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Full-Text Articles in Physical Sciences and Mathematics
Increasing The Biocompatibility Of Graphene-Based Hybrid Nanostructures With Glycopolymer, Aydan Dağ, Pinar Si̇nem Omurtag Özgen, Belma Zengi̇n Kurt, Zehra Durmuş
Increasing The Biocompatibility Of Graphene-Based Hybrid Nanostructures With Glycopolymer, Aydan Dağ, Pinar Si̇nem Omurtag Özgen, Belma Zengi̇n Kurt, Zehra Durmuş
Turkish Journal of Chemistry
Hybrid nanostructures decorated with glycopolymers are appropriate for biomedical applications. In this paper, the results are obtained from nanographene (NG) decorated with glycoblock copolymer to increase their potential in use in therapies and in examining lectin interactions. A pyren-1-ylmethyl 4-cyano-4-((phenylcarbonothioyl)thio)pentanoate (CPADB-py) chain transfer agent was used in the synthesis of methyl methacrylate glycoblock copolymers (P2 and P3) by reversible addition-fragmentation chain transfer (RAFT) polymerization to adhere the polymer to the nanographene surface. Hybrid nanographenes (NG-1 and NG-2) were obtained by the non-covalent interaction of deprotected P2 and P3 with different fructopyranose groups (3-O-methacryloyl-1,2:4,5- di-O-isopropylidene-β-D-fructopyranose and 1-O-methacryloyl-2,3:4,5-di-O-isopropylidene-β-D-fructopyranose) in their backbones. Images …
Cerium And Europium Doped Tio2 Thin Films Deposited By A Sol-Gel Dip-Coating Process: Characterization And Photocatalytic Activity Toward Dye Degradation, Dalanda Hamdi, Lobna Mansouri, Varsha Srivastava, Mika Sillanpaa, Latifa Bousselmi
Cerium And Europium Doped Tio2 Thin Films Deposited By A Sol-Gel Dip-Coating Process: Characterization And Photocatalytic Activity Toward Dye Degradation, Dalanda Hamdi, Lobna Mansouri, Varsha Srivastava, Mika Sillanpaa, Latifa Bousselmi
Turkish Journal of Chemistry
Cerium (Ce) and europium (Eu)-doped TiO2 thin films were obtained by sol-gel dip-coating technique. SEM micrographs showed that the surfaces are covered by agglomerated particles due to the repeating coating process. XRD patterns showed the presence of TiO2 anatase phase. Raman spectra revealed that the peaks recorded at 146 cm-1(Eg) and 397 cm-1(B1g) were related to the anatase phase. EIS measurements proved that Ce-TiO2 (1wt%) and Eu-TiO2 (0.1wt%) photocatalysts possessed a lower electron transfer resistance than pure TiO2, which can lead to effective separation of electron/ hole pairs during the photoreactions. The photoactivity of Ce and Eu-doped TiO2 was investigated …
Selective Catalytic Hydrogenation Of Cellulose Into Sorbitol With Ru-Based Catalysts, Ceren Orak, Aycan Sapmaz, Asli Yüksel Özşen
Selective Catalytic Hydrogenation Of Cellulose Into Sorbitol With Ru-Based Catalysts, Ceren Orak, Aycan Sapmaz, Asli Yüksel Özşen
Turkish Journal of Chemistry
Sorbitol is one of the platform chemicals and can be produced from various renewable and sustainable sources via different processes. Hydrothermal liquefaction is an effective and promising approach to produce sorbitol, since the subcritical reaction media and appropriate catalysts provide a selective production of platform chemicals. In this study, sorbitol was produced from different renewable sources (cellulose and glucose) in the presence of Ru-based catalysts (Ru/SiO2, Ru/AC, Ru/SBA-15, and Ru/SBA-15-SO3) under subcritical conditions. The highest cellulose conversion was achieved as 90% in the presence of Ru/SBA-15-SO3 for 1 h of reaction duration. The highest sorbitol yield (%) by hydrothermal liquefaction …
Study On The Alkylation Of Aromatic Hydrocarbons And Propylene, Wanglai Dong, Wentao Ma, Xinyao Li, Xingbang Hu, Zheng Zhou
Study On The Alkylation Of Aromatic Hydrocarbons And Propylene, Wanglai Dong, Wentao Ma, Xinyao Li, Xingbang Hu, Zheng Zhou
Turkish Journal of Chemistry
In order to improve the efficiency of the alkylation reaction to aromatic hydrocarbons and propylene, different types of catalysts were screened, including ultra-stable Y molecular sieves (USY), solid phosphoric acid (SPA), ZSM type molecular sieve (HZSM), etc. The effects of reaction temperature, catalyst loading, and reaction time on the conversion rate of aromatic hydrocarbons and the selectivity of target products were investigated using the high-pressure reaction device. The catalysts were characterized by XRD, BET, SEM, FT-IR, NH3-TPD, and other methods. The experimental results show that the USY catalyst exhibits higher catalytic activity for alkylation. This catalyst can be used for …
