an undirected neutrosophic weighted connected graph (abbr. UNWCG) where the arc/edge lengths are represented by a single valued neutrosophic numbers. To build the MST of UNWCG, a new algorithm based on matrix approach has been introduced. The proposed algorithm is compared to other existing methods and finally a numerical example is provided.
Operadores Con Conjunto Neutrosóficos De Valor Único Oversets, Undersets Y Offset, Florentin Smarandache
Operadores Con Conjunto Neutrosóficos De Valor Único Oversets, Undersets Y Offset, Florentin Smarandache
Branch Mathematics and Statistics Faculty and Staff Publications
Neutrosophic Over-/Under-/Off-Set and Logic were defined for the first time in 1995 and published in 2007. During 1995-2016 was presented them to various national and international conferences and seminars. These new notions are totally different from other sets/logics/probabilities. We extended the neutrosophic set respectively to Neutrosophic Overset {when some neutrosophic component is > 1}, to Neutrosophic Underset {when some neutrosophic component is < 0}, and to Neutrosophic Offset {when some neutrosophic components are off the interval [0, 1], i.e. some neutrosophic component > 1 and other neutrosophic component < 0}. This is no surprise since our realworld has numerous examples and applications of over-/under-/off-neutrosophic components. Palabras clave. desbordado neutrosophic, underset neutrosophic, neutrosophic offset, neutrosophic sobre la lógica, neutrosophic bajo la lógica, neutrosophic off lógica, neutrosophic sobre la probabilidad, neutrosophic bajo probabilidad, neutrosophic de probabilidad, más de miembros (grado de pertenencia> 1), bajo de miembros (grado de pertenencia <0) , (grado de pertenencia fuera del intervalo [0, 1]) offmembership.
Neutrosophic Computing With Sympy (Computación Neutrosófica Mediante Sympy ), Maykel Leyva-Vazquez, Florentin Smarandache
Neutrosophic Computing With Sympy (Computación Neutrosófica Mediante Sympy ), Maykel Leyva-Vazquez, Florentin Smarandache
Branch Mathematics and Statistics Faculty and Staff Publications
In this article the concept of neutrosophic number is presented. Jupyter through Google Colaboratory is introduced for calculations. The Sympy library is used to perform the process of neutrosophic computation. Systems of linear neutrosóficas equations are solved by means of the symbolic computation in python. A case study was developed for the determination of vehicular traffic with indeterminacy. As future works are the development of new applications in different areas of engineering and science.
Fundamentals Of Neutrosophic Logic And Sets And Their Role In Artificial Intelligence (Fundamentos De La Lógica Y Los Conjuntos Neutrosóficos Y Su Papel En La Inteligencia Artificial ), Florentin Smarandache, Maykel Leyva-Vazquez
Fundamentals Of Neutrosophic Logic And Sets And Their Role In Artificial Intelligence (Fundamentos De La Lógica Y Los Conjuntos Neutrosóficos Y Su Papel En La Inteligencia Artificial ), Florentin Smarandache, Maykel Leyva-Vazquez
Branch Mathematics and Statistics Faculty and Staff Publications
Neutrosophy is a new branch of philosophy which studies the origin, nature and scope of neutralities. This has formed the basis for a series of mathematical theories that generalize the classical and fuzzy theories such as the neutrosophic sets and the neutrosophic logic. In the paper, the fundamental concepts related to neutrosophy and its antecedents are presented. Additionally, fundamental concepts of artificial intelligence will be defined and how neutrosophy has come to strengthen this discipline.
N-Valued Refined Neutrosophic Logic And Its Applications To Physics (Lógica Neutrosófica Refinada N-Valuada Y Sus Aplicaciones A La Física), Florentin Smarandache
N-Valued Refined Neutrosophic Logic And Its Applications To Physics (Lógica Neutrosófica Refinada N-Valuada Y Sus Aplicaciones A La Física), Florentin Smarandache
Branch Mathematics and Statistics Faculty and Staff Publications
In this paper we present a short history of logics: from particular cases of 2-symbol or numerical valued logic to the general case of n-symbol or numerical valued logic. We show generalizations of 2-valued Boolean logic to fuzzy logic, also from the Kleene’s and Lukasiewicz’ 3-symbol valued logics or Belnap’s 4-symbol valued logic to the most general nsymbol or numerical valued refined neutrosophic logic. Examples of applications of neutrosophic logic to physics are listed in the last section. Similar generalizations can be done for n-Valued Refined Neutrosophic Set, and respectively.
