Applied Mathematics Commons^™

Multiscale Modelling Of Brain Networks And The Analysis Of Dynamic Processes In Neurodegenerative Disorders, Hina Shaheen

Theses and Dissertations (Comprehensive)

The complex nature of the human brain, with its intricate organic structure and multiscale spatio-temporal characteristics ranging from synapses to the entire brain, presents a major obstacle in brain modelling. Capturing this complexity poses a significant challenge for researchers. The complex interplay of coupled multiphysics and biochemical activities within this intricate system shapes the brain's capacity, functioning within a structure-function relationship that necessitates a specific mathematical framework. Advanced mathematical modelling approaches that incorporate the coupling of brain networks and the analysis of dynamic processes are essential for advancing therapeutic strategies aimed at treating neurodegenerative diseases (NDDs), which afflict millions of …

A Class Of Game-Theoretic And Fokker-Planck Optimal Control Frameworks In Colon And Esophageal Cancer, Mesfer Alajmi Phd

Mathematics Dissertations - Archive

In this dissertation, we first present a new stochastic framework for parameter estimation and uncertainty quantification in colon cancer-induced immune responses. A stochastic process that captures the system's inherent randomness determines the dynamics of colon cancer. The stochastic framework is based on the Fokker-Planck equation, which represents the evolution of the probability density function corresponding to the stochastic process. We formulate an optimization problem that takes individual patient data with randomness present and solves it to obtain the unknown parameters corresponding to the individual tumor characteristics. Furthermore, we perform a sensitivity analysis of the optimal parameter set to identify the …

A Novel Scheme Based On Bessel Operational Matrices For Solving A Class Of Nonlinear Systems Of Differential Equations, Atallah El-Shenawy, Mohamed El-Gamel, Muhammad E. Anany

Mansoura Engineering Journal

The system of ordinary differential equations arises in many natural phenomena, especially in the field of disease spread. In this paper, a perfect spectral technique is introduced to solve systems of nonlinear differential equations. The technique enhanced the Bessel collocation technique by converting the series notation of unknown variables and their derivatives to matrix relations. The Newton algorithm is developed to solve the resulting nonlinear system of algebraic equations. The effectiveness of the scheme is proved by the convergence analysis and error bound as demonstrated in Theorem 1. The scheme of solution is tested to clarify the efficiency and the …

Characterizing Probabilities Of Outbreaks Of Dengue In Central Argentina Using A Temperature-Dependent Stochastic Model, Morgan H. Jackson, Elizabet L. Estallo, Cheng Ly, Michael A. Robert

Graduate Research Posters

Dengue virus (DENV) causes over 390 million infections and around 40,000 deaths worldwide each year. DENV is primarily transmitted by the mosquito Aedes aegypti, and both the life cycle of these mosquitoes and dengue transmission are significantly impacted by temperature. In the temperate region of Central Argentina, where dengue outbreaks first began in 2009, outbreaks of dengue can only occur due to new introductions of DENV from other regions. Due to the relationships between temperature and dengue, the risk of outbreak changes throughout the year.

We develop a stochastic model including temperature-dependent mosquito life history traits and transmission-related parameters. …

Advanced Techniques In Time Series Forecasting: From Deterministic Models To Deep Learning, Xue Bai

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation discusses three instances of temporal prediction, applied to population dynamics and deep learning.

In population modeling, dynamic processes are frequently represented by systems of differential equations, allowing for the analysis of various phenomena. The first application explores modeling cloned hematopoiesis in chronic myeloid leukemia (CML) via a nonlinear system of differential equations. By tracking the evolution of different cell compartments, including cycling and quiescent stem cells, progenitor cells, differentiated cells, and terminally differentiated cells, the model captures the transition from normal hematopoiesis to the chronic and accelerated-acute phases of CML. Three distinct non-zero steady states are identified, representing …

Estimating Modeling Parameters For Covid-19 Spread On Campus, Aviel S. Crigger

Honors Undergraduate Theses

Understanding the true burden of community transmission of communicable diseases like COVID-19 is crucial for effective public health response. Clinical cases, while important, only represent a fraction of the actual disease prevalence within a population. In this thesis, we investigate methods to estimate parameters that link clinical cases to the true disease prevalence using a modified compartmental model known as SICR (Susceptible, Infected, Cases, Recovered). We employ Bayesian inference and ensemble Markov chain Monte Carlo (MCMC) simulations to analyze clinical case data provided by the University of Central Florida Health Center from 2020 to 2022. Our goal is to estimate …

Mathematical Modeling And Analysis Of Inflammation And Tissue Repair: Lung Inflammation And Wound Healing In Corals Under Stress, Quintessa Hay

Theses and Dissertations

A variety of insults, including tissue injury and/or exposure to pathogen, elicit an immune response in many organisms. An improperly regulated immune response can result in deleterious effects to the organism. Here we present models for lung injury in young and old mice and models for wound healing in coral reefs.

