Physical Sciences and Mathematics Commons^™

Contractible N-Manifolds And The Double N-Space Property, Pete Sparks

Theses and Dissertations

We are interested in contractible n-manifolds M which decompose or split as M = A union B where A,B, and A intersect B are all homeomorphic to Euclidean n-space or A,B, and A intersect B are all homeomorphic to the n-dimensional unit ball. We introduce a 4-manifold M containing a spine which splits as A union B with A,B, and A intersect B all collapsible which in turn implies M splits as the union of two 4-balls whose intersection is also a 4-ball. From M we obtain a countably infinite collection of distinct 4-manifolds all of which split this way. …

Inferential Procedures For Dominance Analysis Measures In Multiple Regression, Shuwen Tang

Theses and Dissertations

In order to better interpret a selected multiple regression model, researchers are often interested in whether a predictor is significantly more important than another or not. This study investigates the performance of the Normal-Theory based (asymptotic) confidence interval and bootstrap confidence intervals for predictors' dominance relationships using both normal and non-normal data. The results show that asymptotic confidence interval method is adequate to make inferences for comparing two general dominance measures when the distribution is multivariate normal or slightly non-normal and when the effect size is no less than 0.15 and the sample size is at least 100. However, the …

Cellular Zinc Trafficking: The Zinc Proteome And Its Reactions With Cadmium, Mohammad Ali Namdarghanbari

Theses and Dissertations

Metals play a crucial role in living systems. Iron, zinc, copper, molybdenum, and manganese are involved in many essential biological activities. Among transition metals, zinc after iron is the most abundant transition metal in the human body and the most abundant in the brain. It exists in more than 3000 proteins, which comprise about 10% of the human proteome. Zn2+ dyshomeostasis is associated with chronic diseases such as metabolic syndrome, diabetes and related complications, bone loss, growth retardation in young children, and neurological and behavioral problems. Despite a good knowledge obtained for metabolism of some metal ions such as copper, …

Three Essays On Opinion Mining Of Social Media Texts, Shuyuan Deng

Theses and Dissertations

This dissertation research is a collection of three essays on opinion mining of social media texts. I explore different theoretical and methodological perspectives in this inquiry. The first essay focuses on improving lexicon-based sentiment classification. I propose a method to automatically generate a sentiment lexicon that incorporates knowledge from both the language domain and the content domain. This method learns word associations from a large unannotated corpus. These associations are used to identify new sentiment words. Using a Twitter data set containing 743,069 tweets related to the stock market, I show that the sentiment lexicons generated using the proposed method …

Text Mining Of Patient Demographics And Diagnoses From Psychiatric Assessments, Eric James Klosterman

Theses and Dissertations

Automatic extraction of patient demographics and psychiatric diagnoses from clinical notes allows for the collection of patient data on a large scale. This data could be used for a variety of research purposes including outcomes studies or developing clinical trials. However, current research has not yet discussed the automatic extraction of demographics and psychiatric diagnoses in detail. The aim of this study is to apply text mining to extract patient demographics - age, gender, marital status, education level, and admission diagnoses from the psychiatric assessments at a mental health hospital and also assign codes to each category. Gender is coded …

Part I: Synthesis And Biological Evaluations Of Potent Class L Selective Histone Deacetylase Inhibitors Part Ii: Aqueous Complexes For Efficient Sizebased Separation Of Americium From Curium Part Iii: Designing Strong Chiral Bronsted Acids And Their Application For Oxaxinanones Derivatization And The Aza-Henry Reaction, Joseph Steve Ulicki

Theses and Dissertations

PART I: SYNTHESIS AND BIOLOGICAL EVALUATIONS OF POTENT CLASS l SELECTIVE HISTONE DEACETYLASE INHIBITORS

Histone deacetylase inhibitors (HDACi) have found a wide variety of medicinal uses and are most noted for their specific apoptotic action towards cancer cells1. Several hydroxamates and tetrapeptides HDACi have since been moved on to phase 1 and 2 clinical trials, with FK228 & SAHA having already been approved for treatment of advanced cutaneous T-cell lymphoma (CTCL). FK228 & SAHA are pan-HDACi which d compounds describes the unselective inhibition for any of the 11 Zn2+-dependent HDAC isoforms. Research in the past five years, has shifted towards …

The 1852 Banda Arc Mega-Thrust Earthquake And Tsunami In Indonesia, Tsz Man Fisher

