Physical Sciences and Mathematics Commons^™

The Fast And The Curious: Accelerating Literature Reviews With Ai, Jennifer Freer, Natalia Tingle Dolan, Gabrielle Wiersma

Presentations and other scholarship

As the world of academic research shifts gears into the digital age, AI-powered tools are beginning to shape the scholarly landscape. Just as high-performance vehicles transformed the world of car racing, AI-powered tools like scite, Elicit, and Research Rabbit have the potential to revolutionize the traditional literature review process. This presentation will accelerate your understanding of AI literature review tools and how these technologies can turbocharge the research process. Navigating between traditional library tools and AI-powered systems can be like choosing the right vehicle for the race. AI tools can enhance the speed, depth, and breadth of literature reviews, allowing …

An Investigation Of The Relationship Between Math Curricula And Students' College Readiness, Nancy A. Deluca

Scholar Week 2016 - present

State learning standards with increased rigor have required higher levels of achievement from students on standardized tests, high-school grades, and national percentile ranks which are used for collegiate acceptance and course placement. As a result, preparation of students for standardized tests such as the ACT and SAT have become increasingly more challenging. The current quantitative, quasi-experimental study examined the relationship between the tangible math curricula used for instruction and students’ readiness for collegiate coursework. From sample sizes of 128 and 169 high-school students in two consecutive school years, there were several statistically significant relationship differences. Analysis of test results indicated …

Synthesis Of Cyclopropyl Analogs Of Stereochemically Rigid Probes Of Certain Pharmacological Receptors, Douglas Armstrong, Zachary Emptage, Anderson Verhoeven

Scholar Week 2016 - present

Douglas Armstrong, lead ONU faculty researcher, and his two research students, Zachary Emptage and Anderson Verhoeven, expanded their previous research (centered around acetylcholine and cholinergic activity), to include other types of pharmacological receptors, but again, aiming at the same type of compounds (cyclopropyl) to confer conformational (stereochemical) rigidity. The focus now is on compounds which, like acetylcholine, also contain an oxygen atom and a nitrogen atom separated by two carbon atoms, but which have pharmacological activity other than cholinergic. Several pharmacological categories have this pattern as known medicinal agents (“drugs”), including certain antidepressants, antihistamines, anti-anxiety drugs, etc. For some, there …

Computational Chemistry - Ulk 101, Michaela Montpas

Scholar Week 2016 - present

Autophagy is a process that generates the necessary building components for cells by cytoplasmic breakdown of unnecessary materials (Martin, Celano, Solitro, Gunaydin, Scott, et. al., 2018). This is a survival technique for cells in times of stress, especially during periods of nutrient starvation. Cancer cells, unfortunately, benefit from this process due to their ability to flourish in nutrient-starved environments, becoming resistant to therapy. The primary protein in mammals responsible for this process is a serine/threonine kinase called ULK 1 (unc-51 like autophagy initiating kinase 1). As such, inhibitors of ULK 1 can be used in cancer therapies in order to …

Evaluating The Scalability Of Graphene Synthesis, Evan Dexter

Scholar Week 2016 - present

Graphene is a new material, first isolated in 2004, consisting of one to a few atomic layers of carbon in a lattice sheet structure. Graphene has high tensile strength, high surface area, very low electrical resistance, and various other special properties that make it an excellent material for use in emerging technologies in the categories of electrical components, energy systems, and high strength applications. The production scale of graphene sheets and its variations is currently limited to laboratory use, with a great amount of current research going into the development of manufacturing techniques of the material. I conducted experiments to …

Using Principle Component Analysis To Analyze Tertiary And Quaternary Spectral Mixtures, David Burnett

Scholar Week 2016 - present

CRISM images from Mars are expected to contain carbonates such as magnesite. Prior research has been successfully able to determine the approximate percent composition of phyllosilicates in binary lab mixtures using Principle Component Analysis (PCA). In order to expand this model to work on CRISM images, one of preliminary steps is allowing the algorithm to work on mixtures with more than two components, which was the primary purpose of this research.

Generating Spectra Using Pca-Based Spectral Mixture Models, Joseph S. Makarewicz, Heather D. Makarewicz

Scholar Week 2016 - present

PCA-based spectra mixture models have been created for several laboratory mixture data sets. This presentation provides examples of spectra that were generated using PCA-based spectra mixture models.

