Applied Mathematics Commons^™

Modeling Sickle Cell Disease Using A Sleep-Pain-Inflammation Cycle, Milan Marsh

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Modeling And Analysis Of The Impacts Of The Rise In Ai Use On Data Center Growth, Resulting Workforce Displacement, And Environmental Impacts Through A Coupled System Of Ordinary Differential Equations Within A Feedback Framework, Divya Laddha, Alonso Gabriel Ogueda, Padmanabhan Seshaiyer

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Using Compartmental Systems Of Ordinary Differential Equations And Optimal Control Theory To Compute Ideal Quantities Of Mentors For Student Populations, Timofey B. Gafurov

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Modeling Probiotic Bacterial Control Of White-Nose Syndrome In Little Brown Bat Colonies, Bethany Droubay, Alex Capaldi

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

A Compartmental Model For Diurnal Atlantic Stingray Migration, Rhianna Yates, Leah Glasser, Elena Wheatley, Christopher Hay-Jahans

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Mathematically Modeling Stoichiometric Drivers Of Heterotrophic N2 Fixation, Corday R. Selden, Rebecca Everett, Halvor H. Halvorson, Megan E. Berberich, Luca Schenone, Angela Peace, Renn Schipper, Edwin Cruz-Rivera, James Powell, Keisuke Inomura, Robinson W. Fulweiler, Amy M. Marcarelli, J Thad Scott

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

A Compartmental Model For Annual Bat Migration, Elena D. Wheatley, Rhianna Yates, Leah Glasser, Christopher Hay-Jahans

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Modeling The Impact Of Treatment During An Ongoing Tuberculosis Outbreak, Bach Le, Jude Shive, Erin N. Bodine

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Balancing Stability And Complexity In Boolean Models Of Biological Networks, Venkata Sai Narayana Bavisetty

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

A Compartmental Model For Periodic Animal Migration, Rhianna Yates, Leah Glasser, Elena Wheatley, Christopher Hay-Jahans

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Spatial Strategies In Ants: Modeling Polydomy, Saya Zeleznik, Fred Adler

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Optimizing The Distribution Of Fruiting Agave On Bat-Friendly Tequila Plantations, Grace Gorreck, Clarissa Azurin, Lois Carpenter

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Investigating Potential Alzheimer's Disease Therapies Through An Agent-Based Model Of Impaired Microglia Metabolismmodeling Impaired Microglia Metabolism, Cheyenne Ty, Abigail Penland, John Gerving, Martin Mendoza-Ceja, Megan Pratt, Kamila Larripa

Spora: A Journal of Biomathematics

Alzheimer’s disease is the leading cause of dementia globally and is marked by amyloid-β plaque accumulation, decreased brain pH, disrupted metabolism, and increased permeability of the blood-brain barrier. Microglia, the resident immune cells of the central nervous system, are essential for maintaining brain homeostasis and are critically involved in the progression of AD. While microglia can initiate protective immune responses to injury and disease, dysregulated microglial metabolism may contribute to the exacerbation of Alzheimer's pathology. To investigate potential therapeutic strategies, we developed an agent-based model simulating the effects of exercise and metabolic enhancement on dysfunctional microglia. Our findings suggest that …

Modeling, Analysis, And Prediction Of Covid-19 Dynamics With Interacting Subpopulations And Implicit Behavior Using Physics-Informed Neural Networks, Naima Aubry-Romero, Alonso Ogueda-Oliva, Padmanabhan Seshaiyer

Spora: A Journal of Biomathematics

In this paper, we consider an extended SEIR compartmental model that incorporates young and old interacting subpopulations, allowing for cross-group transmission dynamics. Implicit behavioral changes are included to determine the influence of social behavior on coronavirus transmission dynamics. The basic reproduction number, the average number of secondary cases of infection produced by a single primary case, is derived for both the explicit and implicit model using the next-generation matrix method. We solve the associated differential equation systems and estimate useful parameters in the explicit model using physics-informed neural networks (PINNs). Our results point to how the PINNs approach offers an …

Using A Pharmacokinetic Model To Design And Evaluate An Early Ctdna Biomarker For Response To Targeted Therapy, Aaron Li

Spora: A Journal of Biomathematics

Early prediction of response to therapy or lack thereof can help physicians plan treatment more efficiently. Biomarkers based on circulating tumor DNA (ctDNA) are promising. However, biomarkers beyond direct comparison to baseline have not been thoroughly explored. We develop a model for ctDNA shedding under targeted therapy that incorporates pharmacokinetics. Using a simulated cohort of virtual patients with varied parameters, we define and analyze a biomarker based on ctDNA samples at baseline, 12 hours, and 24 hours after initiation of treatment. The biomarker identified patients who would achieve partial or complete response with high sensitivity and specificity and was able …