Theses and Dissertations

In 1852, a five-minute long earthquake hit the Banda Arc region that was felt over most of Indonesia. It caused uplift of new islands and sent a tsunami across the Banda Sea that reached a height of 8 meters at Banda Neira and was also registered at Ambon, Saparua and other islands. Records of the 1852 earthquake at multiple locations provide the constraints needed to reconstruct the disastrous event through earthquake intensity analysis and numerical modeling of the tsunami. Using tsunami heights and arrival times as the major constraints, best fit numerical models of the tsunami were constructed using Clawpack. …

Algebraic Semi-Classical Model For Reaction Dynamics, Tim Glenn Wendler

Theses and Dissertations

We use an algebraic method to model the molecular collision dynamics of a collinear triatomic system. Beginning with a forced oscillator, we develop a mathematical framework upon which inelastic and reactive collisions are modeled. The model is considered algebraic because it takes advantage of the properties of a Lie algebra in the derivation of a time-evolution operator. The time-evolution operator is shown to generate both phase-space and quantum dynamics of a forced oscillator simultaneously. The model is considered semi-classical because only the molecule's internal degrees-of-freedom are quantized. The relative translation between the colliding atom and molecule in an exchange reaction …

The Existence Of A Discontinuous Homomorphism Requires A Strong Axiom Of Choice, Michael Steven Andersen

Theses and Dissertations

Conner and Spencer used ultrafilters to construct homomorphisms between fundamental groups that could not be induced by continuous functions between the underlying spaces. We use methods from Shelah and Pawlikowski to prove that Conner and Spencer could not have constructed these homomorphisms with a weak version of the Axiom of Choice. This led us to define and examine a class of pathological objects that cannot be constructed without a strong version of the Axiom of Choice, which we call the class of inscrutable objects. Objects that do not need a strong version of the Axiom of Choice are scrutable. We …

Chaperone-Mediated Folding And Assembly Of Β-Propeller Proteins Into Cellular Signaling Complexes, Rebecca L. Plimpton

Theses and Dissertations

G protein signaling depends on the ability of the individual subunits of the G protein heterotrimer to assemble into a functional complex. Formation of the G protein βγ (Gβγ) dimer is particularly challenging because it is an obligate dimer in which the individual subunits are unstable on their own. Recent studies have revealed an intricate chaperone system that brings the Gβ and Gγ subunits together. This system includes the cytosolic chaperonin containing TCP-1 (CCT) and a co-chaperone phosducin-like protein 1 (PhLP1). Two key intermediates in the Gβγ assembly process, the Gβ-CCT and the PhLP1-Gβ-CCT complexes, were isolated and their structures …

Pro-Covering Fibrations Of The Hawaiian Earring, Nickolas Brenten Callor

Theses and Dissertations

Let H be the Hawaiian Earring, and let H denote its fundamental group. Assume (Bi) is an inverse system of bouquets of circles whose inverse limit is H. We give an explicit bijection between finite normal covering spaces of H and finite normal covering spaces of Bi. This bijection induces a correspondence between a certain family of inverse sequences of these covering spaces. The correspondence preserves the inverse limit of these sequences, thus offering two methods of constructing the same limit. Finally, we characterize all spaces that can be obtained in this fashion as a particular type of fibrations of …

The Bioluminescence Heterozygous Genome Assembler, Jared Calvin Price

Theses and Dissertations

High-throughput DNA sequencing technologies are currently revolutionizing the fields of biology and medicine by elucidating the structure and function of the components of life. Modern DNA sequencing machines typically produce relatively short reads of DNA which are then assembled by software in an attempt to produce a representation of the entire genome. Due to the complex structure of all but the smallest genomes, especially the abundant presence of exact or almost exact repeats, all genome assemblers introduce errors into the final sequence and output a relatively large set of contigs instead of full-length chromosomes (a contig is a DNA sequence …

Normal Fault Block Or Giant Landslide? Baldy Block, Wasatch Range, Utah, Eric R. Meyer

Theses and Dissertations

Understanding the interplay between surficial and tectonic processes in the development of Utah's Wasatch Range is vital to evaluating geologic hazards along the Wasatch Front. Baldy is a large (6.125 km3) block of limestone and sandstone structurally overlying shale on the western flank of Mount Timpanogos. It has been mapped as a downdropped normal fault block of Permian units, but no other trace of such a fault exists along the range. The Baldy block structurally overlies the weak Manning Canyon shale, which has produced a regional geomorphology replete with faceted spurs, landslide scarps and deposits. Structural, bio- and litho-stratigrahic mapping …