Schiff Base Functionalized Silica Gel For Simultaneous Separation And Preconcentration Of Cu(Ii), Ni(Ii), And Cd(Ii) In Pharmaceuticals And Water Samples, Feyzullah Tokay, Sema Bağdat
Schiff Base Functionalized Silica Gel For Simultaneous Separation And Preconcentration Of Cu(Ii), Ni(Ii), And Cd(Ii) In Pharmaceuticals And Water Samples, Feyzullah Tokay, Sema Bağdat
Turkish Journal of Chemistry
A method for separation and preconcentration of Cu(II), Ni(II), and Cd(II) using N-N'-bis(5-methoxsalicylidene)-2-hydroxy-1,3-propanediamine modified silica gel was improved for aqueous samples and pharmaceuticals. Determination of the analytes was achieved by inductively coupled plasma optic emission spectrometry. The experimental conditions including pH value, sample volume, eluent type and volume, sorbent mass, sample, and eluent flow rates were optimized with univariate and multivariate optimization tools. The relative standard deviations of the method were 2.9% for Cu(II), 3.0% for Ni(II), and 3.3% for Cd(II) with recovery values between 98.8 ± 3.2-101.5 ± 3.0%. The limits of detection were found to be 62.4, 39.5, …
Fluorometric Determination Of Ornidazole By Using Bsa Coated Copper Nanoclusters As A Novel Turn Off Sensor, Mehmetcan Bi̇lkay, Hayri̇ye Eda Şatana Kara
Fluorometric Determination Of Ornidazole By Using Bsa Coated Copper Nanoclusters As A Novel Turn Off Sensor, Mehmetcan Bi̇lkay, Hayri̇ye Eda Şatana Kara
Turkish Journal of Chemistry
A fluorescent probe based on bovine serum albumin stabilized copper nanoclusters (BSA-CuNCs) was developed for the selective and sensitive determination of ornidazole (ORN). The nanoclusters were synthesized via a one-pot hydrothermal process in basic media. The synthesized and characterized BSA-CuNCs have less than 3 nm particle size and exhibited blue emission at 405 nm when excited at 325 nm. Synthesized and characterized nanoclusters were successfully applied as a turn-off fluorescent probe for the determination of ORN in pharmaceutical dosage forms. The quenching mechanism created an was inner filter effect (IFE). The method was linear in the concentration range of 0.52-13.56 …
Bovine Serum Albumin Detection By Using Molecularly Imprinted Surface Plasmon Resonance Sensors, Ali̇ Araz
Bovine Serum Albumin Detection By Using Molecularly Imprinted Surface Plasmon Resonance Sensors, Ali̇ Araz
Turkish Journal of Chemistry
Molecular imprinted polymers (MIP) have key-lock pattern binding properties specific to the size and shape of target molecules. In this study, we have prepared detection platforms based on a molecularly imprinted surface plasmon resonance (SPR) sensor that can detect bovine serum albumin (BSA) sensitively, selectively, quickly, and in real time. The polymeric film prepared on the SPR sensor surface by molecular imprinting method was obtained by selecting the N-methacryloyl-(L)-glutamic acid molecule as a suitable functional monomer using ultraviolet polymerization. Three different imprinting methods, such as epitope, bulk, and surface imprinting methods, were used to examine the imprinting efficiency. Real-time measurements …
New Bis-Isoxazole With Monoterpenic Skeleton: Regioselective Synthesis, Spectroscopicinvestigation, Electrochemical, And Density Functional Theory (Dft) Studies, Ali Oubella, Meryem Hrimla, Mouhi Eddine Hachim, Mourad Fawzi, Abdoullah Bimoussa, Lahoucine Bahsis, Aziz Boutouil, Aziz Auhmani, Abdelkhalek Riahi, My Youssef Ait Itto
New Bis-Isoxazole With Monoterpenic Skeleton: Regioselective Synthesis, Spectroscopicinvestigation, Electrochemical, And Density Functional Theory (Dft) Studies, Ali Oubella, Meryem Hrimla, Mouhi Eddine Hachim, Mourad Fawzi, Abdoullah Bimoussa, Lahoucine Bahsis, Aziz Boutouil, Aziz Auhmani, Abdelkhalek Riahi, My Youssef Ait Itto
Turkish Journal of Chemistry
