Physical Sciences and Mathematics Commons^™

A Physiologically-Based Pharmacokinetic Model For Vancomycin, Rebekah White

Undergraduate Honors Theses

Vancomycin is an antibiotic used for the treatment of systemic infections. It is given

intravenously usually every twelve or twenty-four hours. This particular drug has a

medium level of boundedness, with approximately fty percent of the drug being free

and thus physiologically eective. A physiologically-based pharmacokinetic (PBPK)

model was used to better understand the absorption, distribution, and elimination of

the drug. Using optimal parameters, the model could be used in the future to test

how various factors, such as BMI or excretion levels, might aect the concentration

of the antibiotic.

Raman Spectroscopic Analysis Of Oral Squamous Cell Carcinoma And Oral Dysplasia In The High-Wavenumber Region, Hugh Byrne, Luis Felipe Carvalho, Fiona Lyng, Franck Bonnier

Articles

Raman spectroscopy can provide a molecular-level signature of the biochemical composition and structure of cells with excellent spatial resolution and could be useful to monitor changes in composition for early stage and non-invasive cancer diagnosis, both ex-vivo and in vivo. In particular, the fingerprint spectral region (400–1,800 cm^-1) has been shown to be very promising for optical biopsy purposes. However, limitations to discrimination of dysplastic and inflammatory processes based on the fingerprint region still persist. In addition, the Raman spectral signal of dysplastic cells is one important source of misdiagnosis of normal versus pathological tissues. The high wavenumber …

Fecal Microbe Contamination In The Otter Creek Watershed, Madison County, Kentucky, Jacob L. Robin, Walter S. Borowski

EKU Faculty and Staff Scholarship

No abstract provided.

Syneresis And Rheology Mechanisms Of A Latex-Heur Associative Thickener System, Travis Bruno Smith

Master's Theses

Rheology modifiers are used in paints and coatings to ease their application to a surface, prevent sagging once applied, and allow the leveling of brushstrokes, among other benefits. The early rheology modifiers were hydroxyethyl celluloses (HECs), a type of non-associative thickener that is relatively inexpensive and synthesized from cellulose, which is abundant. However, coatings that are modified with HECs tend to suffer from poor leveling and syneresis (phase separation). HECs have since been replaced with associative thickeners (ATs). These thickeners, when properly formulated, produce stable dispersions that have improved rheological properties, yet, unlike HECs, are sensitive to changes to the …

Boundary Conditions As Dynamical Fields, V. Parameswaran Nair, Dimitra Karabali

Publications and Research

The possibility of treating boundary conditions in terms of a bilocal dynamical field is formalized in terms of a boundary action. This allows for a simple path-integral perturbation theory approach to physical effects such as radiation from a time-dependent boundary. The nature of the action which governs the dynamics of the bilocal field is investigated for a limited case (which includes the Robin boundary conditions).

Label Free Analysis Of Native Planktonic P. Aeruginosa Cells And Growth Media By Near Infrared (Nir) Binary Spectronephelometry (Bsn), Steven Ortiz

Dissertations - ALL

Current noninvasive methods are unable to continuously and simultaneously monitor the concentration of cells and chemical components that define the state of native bacterial cultures because of the changing turbidity. We seek to solve this problem without subjecting the growing culture to the risk of contamination afforded by physical sampling. The Binary Spectronephelometry (BSN) algorithm uses laser induced emission to probe mildly turbid media. A training set spanning the linear range of elastic emission (EE) i.e. physical scattering and inelastic emission (IE) i.e. fluorescence and Raman emission was produced with varying concentrations of bacteria and standard media using a modified …

Angular Trapping Of A Mirror Using Radiation Pressure, David Bruce Kelley

Dissertations - ALL

Alignment control in gravitational-wave detectors has consistently proven to be a

dicult problem due to the stringent noise contamination requirement for the gravitational

wave readout and the radiation-pressure induced angular instability in Fabry-

Perot cavities (Sidles-Sigg instability). In this thesis, I present optical springs as a

tool to damp the motion of a mirror. I discuss the design and implementation of a single

degree-of-freedom optical spring system and the importance of the photothermal

eect in properly predicting optical spring behavior.

