Applied Mathematics Commons^™

Brief Review: Low Frequency Event Charts (G-Charts) In Healthcare, James Espinosa, David Ho, Alan Lucerna, Henry Schuitema

Rowan-Virtua Research Day

The ability to determine if a change in a system is actually an improvement—or worsening in function—is one of the essential desiderata of quality improvement efforts. There are many ways to look at the issue. A special problem occurs when the event being studied is low frequency by nature. By way of example, patient falls in a given hospital or division of a hospital may occur in a way that is low frequency—yet each event is important. Process engineering has developed an approach to low frequency events. Part of this approach may involve specialized charts that look at the “time-between-events”—as …

Dynamics Of Inertial And Non-Inertial Particles In Geophysical Flows, Nishanta Baral

Theses, Dissertations and Culminating Projects

We consider the dynamics of inertial and non-inertial particles in various flows. We investigate the underlying structures of the flow field by examining their Lagrangian coherent structures (LCS), which are found by computing finitetime Lyapunov exponents (FTLE). We compare the behavior of massless noninertial particles using the velocity fields from four models, the Duffing oscillator, the Bickley jet, the double-gyre flow, and a quasi-geostrophic geophysical flow model, with that of inertial particles. For inertial particles with finite size and mass, we use the Maxey-Riley equation to describe the particle’s motion. We explore the preferential aggregation of inertial particles and demonstrate …

Parameter Optimization For Excitable Cell Models, Amrit Parmar

Theses, Dissertations and Culminating Projects

The electrophysiology of nodose ganglia neurons is of great interest in the analysis of cell membrane currents and action potential behavior. This behavior was initially outlined in the Hodgkin-Huxley conductance model [1] using a system of nonlinear differential equations. Later, Schild et al. [2] developed an extension of the Hodgkin-Huxley model to provide a more exhaustive description of ion channels involved in nodose neuronal action potential activity. We consider a variety of methods to fit the parameters of both the Hodgkin-Huxley and Schild et al. models to an empirical stimulus response dataset. Our methods were validated using synthetic datasets, as …

Machine Learning-Based Data And Model Driven Bayesian Uncertanity Quantification Of Inverse Problems For Suspended Non-Structural System, Zhiyuan Qin

All Dissertations

Inverse problems involve extracting the internal structure of a physical system from noisy measurement data. In many fields, the Bayesian inference is used to address the ill-conditioned nature of the inverse problem by incorporating prior information through an initial distribution. In the nonparametric Bayesian framework, surrogate models such as Gaussian Processes or Deep Neural Networks are used as flexible and effective probabilistic modeling tools to overcome the high-dimensional curse and reduce computational costs. In practical systems and computer models, uncertainties can be addressed through parameter calibration, sensitivity analysis, and uncertainty quantification, leading to improved reliability and robustness of decision and …

A Machine Learning Approach To Evaluate The Effect Of Sodium-Glucose Cotransporter-2 Inhibitors On Chronic Kidney Disease In Diabetes Patients, Solomon Eshun

Theses and Dissertations

Chronic kidney disease (CKD) is a significant complication that contributes to diabetes-related mortality in the United States, and there is growing evidence that sodium-glucose cotransporter 2 inhibitors (SGLT2i) can slow its progression. However, observational studies may suffer from confounding by indication, where patient characteristics and disease severity influence the decision to prescribe SGLT2i. This study utilized electronic health records of individuals with diabetes (from TriNetX) to investigate the effectiveness of SGLT2i on CKD progression. The database provided detailed information on patients’ CKD status, demographics, diagnosis, procedures, and medications, along with corresponding dates of diagnosis and prescription. The study comprised of …

Inference For Multiple Utility In Time-Dependent Choice Pairs Under Copula-Based Models, Sasanka Adikari

Mathematics & Statistics Theses & Dissertations

Models for discrete choice experiments (DCE) are frequently used to analyze consumer choices about products and services. A family of DCE, best-worst scaling experiments, offers more in-depth insights into consumer preferences by eliciting a best and worst choice from a set of options, rather than just a single preference. Traditional approaches often assume that choices are mutually exclusive over time, which may not always be the case. This dissertation proposes a novel model for DCE that takes into account the changing nature of consumer choices over time and the priority constraint of transition probabilities. The model introduces a copula combination …