A novel bis-isoxazole was synthesized from (R)-Carvone and p-methylbenzaldoxime, via two successive [3+2] cycloaddition reactions (32CA). The newly obtained bis-isoxazole has been fully characterized by HRMS and NMR spectroscopy. The HMBC experiment was performed to determine the stereo and the regioselectivity of the reaction. The electrochemical behavior of the studied compound, in oxidation and reduction processes, was examined using the cyclic voltammetry technique. In addition, the regioselectivity of the [3+2] cycloaddition reaction and the molecular structure of the title compound was performed by density functional theory (DFT). The HOMO and LUMO orbitals were investigated to determine the electronic properties of …
A Bodipy Based Probe For The Reversible "Turn On" Detection Of Au(Iii) Ions, Muhammed Üçüncü
A Bodipy Based Probe For The Reversible "Turn On" Detection Of Au(Iii) Ions, Muhammed Üçüncü
Turkish Journal of Chemistry
A new "turn on" fluorescent probe for the rapid and selective detection of Au3+ ions over other metal ions was developed. The probe design was constructed on a BODIPY-2-aminopyridine skeleton showing a weak fluorescence emission signal which increased substantially after the coordination of Au3+ ions. The probe displayed remarkable sensing performances such as a low limit of detection (17 nM), a short response time (
Investigation Of The Oxygen Reduction Kinetics And Mechanism On Ordered Mesoporouscarbon-Supported Pt-Based Catalysts, Si̇lver Güneş, Fatma Çi̇ğdem Güldür
Investigation Of The Oxygen Reduction Kinetics And Mechanism On Ordered Mesoporouscarbon-Supported Pt-Based Catalysts, Si̇lver Güneş, Fatma Çi̇ğdem Güldür
Turkish Journal of Chemistry
The kinetics and mechanism of oxygen reduction reaction (ORR) on the surface of Pt and PtAgFe catalysts supported by ordered mesoporous carbon (OMC) were investigated. Metal particles were loaded by the wet impregnation-reduction method on two types of OMC, one being surface-modified by HNO3 and the other unmodified. Cyclic voltammetry measurements showed that Pt on modified OMC, namely Pt/OMC-M, had the highest electroactive surface area among OMC-supported catalyts with 987 cm2/mg. This catalyst had also a mass activity of 39.1 mA/mgPt, which was the same as the carbon black supported commercial Pt/C catalyst. Rotating disk electrode (RDE) studies revealed that …
Preparation Of Zno Nanoparticles Modified With Silane Coupling-Agents To Fabricateanti-Uv Poly(Vinyl Chloride) Films, Xiangmei Ma, Zhehao Dong, Bin Wang, Limin Liu, Ruojun Ye
Preparation Of Zno Nanoparticles Modified With Silane Coupling-Agents To Fabricateanti-Uv Poly(Vinyl Chloride) Films, Xiangmei Ma, Zhehao Dong, Bin Wang, Limin Liu, Ruojun Ye
Turkish Journal of Chemistry
The uses of inorganic metal oxide as ultraviolet (UV) absorbers have potential to increase the production of UV protection and can also overcome the disadvantages of organic molecules. In this article, we report an effective technique to fabricating polyvinyl chloride (PVC) films with well UV shielding efficiency. Surface modification of zinc oxide (ZnO) nanoparticles (NPs) with different silane coupling-agents were achieved, and through solution casting technique dispersed within the PVC matrix. Infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), thermogravimetric analysis (TGA) and UV spectrophotometer were applied to study the structures, dispersions, and optical properties. The results showed that the functionalized …
Preconcentration Of Trace Amount Cu(Ii) By Solid-Phase Extraction Method Usingactivated Carbon-Based Ion-Imprinted Sorbent, Kübra Turan, Ruki̇ye Saygili Canlidi̇nç, Orhan Murat Kalfa
Preconcentration Of Trace Amount Cu(Ii) By Solid-Phase Extraction Method Usingactivated Carbon-Based Ion-Imprinted Sorbent, Kübra Turan, Ruki̇ye Saygili Canlidi̇nç, Orhan Murat Kalfa
Turkish Journal of Chemistry
In this study, preconcentration conditions of trace amounts of copper ions were investigated with solid-phase extraction (SPE) method by synthesizing activated carbon-based ion-imprinted sorbent (Cu(II)-IAC) with a novel and selective approach. Flame atomic absorption spectrometry (FAAS) was used for the determination of metal ions concentrations. For the characterization of the sorbents, scanning electron microscopy, energy dispersive X-ray (SEM/EDX) analysis, and Fourier transform infrared spectroscopy (FTIR) were used. Optimum conditions for the SPE procedure, various parameters such as pH value, eluent type and concentration, sample volume, sample flow rate, adsorption capacity, and selectivity were studied. The adsorption isotherm was analyzed by …
