Physical Sciences and Mathematics Commons^™

Challenges And Countermeasures For Treatment And Remediation Of Contaminated Mega-Sites In China, Xiaoyong Liao, Yixuan Hou, You Li, Tianyi Wang

Bulletin of Chinese Academy of Sciences (Chinese Version)

The treatment and remediation of pollution at contaminated mega-sites poses a significant challenge in the environmental science both domestically and internationally. Contaminated mega-sites are characterized by their widespread impact, multiple types of pollutants, and significant ecological and environmental threats. The environmental behavior cognition and efficient remediation at contaminated mega-sites face enormous challenges, among which key technological issues such as the formation mechanism of soil and groundwater pollution, accurate identification of pollution sources, and intelligent decision-making optimization urgently need to be solved. In China, contaminated mega-sites are concentrated in economically developed regions such as Beijing-Tianjin-Hebei, the Yangtze River Economic Belt, and …

Ten Problems And Solutions For Restoration Of Karst Ecosystem In Southwest China, Xiaoyong Bai, Sirui Zhang, Chen Ran, Luhua Wu, Chaochao Du, Lei Dai, Xingyi Yang, Zilin Li, Yingying Xue, Mingkang Long, Minghui Li, Shu Yang, Qing Luo, Xiaoyun Zhang, Xiaoqian Shen, Fei Chen, Qin Li, Yuanhong Deng, Zeyin Hu, Chaojun Li

Bulletin of Chinese Academy of Sciences (Chinese Version)

The karst areas in southwest China are one of the key but difficult areas targeted in the “Beautiful China” construction initiative, which focuses on soil erosion, proportion of farmland, water pollution, karst drought, ecological restoration, carbon sink, ecological effects of urbanization, rocky desertification management indicators, and biodiversity and sustainability assessment. The study synthesizes the knowledge accumulated during ecological restoration practice in karst areas into 10 problems and solutions that are strong, universal and empirically supported. These problems and solutions help to explain the challenges of achieving sustainability in karst ecology restoration and thus point to solutions. They constitute a core …

Research On Geographical Landscape Design Of Ecological Civilization Construction In China, Wenzhong Zhang, Jianhui Yu

Bulletin of Chinese Academy of Sciences (Chinese Version)

As the fundamental goal of ecological civilization construction in the new era of China, the building of a Beautiful China is an important measure to promote the study of Chinese man-land relationships to a higher level and a new stage of development. This study takes the construction of ecological civilization of Beautiful China as the orientation, and carries on the frame design to the geographical landscape. The geographical landscape takes the elements of geoscience as the research object and makes a series of reasonable outlook about man-land system according to the interaction mechanism of human-land relationship and the influence of …

Evolution Of Urbanized Area’S Entities And Flow Space Towards High-Quality Development Path In China, Mingxing Chen, Liangkan Chen, Yue Xian, Jiafan Cheng, Longwu Liang, Jing Ma

Bulletin of Chinese Academy of Sciences (Chinese Version)

The eco-environmental conservation and Beautiful China have entered the critical phase. Urbanized areas serve as important spatial carriers in the Beautiful China initiative scenarios, but the most prominent challenges in human-environment relationship and difficult points in building Beautiful China. This study focuses on the physical urban area, and utilizing big data technology to reexamine the spatiotemporal distribution and grouped evolution characteristics of impervious surface in cities, as well as the structural features of urban flow networks from space of flows. Moreover, preliminary thoughts and policy recommendations are provided for promoting high-quality development in urbanized areas of the new era. More …

Studying The Impact Of The Geospace Environment On Solar Lithosphere Coupling And Earthquake Activity, Dimitar Ouzounov, Galina Khachikyan

