Physical Sciences and Mathematics Commons^™

Dissecting Trypanosome Metabolism By Discovering Glycolytic Inhibitors, Drug Targets, And Glycosomal Ph Regulation, Daniel Hale Call

Theses and Dissertations

Trypanosoma brucei, the causative agent of African trypanosomiasis, and its relatives Trypanosoma cruzi and several Leishmania species belong to a class of protozoa called kinetoplastids that cause a significant health burden in tropical and semitropical countries across the world. While an improved therapy was recently approved for African trypanosomiasis, the therapies available to treat infections caused by T. cruzi and Leishmania spp. remain relatively poor. Improving our understanding of T. brucei metabolism can inform on metabolism of its relatives. The purpose of the research presented in this dissertation was to develop novel tools and methods to study metabolism in T. …

The Impact Of Heterogeneous Voting Strategies And Candidate Issue Adaptation On Elections: An Agent-Based Model, Harmony Peura

Student Research Submissions

Political candidates in a democracy articulate positions on the issues of the day, but they are also highly aware of voter sentiment on those issues, and tailor their campaigns accordingly as they seek to win elections. Voters, too, adjust their political opinions based on (among other things) interactions with others in their social network. I present an agent-based simulation that models this dynamic interplay between candidates and voters, in order to shed light on what outcomes candidates can expect to result from a policy of “chasing” votes. The voters in the simulation differ from one another in the decision procedure …

Effects Of Urbanization On Eutrophication Parameters In Three Tidal Creeks, Ella Swantek

Honors Theses

Marshes and swashes are vital environments as a controlling barrier between land affected by various pollutants and the ocean. Eutrophication and the effects of this process can be detrimental for the areas experiencing it. I am interested in ways areas that have little contact with human interactions compare to areas that are heavily urbanized, and whether either of these locations is at a higher risk for eutrophication. Using spectrophotometry and fluorometry, I analyzed samples collected from the relatively undeveloped and restricted-access locations of Waities Island Beach and Dunn Sound monthly for dissolved nutrients, and chlorophyll. At the time of sampling, …

Techniques And Trials In Pteridophyte Conservation And Cultivation, Jessica Bartel

Senior Theses and Projects

With the progressive nature of climate change conditions globally over the past century, there has been increasing focus on conservation of all species, but particularly those already endangered. Over 12,000 species of ferns live on Earth, and they do not produce seeds, so an investigation into their spores and how they reach maturity will allow us to preserve more genetic material in the future for these species. As a result, we investigated ex situ conservation and survivability of in vitro cultured gametophytes of within the genus Dryopteridaceae through herbarium sample germination rates across samples representing a wide age range ( …

Gis Analysis Application Of Flood Risk Map In Beijing, China, Yuxuan Liu

Honors Capstones

From the end of July to the beginning of August 2023, Beijing, China, affected by Typhoon "Dusuri" experienced the most precipitation in the Beijing area in 140 years of instrument measurement records. This event led to the evacuation of more than 1.8 million people across the Beijing-Tianjin-Hebei region and the tragic loss of 62 lives. After experiencing such fierce heavy rainfall and flood disasters, how to predict and prepare for such catastrophic events and avoid losses in the future has become a crucial problem. Geographic information systems (GIS) can integrate different layers of geospatial information and provide us with powerful …

Investigating The Drought Sensitivity Of Intermontane-Basin Groundwater Systems In Western Montana Using Standardized Drought Indices, Daniel Buckley

Graduate Theses & Non-Theses

Drought is a worldwide phenomenon, and many metrics have been developed to help monitor and understand drought. In this study, the drought sensitivity of two different western Montana intermontane-basin groundwater systems were analyzed: the Bitterroot Valley and the Gallatin Valley. Different standardized meteorological drought indices, namely, the Standardized Precipitation Index (SPI) and the Standardized Precipitation Evapotranspiration Index (SPEI), were compared against the Standardized Groundwater level Index (SGI) to better understand groundwater sensitivity to meteorological forcing. The SPI and SPEI were computed using precipitation and reference evapotranspiration data from the gridMET dataset. Groundwater level data from the Montana Bureau of Mines …