Development Of Dual Enzyme Responsive Molecular And Logic Gate, Sündüs Erbaş Çakmak
Development Of Dual Enzyme Responsive Molecular And Logic Gate, Sündüs Erbaş Çakmak
Turkish Journal of Chemistry
Molecular logic gates are information processing devices that can respond to environmental signals and produce a readable output in response through Boolean logic operations. Molecules with these properties have been used to build smart sensors and therapeutic agents. In this work, dual enzyme-responsive molecular AND logic gate is developed with the intention to discriminate various combinations of enzyme level and/or activity. A resorufin-based sensor is substituted with self-immolative tyrosinase recognition site, 3-hydroxy benzyl group. The Hydroxyl group is protected with acetyl moiety which decreases the affinity of the enzyme. When both tyrosinase and esterase are present in the solution, the …
Determination Of Formaldehyde In Textile Dye And Auxiliary Chemicals With Headspace Gas Chromatography-Flame Ionization Detector, Korel Güneş, Zi̇ya Can, Ayşem Arda
Determination Of Formaldehyde In Textile Dye And Auxiliary Chemicals With Headspace Gas Chromatography-Flame Ionization Detector, Korel Güneş, Zi̇ya Can, Ayşem Arda
Turkish Journal of Chemistry
Formaldehyde is a chemical used in many different industrial sectors and is classified as a carcinogen as well as causing allergic reactions. Due to the health effects of formaldehyde, which is widely used in textile dyes and auxiliary chemicals, its analysis in this type of matrices becomes important. In this study, in order to meet these requirements, formaldehyde was converted to oxime derivative by derivatization with o-(2,3,4,5,6-Pentafluorobenzyl)hydroxylamine hydrochloride. This derivative was successfully sampled with the headspace technique and analyzed with a gas chromatography-flame ionization detector (GC-FID). For the developed method, derivatization and salt effect parameters were investigated. For the method, …
A Systematic Review Of Rdrp Of Sars-Cov-2 Through Artificial Intelligence And Machine Learning Utilizing Structure-Based Drug Design Strategy, Fariha Imtiaz, Mustafa Kamal Pasha
A Systematic Review Of Rdrp Of Sars-Cov-2 Through Artificial Intelligence And Machine Learning Utilizing Structure-Based Drug Design Strategy, Fariha Imtiaz, Mustafa Kamal Pasha
Turkish Journal of Chemistry
Since the coronavirus disease has been declared a global pandemic, it had posed a challenge among researchers and raised common awareness and collaborative efforts towards finding the solution. Caused by severe acute respiratory coronavirus syndrome-2 (SARS-CoV-2), coronavirus drug design strategy needs to be optimized. It is understandable that cognizance of the pathobiology of COVID-19 can help scientists in the development and discovery of therapeutically effective antiviral drugs by elucidating the unknown viral pathways and structures. Considering the role of artificial intelligence and machine learning with its advancements in the field of science, it is rational to use these methods which …
Biological Potential Of Copper Complexes: A Review, Jamshaid Ashraf, Muhammad Asad Riaz
Biological Potential Of Copper Complexes: A Review, Jamshaid Ashraf, Muhammad Asad Riaz
Turkish Journal of Chemistry
This review comprises the inorganic compounds particularly metal coordinated complexes, as drugs play a relevant role in medicinal chemistry. It has been observed that copper complexes are potentially attractive as medicinal importance. In this review, the most remarkable achievements of copper complexes undertaken over the past few decades as antimicrobial, antioxidant, enzyme inhibition activity, and anti-cancer agents are discussed. This work was motivated by the observation that no comprehensive surveys of the diversity of biological activities of copper complexes were available in the literature.