Mathematics, Physics, and Computer Science Faculty Articles and Research

In solar–terrestrial physics, there is an open question: does a geomagnetic storm affect earthquakes? We expand research in this direction, analyzing the seismic situation after geomagnetic storms (GMs) accompanied by the precipitation of relativistic electrons from the outer radiation belt to form an additional radiation belt (RB) around lower geomagnetic lines. We consider four widely discussed cases in the literature for long-lived (weeks, months) RBs due to GMs and revealed that the 1/GMs 24 March 1991 with a new RB at L~2.6 was followed by an M7.0 earthquake in Alaska, 30 May 1991, near footprint L = 2.69; the 2/GMs …

Progress And Prospects On Institutional System Construction Of Ecological Civilization In China, Linsheng Yang, Yanan Guo, Huiyi Zhu, Gaodi Xie, Xiaoyong Liao, Quansheng Ge

Bulletin of Chinese Academy of Sciences (Chinese Version)

Since the 18th National Congress of the Communist Party of China, the construction of Ecological Civilization (EC) in China has undergone historic, transitional, and comprehensive changes from theory to practice. The construction of system is the core content and the basic guarantee for the success of EC construction. Based on the government documents of EC construction and related research literatures, this study analyzes the formation and evolution characteristics of China’s EC construction system, parses the development process of representative innovation policies, and then predicts the trend of the further deepening reform of EC system. The results show that the relevant …

Synergism Utilization Of Urban Multi-Source Solid Waste And District Green Recycling Development—Taking Dongguan Haixinsha National Resource Recycling Demonstration Base As An Example, Yao Shi, Huiquan Li, Shaohua Chen, Weiqiang Chen, Caihong Xiong, Songgeng Li, Yin Wang, Peng Qian, Shuangde Li, Chao Hua, Ping Lu, Yupeng Liu, Chenmu Zhang, Jianwen Chu, Xin Lu

Bulletin of Chinese Academy of Sciences (Chinese Version)

The long-term storage and extensive disposal of solid waste have caused serious water soil air composite pollution. It is necessary to strengthen the scientific and effective utilization of solid waste, which is not only conducive to solving the major pollution problem of solid waste, but also alleviates the shortage of resources and energy in China. This study summarizes three typical types of urban solid waste comprehensive treatment experience models, and points out that the solid waste circular economy model characterized by centralization, resource utilization, and greening is the main way to solve the complex problem of solid waste. Therefore, it …

Synthetical Solution Of Disaster Risk Reduction And Green Development: A Novel Mode Promoting High-Quality Development In Mountain Areas Of China, Ming Li, Qin Liu, Yukuan Wang, Peng Cui, Xing Gao, Baofeng Di, Jinfeng Liu, Shengwen Qi, Rong Chen, Chunping Tan, Mengzhen Xu, Hao Sun, Jianqiang Zhang, Jiangang Chen, Qiang Zou

Bulletin of Chinese Academy of Sciences (Chinese Version)

China is a mountainous country, with hills, mountains, and plateaus cover about two-thirds of its total land area. The vast area, huge population, rich natural resources, and great potential of development in mountain areas make them the most important “rear garden” supporting the sustainable development of the whole country. Nevertheless, China’s mountain areas are also prone to various kinds of natural disasters, and thus formed a scenario of high overlap between the high-risk zone of natural disasters and the lagging zone of social and economic development. And such scenario has caused significant waste of various related inputs, and becoming a …

Innovation And Practice On Biodiversity Conservation In Sanjiangyuan National Park, Xinquan Zhao, Shixiao Xu, Liang Zhao, Tongzuo Zhang, Linyong Hu, Qi Li, Tongqing Guo

Bulletin of Chinese Academy of Sciences (Chinese Version)

Sanjiangyuan National Park, is one of the first batch of national parks in China, and serves as the largest national park in China. As an important ecological security barrier and a alpine biological germplasm resource base, it has significant conservation value in China and even in the world. Lots of protocols have been taken aiming at ecological tacking protection issues including loss of biodiversity and wildlife habitats, degradation of alpine grassland and overgrazing in Sanjiangyuan National Park. It promotes the implementation of major ecological restoration projects, and has formed the Sanjiangyuan National Park Biodiversity Conservation and Ecological Protection Program with …