Electric Vehicle Uptake: What Factors Are Motivating The Shift For College-Aged And Older Groups?, Jake Cardines

Honors Projects in Mathematics

Electric vehicles (EVs) arguably are the most quickly expanding form of transportation as the world races toward a greener future with advanced technology and reduced reliance on fossil fuels. This study analyzes various expected inputs to motivating consumers of particular age groups to purchase EVs, including examination of how the idea of EV ownership is currently perceived and testing which factors influence it positively and negatively. Data collected from 113 survey respondents serves as the basis for determining the responsiveness of potential future EV owners to variables such as vehicle brand and charging availability, electric range, costs associated with purchase …

From Big Farm To Big Pharma: A Differential Equations Model Of Antibiotic-Resistant Salmonella In Industrial Poultry Populations, Rilyn Mckallip

Honors Theses

Antibiotics are used in poultry production as prophylaxis, curative treatment, and growth promotion. The first use is as prophylaxis, or prevention of common bacterial diseases. The crowded conditions in concentrated animal feeding operations necessitate management of infectious disease to ensure overall animal health and the profitability of such operations. In these farms, between 20,000 and 125,000 birds are raised in shed-like enclosures [3], with an average of less than one square foot of space per chicken [34]. Antibiotics are currently used in chicken farms to manage and prevent common bacterial diseases such as respiratory and digestive tract infections, as well …

National Residency Matching Program: Looking At The Data Through Linear Regressions, Jacklyn Tellez

Undergraduate Theses

The National Residency Matching Program (NRMP) oversees the process of medical school graduates being matched to a residency program. The NRMP determines both the hospital and residency program for medical students. Prior to matching, both hospital programs and students rank each other. The NRMP uses these lists to determine the matches. Four distinct models using data from hospitals and applicants were used to determine what characteristics lead to a chance of being matched. Each model went through multiple rounds of testing to determine the importance of the different independent variables. In each data set, the dependent variable is either the …

A Graphical User Interface Using Spatiotemporal Interpolation To Determine Fine Particulate Matter Values In The United States, Kelly M. Entrekin

Honors College Theses

Fine particulate matter or PM2.5 can be described as a pollution particle that has a diameter of 2.5 micrometers or smaller. These pollution particle values are measured by monitoring sites installed across the United States throughout the year. While these values are helpful, a lot of areas are not accounted for as scientists are not able to measure all of the United States. Some of these unmeasured regions could be reaching high PM2.5 values over time without being aware of it. These high values can be dangerous by causing or worsening health conditions, such as cardiovascular and lung diseases. Within …

Multilevel Optimization With Dropout For Neural Networks, Gary Joseph Saavedra

Mathematics & Statistics ETDs

Large neural networks have become ubiquitous in machine learning. Despite their widespread use, the optimization process for training a neural network remains com-putationally expensive and does not necessarily create networks that generalize well to unseen data. In addition, the difficulty of training increases as the size of the neural network grows. In this thesis, we introduce the novel MGDrop and SMGDrop algorithms which use a multigrid optimization scheme with a dropout coarsening operator to train neural networks. In contrast to other standard neural network training schemes, MGDrop explicitly utilizes information from smaller sub-networks which act as approximations of the full …

Using Physics-Informed Neural Networks For Multigrid In Time Coarse Grid Equations, Jonathan P. Gutierrez

Mathematics & Statistics ETDs

For parallel-in-time integration methods, the multigrid-reduction-in-time (MGRIT) method has shown promising results in both improved convergence and increased computational speeds when solving evolution problems. However, one problem the MGRIT algorithm currently faces is it struggles solving hyperbolic problems efficiently. In particular, hyperbolic problems are generally solved using explicit methods and this causes issues on the coarser multigrid levels, where larger (coarser) time step sizes can violate the stability condition. In this thesis, physics-informed neural networks (PINNs) are used to evaluate the coarse grid equations in the MGRIT algorithm with the goal to improve convergence for problems with hyperbolic behavior, as …