Synthesis, Predictions Of Drug-Likeness, And Pharmacokinetic Properties Of Some Chiral Thioureas As Potent Enzyme Inhibition Agents, Yusuf Sicak
Turkish Journal of Chemistry
A series of chiral thioureas (1 - 17) were synthesized from and tested for their anticholinesterase, tyrosinase, and urease enzyme inhibitor activities. Various phenylisothiocyanates were added to solution of L-cysteine in methanol: water (1 : 1 v / v) at room temperature and stirred for 24 h. The precipitated solid was recrystallized from n-butanol. Pure compounds were characterized by NMR (1H and 13C), FTIR, and CHNS. Tertiary amine containing N-(4-(diethylamino)phenyl)-N'-(2-mercapto-carboxyethanyl)thiourea 17, N-(4-(dimethylamino)phenyl)-N'-(2-mercapto-carboxyethanyl)thiourea 16 and trimethoxy containing N-(3,4,5-trimethoxyphenyl)-N'-(2-mercapto-carboxyethanyl)thiourea 14 were more active than galantamine against AChE and BChE enzymes. In tyrosinase enzyme inhibition activity, compound 14, 10, 12, 6, 13, and …
Polymer Based Advanced Recipes For Imidazoles: A Review, Shivnath Patel, Rajendra Patil, Jagdish Chavan, Anil Beldar
Polymer Based Advanced Recipes For Imidazoles: A Review, Shivnath Patel, Rajendra Patil, Jagdish Chavan, Anil Beldar
Turkish Journal of Chemistry
Imidazoles and their scaffold are an extraordinarily essential class of nitrogen bearing azole heterocyclic compounds. They have different place in wide area of organic synthesis, which can be utilized in a variety of applications in diverse fields including agriculture, medicine, polymer and various industries. Numerous methods for synthesis of imidazole derivatives are reported in last few decades. Existing conventional methods are more or less significant and confined due to its time-consuming reactions, high cost of catalyst, extensive methodologies, low yield rate or no reusability respectively. Overcoming to inefficient conventional methods, finding of novel and effective methods of imidazole synthesis becomes …
Selective Hydrogenation Of Diphenylacetylene Using Nico Nanoparticles Supported On Mesoporous Carbon As Catalyst, Alyaa Shiddiqah, Iman Abdullah, Yuni Krisnandi
Selective Hydrogenation Of Diphenylacetylene Using Nico Nanoparticles Supported On Mesoporous Carbon As Catalyst, Alyaa Shiddiqah, Iman Abdullah, Yuni Krisnandi
Turkish Journal of Chemistry
Hydrogenation of alkynes to alkenes is an important procedure in the synthesis of organic compounds. In this study, selective hydrogenation was carried out on diphenylacetylene as a model of alkyne compounds using NaBH4 as a hydrogen source and NiCo bimetallic nanoparticles supported on mesoporous carbon (NiCo/MC) as a catalyst. The mesoporous carbon was prepared using the soft-templated method from phloroglucinol and formaldehyde as precursors while the NiCo/MC catalyst was synthesized using a wet impregnation method. Based on surface area analysis, it was found that the pore diameters of MC, Ni/MC, and NiCo/MC were 12.8 nm, 13.4 nm, and 12.7 nm …
Computational Investigation Of Unsaturated Ketone Derivatives As Mao-B Inhibitors By Using Qsar, Adme/Tox, Molecular Docking, And Molecular Dynamics Simulations, Abdellah El Aissouq, Mohammed Bouachrine, Abdelkrim Ouammou, Fouad Khalil
Computational Investigation Of Unsaturated Ketone Derivatives As Mao-B Inhibitors By Using Qsar, Adme/Tox, Molecular Docking, And Molecular Dynamics Simulations, Abdellah El Aissouq, Mohammed Bouachrine, Abdelkrim Ouammou, Fouad Khalil
Turkish Journal of Chemistry