Conception On Asian Elephant Ecological Corridor Planning With Implications For Conservation, Xueyou Li, Qiupeng Yu, Zhechang Hu, Xuelong Jiang

Bulletin of Chinese Academy of Sciences (Chinese Version)

In order to practice the concept of coordinated development of “Lucid Waters and Lush Mountains are Invaluable Assets” and “mountains, rivers, forests, farmlands, lakes, grasslands and deserts are part of the community of life”, this study takes “pursuing green development and promoting harmony between humanity and nature” proposed in the report of the 20th National Congress of the Communist Party of China as the theoretical guidance. With the goal of enhancing ecosystem integrity and connectivity, enhancing population communication, enhancing population viability, and providing a model for the construction of ecological corridors for flagship species, based on the current distribution and …

Atmospheric 14Co2 Observation: A Novel Method To Evaluate Carbon Emissions, Zhenchuan Niu, Peng Wang, Shugang Wu, Weijian Zhou

Bulletin of Chinese Academy of Sciences (Chinese Version)

As an important carbon emitter, China faces the stress of carbon peaking and carbon neutrality goals and international carbon reduction duty. The accurate data of carbon emissions are important to evaluate the carbon peaking and carbon neutrality goals and fulfill the international duty of carbon reduction. The Intergovernmental Panel on Climate Change (IPCC) report recommends the combination of top-down atmospheric CO₂ observation with atmospheric inversion to verify the bottom-up inventory of carbon emissions, and the atmospheric ¹⁴CO₂ observation can make the verification more accurate. Radiocarbon (14C) is the most precise tracer of fossil fuel CO₂ and …

Effectiveness And Challenges Of Aquatic Ecological Restoration Of Chishui River In Upper Yangtze River, Fei Liu, Huanzhang Liu

Bulletin of Chinese Academy of Sciences (Chinese Version)

“To set an example of green development and strength ecological environmental protection in the Chishui River basin” is an important proposal listed in the Outline of the 14th Five-Year Plan (2021--2025) for National Economic and Social Development and Vision 2035 of the People’s Republic of China. Strengthening eco-environmental protection in the Chishui River will play an exemplary and leading role in maintaining fish diversity of the upper Yangtze River, promoting regional high-quality development, and creating a new situation of ecological civilization and Beautiful China. This study interprets the ecological functions of the Chishui River in the upper Yangtze River, expounds …

Impacts, Contributing Factors And Countermeasures Of Extreme Droughts In Poyang Lake, Qi Zhang, Chenyang Xue, Jun Xia

Bulletin of Chinese Academy of Sciences (Chinese Version)

In the past 20 years, the hydrological regime of Poyang Lake changed significantly. The lake water level has been continuously decreasing, resulting in severe droughts. In particular, an extreme drought occurred in 2022, when the lake area shrank to less than 300 km2. The 2022 extreme drought in Poyang Lake had great impacts on economy, society and ecological environment, which aroused great attentions and wide concerns. Based on long-term data series of meteorological and hydrological data and the existing research outcomes and with the aid of hydrological modeling, this study analyzed the impacts and contributing factors of the 2022 drought …

An Innovative Restoration Mode “Macrophytes–Fishes–Benthons–Birds” Implemented In Aesthetic Plateau Wetlands, Junxing Yang, Xiaoai Wang, Xiaofu Pan, Yuanwe Zhang, Heqi Wu, Anli Wu

Bulletin of Chinese Academy of Sciences (Chinese Version)

Affected by both increasing human activities and climate change, Yunnan Plateau lakes were faced with threats such as water level decreasing, water-body reducing, and severe pollution. Many indigenous species were endangered or even disappeared. The ecological restorations implemented since 1980s almost all used alien species. As an inevitable result, severe negative impacts from alien species were observed on the Plateau wetland ecosystem and indigenous species. To solve these problems, with the support of relevant projects, an innovative restoration mode mainly with indigenous flag-species “macrophytes – fishes – benthons – birds” was proposed. This innovative mode was implemented respectively in Dianchi …