I also present the development and implementation of an angular control scheme,

attempting to damp two degrees of freedom with …

Neural Networks For Autonomous Control Of Unmanned Helicopters, Padraig M. Moriarty

Theses

Landing a helicopter on a ship in high seas can be a dangerous endeavour. This thesis proposes to examine the possible uses of Artificial Neural Networks (A.N.N.) in the aiding and/or the landing of an Unmanned Aerial Vehicle (U.A.V.). It proposes that this procedure can be segregated into three distinct phases. The data for the A.N.N. training and testing sets is generated through simulation in the Unity cross-platform game engine. Phase 1 is intended to convert video images from an on-board camera to a set of numeric outputs suitable for use in Phase 2. Phase 2 estimates the current relative …

Improving The Resilience Of Mixed-Farm Systems To Pending Climate Change In Far Western Nepal: Endline Survey Report, D. Layne Coppock

Environment and Society Faculty Publications

This report presents general findings from an endline survey carried out during May 2015 in Jugada, Budhiganga, Attichaur and Gudukhati Village Development Committees (VDCs) in Bajura District. A total of 320 households were surveyed, a total of 80 per VDC. Two of the VDCs—Jugada and Budhiganga—received capacity-building interventions for 16 months concerning climate-change adaptation, poverty reduction, and other aspects of well-being, while two VDCs—Attichaur and Gudkhati—were their "paired controls," respectively, that did not receive interventions. The interventions were largely delivered as informal educational or training modules.

Integrating Freight Into Livable Communities, Kristine M. Williams, Alexandria Carroll

TREC Final Reports

Where livability is a goal of the planning process, freight runs the risk of not being considered except as an afterthought or as something to be excluded. Yet, freight is an integral part of local economic development. Because economic prosperity is a key characteristic of livable communities, freight must be incorporated into the planning process. This study explores the relationship between freight and livability through a comprehensive literature review and case study research. The final report includes a menu of strategies and case study perspectives that highlight the importance of transportation and land use integration, interagency coordination, and context-sensitivity in …

Facilitating Corpus Annotation By Improving Annotation Aggregation, Paul L. Felt

Theses and Dissertations

Annotated text corpora facilitate the linguistic investigation of language as well as the automation of natural language processing (NLP) tasks. NLP tasks include problems such as spam email detection, grammatical analysis, and identifying mentions of people, places, and events in text. However, constructing high quality annotated corpora can be expensive. Cost can be reduced by employing low-cost internet workers in a practice known as crowdsourcing, but the resulting annotations are often inaccurate, decreasing the usefulness of a corpus. This inaccuracy is typically mitigated by collecting multiple redundant judgments and aggregating them (e.g., via majority vote) to produce high quality consensus …

Optimization Of The Development Process For Air Sampling Filter Standards, Rajah Marie Mena

UNLV Theses, Dissertations, Professional Papers, and Capstones

Air monitoring is an important analysis technique in health physics. However, creating standards which can be used to calibrate detectors used in the analysis of the filters deployed for air monitoring can be challenging. The activity of a standard should be well understood, this includes understanding how the location within the filter affects the final surface emission rate. The purpose of this research is to determine the parameters which most affect uncertainty in an air filter standard and optimize these parameters such that calibrations made with them most accurately reflect the true activity contained inside. A deposition pattern was chosen …

Characterization Of Gold And Related Mineralization At The North Bullion Carlin System, Railroad Project, A Nevada Carlin-~Type Gold Prospect, Melanie Nicole Newton

UNLV Theses, Dissertations, Professional Papers, and Capstones

A study of the North Bullion Carlin system, a Nevada Carlin-type gold prospect located on trend with the large Carlin-type gold deposits (CTGD) of the Carlin Trend, identified characteristics of ore and alteration mineralization, mineral paragenesis, and pyrite and whole rock geochemistry that are similar to characteristics that typify Carlin-type gold deposits. The North Bullion Carlin system is hosted in Devonian shelf carbonates and the Mississippian overlap assemblage, host rocks that are different from typical CTGD shelf-slope carbonate assemblage host rocks. The mineralogy and ore-stage gold-bearing pyrite rims at North Bullion are not as well developed as they are in …