Unsaturated ketone derivatives are known as monoamine oxidase B (MAO-B) inhibitors, a potential drug target for Parkinson?s disease. Here, molecular modeling studies, including 2D-QSAR, ADMET prediction, molecular docking, and MD simulation, were performed on a new series of MAO-B inhibitors. The objective is to identify new MAO-B inhibitors with high inhibitory efficacy. The developed 2D-QSAR model was based on the descriptors of MOE software. The most appropriate model, using the partial least squares regression (PLS regression) method, yielded 0.88 for the determination coefficient (r2), 0.28 for the root-mean-square error (RMSE), and 0.2 for the mean absolute error (MAE). The predictive …
Synthesis Of A Novel Antiweathering Nanocomposite Superhydrophobic Room Temperaturevulcanized (Rtv) Silicon Rubber Enhanced With Nanosilica For Coating High Voltageinsulators, Khalid K. Abbas, Mayyadah S. Abed, Ali F. Jasim
Synthesis Of A Novel Antiweathering Nanocomposite Superhydrophobic Room Temperaturevulcanized (Rtv) Silicon Rubber Enhanced With Nanosilica For Coating High Voltageinsulators, Khalid K. Abbas, Mayyadah S. Abed, Ali F. Jasim
Turkish Journal of Chemistry
A new nanocomposite superhydrophobic of the RTV (room temperature vulcanized) silicon rubber reinforced with a different percentage of nanosilica was prepared by a two-stage sol-gel route to obtain a superhydrophobic surface coating on high voltage glass insulator, preventing the dust-water droplet from adhering to its surface. The cold spraying technique was utilized to build up a thin nanocomposite superhydrophobic layer on the glass insulator containing different percentages of the nanosilica particles, such as 23 wt %, 33 wt %, and 44 wt % with RTV silicon substrate. The synthesized nanocomposite was analyzed using the contact angle, roughness, adhesion, hardness, and …
An Experimental And Theoretical Analysis Of Supercritical Carbon Dioxide Extraction Of Cu(Ii) And Pb(Ii) Ions In The Form Of Dithizone Bidentate Complexes, Jeton Halili, Avni Berisha
An Experimental And Theoretical Analysis Of Supercritical Carbon Dioxide Extraction Of Cu(Ii) And Pb(Ii) Ions In The Form Of Dithizone Bidentate Complexes, Jeton Halili, Avni Berisha
Turkish Journal of Chemistry
For more than five decades, dithizone has been widely used as an analytical reagent. This ligand forms strongly colored complexes with metal ions and this ability to form complexes can be used for extraction/removal of certain metal ions in addition to analytical determination. In static mode, the supercritical carbon dioxide extraction of copper and lead ions from aqueous solutions after complexation by the dithizone ligand is studied (at two different conditions: a) p = 120 bar, T = 30 °C, and b) p = 72 bar, T = 50 °C). The addition of methanol improved the extraction process by modulating …
Catalytic Activity Of Ethylbenzene With Product Selectivity By Gold Nanoparticlessupported On Zinc Oxide, Afiq Anwar, Azman Ma'amor, H.N.M. Ekramul Mahmud, Wan Jefrey Basirun, Iskandar Abdullah
Catalytic Activity Of Ethylbenzene With Product Selectivity By Gold Nanoparticlessupported On Zinc Oxide, Afiq Anwar, Azman Ma'amor, H.N.M. Ekramul Mahmud, Wan Jefrey Basirun, Iskandar Abdullah
Turkish Journal of Chemistry
The oxidation of ethylbenzene (EB) using tert-butyl hydroperoxide as the oxidizing agent was carried out in presence of gold nanoparticles (3 nm) supported on zinc oxide in acetonitrile solution. A higher selectivity towards acetophenone (ACP) as the major product, and a moderate selectivity towards other products such as 1-phenylethanol (PE), benzaldehyde (BZL), and benzoic acid (BzA) were observed using the prepared Au/ZnO nanocatalysts at 100 °C for 24 h. It is suggested the reaction produces an intermediate product, which is dimethylethyl-1-phenylethyl peroxide through a radical mechanism. A small amount of benzaldehyde was observed because benzaldehyde went autoxidation to form benzoic …
Synthesis Of Some New Isoxazole Compounds And Their Biological Tyrosinase And Antioxidant Activities, Seda Fandakli