Characterizing The Engineering Properties Of Three Lithologies From Montana And Idaho Using Acoustic Emissions And Stress-Strain Measurements, Mary Humphreys

Graduate Theses & Non-Theses

In this study, stress and strain measurements from unconfined compression tests were used to determine the peak stress, yield stress, Young’s modulus, and Poisson’s ratio of 20 specimens representing three lithologies (sandstone, norite, and argillite-quartzite mix) from Idaho and Montana. Along with traditional strength and deformation parameters, crack initiation (CI) and crack damage (CD) values were also interpreted, corresponding to the stress levels associated with the formation and coalescence of microcracks as a specimen is exposed to increasing stress levels. Acoustic emissions (AE) data were collected along with traditional stress-strain data as this has become a popular method for interpreting …

Phase Equilibria And Heat Capacities For Tetraarylphosphonium-Based Ionic Liquids, Allan Wilson

Honors Theses

Climate change is one of the most pressing issues facing humanity in the 21st century. A major contributing factor to this problem is the continued use of fossil-fuel based sources of energy. Concentrated solar power (CST) with thermal energy storage (TES) provides a potential opportunity to support this transition away from fossil fuels but suffers from high costs and extended downtimes. Current heat transfer fluids used in these processes often consist of a mixture of alkali metal nitrates with melting points above 200°C. For CST and TES to be viable, a thermally stable, low melting fluid is needed. Ionic liquids …

Sedimentary Conditions At A Tidal Creek That Exhibits Seasonal Pelagic-Benthic Variations, Jack B. Corbin

Honors Theses

Tidal creeks in the Grand Strand of South Carolina are small but numerous connectors between land and ocean. One of these creeks, White Point Swash, exhibits a seasonal switch between planktonic and benthic photosynthesizers. As plankton become less abundant in fall, benthic macroalgae bloom, aided by lower water levels due to fall-winter dredging of the main channel, until late Spring. This study builds on previous findings and examines sedimentary conditions at this site further. Sedimentary chlorophyll a (in microphytobenthos) and pore water nutrient concentrations are confirmed to be higher than water-column concentrations. Sedimentary nutrient fluxes to the sediment-water interface, calculated …

Impacts Of Hurricane Idalia’S Surge On Coastal Sand Biogeochemistry, Wendy "Cor" Mchone

Honors Theses

Beaches are heavily influenced by extreme events, such as hurricanes. Biological and chemical processes, such as primary production and diagenesis are often interrupted by these events. To examine the effects of hurricanes on coastal biogeochemistry, this study used sand and porewater samples from Waties Island, SC, which were collected before and after Hurricane Idalia. The samples were analyzed for macronutrient concentrations, organic content, and chlorophyll concentrations. Macronutrient pore water concentration changes were not uniform. The inventory of nitrite decreased significantly after the storm, which was reflected in slight increases in the inventories of nitrate and ammonium. Concentrations of nitrate, which …

Boolean Group Structure In Class Groups Of Positive Definite Quadratic Forms Of Primitive Discriminant, Christopher Albert Hudert Jr.

Student Research Submissions

It is possible to completely describe the representation of any integer by binary quadratic forms of a given discriminant when the discriminant’s class group is a Boolean group (also known as an elementary abelian 2-group). For other discriminants, we can partially describe the representation using the structure of the class group. The goal of the present project is to find whether any class group with 32 elements and a primitive positive definite discriminant is a Boolean group. We find that no such class group is Boolean.

Signal Processing Algorithms For Doppler Lidar Sensors, Samantha Grubb

Physics and Astronomy Honors Papers

Light detection and ranging (LiDAR) is a remote sensing technology that obtains relative distance and velocity measurements between a sensor and a defined target by using light transmitted and received from the target. FMCW Doppler LiDAR, a particular variant of LiDAR, functions by analyzing the frequency shift in the reflected light to determine the target's range and velocity. This technology plays a crucial role across various sectors including defense, aerospace, and automotive. This paper presents signal processing algorithms designed to optimize data obtained from Doppler LiDAR sensors. By applying various window functions to time domain data, the Signal-to-Noise Ratio (SNR) …