A Statistical Analysis Of The Change In Age Distribution Of Spawning Hatchery Salmon, Rachel Macaulay, Emily Barrett, Grace Penunuri, Eli E. Goldwyn

Spora: A Journal of Biomathematics

Declines in salmon sizes have been reported primarily as a result of younger maturation rates. This change in age distribution poses serious threats to salmon-dependent peoples and ecological systems. We perform a statistical analysis to examine the change in age structure of spawning Alaskan chum salmon Oncorhynchus keta and Chinook salmon O. tshawytscha using 30 years of hatchery data. To highlight the impacts of this change, we investigate the average number of fry/smolt that each age of spawning chum/Chinook salmon produce. Our findings demonstrate an increase in younger hatchery salmon populations returning to spawn, and fewer amounts of fry produced …

An Adaptive Algorithm For `The Secretary Problem': Alternate Proof Of The Divergence Of A Maximizer Sequence, Andrew Benfante, Xiang Xu

OUR Journal: ODU Undergraduate Research Journal

This paper presents an alternate proof of the divergence of the unique maximizer sequence {𝑥∗ 𝑛} of a function sequence {𝐹𝑛(𝑥)} that is derived from an adaptive algorithm based on the now classic optimal stopping problem, known by many names but here ‘the secretary problem’. The alternate proof uses a result established by Nguyen, Xu, and Zhao (n.d.) regarding the uniqueness of maximizer points of a generalized function sequence {𝑆𝜇,𝜎 𝑛 } and relies on the strict monotonicity of 𝐹𝑛(𝑥) as 𝑛 increases in order to show divergence of {𝑥∗ 𝑛}. Towards this, limits of the exponentiated Gaussian CDF are …

Meta-Analysis Of Mesenchymal Stem Cell Gene Expression Data From Obese And Non-Obese Patients, Dakota William Shields

Masters Theses

"The prevalence of gene expression microarray datasets in public repositories gives opportunity to analyze biologically interesting datasets without running the laboratory aspect in house. Such experimentation is expensive in terms of finances, time, and expertise, which often results in low numbers of replicates. Meta-analysis techniques attempt to overcome issues due to few biological or technical replicates by combining separate experiments together to increase statistical power. Proper statistical considerations help to offset issues like simultaneous testing of thousands of genes, unintended hybridization, and other noises.

Microarrays contain light intensities from tens of thousands of hybridized probes giving a measure of gene …

Graphs Without A 2c3-Minor And Bicircular Matroids Without A U3,6-Minor, Daniel Slilaty

Mathematics and Statistics Faculty Publications

In this note we characterize all graphs without a 2C3-minor. A consequence of this result is a characterization of the bicircular matroids with no U3,6-minor.

Novel Bayesian Neural Networks And Uncertainty Quantification Of Computational Mechanics Models, Ponkrshnan Thiagarajan

Dissertations, Master's Theses and Master's Reports

Computational and data-driven models suffer from a wide range of uncertainties that impact the reliability of such models. Given the exponential proliferation of machine learning models in real-world systems, establishing a degree of confidence in their predictions becomes paramount. Reliability in predictions takes on utmost significance in domains such as autonomous driving, medical image analysis, etc., where human lives are involved, and inaccuracies in predictions could lead to disastrous outcomes. For these reasons, comprehending and quantifying uncertainties in computational and data-driven models is of utmost importance. A number of techniques have been developed to quantify uncertainties in machine learning models. …

Beginner's Analysis Of Financial Stochastic Process Models, David Garcia

HMC Senior Theses

This thesis explores the use of geometric Brownian motion (GBM) as a financial model for predicting stock prices. The model is first introduced and its assumptions and limitations are discussed. Then, it is shown how to simulate GBM in order to predict stock price values. The performance of the GBM model is then evaluated in two different periods of time to determine whether it's accuracy has changed before and after March 23, 2020.