Synthesis Of Some New Isoxazole Compounds And Their Biological Tyrosinase And Antioxidant Activities, Seda Fandakli
Turkish Journal of Chemistry
In this study, 7 new isoxazole compounds (8-14) were synthesized from the cyclization of chalcone compounds (1-7) containing different functional groups with hydroxylamine hydrochloride in alkaline medium. Tyrosinase and antioxidant properties of 8-14 were investigated. IC50 values for the tyrosinase enzyme inhibition of compounds 8, 11, 12, and 13 were varied between 61.47 ± 3.46 and 188.52 ± 5.85, while compounds 9, 10 and 14 did not show any inhibition effect. The antioxidant properties of 8-14 were investigated by DPPH and CUPRAC methods. Compound 12 showed the best DPPH radical scavenging activity (SC50: 40.21 ± 2.71), while 12 and 13 …
Removal Of Cd2+ Metal Ions From Aqueous Solutions By Na-Alginate-Containingcomposite Biosorbent, Ramazan Donat
Removal Of Cd2+ Metal Ions From Aqueous Solutions By Na-Alginate-Containingcomposite Biosorbent, Ramazan Donat
Turkish Journal of Chemistry
This research is related to the effect of alginate-containing composite biosorbent on the sorption capacity of heavy metal Cd2+ ions. The study aims to determine the character and optimization of the sorption of Na-alginate-containing composite biosorbent on the sorption of heavy metal Cd2+ metal ions in an aqueous solution. Optimum conditions of parameters such as biosorbent amount, pH value effect, concentration effect, contact time, and temperature that affect the sorption of Cd2+ ions were determined. Langmuir, Freundlich, D-R isotherms were applied to the obtained data, and it was noted that the sorption Cd2+ ions are better explained with Freundlich and …
Synthesis Of 2-Aryl-5-(Arylsulfonyl)-1,3,4-Oxadiazoles As Potent Antibacterial Andantioxidant Agents, S N Murthy Boddapati, Subrahmanyam Talari, A Emmanuel Kola, Bhuvaneswari Chalapaka
Synthesis Of 2-Aryl-5-(Arylsulfonyl)-1,3,4-Oxadiazoles As Potent Antibacterial Andantioxidant Agents, S N Murthy Boddapati, Subrahmanyam Talari, A Emmanuel Kola, Bhuvaneswari Chalapaka
Turkish Journal of Chemistry
Ten novel 2-aryl-5-(arylsulfonyl)-1,3,4-oxadiazoles were produced and assessed for their in vitro antibacterial and antioxidant activities. Diverse spectroscopic methods li1H NMR, 13C NMR, IR, and LCMS were used for the characterization of the prepared samples and all the data was in good agreement with the anticipated structures. The prepared compounds 6a-j were screened for their in vitro antibacterial activity against bacterial strains Pseudomonas aeruginosa, Enterobacter aerogenes, Escherichia coli (grampositive), and Bacillus cerus, Staphylococcus aureus, Bacillus subtilis (gram-negative). The antimicrobial screening outcome revealed that the prepared 2-(3,4-dimethylphenyl)-5-tosyl-1,3,4-oxadiazole (6j), 2-(3-isopropylphenyl)-5-tosyl-1,3,4-oxadiazole (6c), and 2-(2-ethylphenyl)-5-tosyl-1,3,4-oxadiazole (6i) are most potent among all the examined compounds. Furthermore, …
Ultrafiltration-Based Sample Preparation And Hplc-Uv Determination Of Diclofenac In Human Plasma Samples, Merve Nenni̇, Ayşegül Doğan, Mustafa Çelebi̇er, Murat Soyseven, Mustafa Si̇nan Kaynak, Hassan Y. Aboul-Enein, Göksel Arli̇
Ultrafiltration-Based Sample Preparation And Hplc-Uv Determination Of Diclofenac In Human Plasma Samples, Merve Nenni̇, Ayşegül Doğan, Mustafa Çelebi̇er, Murat Soyseven, Mustafa Si̇nan Kaynak, Hassan Y. Aboul-Enein, Göksel Arli̇
Turkish Journal of Chemistry