Teachers' Curricular Reasoning And Mkt In The Context Of Algebra And Statistics, Kolby J. Gadd

Theses and Dissertations

This study investigates 7th grade teachers' curricular reasoning and MKT in algebra and statistics. Although the use of curriculum materials and MKT both influence the quality of mathematics instruction, no relationship between teachers' curricular reasoning and MKT was found. Further, teachers' curricular reasoning across algebra and statistics was very similar despite differences in these fields and differences in MKT. A model for thinking about the knowledge needed to provide high quality instruction is proposed by considering the role of curricular reasoning and MKT in instruction.

Compositional Analysis Of Three Clay Artifact Collections From The Southwestern United States, Kathleen R. Kirkham

Theses and Dissertations

This study assessed ways compositional analysis, facilitated by portable X-ray fluorescence technology (PXRF), can be applied in the museum setting to resolve provenance issues and other collections management questions. A major segment of the study evaluated PXRF as a non-invasive geochemical analysis technique to address concerns about whether the resolution of results is sufficient to draw meaningful conclusions. Compositional analysis, mainly facilitated by PXRF, was successfully applied to three clay artifact collections from the southwestern United States. Pottery sherds from Fourmile Ruin were analyzed using PXRF and compared to analyses from invasive wavelength-dispersive XRF and X-ray diffraction techniques. Expanding the …

Evaluating The Surface Layer Wind Profile In The Wrf, Robert Stephen James

Theses and Dissertations

The purpose of this thesis is to investigate how the surface vertical wind profile responds to different planetary boundary layer schemes in computer models. Local surface roughness is one of the elements represented in these schemes, and is used when interpolating winds down from the lowest model level to the surface, so this needs to be accurately represented in the model. Computer models rely on one bulk estimate of surface roughness for a given grid point, despite the complexity of surrounding terrain. Data for this research was gathered from local surface observations and computer simulations, which looked at two different …

Replication And Knowledge Production In Empirical Software Engineering Research, Jonathan L. Krein

Theses and Dissertations

Although replication is considered an indispensable part of the scientific method in software engineering, few replication studies are published each year. The rate of replication, however, is not surprising given that replication theory in software engineering is immature. Not only are replication taxonomies varied and difficult to reconcile, but opinions on the role of replication contradict. In general, we have no clear sense of how to build knowledge via replication, particularly given the practical realities of our research field. Consequently, most replications in software engineering yield little useful information. In particular, the vast majority of external replications (i.e., replications performed …

Microchip Thermal Gradient Gas Chromatography, Anzi Wang

Theses and Dissertations

Although the airbath oven is a reliable heating method for gas chromatography (GC), resistive heating is needed for higher analytical throughput and on-site chemical analysis because of size, heating rate and power requirements. In the last thirty years, a variety of resistive heating methods were developed and implemented for both benchtop and portable GC systems. Although fast heating rates and low power consumption have been achieved, losses in column efficiency and resolution, complex construction processes and difficulties experienced in recovering damaged columns have also become problematic for routine use of resistively heated columns. To solve these problems, a new resistively …

Framework To Implement Authentication, Authorization And Secure Communications In A Multiuser Collaborative Cax Environment, Francis Mensah

Theses and Dissertations

Computer Aided Design (CAD) applications have historically been based on a single user per application architecture. Although this architecture is still popular to date, it does have several drawbacks. First of all the single user CAD architecture inhibits a concurrent engineering design process where several designers can work on the same model simultaneously. This limitation introduces time inefficiency especially when a project involves geographically dispersed designers. A solution to these drawbacks could be a transition from the traditional single user CAD architecture to a multiuser collaborative architecture. Advances in computer networking technologies, especially relating to the Internet, have provided the …

A Covering System With Minimum Modulus 42, Tyler Owens

Theses and Dissertations

We construct a covering system whose minimum modulus is 42. This improves the previous record of 40 by P. Nielsen.