Analytical And Numerical Analysis Of The Sirs Model, Catherine Nguyen

Student Research Submissions

Mathematical models in epidemiology describe how diseases affect and spread within a population. By understanding the trends of a disease, more effective public health policies can be made. In this paper, the Susceptible-Infected-Recovered-Susceptible (SIRS) Model was examined analytically and numerically to compare with the data for Coronavirus Disease 2019 (COVID-19). Since the SIRS model is a complex model, analytical techniques were used to solve simplified versions of the SIRS model in order to understand general trends that occur. Then by Euler's Method, the Runge-Kutta Method, and the Predictor-Corrector Method, computational approximations were obtained to solve and plot the SIRS model. …

Crash Detecting System Using Deep Learning, Yogesh Reddy Muddam

Electronic Theses, Projects, and Dissertations

Accidents pose a significant risk to both individual and property safety, requiring effective detection and response systems. This work introduces an accident detection system using a convolutional neural network (CNN), which provides an impressive accuracy of 86.40%. Trained on diverse data sets of images and videos from various online sources, the model exhibits complex accident detection and classification and is known for its prowess in image classification and visualization.

CNN ensures better accident detection in various scenarios and road conditions. This example shows its adaptability to a real-world accident scenario and enhances its effectiveness in detecting early events. A key …

On Distortion Of Surface Groups In Right-Angled Artin Groups, Lucas Bridges

Mathematical Sciences Undergraduate Honors Theses

Surfaces have long been a topic of interest for scholars inside and outside of mathe- matics. In a topological sense, surfaces are spaces which appear flat on a local scale. Surfaces in this sense have a restricted set of properties, including the behavior of loops around a surface, codified in the fundamental group.

All but 3 surface groups have been shown to embed into a class of groups called right-angled Artin groups. The method through which these embeddings are created places large restrictions on all homomorphisms from surface groups to right-angled Artin groups.

One such restriction on these homomorphisms is …

High-Dimensional Mediation Analysis Of Multi-Omics Data, Sunyi Chi

Dissertations & Theses (Open Access)

Environmental exposures such as cigarette smoking influence health outcomes through intermediate molecular phenotypes, such as the methylome, transcriptome, and metabolome. Mediation analysis is a useful tool for investigating the role of potentially high-dimensional intermediate phenotypes in the relationship between environmental exposures and health outcomes. Rapid development of high-throughput technologies have made mediation analysis of multi-omics data critical to gain groundbreaking insights into the biological mechanisms underlying the disease etiology. This dissertation aims to develop mediation analysis methods that utilize the enormous amount of multi-omics data in assessing mechanisms of disease etiology. It contains three projects where I propose advanced mediation …

Code For Care: Hypertension Prediction In Women Aged 18-39 Years, Kruti Sheth

Electronic Theses, Projects, and Dissertations

The longstanding prevalence of hypertension, often undiagnosed, poses significant risks of severe chronic and cardiovascular complications if left untreated. This study investigated the causes and underlying risks of hypertension in females aged between 18-39 years. The research questions were: (Q1.) What factors affect the occurrence of hypertension in females aged 18-39 years? (Q2.) What machine learning algorithms are suited for effectively predicting hypertension? (Q3.) How can SHAP values be leveraged to analyze the factors from model outputs? The findings are: (Q1.) Performing Feature selection using binary classification Logistic regression algorithm reveals an array of 30 most influential factors at an …

Atmospheric Deposition Trends Are Primarily Decreasing In Arkansas And Tennessee, Anna Mccarty

Crop, Soil and Environmental Sciences Undergraduate Honors Theses

Atmospheric deposition has likely changed with the influence of increasing global temperatures and subsequent changes in precipitation across the United States and globally. The objective of this project was to analyze atmospheric deposition across northern Arkansas and Tennessee. The three specific objectives were to: i) evaluate trends in atmospheric deposition of various element/compounds, ii) assess the relationship between atmospheric deposition and rainfall, and iii) evaluate if rainfall-adjusted atmospheric deposition is changing over time. Six sites were analyzed from 1980 to 2022, including AR16, AR27, TN00, TN04, TN11, and TN14, which span over northern Arkansas and across Tennessee. The Mann-Kendall Test …

Traffic Analysis Of Cities In San Bernardino County, Sai Kalyan Ayyagari

Electronic Theses, Projects, and Dissertations

This research offers an in-depth analysis of vehicular traffic within San Bernardino County, California, aiming to spotlight congestion areas and suggest improvements for more efficient and sustainable transportation. Leveraging 2021 data from StreetLight Data, traffic patterns in 15 key cities were examined based on their population sizes, covering various vehicle types to dissect dynamics and flow. The methodology focused on analyzing trip purposes and metrics to calculate Vehicle Miles Traveled (VMT) and its influence on congestion and environmental factors.