Dissolution Of Nontronite In Low Water Activity Brines And Implications For The Aqueous History Of Mars, Michael Henry Steiner

UNLV Theses, Dissertations, Professional Papers, and Capstones

Water is essential to life on Earth and is likely to play a role in determining the habitability of other planets. Pure liquid water is not stable on the surface of Mars but brines can temporarily remain liquid, and increasing evidence suggests the presence of recent liquid water, including brines, on Mars. Brines can host life at temperatures as low as -30 ºC and some organisms can live at activities of water as low as 0.61. Therefore, if brines have been present on Mars, they may act as habitable environments.

The Fe-rich smectite nontronite, (CaO0.5,Na)0.3 Fe3+2(Si,Al)4O10(OH)2·nH2O, has been detected on …

Testing Established Models Of Hydrothermal Fluid Distribution Around Porphyry Deposits: The Application Of Fluid Inclusion Research To Porphyry Deposit Exploration, Wyatt Moyer Bain

UNLV Theses, Dissertations, Professional Papers, and Capstones

The Kabba porphyry copper prospect in northwestern Arizona contains two zones of porphyry style mineralization and alteration, which are spatially separated by a north-south trending normal fault. These two zones are referred to as the Kabba footwall and hanging wall and are hypothesized to represent the root and intermediate depth levels of the same porphyry-like hydrothermal system, respectively. If this hypothesis is correct, then fluid inclusions found in the hanging wall and footwall should have the physical and chemical characteristics of fluid inclusions in the root and intermediate depth levels of other known porphyry deposits. Vein and alteration petrography, fluid …

Fabrication, Characterization, And Application Of Carbon Nanoparticles For The Detection Of Heavy Metal Ions In Aqueous Media, Aaron Michael Simpson

Graduate Theses/Dissertations

This research set out to develop a method for producing Carbon nanoparticles (CNPs) from glycerol and use them to detect Cu2+, Hg2+, and Pb2+ ions in aqueous solution. Three synthesis methods were developed using the following mixtures: (1) glycerol and silica, (2) glycerol, silica, and H3PO4, and (3) glycerol with H3PO4. The structure of the particles was characterized using a variety of spectroscopic techniques. Size distributions were obtained from scanning electron microscopy images. The particles were spherical with average diameters of 66, 58, and 89 nm respectively and believed to consist of a carbon core with carboxylic acid and alcohol …

Scalable Synthesis And Energy Applications Of Defect Engineered Nano Materials, Mehmet Karakaya

All Dissertations

Nanomaterials and nanotechnologies have attracted a great deal of attention in a few decades due to their novel physical properties such as, high aspect ratio, surface morphology, impurities, etc. which lead to unique chemical, optical and electronic properties. The awareness of importance of nanomaterials has motivated researchers to develop nanomaterial growth techniques to further control nanostructures properties such as, size, surface morphology, etc. that may alter their fundamental behavior. Carbon nanotubes (CNTs) are one of the most promising materials with their rigidity, strength, elasticity and electric conductivity for future applications. Despite their excellent properties explored by the abundant research works, …

Understanding How Synthetic Organic Chemistry Graduate Students Navigate Scifinder, Lindsey Whitfield Cain

All Dissertations

Students pursuing a Ph.D. degree are expected to contribute research to their field, for which the success depends, in part, on their ability to find, interpret, and use scholarly information from the primary literature. However, studies from the information sciences show that graduate students from a variety of fields, including the sciences, frequently struggle to comprehensively search their respective dissertation topics because of insufficient prior content knowledge and lack of guidance from their disciplinary community. This body of literature is consistent with the results of my previous research of chemistry graduate students’ laboratory decision-making processes. Specifically, that study showed their …

Combating Anti-Statistical Thinking Using Simulation-Based Methods Throughout The Undergraduate Curriculum, Nathan L. Tintle, Beth Chance, George Cobb, Soma Roy, Todd Swanson, Jill Vanderstoep