Modelo De Recomendación Basado En Conocimiento Y Números Svn, Maykel Leyva-Vazquez, Florentin Smarandache
Modelo De Recomendación Basado En Conocimiento Y Números Svn, Maykel Leyva-Vazquez, Florentin Smarandache
Branch Mathematics and Statistics Faculty and Staff Publications
Recommendation models are useful in the decision-making process that allow the user a set of options that are expected to meet their expectations. Recommendation models are useful in the decision-making process that offer the user a set of options that are expected to meet their SVN expectations to express linguistic terms.
Weighted Inequalities For Dyadic Operators Over Spaces Of Homogeneous Type, David Edward Weirich
Weighted Inequalities For Dyadic Operators Over Spaces Of Homogeneous Type, David Edward Weirich
Mathematics & Statistics ETDs
A so-called space of homogeneous type is a set equipped with a quasi-metric and a doubling measure. We give a survey of results spanning the last few decades concerning the geometric properties of such spaces, culminating in the description of a system of dyadic cubes in this setting whose properties mirror the more familiar dyadic lattices in R^n . We then use these cubes to prove a result pertaining to weighted inequality theory over such spaces. We develop a general method for extending Bellman function type arguments from the real line to spaces of homogeneous type. Finally, we uses this …
Neutrosophic Hough Transform, Florentin Smarandache, Umit Budak, Yanhui Guo, Abdulkadir Sengur
Neutrosophic Hough Transform, Florentin Smarandache, Umit Budak, Yanhui Guo, Abdulkadir Sengur
Branch Mathematics and Statistics Faculty and Staff Publications
Hough transform (HT) is a useful tool for both pattern recognition and image processing communities. In the view of pattern recognition, it can extract unique features for description of various shapes, such as lines, circles, ellipses, and etc. In the view of image processing, a dozen of applications can be handled with HT, such as lane detection for autonomous cars, blood cell detection in microscope images, and so on. As HT is a straight forward shape detector in a given image, its shape detection ability is low in noisy images. To alleviate its weakness on noisy images and improve its …
Which Factors Influence Student Success In Intermediate Algebra, Math 101-102-103?, Linh T. Ward
Which Factors Influence Student Success In Intermediate Algebra, Math 101-102-103?, Linh T. Ward
Mathematics & Statistics ETDs
At The University of New Mexico (UNM), Intermediate Algebra (MATH 120 and MATH 101-102-103) has historically been a so-called “killer course”, with very low pass rates: approximately 40% in Fall 2009 to Spring 2011 and about 50% from Fall 2011 to Spring 2013. Furthermore, many students failed the class multiple times. Since 2013, a computer system called ALEKS has been used to teach the course and, along with some additional interventions, on Albuquerque/Main campus success rates for MATH 101 have increased to roughly 80% and MATH 102 to about 70%. This thesis provides a strategy to identify those 20-30% as-risk …
Nonlinear Waves, Instabilities And Singularities In Plasma And Hydrodynamics, Denis Albertovich Silantyev
Nonlinear Waves, Instabilities And Singularities In Plasma And Hydrodynamics, Denis Albertovich Silantyev
Mathematics & Statistics ETDs
This work concentrates on Langmuir wave filamentation instability in the kinetic regime of plasma and computation of Stokes wave with high precision using conformal maps.
Nonlinear effects are present in almost every area of science as soon as one tries to go beyond the first order approximation. In particular, nonlinear waves emerge in such areas as hydrodynamics, nonlinear optics, plasma physics, quantum physics, etc. The results of this work are related to nonlinear waves in two areas, plasma physics and hydrodynamics, united by concepts of instability, singularity and advanced numerical methods used for their investigation.
The first part of this …
Trace Formulas For Perturbations Of Operators With Hilbert-Schmidt Resolvents, Bishnu Prasad Sedai
Trace Formulas For Perturbations Of Operators With Hilbert-Schmidt Resolvents, Bishnu Prasad Sedai
Mathematics & Statistics ETDs
In this dissertation, we study Taylor approximations of functions of operators with Hilbert-Schmidt resolvents. We obtain integral representations for traces of the respective Taylor remainders that are analogous to trace formulas obtained in the case of Schatten perturbations in [10, 11, 16].