Odd Solutions To Systems Of Inequalities Coming From Regular Chain Groups, Daniel Slilaty

Mathematics and Statistics Faculty Publications

Hoffman’s theorem on feasible circulations and Ghouila-Houry’s theorem on feasible tensions are classical results of graph theory. Camion generalized these results to systems of inequalities over regular chain groups. An analogue of Camion’s result is proved in which solutions can be forced to be odd valued. The obtained result also generalizes the results of Pretzel and Youngs as well as Slilaty. It is also shown how Ghouila-Houry’s result can be used to give a new proof of the graph- coloring theorem of Minty and Vitaver.

Longitudinal Sport Science Implementation In American Collegiate Men’S Basketball, Jason Stone

Graduate Theses, Dissertations, and Problem Reports (ETD)

The expanding opportunities to implement sport science frameworks in elite-level basketball environments coincide with the sport’s increasing global prominence. Concomitant to these opportunities is the continual growth of the sport technology market (e.g., wearables, force plates) and computational power (e.g., data management tools, coding capabilities), which yields solutions and challenges for both athletes and practitioners. Due to the rapid influx of new sport technologies in high performance environments, particularly American Collegiate Men’s Basketball, more formal and ecologically valid research on how to effectively utilize data derived from them, particularly over long periods of time (i.e., multiple seasons) is needed. To …

Enhancing Control Room Operator Decision Making: An Application Of Dynamic Influence Diagrams In Formaldehyde Manufacturing, Joseph Mietkiewicz, Anders L. Madsen

Articles

Intoday’s rapidly evolving industrial landscape, control room operators must grapple with an ever-growing array of tasks and respon sibilities. One major challenge facing these operators is the potential for task overload, which can lead to decision fatigue and increased reliance on cognitive biases. To address this issue, we propose the use of dynamic influence diagrams (DID) as the core of our decision support system. By monitoring the process over time and identifying anomalies, DIDs can recommend the most effective course of action based on a probabilistic assessment of future outcomes. Instead of letting the operator choose or search for the …

Early Termination In Phase Ii Clinical Trials: Admissible Designs Using Decreasingly Informative Priors, Chen Wang

Theses and Dissertations

In Phase II clinical trials, Thall and Simon’s Bayesian posterior probability design is commonly implemented to allow for an early termination to determine whether a new treatment warrants further investigation in a larger-scale Phase III trial; this in turn requires a pre-selected prior distribution based on known clinical opinion or historical information. Moreover, this Bayesian approach can result in an issue of inflating type I error rate by monitoring interim data to inform early termination decisions. Alternatively, a Bayesian approach with the decreasingly informative prior (DIP), which is an informative yet skeptical prior, can be implemented to overcome the contentious …

Hamilton Cycles In Bidirected Complete Graphs, Arthur Busch, Mohammed A. Mutar, Daniel Slilaty

Mathematics and Statistics Faculty Publications

Zaslavsky observed that the topics of directed cycles in directed graphs and alternating cycles in edge 2-colored graphs have a common generalization in the study of coherent cycles in bidirected graphs. There are classical theorems by Camion, Harary and Moser, Häggkvist and Manoussakis, and Saad which relate strong connectivity and Hamiltonicity in directed "complete" graphs and edge 2-colored "complete" graphs. We prove two analogues to these theorems for bidirected "complete" signed graphs.

Mitigation Impact Of Statewide Non-Pharmaceutical Policies On Covid-19: An Application Of Infectious Disease Transmission Model And Partially Observed Markov Process To New Mexico, Xingya Ma

Mathematics & Statistics ETDs

This thesis is an application of epidemiological models for infectious disease transmission and the use of partially observed Markov process (POMP) for model fitting. It focuses on COVID-19 pandemic in the state of New Mexico. The analysis covered March 2020 to June 2021. Daily data of COVID19 cases and deaths and a daily index of eleven statewide government non-pharmaceutical intervention (NPI) policies were collected from six public sources and were validated. These data were integrated through the Susceptible-Exposed-Infected-Removed (SEIR) model. Estimated daily transmission rates between the model compartments quantify the impact of the mitigation policies, and show that transmission rates …

(R1971) Analysis Of Feedback Queueing Model With Differentiated Vacations Under Classical Retrial Policy, Poonam Gupta, Naveen Kumar, Rajni Gupta