Faculty Work Comprehensive List

The use of simulation-based methods for introducing inference is growing in popularity for the Stat 101 course, due in part to increasing evidence of the methods ability to improve students’ statistical thinking. This impact comes from simulation-based methods (a) clearly presenting the overarching logic of inference, (b) strengthening ties between statistics and probability/mathematical concepts, (c) encouraging a focus on the entire research process, (d) facilitating student thinking about advanced statistical concepts, (e) allowing more time to explore, do, and talk about real research and messy data, and (f) acting as a firmer foundation on which to build statistical intuition. Thus, …

The Effects Of Prompted Tutoring On An Emporium Model Math Course, Juliette Michelle Young

Honors Theses

My research goal is to investigate how specific prompting of students would affect their involvement and progress in an emporium developmental math course. With the aim of increasing the students’ involvement and progress I tested a method that was in tended to increase students’ perceived connectedness with the classroom and promote the use of the available tutors and teachers. I monitored consenting students’ progress in the Spring 2015 courses and sent emails to students who met any one of three different criterion: (1) If the students time investment was below a threshold. (2) If the student’s mastery pace was less …

Investigation Of Groundwater Quality Of Al Hayer Area, (North Of Al Ain City) Using Hydro Geochemical Approach, Mohammed Hosny Ibrahim Gadalla

Theses

Al Hayer is located in the northeast of Al Ain area, Eastern region of the United Arab Emirates. Groundwater abstraction for domestic, agricultural and industrial uses has led to major depletion in the aquifer resulting in groundwater quality deterioration. This study aims to identify the factors affecting the groundwater quality in this area, and to determine the recharge mechanism for the study area to understand the behaviour of major ions in regional groundwater by using hydrogeochemical and isotopic approaches. The hydrochemical analysis of 37 collected samples of groundwater revealed that the groundwater is characterized by moderate salinity and high concentrations …

Extended Lindley Poisson Distribution, Mavis Pararai, Gayan Warahena-Liyanage, Broderick O. Oluyede

Mathematical Sciences: Faculty Publications

The Extended Lindley Poisson (ELP) distribution which is an extension of the extended Lindley distribution [2] is introduced and its properties are explored. This new distribution represents a more flexible model for the lifetime data. Some statistical properties of the proposed distribution including the shapes of the density, hazard rate functions, moments, Bonferroni and Lorenz curves are explored. Entropy measures and the distribution of the order statistics are given. The maximum likelihood estimation technique is used to estimate the model parameters and a simulation study is conducted to investigate the performance of the maximum likelihood estimates. Finally, we present applications …

Identities And Motives Of Naturalist Development Program Attendees And Their Relation To Professional Careers, Jennifer A. Mraz

Dissertations

In recent years, there has been much concern over the decline of biologists who actually identify themselves to be naturalists, which negatively impacts the field of conservation and the study of biology as a whole. This could result in a decrease in individuals who participate in naturalist-like activities, such as informal environmental education and environmental volunteerism. The purpose of my study was to determine what discourse identities were held by naturalist development program participants, how these discourse identities related to their volunteer motives in environmental settings, and how discourse identity related to professional careers. I defined identity through the lens …

Control Of Mesoscopic Transport By Modifying Transmission Channels In Opaque Media, Raktim Sarma, Alexey Yamilov, Seng Fatt Liew, Mikhael Guy, Hui Cao

Physics Faculty Research & Creative Works

While controlling particle diffusion in a confined geometry is a popular approach taken by both natural and artificial systems, it has not been widely adopted for controlling light transport in random media, where wave interference effects play a critical role. The transmission eigenchannels determine not only light propagation through the disordered system but also the energy concentrated inside. Here, we propose and demonstrate an effective approach to modify these channels, whose structures are considered to be universal in conventional diffusive waveguides. By adjusting the waveguide geometry, we are able to alter the spatial profiles of the transmission eigenchannels significantly and …

From Dye Sensitized Solar Cells To Organic Field Effect Transistors: A Computational Investigation Into The Structural And Electronic Properties Of Novel Phthalocyanines, Patrick J. Dwyer

Seton Hall University Dissertations and Theses (ETDs)