Synthesis Of Cyclopropyl Analogs Of Acetylcholine, Douglas Armstrong, Zachary Emptage

Scholar Week 2016 - present

The Ph.D. research by Douglas Armstrong was highly successful for the synthesis of the trans cyclopropyl analog of acetylcholine, but only marginally successful for the cis isomer. In recent years he has developed novel ideas as to how the synthesis of the cis isomer may be improved upon, in ways using more current methods. He has done experiments using some of those methods, and the results, although preliminary, look good.

Microarray Data Analysis And Classification Of Cancers, Grant Gates

Williams Honors College, Honors Research Projects

When it comes to cancer, there is no standardized approach for identifying new cancer classes nor is there a standardized approach for assigning cancer tumors to existing classes. These two ideas are known as class discovery and class prediction. For a cancer patient to receive proper treatment, it is important that the type of cancer be accurately identified. For my Senior Honors Project, I would like to use this opportunity to research a topic in bioinformatics. Bioinformatics incorporates a few different subjects into one including biology, computer science and statistics. An intricate method for class discovery and class prediction is …

Minutes & Seconds: The Scientists, Patrick Aievoli

Zea E-Books Collection

Minutes & Seconds, is a captivating intelligible read for those who strive to understand where the “what if” moment has gone. Succeeding his other captivating books, Aievoli’s deep introspective lens dials his readers in to awaken the proverbial sleeping giant inside of our consciousness. He designs an insightful exciting romp through the surreal landscape of our society and illustrates how various pioneers have lead us to a crossroads. I’m truly impressed with Aievoli’s perspicacious comprehension of where digital has taken us through the hands of these select individuals. --Sequoyah Wharton

In creating Minutes & Seconds, Aievoli has assembled an interesting …

Spectral Mixture Modeling Using Principle Component Analysis, Joseph S. Makarewicz, Heather D. Makarewicz

Scholar Week 2016 - present

A method for modeling mixtures between two end-member spectra using principle component analysis and linear regression was presented. The presentation included results from three binary mixture data sets including orthopyroxene-clinopyroxene, kaolinite-montmorillonite, and nontronite-ferrihydrite.

Effect Of An Arginine-To-Isoleucine Active Site Mutation On Escherichia Coli Malate Dehydrogenase Enzymatic Activity, Jon Zatorski, Bruce J. Heyen

Scholar Week 2016 - present

Citric acid cycle enzymes function in an environment with numerous substrate analogues and therefore contain active site residue organizations that confer high substrate specificity. Extensive research into the catalytic mechanism of Escherichia coli malate dehydrogenase (eMDH) has identified arginine81 as being crucial to catalysis. In this investigation, an engineered eMDH having an Ile81 rather than an Arg81 (R81I) was isolated using a hexahistadine (His6) tag. Enzymatic activity of the R81I mutant with respect to malate, lactate, and pyruvate was explored. The R81I mutant did show significant activity toward malate, but did not show significant activity toward lactate or pyruvate. Investigations …

Design And Evaluation Of 3d-Printed Filar Micrometer, Emily Rull

Scholar Week 2016 - present

This project sought to design and 3D-print a filar micrometer for double star measurements that amateur astronomers could produce cost effectively.

Double stars are celestial objects that allow the mass of stars to be calculated by assessing their orbits. Stellar mass affects every current model of stellar evolution, but the most accurate double star orbits can take decades to record. As a result of the long-term nature of such observations and lack of groundbreaking research in double star studies, professional astronomers are no longer focused on making these measurements. This allows amateur astronomers to pick up where professionals have left …

Discovery Of Community Structures In Static And Dynamic Networks, Shiwen Shen

Theses and Dissertations

With the development of computer technology, researchers are able to observe and collect enormous amount of data, where the independent and identical distributed assumption is violated. For example, in sociology, individuals in an organization interact with each other to change the underlying social structure; in biology, understanding the gene-gene interaction helps researchers to detect potential diseases; in politics, voters are mutually influenced before the election via private/public speeches and parades, which might ultimately change the election results. It is crucial to study how individuals interact with each other from the data, which would lead to tremendous contributions to the society. …

A Spatial Collaboration: Building A Multi-Institution Geospatial Data Discovery Portal, Mara Blake, Karen Majewicz, Ryan Mattke, Kathleen W. Weessies

Collaborative Librarianship

As academic education and research increasingly take advantage of geospatial data and methodologies, we see a corresponding exponential growth in the number of available geospatial resources in the form of GIS datasets and scanned historical maps. However, users can experience difficulty finding these resources due to the unconnected multitude of platforms and clearinghouses that host them. Additionally, the resources are not always well described with web semantic metadata that facilitates discovery. In response to this challenge, The Big Ten Academic Alliance Geospatial Data Project began in 2015 to provide discoverability, facilitate access, and connect scholars to geospatial resources. Our project …

A Tournament Approach To Price Discovery In The Us Cattle Market, Jeffrey Wright

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Cattle price discovery is a process of determining the price in the market through the interactions of cattle buyers (packers) and sellers (ranchers). Locating the price discovery center or market, and estimating price interactions among the regional fed cattle markets and also among feeder cattle markets can help define a relevant fed cattle procurement market. This research identifies that the U.S. cattle markets is discovered in the futures markets, feeder cattle futures and fed futures.