Control Of Invasive Plant Spartina Alterniflora: Concept, Technology And Practice, Baohua Xie, Guangxuan Han

Bulletin of Chinese Academy of Sciences (Chinese Version)

Alien Species Spartina alterniflora occupy the living space of native animals and plants, and lead to the reduction of biodiversity in the intertidal zone and wetland ecological service functions. Therefore, it is urgent to curb the rapid expansion of S. alterniflora in China’s coastal areas. This paper introduced the invasion situation and main ecological hazards of S. alterniflora in China, as well as put forward the concept of S. alterniflora control of “hazard assessment – zoning control – monitoring and early warning”. We summarized the control technologies of S. alterniflora at home and abroad and the current situation of S. …

Spatial Agglomeration And Environmental Effects Of Heavy Polluting Industries In China: Characteristics And Enlightenment, Hongyang Chen, Jianhui Yu, Wenzhong Zhang

Bulletin of Chinese Academy of Sciences (Chinese Version)

Heavy polluting industries are the important sources of industrial pollutant. Understanding the spatial agglomeration characteristics, influencing factors, agglomeration mechanism and environmental effects of China’s heavy polluting industries can help identify potential pollution risk areas to cope with increasingly severe environmental pollution problems. Based on the industrial economic data from 1999 to 2021, the spatial distribution and agglomeration characteristics of heavy polluting industries are characterized. It is found that: (1) Shandong, Jiangsu, Zhejiang, and Guangdong are the regions with high output value of the development of heavy polluting industries in the past 20 years, while Xinjiang, Inner Mongolia, Shanxi, Shaanxi, Henan, …

Five Issues And Countermeasures Of China Cropland Resource Use, Sijing Ye, Changqing Song, Changxiu Cheng, Peichao Gao, Shi Shen, Wangshu Mu

Bulletin of Chinese Academy of Sciences (Chinese Version)

Understand the cropland use situation, analyze management countermeasures, and explore the regional suitable cropland use mode are important prerequisites for the implementation of the strictest protection of cultivated land strategy with Chinese characteristics. At present, the cropland resource utilization in China is facing the five issues of non-agricultural, non-grain, fragmentation, marginalization, and ecological degradation. This study estimates the spatial-temporal changes of these cropland use issues in China, analyzes the challenges of cropland use governance from the aspects of complex driving factors, phase characteristics, cognitive differences of responsible subjects, and dynamic changes of external factors. On this basis, the countermeasures of …

Prt543, A Protein Arginine Methyltransferase 5 Inhibitor, In Patients With Advanced Adenoid Cystic Carcinoma: An Open-Label, Phase I Dose-Expansion Study, Renata Ferrarotto, Paul Swiecicki, Dan Zandberg, Robert Baiocchi, Robert Wesolowski, Cristina Rodriguez, Meredith Mckean, Hyunseok Kang, Varun Monga, Rajneesh Nath, Neil Palmisiano, Naveen Babbar, William Sun, Glenn Hanna

Department of Medical Oncology Faculty Papers

OBJECTIVES: Currently, no systemic treatments are approved for patients with recurrent and/or metastatic (R/M) adenoid cystic carcinoma (ACC). PRT543, a protein arginine methyltransferase 5 inhibitor that downregulates NOTCH1 and MYB signalling in tumours, is a potential candidate for R/M ACC treatment. We report the safety, tolerability and preliminary efficacy of PRT543 in a dose-expansion cohort of patients with R/M ACC.

MATERIALS AND METHODS: This phase I multicentre, open-label, sequential-cohort, dose-escalation and dose-expansion study (NCT03886831) enrolled patients with advanced solid tumours and select haematologic malignancies. Dose-escalation study design and results were reported previously. In the dose expansion, patients with R/M ACC …