Findings indicate considerable disparities in traffic volume, purposes, and timings across different urban areas, with population density and intercity connections significantly …

Artificial Intelligence's Ability To Detect Online Predators, Olatilewa Osifeso

Electronic Theses, Projects, and Dissertations

Online child predators pose a danger to children who use the Internet. Children fall victim to online predators at an alarming rate, based on the data from the National Center of Missing and Exploited Children. When making online profiles and joining websites, you only need a name, an email and a password without identity verification. Studies have shown that online predators use a variety of methods and tools to manipulate and exploit children, such as blackmail, coercion, flattery, and deception. These issues have created an opportunity for skilled online predators to have fewer obstacles when it comes to contacting and …

An Exploration Of Procedural Methods In Game Level Design, Hector Salinas

Computer Science and Computer Engineering Undergraduate Honors Theses

Video games offer players immersive experiences within intricately crafted worlds, and the integration of procedural methods in game level designs extends this potential by introducing dynamic, algorithmically generated content that could stand on par with handcrafted environments. This research highlights the potential to provide players with engaging experiences through procedural level generation, while potentially reducing development time for game developers.

Through a focused exploration on two-dimensional cave generation techniques, this paper aims to provide efficient solutions tailored to this specific environment. This exploration encompasses several procedural generation methods, including Midpoint Displacement, Random Walk, Cellular Automata, Perlin Worms, and Binary Space …

Synthesis And Characterization Of Indole-Based Zinc Dipyrrin Photosensitizers, Jean-Pierre Sanza

Electronic Theses and Dissertations

Metal complexes of dipyrromethene (dipyrrins) used as sensitizers in photocatalysis offer a way to harness solar energy in chemical bonds to create new fuels. This offers the dual role of reducing fossil fuel dependence and atmospheric CO₂ levels. Traditionally, metal dipyrrin complexes are synthesized using substituted pyrroles, aldehydes, and transition metals. Indoles have a more expanded pi-electron system and their dipyrrin-type complex may exhibit visible light absorption, suggesting that they can act as photosensitizers for CO₂ reduction processes. A novel indoledipyrromethene was synthesized using unsubstituted indole and mesitaldehyde. The complex exhibits visible light absorption at 422 nm. Its …

Categorizing The Societal Impacts From Extreme Rainfall In The New York City Metropolitan Area, Evan Belkin

ALL - Honors Theses

Numerous studies have shown that the frequency and intensity of extreme rainfall events have increased significantly across the contiguous United States (CONUS) over the past several decades associated with warming global temperatures. This surge in extreme rainfall has resulted in the loss of life and property within vulnerable communities due to widespread river and flash flooding. For example, 11 of the 14 fatalities in New York City associated with Tropical Cyclone Ida’s remnants in September 2021 occurred in flooded basement apartments. The creation of a scale to differentiate extreme rainfall events with higher societal impacts from those with lower impacts …

Evaluating And Enhancing The New York State Mesonet (Nysm) Snow Accumulation Estimation, Christopher Gilberti

ALL - Honors Theses

This research project aims to examine and enhance the performance of the New York State Mesonet (NYSM) Snow Accumulation Estimation. The NYSM is a state-of-the-art network of 126 standard weather stations located across the state of New York, collecting high-quality meteorological data to improve forecast accuracy, reduce uncertainty, and mitigate harm. All NYSM standard stations measure snow depth with Campbell Scientific’s SR50A ultrasonic distance sensor. This acoustic sensor measures the distance from the sensor to a rigid snowboard if there is no snow on the ground or the top of snow layer. A reference distance and a temperature correction are …