Phthalocyanines (Pc) have gained intense research attention in many diverse application areas due to their highly tunable electronic and structural properties through modification of the molecular periphery and metal center. Throughout this work a series of novel perfluoro-isopropyl substituted MPc have been investigated through theoretical methods. First, the synthetic mechanisms of these Pcs will be explored to gain insight into the experimentally observed Pc product distribution. By examining the electronic structure and formation energies of the various Pc precursors, we explain the product distribution as well as propose the formation of additional Pcs, which were not currently believed to form. …

On The Unreliability Of Bug Severity Data, Yuan Tian, Nasir Ali, David Lo, Ahmed E. Hassan

Research Collection School Of Computing and Information Systems

Severity levels, e.g., critical and minor, of bugs are often used to prioritize development efforts. Prior research efforts have proposed approaches to automatically assign the severity label to a bug report. All prior efforts verify the accuracy of their approaches using human-assigned bug reports data that is stored in software repositories. However, all prior efforts assume that such human-assigned data is reliable. Hence a perfect automated approach should be able to assign the same severity label as in the repository – achieving a 100% accuracy. Looking at duplicate bug reports (i.e., reports referring to the same problem) from three open-source …

A Cooperative Coevolution Framework For Parallel Learning To Rank, Shuaiqiang Wang, Yun Wu, Byron J. Gao, Ke Wang, Hady W. Lauw, Jun Ma

Research Collection School Of Computing and Information Systems

We propose CCRank, the first parallel framework for learning to rank based on evolutionary algorithms (EA), aiming to significantly improve learning efficiency while maintaining accuracy. CCRank is based on cooperative coevolution (CC), a divide-and-conquer framework that has demonstrated high promise in function optimization for problems with large search space and complex structures. Moreover, CC naturally allows parallelization of sub-solutions to the decomposed sub-problems, which can substantially boost learning efficiency. With CCRank, we investigate parallel CC in the context of learning to rank. We implement CCRank with three EA-based learning to rank algorithms for demonstration. Extensive experiments on benchmark datasets in …

Designing, Building And Testing A Solar Thermoelectric Generation, Steg, For Energy Delivery To Remote Residential Areas In Developing Regions, Yacouba Moumouni

UNLV Theses, Dissertations, Professional Papers, and Capstones

New alternatives and inventive renewable energy techniques which encompass both generation and power management solutions are fundamental for meeting remote residential energy supply and demand today, especially if the grid is quasi-inexistent. Solar thermoelectric generators can be a cost-effective alternative to photovoltaics for a remote residential household power supply. A complete solar thermoelectric energy harvesting system is presented for energy delivery to remote residential areas in developing regions. To this end, the entire system was built, modeled, and then validated with LTspice simulator software via thermal-to-electrical analogy schemes. Valuable data in conjunction with two novel LTspice circuits were obtained, showing …

Ediacaran Ocean Redox Evolution, Swapan Kumar Sahoo

UNLV Theses, Dissertations, Professional Papers, and Capstones

The relative role that environmental versus intrinsic biological factors played in

shaping the history of life on Earth is a fundamental but unanswered question in the

natural sciences. Most famously, it has been heavily debated if the emergence and

diversification of early animals during the Ediacaran Period (ca. 635–541 Ma) was tied to

a rise in atmospheric-oceanic oxygen levels. Temporally discontinuous geochemical data and patchy fossil record in literature are inadequate to chart the Ediacaran redox history and its causal relationship with the biotic evolution. My PhD study aims for a multiproxy geochemical record within a well-established stratigraphic framework of …

Ecosystem Response To Recent Climate Change In Alpine Environments, Patrick Shawn Sawyer

UNLV Theses, Dissertations, Professional Papers, and Capstones

Recent variations in meteorological conditions indicate the earth’s climate is changing in ways that can impact delicate ecological balances in sensitive regions. These impacts threaten the essential services provided by such ecosystems. Determining how climate changes are affecting the biosphere is essential to adapt and mitigate harmful consequences. In order to mitigate the negative effects of climate change and adapt to shifting ecological resource constraints, it is imperative to locate such changes and determine vulnerability of ecological resources to changing environmental conditions.

Identifying climate driven ecological changes faces numerous challenges given the reliance on vegetation indices as the primary measure …