Stereotactic Mr-Guided On-Table Adaptive Radiation Therapy (Smart) For Borderline Resectable And Locally Advanced Pancreatic Cancer: A Multi-Center, Open-Label Phase 2 Study, Michael Chuong, Percy Lee, Daniel Low, Joshua Kim, Kathryn Mittauer, Michael Bassetti, Carri Glide-Hurst, Ann Raldow, Yingli Yang, Lorraine Portelance, Kyle Padgett, Bassem Zaki, Rongxiao Zhang, Hyun Kim, Lauren Henke, Alex Price, Joseph Mancias, Christopher Williams, John Ng, Ryan Pennell, M Raphael Pfeffer, Daphne Levin, Adam Mueller, Karen Mooney, Patrick Kelly, Amish Shah, Luca Boldrini, Lorenzo Placidi, Martin Fuss, Parag Jitendra Parikh

Department of Radiation Oncology Faculty Papers

BACKGROUND AND PURPOSE: Radiation dose escalation may improve local control (LC) and overall survival (OS) in select pancreatic ductal adenocarcinoma (PDAC) patients. We prospectively evaluated the safety and efficacy of ablative stereotactic magnetic resonance (MR)-guided adaptive radiation therapy (SMART) for borderline resectable (BRPC) and locally advanced pancreas cancer (LAPC). The primary endpoint of acute grade ≥ 3 gastrointestinal (GI) toxicity definitely related to SMART was previously published with median follow-up (FU) 8.8 months from SMART. We now present more mature outcomes including OS and late toxicity.

MATERIALS AND METHODS: This prospective, multi-center, single-arm open-label phase 2 trial (NCT03621644) enrolled 136 …

Taking Science To The Streets: Participatory Research Approaches To Improve Environment, Health, And Quality Of Life In Urban Areas, Na'taki Osborne Jelks

Sustainability Seminar Series

Environmental justice communities, those disproportionately affected by pollutants, are simultaneously exposed to multiple environmental stressors and also experience social and cultural factors that may heighten their health risks in comparison to other communities. Availability of fine-grained, community-level data is limited to support said communities’ appeals for public health practice, planning, and policy changes. In Northwest Atlanta, Georgia’s Proctor Creek Watershed community residents (watershed researchers), academics, and non-profit organizations have leveraged local, community knowledge; community science methods; and participatory approaches to identify, document, and analyze the impacts of local environmental hazards and quality of life stressors. This highly collaborative and interdisciplinary …

Social Justice Mathematics: Classroom Practices That Give Students Rigor While Building Agency, Emily Marquise

Masters Theses (Archived)

The purpose of this study is to examine the impact of a social justice approach to mathematics instruction. While many students have math aversion, students in low socioeconomic communities exhibit this to a higher degree putting them at a disadvantage as they progress through their educational career. More than 3.4 million K-12 students in the United States come from families that earn less than the median income yet achieve scores in the top percentile (Wyner et al., 2007). This raises the question of why so many students in low-socioeconomic settings are not given rigorous content that will keep them competitive …

Improving The Quality Of Micronutrient Food Composition Data In Sub-Saharan Africa Using Predictive Analytics, Junior Mbuyamba Muka

Theses and Dissertations

High-quality food composition data are indispensable for decision making in several health, agricultural, and nutrition-related activities. Analytical data are the most accurate type of food composition data (FCD). Yet, most food composition databases (FCDBs) compiled in Sub-Saharan Africa only contain a small amount of analytical data collected from foods consumed in this region. Most of the data are either borrowed / copied from FCDBs collected in other parts of the world, calculated, imputed, or presumed data. Even with these alternative types, FCDBs in Sub-Saharan Africa have not reached a satisfactory level of completeness, as they still have missing data for …

Understanding The Origin, Evolution, And Dynamics Of Transneptunian Binaries, Benjamin C N Proudfoot

Theses and Dissertations

This dissertation discusses research that focuses on understanding transneptunian objects (TNOs) using a variety of techniques and approaches. In Chapter 1, I introduce the main concepts used throughout this dissertation and discuss the current understanding of the transneptunian region. In Chapter 2, I discuss my efforts to understand how Neptune's late stages of migration affect the Haumea family, the only known collisional family in the transneptunian region. Using advanced simulations of Neptune migration, I find that the Haumea family can plausibly form before the termination of giant planet migration and show that this extensively mixes the family. The simplest explanation …