Evaluation And Enhancement Of Clean Energy Systems: Analytical, Computational And Experimental Study Of Solar And Nuclear Cycles, Nima Fathi
Mechanical Engineering ETDs
Clean (and specifically renewable) energy is steadily improving its global share. However, finite availability of fossil fuels and the growing effects of climate change make it an urgent priority to convince the industry and governments to incentivize investment in the renewable energy field and to make it more attractive by decreasing the capital cost. Until recently, uncertainties in funding limited renewable energy development, especially in the US. That limitation has been one of the barriers to progress. Another limitation of many renewable energy systems is the variability in their output, which makes them unsuitable for baseline power production. Therefore, fossil …
High Order Hermite And Sobolev Discontinuous Galerkin Methods For Hyperbolic Partial Differential Equations, Adeline Kornelus
High Order Hermite And Sobolev Discontinuous Galerkin Methods For Hyperbolic Partial Differential Equations, Adeline Kornelus
Mathematics & Statistics ETDs
Many real-world problems involving dynamics of solid or fluid bodies can be modeled by hyperbolic partial differential equations (PDEs). Up to this point, only solutions to selected PDEs are available. Many PDEs are physically or geometrically complex, resulting in difficulties computing the analytical solutions. In this thesis, we focus on numerical methods for approximating solutions to hyperbolic PDEs. Long-term simulation for the motion of the body described by the PDE requires a method that is not only robust and efficient, but also produces small error because the error will be propagated and accumulated over the course of the simulation. Therefore, …
Comparison Of Two Methods In Estimating Standard Error Of Simulated Moments Estimators For Generalized Linear Mixed Models, Danielle K. Duran
Comparison Of Two Methods In Estimating Standard Error Of Simulated Moments Estimators For Generalized Linear Mixed Models, Danielle K. Duran
Mathematics & Statistics ETDs
We consider standard error of the method of simulated moment (MSM) estimator for generalized linear mixed models (GLMM). Parametric bootstrap (PB) has been used to estimate the covariance matrix, in which we use the estimates to generate the simulated moments. To avoid the bias introduced by estimating the parameters and to deal with the correlated observations, (Lu, 2012) proposed a multi-stage block nonparametric bootstrap to estimate the standard errors. In this research, we compare PB and nonparametric bootstrap methods (NPB) in estimating the standard errors of MSM estimators for GLMM. Simulation results show that when the group size is large, …
Shortest Path Problem On Single Valued Neutrosophic Graphs, Florentin Smarandache, Said Broumi, Mohamed Talea, Assia Bakali, Kishore Kumar
Shortest Path Problem On Single Valued Neutrosophic Graphs, Florentin Smarandache, Said Broumi, Mohamed Talea, Assia Bakali, Kishore Kumar
Branch Mathematics and Statistics Faculty and Staff Publications
A single valued neutrosophic graph is a generalized structure of fuzzy graph, intuitionistic fuzzy graph that gives more precision, flexibility and compatibility to a system when compared with systems that are designed using fuzzy graphs and intuitionistic fuzzy graphs. This paper addresses for the first time, the shortest path in an acyclic neutrosophic directed graph using ranking function. Here each edge length is assigned to single valued neutrosophic numbers instead of a real number. The neutrosophic number is able to represent the indeterminacy in the edge (arc) costs of neutrosophic graph. A proposed algorithm gives the shortest path and shortest …
Optimal Experimental Design To Characterize A Wave Source Using Dosimeter Measurements, Renee L. Gooding
Optimal Experimental Design To Characterize A Wave Source Using Dosimeter Measurements, Renee L. Gooding
Mathematics & Statistics ETDs
When modeling physical phenomena we want to solve the inverse problem by estimating the parameters that characterize the source model that we are interested in. In this thesis, we focus on the optimal placement of a finite number of individual sensors, called dosimeters, in two and three dimensions with a time dependent Gaussian wave source. Using a computational model along with experimental data, we design an iterative process to determine the optimal placement of an additional sensor such that the noise in the measurements has a minimal effect on the parameter estimation. First, we estimate the parameters that characterize the …
Deterministic And Probabilistic Methods For Seismic Source Inversion, Juan Pablo Madrigal Cianci
Deterministic And Probabilistic Methods For Seismic Source Inversion, Juan Pablo Madrigal Cianci
Mathematics & Statistics ETDs
The national Earthquake Information Center (NEIC) reports an occurrence of about 13,000 earthquakes every year, spanning different values on the Richter scale from very mild (2) to "giant earthquakes'' (8 and above). Being able to study these earthquakes provides useful information for a wide range of applications in geophysics. In the present work we study the characteristics of an earthquake by performing seismic source inversion; a mathematical problem that, given some recorded data, produces a set of parameters that when used as input in a mathematical model for the earthquake generates synthetic data that closely resembles the measured data. There …
Cancer Modeling: From Optimal Cell Renewal To Immunotherapy, Cesar L. Alvarado
Cancer Modeling: From Optimal Cell Renewal To Immunotherapy, Cesar L. Alvarado
Mathematics & Statistics ETDs
Cancer is a disease caused by mutations in normal cells. According to the National Cancer Institute, in 2016, an estimated 1.6 million people were diagnosed and approximately 0.5 million people died from the disease in the United States. There are many factors that shape cancer at the cellular and organismal level, including genetic, immunological, and environmental components. In this thesis, we show how mathematical modeling can be used to provide insight into some of the key mechanisms underlying cancer dynamics. First, we use mathematical modeling to investigate optimal homeostatic cell renewal in tissues such as the small intestine with an …