Applications and Applied Mathematics: An International Journal (AAM)

This paper analyzes an M/M/1 retrial queue under differentiated vacations and Bernoulli feedback policy. On receiving the service, if the customer is not satisfied, then he may join the retrial group again with some probability and demand for service or may leave the system with the complementary probability. Using the probability generating functions technique, the steady-state solutions of the system are obtained. Furthermore, we have obtained some of the important performance measures such as expected orbit length, expected length of the system, sojourn times and probability of server being in different states. Using MATLAB software, we have represented the graphical …

(R1984) Analysis Of M^[X1], M^[X2]/G1, G_2^(A,B)/1 Queue With Priority Services, Server Breakdown, Repair, Modified Bernoulli Vacation, Immediate Feedback, G. Ayyappan, S. Nithya, B. Somasundaram

Applications and Applied Mathematics: An International Journal (AAM)

In this investigation, the steady state analysis of two individualistic batch arrival queues with immediate feedback, modified Bernoulli vacation and server breakdown are introduced. Two different categories of customers like priority and ordinary are to be considered. This model propose nonpreemptive priority discipline. Ordinary and priority customers arrive as per Poisson processes. The server consistently afford single service for priority customers and the general bulk service for the ordinary customers and the service follows general distribution. The ordinary customers to be served only if the batch size should be greater than or equal to "a", else the server should not …

Efficient Hierarchical Space-Time Models For Large Areal Datasets With Application To Forest Inventory Mapping Using Remote Sensing Imagery, Md Kamrul Hasan Khan

Graduate Theses and Dissertations

The focus of this dissertation is development of a novel hierarchical framework, that can be used for predictive modeling of Forest Inventory and Analysis (FIA) data over large regions. This dissertation has two significant contributions. Based on a study region in north-central Wisconsin, we analyze satellite imagery, along with a sample of national forest inventory field plots, to monitor and predict changes in forest conditions over time. The auxiliary data from the satellite imagery of this region are relatively dense in space and time, and can be used to learn how forest conditions changed over that decade. However, these records …

Statistical Methods For Meta-Analysis In Large-Scale Genomic Experiments, Wimarsha Thathsarani Jayanetti

Mathematics & Statistics Theses & Dissertations

Recent developments in high throughput genomic assays have opened up the possibility of testing hundreds and thousands of genes simultaneously. With the availability of vast amounts of public databases, researchers tend to combine genomic analysis results from multiple studies in the form of a meta-analysis. Meta-analysis methods can be broadly classified into two main categories. The first approach is to combine the statistical significance (pvalues) of the genes from each individual study, and the second approach is to combine the statistical estimates (effect sizes) from the individual studies. In this dissertation, we will discuss how adherence to the standard null …

Convexity Of Regularized Optimal Transport Dissimilarity Measures For Signed Signals, Christian P. Fowler

Mathematics & Statistics ETDs

Debiased Sinkhorn divergence (DS divergence) is a distance function of

regularized optimal transport that measures the dissimilarity between two

probability measures of optimal transport. This thesis analyzes the advantages of

using DS divergence when compared to the more computationally expensive

Wasserstein distance as well as the classical Euclidean norm. Specifically, theory

and numerical experiments are used to show that Debiased Sinkhorn divergence

has geometrically desirable properties such as maintained convexity after data

normalization. Data normalization is often needed to calculate Sinkhorn

divergence as well as Wasserstein distance, as these formulas only accept

probability distributions as inputs and do not directly …

Statistical Methods For Differential Gene Expression Analysis Under The Case-Cohort Design, Lidong Wang

Mathematics & Statistics ETDs

Differential gene expression analysis has the potential to discover candidate biomarkers, therapeutic targets, and gene signatures. How to save money when using an unaffordable sample is a practical question. The case-cohort (CCH) study design can blend the economy of case-control studies with the advantages of cohort studies. But it has not been seen in the medical research literature where high-throughput genomic data were involved.

A score test does not need to fit the Cox PH model iteratively; hence, it can save computing time and avoid potential convergence issues. We developed a score test under the CCH design to identify DEGs …