Synthesis And Characterization Of Porphyrin And Phthalocyanine-Based Photosensitizers For Energy And Biomedical Applications, Mavis Forson

Theses and Dissertations

Porphyrins have been widely used as photosensitizers in research due to their important role in many biological processes. Phthalocyanines have also gained interest in biological applications such as photodynamic therapy (PDT). This dissertation is focused on the synthesis of different photosensitizers for various applications. This dissertation's first section focuses on research involving synthesizing covalently bonded donor-acceptor systems as photosensitizers. Specifically in this work, two porphyrin-fullerene dyads were synthesized using a modified tetraphenyl porphyrin with varying bridges between the porphyrin and fullerene. Metal was incorporated in the porphyrin core to enhance the properties of the dyads as photosensitizers. Detailed photophysical properties, …

Final 2023 Residential Metals Abatement Program (Rmap) Brw/Belgrade Borrow Submittal, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Mitigation Of Impacts To Historic Features At The Butte Reduction Works (Brw) Smelter, Kate Mccourt

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Choosing A Sophisticated, Robust, And Secure Programming Language, J. Simon Richard

The Downtown Review: An Interdisciplinary Journal Written and Peer-Reviewed by Mandel Honors College Students at Cleveland State University

This paper explores which programming languages maximize the quality and efficiency of software development projects requiring high levels of sophistication, security, and stability. Of the four languages discussed in this paper—C, C++, Java, and Rust—we conclude that Rust is the best for this application.

Lipid Membrane Self-Assembly And Synthesis In The Lab By Rapid, Low-Cost Microfluidics Approaches, Kathleen Hardwick, Shane O'Reilly

SURE Journal: Science Undergraduate Research Experience Journal

Lipid membranes, which self-assemble in nature and under laboratory conditions, can form vesicles called liposomes. The main uses for liposomes are in drug delivery systems and as animal cell models. From the initial research into lipid membrane science, to the systematic literature review using Web of Science, to refining the project scope, to the description of the method, this project follows the process of developing a method for lipid membrane self-assembly and synthesis in the lab. The result was a rapid prototyping method for fabricating microfluidic devices to test different designs for channels, for use with a liposome synthesis protocol. …

Regulation Of Mirnas In Obesity And Diabetes, Eva Maher, Ava O'Meara, Cathy Brougham

SURE Journal: Science Undergraduate Research Experience Journal

Introduction: The prevalence of obesity and obesity-related secondary disorders has increased dramatically in recent years. Dysregulated microRNA (miRNA) expression has been linked to the development of obesity and its associated disorders. Adipose derived stem cells (ADSCs) are promising cell models of obesity, obesity-related inflammation and diabetes. Furthermore, miRNA expression profiles have emerged as promising targets for the novel treatment of diseases such as obesity. In order to enhance miRNA-based therapies, the miRNA expression profile of obesity and its related disorders must be monitored to further understand the underlying mechanisms of obesity and to identify novel targets.

Aim: The aim of …

The Potential Of Stem Cell Therapy In Multiple Sclerosis Treatment: A Review, Sorina Amarculesei, Ava O'Meara Cushen, Cathy Brougham

SURE Journal: Science Undergraduate Research Experience Journal

Multiple Sclerosis is an autoimmune and neurodegenerative disease of the central nervous system. There are currently 2.8 million people living with Multiple Sclerosis worldwide, including 9000 people in Ireland, with a prevalence of 193 per 100,000 people. Symptoms of Multiple Sclerosis include sensory loss, fatigue, cognitive dysfunction, spasticity, depression, optic neuritis, gait ataxia, diplopia, and loss of bladder control. Currently, there is no standardised treatment or cure for Multiple Sclerosis with many strategies focusing on symptoms. Stem cells have emerged as promising approaches for Multiple Sclerosis therapeutics. Clinical trials primarily focus on mesenchymal stem cell-based therapies for Multiple Sclerosis. Furthermore, …