Overcoming The Adverse Impact Of Internal Subculture Communications Within Organizations, Terrence Lee Farrier

Walden Dissertations and Doctoral Studies

The need for clear and organizationally effective communications is necessary to maintain sustainability as competition increases. Current research has not addressed problems associated with senior managers' clarity and intent and the misinterpretation by midlevel managers of that intent, causing division managers to misinterpret the company plans. Unresolved miscommunications may lead to destructive subculture development. This mixed methods design focused on how to minimize the confusion that manifests between senior and midlevel management within diverse and decentralized decision support structures. The secondary purpose was to advocate for the identification of divisional misalignment and provide information for a tool to help senior …

Two Roads, One Destination: A Journey Of Discovery, Karen Joc, Peta J. Hopkins, Jessie Donaghey, Wendy Abbott

Peta Hopkins

The adoption of resource discovery platforms has been a growing trend in libraries. However, few libraries have reported on the transition from one discovery layer to another, and only a few institutions have discussed two discovery layers available in the same institution at the same time. Bond University Library recently implemented Alma as its library management system, and with this change a new discovery platform, Primo, was implemented to supersede the existing Summon platform. This paper presents the results of a usability study undertaken at Bond University Library in the move from one discovery layer to another.

Two Roads, One Destination: A Journey Of Discovery, Karen Joc, Peta J. Hopkins, Jessie Donaghey, Wendy Abbott

Karen Joc

The adoption of resource discovery platforms has been a growing trend in libraries. However, few libraries have reported on the transition from one discovery layer to another, and only a few institutions have discussed two discovery layers available in the same institution at the same time. Bond University Library recently implemented Alma as its library management system, and with this change a new discovery platform, Primo, was implemented to supersede the existing Summon platform. This paper presents the results of a usability study undertaken at Bond University Library in the move from one discovery layer to another.

Two Roads, One Destination: A Journey Of Discovery, Karen Joc, Peta J. Hopkins, Jessie Donaghey, Wendy Abbott

Wendy Abbott

The adoption of resource discovery platforms has been a growing trend in libraries. However, few libraries have reported on the transition from one discovery layer to another, and only a few institutions have discussed two discovery layers available in the same institution at the same time. Bond University Library recently implemented Alma as its library management system, and with this change a new discovery platform, Primo, was implemented to supersede the existing Summon platform. This paper presents the results of a usability study undertaken at Bond University Library in the move from one discovery layer to another.

Two Roads, One Destination: A Journey Of Discovery, Karen Joc, Peta J. Hopkins, Jessie Donaghey, Wendy Abbott

Wendy Abbott

The adoption of resource discovery platforms has been a growing trend in libraries. However, few libraries have reported on the transition from one discovery layer to another, and only a few institutions have discussed two discovery layers available in the same institution at the same time. Bond University Library recently implemented Alma as its library management system, and with this change a new discovery platform, Primo, was implemented to supersede the existing Summon platform. This paper presents the results of a usability study undertaken at Bond University Library in the move from one discovery layer to another.

Book Review: Love And Math: The Heart Of Hidden Reality By Edward Frenkel, Emily R. Grosholz

Journal of Humanistic Mathematics

This review traces Edward Frenkel’s attempt to convey the excitement of mathematical research to a popular audience. In his expositions and explanations of his own research program, he shows how processes of mathematical discovery depend on the juxtaposition of various iconic and symbolic modes of representation as disparate fields of research are brought together in the service of problem solving. And he shows how crucial the encouragement of various older mathematicians was to his own development, as they guided his choice of problems, and served as inspiration.