Exploration Of Differential Equation Models For Phage-Bacteria Population Dynamics, John Lawrence Palacios, Rebecca A. Segal

Spora: A Journal of Biomathematics

Bacteriophages are viruses that infect and replicate within bacteria. Lytic phages cause the bacterial cell to burst, killing the bacteria. These types of phages can be used to treat patients with antibiotic-resistant bacterial infections. As a step in developing successful treatment protocols, we aim to understand the population dynamics of phages and bacteria using an in vitro model. We model the dynamics using the Campbell model, which consist of a delay differential equation (DDE), as a base model. We extended the model by including the emergence of phage resistance. We then compared the DDE model with a parallel ordinary differential …

An Agent-Based Model Of Microglia And Neuron Interaction: Implications In Neurodegenerative Disease, Cheyenne Ty, Amanda Case, Emmanuel Mezzulo, Abigail Penland, Kamila Larripa

Spora: A Journal of Biomathematics

Whether immune cells protect or harm the brain is an open question depending on context, and their role is implicated in multiple diseases such as Alzheimer's disease, dementia, and other neurological disorders. Microglia, a specific type of immune cell in the central nervous system, play a key role in homeostasis, and genes associated with an elevated risk of Alzheimer's disease correspond with deficiencies in their behavior. We created an agent-based model that incorporates inflammatory signaling, chemotaxis, and phagocytosis of damaged neurons and allows the exploration of crucial pathways in the maintenance of brain health. We specifically investigated pathways related to …

On Solving Differential Equations Describing The Ecology Of Shallow Lakes: A Comparison Of Classical And Modern Computational Methods Through Python, Vruddhi Kapre, Jeffrey R. Anderson, Alessandro Maria Selvitella

Spora: A Journal of Biomathematics

In this exposition paper, we describe some computational methodologies to solve numerically differential equations modeling the shallow lake ecosystem, with particular focus on the dynamics of the phosphorus. We describe in detail Python implementations of classical algorithms, like Runge-Kutta, and more modern approaches, including physics-informed neural networks.

Centralized Deep Reinforcement Learning For Homogeneous Multi-Component Maintenance Optimization, Joseph W. Wittrock

Theses and Dissertations

This thesis explores an application of reinforcement learning (RL) in maintenance optimization. Recent advances in hardware-accelerated computation and deep learning have made RL a powerful tool for solving optimization problems which are too complex for traditional methods. Maintenance optimization involves improving the efficiency and effectiveness of maintenance activities through data-driven approaches, ultimately reducing costs and increasing asset availability. Making informed maintenance decisions is crucial to long-term sustainability.

A desirable maintenance policy maximizes a utility signal while minimizing the cost of maintenance. Techniques in sequential decision making such as dynamic programming (DP) and RL have found success in optimizing these maintenance …

Leveraging Quantitative Systems Pharmacology For Dose Optimization In Oncology Drug Development, Blerta Shtylla

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Kreig: Gaining Insight Into Epidemics Through Use Of Mathematical Modeling, Christina Edholm

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Shevtsov: Growing Pains And Growing Gains: The Arizona Experience, Tynan Lazarus, Jane Shevtsov

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Early Ctdna Kinetics As A Dynamic Biomarker Of Cancer Treatment Response, Aaron Li, Emil Lou, Kevin Leder, Jasmine Foo

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

A Paradigm For Ecological Dynamics In Predator-Prey Systems: Applications To Climate Change, Grayson D. Adams, Aditi Ghosh Dr.

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Kreig: Examining Affinity Maturation And Antigenic Drift With An Agent-Based Model, Jasmine Af Kreig, Jannatul Ferdous, Ruian Ke, Ruy M. Ribeiro

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Modelling Saccharomyces Cerevisiae For The Production Of Fermented Beverages, Paul A. Valle Dr., Yolocuauhtli Salazar Dr., Luis N. Coria Dr., Oscar N. Soto Dr., Jesus B. Paez Dr.

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Network Analysis Of Progress In Mathematics Research, Anna Singley

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

From Ecology To Modeling Apps - Newts, Crayfish, And Slopes, Timothy Lucas

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Bodine: Exploring The Versatility Of Agent-Based Modeling In Netlogo: Lessons From Education And Research, Anne E. Yust

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Bayesian Networks And Machine Learning For Predicting Breast Cancer Growth From In Vitro Cell Count Data, Widodo Samyono

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.