It is well known that the immune response becomes less effective in older individuals. This is of particular interest in pulmonary insults such as ventilator induced lung injury (VILI) or lung infection. We extended a mathematical model for the inflammatory response to VILI and used experimental data to select …

Mathematical Analysis Of Eukaryotic Pericentromere, Puranjan Ghimire

Theses and Dissertations

The centromere is crucial for chromosomal stability and their proper segregation during cell division in eukaryotes. Surrounding the centromere are pericentromeres, made of repetitive DNA elements called pericentromeric repeats, varying from 10 in fission yeast to thousands in humans. These repeats form densely packed heterochromatin, where genes are usually silenced. The silencing mechanism across different pericentromeric repeats remains unclear.

Despite variations in sequence and length, pericentromeric repeats are conserved across eukaryotes, indicating their functional importance. This dissertation presents mathematical models to quantify gene silencing in fission yeast and humans. In fission yeast, my model predicts that silencing occurs only with …

Mathematical Modeling Of Phage-Bacteria Population Dynamics, John Lawrence D. Palacios

Theses and Dissertations

Bacteriophages are viruses that infect and replicate within bacteria. Lytic phages cause the bacterial cell to burst, killing the bacteria. These types of phages can be used to treat patients with antibiotic-resistant bacterial infections. As a step in developing successful treatment protocols, we aim to understand the population dynamics of phages and bacteria using an in vitro model. We model the dynamics using the Campbell model, which consists of a delay differential equation (DDE), as a base model. We extended the model by including the emergence of phage resistance. We then compared the DDE model with a parallel ordinary differential …

Analyzing A Smartphone Battle Using Bass Competition Model, Maila Hallare, Alireza Hosseinkhan, Hasala Senpathy K. Gallolu Kankanamalage

CODEE Journal

Many examples of 2x2 nonlinear systems in a first-course in ODE or a mathematical modeling class come from physics or biology. We present an example that comes from the business or management sciences, namely, the Bass diffusion model. We believe that students will appreciate this model because it does not require a lot of background material and it is used to analyze sales data and serve as a guide in pricing decisions for a single product. In this project, we create a 2x2 ODE system that is inspired by the Bass diffusion model; we call the resulting system the Bass …

Reducing Food Scarcity: The Benefits Of Urban Farming, S.A. Claudell, Emilio Mejia

Journal of Nonprofit Innovation

Urban farming can enhance the lives of communities and help reduce food scarcity. This paper presents a conceptual prototype of an efficient urban farming community that can be scaled for a single apartment building or an entire community across all global geoeconomics regions, including densely populated cities and rural, developing towns and communities. When deployed in coordination with smart crop choices, local farm support, and efficient transportation then the result isn’t just sustainability, but also increasing fresh produce accessibility, optimizing nutritional value, eliminating the use of ‘forever chemicals’, reducing transportation costs, and fostering global environmental benefits.

Imagine Doris, who is …

Controlled Manipulation And Transport By Microswimmers In Stokes Flows, Jake Buzhardt

All Dissertations

Remotely actuated microscale swimming robots have the potential to revolutionize many aspects of biomedicine. However, for the longterm goals of this field of research to be achievable, it is necessary to develop modelling, simulation, and control strategies which effectively and efficiently account for not only the motion of individual swimmers, but also the complex interactions of such swimmers with their environment including other nearby swimmers, boundaries, other cargo and passive particles, and the fluid medium itself. The aim of this thesis is to study these problems in simulation from the perspective of controls and dynamical systems, with a particular focus …

(R2056) Convergence Criteria For Solutions Of A System Of Second Order Nonlinear Differential Equations, Akinwale Olutimo

Applications and Applied Mathematics: An International Journal (AAM)

In this paper, we investigate the convergence of solutions of certain nonlinear system of two differential equations using a suitable Lyapunov functional with sufficient conditions to establish our new result. An example is given to demonstrate the effectiveness of the result obtained and geometric argument to show that the solutions of the system are better rapidly converging under the criteria obtained.