Discovery Of X-Ray Pulsations From A Massive Star., Lidia Oskinova, Yael Nazé, Helge Todt, David Huenemoerder, Richard Ignace, Swetlana Hubrig, Wolf-Rainer Hamann

ETSU Faculty Works

X-ray emission from stars much more massive than the Sun was discovered only 35 years ago. Such stars drive fast stellar winds where shocks can develop, and it is commonly assumed that the X-rays emerge from the shock-heated plasma. Many massive stars additionally pulsate. However, hitherto it was neither theoretically predicted nor observed that these pulsations would affect their X-ray emission. All X-ray pulsars known so far are associated with degenerate objects, either neutron stars or white dwarfs. Here we report the discovery of pulsating X-rays from a non-degenerate object, the massive B-type star ξ1 CMa. This star is a …

Chemical Literature Databases: Conflict Of Interest?, Belinda L. Hurley

Library Philosophy and Practice (e-journal)

A publisher of a research database controls the search algorithms of its database and, at a minimum, partially controls the indexing metadata attached to journal articles indexed in its database. A publisher of a journal partially controls the indexing metadata attached to articles in that journal. A publisher who publishes both a research database and journals that are indexed in that database has significant control over two major aspects of the discovery process. This allows the possibility for a publisher to introduce a bias into its algorithm that could favor discovery of its own articles. This work looks at search …

Expert Mining And Required Disclosure, Jonah B. Gelbach

All Faculty Scholarship

No abstract provided.

Induced Pluripotent Stem Cells As Tools For Disease Modelling And Drug Discovery In Alzheimer's Disease, Lezanne Ooi, Kuldip Sidhu, Anne Poljak, Greg Sutherland, Michael D. O'Connor, Perminder Sachdev, Gerald Munch

Faculty of Science - Papers (Archive)

Alzheimer’s disease (AD) is a progressive neurodegenerative brain disorder that leads to a progressive decline in a person’s memory and ability to communicate and carry out daily activities. The brain pathology in AD is characterized by extensive neuronal loss, particularly of cholinergic neurons, intracellular neurofibrillary tangles composed of the tau protein (NFTs) and extracellular deposition of plaques composed of β-amyloid (Aβ), a cleavage product of the amyloid precursor protein (APP). These two insoluble protein aggregates are accompanied by a chronic inflammatory response and extensive oxidative damage. Whereas dys-regulation of APP expression or processing appears to be important for the familial, …

Towards Qos-Based Web Services Discovery, Jun Yan, Jingtai Piao

Dr Jun Yan

The current UDDI-based web services discovery technologies are designed to discover services which can satisfy consumers’ functional requirements. The consumers’ non-functional requirements such as quality of services are largely ignored in discovery. This may lead to the problem that the services returned from discovery are ineffective and even useless. To solve this problem, this paper presents an approach to achieving QoS-based Web services discovery. Data structures are proposed for both service providers and service consumers to describe non-functional information about services. A serial of algorithms are developed for matching and ranking services according to consumers’ non-functional requirements.

Business Rules Discovery From Process Design Repositories, Jantima Polpinij, Aditya K. Ghose, Hoa Khanh Dam

Professor Aditya K. Ghose

Traditional process mining approaches focus on extracting process constraints or business rules from repositories of process instances. In this context, process designs or process models tend to be overlooked although they contain information that are valuable for the process of discovering business rules. This paper will propose an alternative approach to process mining in terms of using process designs as the mining resources. We propose a number of techniques for extracting business rules from repositories of business process designs or models, leveraging the well-known Apriori algorithm. Such business rules are then used as a prior knowledge for further analysing, verifying, …

Waypoints On A Journey Of Discovery: Mental Models In Human Environment Interactions, Timothy Lynam, Raphael Mathevet, Michel Etienne, Samantha Stone-Jovicich, Anne Leitch, Nathalie Jones, Helen Ross, Derick Du Toit, Sharon Pollard, Harry Biggs, Pascal Perez

Professor Pascal Perez

Although the broad concept of mental models is gaining currency as a way to explore the link between how people think and interact with their world, this concept is limited by a theoretical and practical understanding of how it can be applied in the study of human-environment relationships. Tools and processes are needed to be able to elicit and analyze mental models. Because mental models are not directly observable, it is also important to understand how the application of any tools and processes affects what is measured. Equally important are the needs to be clear on the intent of the …

Business Rules Discovery From Process Design Repositories, Jantima Polpinij, Aditya K. Ghose, Hoa Khanh Dam

Dr Hoa Dam

Traditional process mining approaches focus on extracting process constraints or business rules from repositories of process instances. In this context, process designs or process models tend to be overlooked although they contain information that are valuable for the process of discovering business rules. This paper will propose an alternative approach to process mining in terms of using process designs as the mining resources. We propose a number of techniques for extracting business rules from repositories of business process designs or models, leveraging the well-known Apriori algorithm. Such business rules are then used as a prior knowledge for further analysing, verifying, …