Comparative Analysis Of Surrogate Models For The Dissolution Of Spent Nuclear Fuel, Dayo Awe

Electronic Theses and Dissertations

This thesis presents a comparative analysis of surrogate models for the dissolution of spent nuclear fuel, with a focus on the use of deep learning techniques. The study explores the accuracy and efficiency of different machine learning methods in predicting the dissolution behavior of nuclear waste, and compares them to traditional modeling approaches. The results show that deep learning models can achieve high accuracy in predicting the dissolution rate, while also being computationally efficient. The study also discusses the potential applications of surrogate modeling in the field of nuclear waste management, including the optimization of waste disposal strategies and the …

Factors Predictive Of The Development Of Surgical Site Infection In Thyroidectomy, A Replication Study Of Myssiorek (2018), Kaitlyn M. Kenig

Capstone Experience

The original study aimed to show that thyroidectomy does not result in surgical site infection (SSI) in most cases, and thus routine prescription of antibiotics is not necessary. The study looked to see what risk factors could predict the incidence of SSI. This would highlight those individuals who were at most risk of developing SSI, and then antibiotics would only be prescribed to these individuals instead of all or most individuals who undergo thyroidectomy.

This study used NSQIP data to look at incidence of SSI and look for risk factors that may be predictive of SSI. Only surgeries that were …

Using The History Of Statistics To Teach Introductory Statistics, Melissa Hansen

All Graduate Reports and Creative Projects, Fall 2023 to Present

While often taught in high school and required as part of a college degree, statistics classes are sometimes viewed by students as an obstacle rather than a support for their overall goals. One way to increase student engagement in a statistics course is to use the history of statistics. Within the literature review, the advantages to using the history of statistics are discussed as well as the more extensive research on using the history of mathematics in mathematics courses. Included are instructional strategies for using the context around the development of mathematical ideas in math classrooms which can be extended …

Evaluation Of An End-To-End Radiotherapy Treatment Planning Pipeline For Prostate Cancer, Mohammad Daniel El Basha, Court Laurence, Carlos Eduardo Cardenas, Julianne Pollard-Larkin, Steven Frank, David T. Fuentes, Falk Poenisch, Zhiqian H. Yu

Dissertations & Theses (Open Access)

Radiation treatment planning is a crucial and time-intensive process in radiation therapy. This planning involves carefully designing a treatment regimen tailored to a patient’s specific condition, including the type, location, and size of the tumor with reference to surrounding healthy tissues. For prostate cancer, this tumor may be either local, locally advanced with extracapsular involvement, or extend into the pelvic lymph node chain. Automating essential parts of this process would allow for the rapid development of effective treatment plans and better plan optimization to enhance tumor control for better outcomes.

The first objective of this work, to automate the treatment …

The Analysis Of Mechanical Exfoliation Of Graphene For Various Fabrication And Automation Techniques, Lance Yarbrough

Mechanical Engineering Undergraduate Honors Theses

Mechanical Exfoliation of Graphene is an often-overlooked portion of the fabrication of quantum devices, and to create more devices quickly, optimizing this process to generate better flakes is critical. In addition, it would be valuable to simulate test pulls quickly, to gain insight on flake quality of various materials and exfoliation conditions. Physical pulls of graphene at various temperatures, pull forces, and pull repetitions were analyzed and compared to the results of ANSYS simulations, solved for similar results. Using ANSYS’ ability to predict trends in exfoliations, flake thickness and coverage using stress and deflection analyses were investigated. Generally, both strongly …

Divergence-Free Tensor Densities In Two Dimensions, Tyler Hansen

All Graduate Theses and Dissertations, Fall 2023 to Present

In physics, a common method for exploring the way a physical system changes over time is to look at the system’s energy. Roughly speaking, the energy in these systems are either motion-based (kinetic energy, a bullet in flight) or position-based (potential energy, a rock sitting at the top of a hill). The difference between the system’s total kinetic and potential energies is quantified by an expression called the Lagrangian. Using a special procedure, this Lagrangian is massaged to produce a group of equations called the Euler-Lagrange equations; if the initial configuration of the system is provided, the solution to these …