The sample preparation step is the initial step in pharmaceutical analysis. While ultrafiltration is a well-known technique used in the food and pharmaceutical industries, it has rarely been used to measure the plasma concentration of active pharmaceutical ingredients. This study aimed to analyze diclofenac sodium (DS) in human plasma samples using ultrafiltration-based sample preparation before high-performance liquid chromatography (HPLC) analysis. The advantages and limitations of ultrafiltration-based sample preparation in bioanalysis were evaluated by comparing the results with conventional methods. The precipitating agent was used before ultrafiltration. The analysis was carried on an HPLC-UV system with a C18 column (250 ×4.6 …
Synthesis And In Vitro Α-Glucosidase And Cholinesterases Inhibitory Actions Of Watersolublemetallophthalocyanines Bearing ({6-[3-(Diethylamino)Phenoxy]Hexyl}Oxy Groups, Turgut Keleş, Zekeri̇ya Biyiklioğlu, Di̇dem Akkaya, Arzu Özel, Burak Barut
Synthesis And In Vitro Α-Glucosidase And Cholinesterases Inhibitory Actions Of Watersolublemetallophthalocyanines Bearing ({6-[3-(Diethylamino)Phenoxy]Hexyl}Oxy Groups, Turgut Keleş, Zekeri̇ya Biyiklioğlu, Di̇dem Akkaya, Arzu Özel, Burak Barut
Turkish Journal of Chemistry
In this paper, we have prepared peripherally tetra-({6-[3-(diethylamino)phenoxy]hexyl}oxy substituted cobalt(II), copper(II), manganese(III) phthalocyanines (3, 4, 5) and their water-soluble derivatives (3a, 4a, 5a). Then, in vitro α-glucosidase and cholinesterases inhibitory actions of the water-soluble 3a, 4a, 5a were examined using spectrophotometric methods. 4a had the highest inhibitory effects among the tested compounds against α-glucosidase due to IC50 values. 4a and 5a had 40 fold higher inhibitory effects than the positive control. For cholinesterases, the compounds showed significant inhibitory actions that of galantamine which was used as a positive control. According to the SI value, 3a inhibited acetylcholinesterase enzyme selectively. In …
Induction Of Lutein Production In Scenedesmus Obliquusunder Different Culture Conditions Prior To Its Semipreparative Isolation, Ayşegül Erdoğan, Ayça Büşra Karataş, Zeli̇ha Demi̇rel, Meltem Dalay
Induction Of Lutein Production In Scenedesmus Obliquusunder Different Culture Conditions Prior To Its Semipreparative Isolation, Ayşegül Erdoğan, Ayça Büşra Karataş, Zeli̇ha Demi̇rel, Meltem Dalay
Turkish Journal of Chemistry
Microalgae with their improved growth rates and accumulation of high-value-added products make their commercial production attractive. Among them, lutein, which is a carotenoid, plays a very important role due to its various applications in the food and pharmaceutical industry. Induction of its biosynthesis can be triggered by various stress conditions like light. In this study, three different light intensities (50,150 and 300 μmol photons/m2s) and aeration rates (1, 3, and 5 L/min) were utilized to induce the lutein biosynthesis and biomass productivity in Scenedesmus obliquus. Lutein was isolated by preparative chromatography using a semiprep C30 column (10 × 250 mm, …
Drug Delivery System For Controlled Release Of Empagliflozin From Alginate-Chitosannanocarrier System, Nasim Ramazanzadeh, Nosrat O. Mahmoodi
Drug Delivery System For Controlled Release Of Empagliflozin From Alginate-Chitosannanocarrier System, Nasim Ramazanzadeh, Nosrat O. Mahmoodi
Turkish Journal of Chemistry
biocompatible nanocarrier system was prepared in this research through the reaction of calcium alginate (CA) with chitosan (CS). The structure of developed nanocarriers (CS-CA) was characterized by thermogravimetric analysis (TGA), Fourier transforms infrared (FT-IR) spectroscopy, field emission scanning electron microscopy (FE-SEM), X-ray diffraction (XRD) atomic force microscopy (AFM), and transmission electron microscopy (TEM). Swelling properties of CS-CA and CA, and their ability for loading and in vitro release of empagliflozin (EMP) were also investigated. The results showed the higher loading capacity of CS-CA compared to CA. For both nanocarriers, the drug release was higher at neutral pH (7.4 and 6.8) …