Game-Theoretic Approaches To Optimal Resource Allocation And Defense Strategies In Herbaceous Plants, Molly R. Creagar

Department of Mathematics: Dissertations, Theses, and Student Research

Empirical evidence suggests that the attractiveness of a plant to herbivores can be affected by the investment in defense by neighboring plants, as well as investment in defense by the focal plant. Thus, allocation to defense may not only be influenced by the frequency and intensity of herbivory but also by defense strategies employed by other plants in the environment. We incorporate a neighborhood defense effect by applying spatial evolutionary game theory to optimal resource allocation in plants where cooperators are plants investing in defense and defectors are plants that do not. We use a stochastic dynamic programming model, along …

(R2059) Modeling The Spread Of Coronavirus With Self-Protection And Quarantine Effect, Dileep Sharma, Agraj Tripathi, Ram Naresh Tripathi

Applications and Applied Mathematics: An International Journal (AAM)

A nonlinear mathematical model to study the effect of transmission dynamics of COVID-19 virus in a population with variable size structure is proposed and analyzed. The model divides the total human population into five subclasses: susceptibles, self-protected susceptibles, infectives, quarantined infectives, and recovered population including a class representing cumulative density of coronavirus in the environmental reservoir. The model exhibits two equilibria, namely, the diseasefree and the endemic equilibrium. Model analysis reveals the global dynamics of the spread of COVID-19 is completely determined by the basic reproduction number. If basic reproduction number is greater than one, the endemic equilibrium is locally …

(R2061) Differential Equations Involving A New Definition Of Complex Number Derivatives, Mehmet Pakdemirli

Applications and Applied Mathematics: An International Journal (AAM)

The recently proposed complex number differential operator is used in formulating ordinary differential equations for the first time. The differential operator definition is totally different than the real number differentiation of complex valued functions. The basic definitions and properties of the differential operator are given first. Various linear differential equations are treated containing the new differential operator. Associated theorems with the differential equations are given. Then the nonlinear differential equations of complex valued functions are treated. In separated form, the complex differential operator equations lead to nonlinear coupled real valued equations. Various nonlinear differential equations with complex number derivatives are …

Long-Acting Cabotegravir And The Emergence Of Drug-Resistant Hiv, Katharine Gurski

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Utilizing Non-Negative Least Squares For Data-Driven Discovery Of Dynamics, Tracey G. Oellerich

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Effect Of Under-Reporting, Vaccine Efficiency And Social Behavior On Epidemic Progression, Samiran Ghosh, Samiran Ghosh

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Incorporating Adaptive Human Behavior Into Epidemiological Models Using Equation Learning, Austin Barton, Jordan Klein, Jonathan Greer, Kevin Flores, Patrick Haughey

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

An Ode Model For Investigating The Sleep-Pain Relationship In Sickle Cell Disease, Quindel Jones, Angela Reynolds, Rebecca Segal, Reginald Mcgee

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Baa-Ttling Sore Mouth In Sheep With Mathematical Modeling, David C. Elzinga, W. Christopher Strickland

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Understanding Impact Of Educational Awareness And Vaccines As Optimal Control Mechanisms For Changing Human Behavior In Disease Epidemics, Manal Badgaish, Dr. Padmanabhan Seshaiyer

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Parameter Estimation In Epidemiological And Climate Models Using Ensemble Smoothing With Multiple Data Assimilation, Emmanuel Fleurantin

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Modeling-Forward Initiatives In Differential Equations, Laura Ellwein

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Modeling, Analysis, And Simulation Of High School Student Mental Health Using Compartmental Models And Physics Informed Neural Networks, Sashwat Ravishankar, Padmanabhan Seshaiyer

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Thoracoabdominal Asynchrony In A Virtual Preterm Infant: Computational Modeling And Analysis, Richard R. Foster, Bradford Smith, Laura Ellwein Fix

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Nutrient Driven Dynamics Of Ecosystem Diseases, Rebecca Everett

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Modeling Multiphage-Bacteria Kinetics To Predict Phage Therapy Outcomes, Rebecca Segal, Zhiyuan Yu, Tiffany Luong, Selenne Banuelos, Andrew Sue, Mary Ann Horn, Hwayeon Ryu, Qimin Huang, Dwayne Roach

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Optimal Harvest Control Within A Predator-Prey System: A Case Study In Chesapeake Bay Fishes, Iordanka Panayotova

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.