Classifying And Cataloging Cyber-Security Incidents Within Cyber-Physical Systems, William B. Miller

Theses and Dissertations

In the past, there were perceived delineations between the cyber world and the physical world. We are becoming increasingly aware of the overlap between these two worlds, and the overlap itself is increasing. The overlap between these two worlds is known as cyber-physical systems. There have been several incidents involving cyber-physical systems and the number of these incidents is increasing dramatically. In the past there has been no effort to identify methods for describing these incidents in the unique context of cyber-physical systems. This research provides a taxonomy for classifying these incidents that focuses on cross domain, impact oriented analysis. …

Fabrication, Characterization, Optimization And Application Development Of Novel Thin-Layer Chromatography Plates, Supriya Singh Kanyal

Theses and Dissertations

This dissertation describes advances in the microfabrication of thin layer chromatography (TLC) plates. These plates are prepared by the patterning of carbon nanotube (CNT) forests on substrates, followed by their infiltration with an inorganic material. This document is divided into ten sections or chapters. Chapter 1 reviews the basics of conventional TLC technology. This technology has not changed substantially in decades. This chapter also mentions some of the downsides of the conventional approach, which include unwanted interactions of the binder in the plates with the analytes, relatively slow development times, and only moderately high efficiencies. Chapter 2 focuses primarily on …

Synthesis And Characterization Of Complex Molecular Assemblies On Surfaces, Nitesh Madaan

Theses and Dissertations

The research presented in this dissertation is focused on the construction of complex molecular structures on planar gold and silicon dioxide surfaces using a variety of surface modification techniques, along with thorough surface characterization at each modification step. The dissertation is structured into six separate chapters. In Chapter 1, an introduction to the importance and implications of molecular level surface modification, commonly employed surface modification methods, and available surface characterization techniques is presented. Chapter 2 shows applications of novel methodologies for the functionalization of gold surfaces using alkane dithiol self-assembled monolayers and thiol-ene click chemistry. The resulting functionalized gold substrates …

Using Random Forest In The Field Of Metabolomics, Curtis White

Theses and Dissertations

Metabolomics is the science of comprehensive evaluation of changes in the metabolome with a goal to elucidate underlying biological mechanisms of a living system. There is an opinion in the field of metabolomics, the study of the set of metabolites present within an organism, cell, or tissue, that the future development of the field is contingent upon two factors. One of the factors is the advancement of analytical instrumentation, and the other is developing data mining methodologies for extracting meaningful and interpretable experimental results. There are many different types of data mining methodologies, but the undertaking of selecting a particular …

A Privacy Risk Scoring Framework For Mobile, Jedidiah Spencer Montgomery

Theses and Dissertations

Protecting personal privacy has become an increasingly important issue as computers become a more integral part of everyday life. As people begin to trust more personal information to be contained in computers they will question if that information is safe from unwanted intrusion and access. With the rise of mobile devices (e.g., smartphones, tablets, wearable technology) users have enjoyed the convenience and availability of stored personal information in mobile devices, both in the operating system and within applications.For a mobile application to function correctly it needs permission or privileges to access and control various resources and controls on the mobile …

The Nature And Origin Of Pebble Dikes And Associated Alteration: Tintic Mining District (Ag-Pb-Zn), Utah, Douglas M. Johnson

Theses and Dissertations

In many ore deposits throughout the world, brecciation often accompanies or occurs in association with mineralization (Sillitoe, 1985). Such is the case in the Tintic Mining District (Ag-Pb-Zn) of north-central Utah, where unique breccia features called pebble dikes occur alongside significant mineralization. Pebble dikes are tabular bodies of breccia, which consist of angular to rounded clasts of quartzite, shale, carbonate, and minor igneous rock cemented in a fine-grained clastic matrix. All clasts now lie above or adjacent to corresponding source rocks. Dikes are thin, typically less than 0.3 m wide to as much as 1 m, and can exceed 100 …

Using Variations Of Shape And Appearance In Alignment Methods For Classifying Human Actions, Sultan Mohammad Almotairi

Theses and Dissertations

In this dissertation, we address the problem of recognizing human-action from videos. The recognition aims at recovering action information from the image sequences using different features such as variations of the human shape. Approaches based on such features often use sequence-alignment methods. We propose two novel methods for human-action recognition. We also propose an elliptical-shaped band for the Dynamic Time Warping (DTW) that provides a good compromise between alignment accuracy and computational speed. First, we study the applicability of the pairwise shape-similarity measurements for human-action recognition. Since action can be seen as a sequence of shapes of silhouette poses, there …

The Relationship Between Environmental Factors And Cyanobacteria Population In Lake Bloomington And Evergreen Lake In Mclean County, Illinois, Matthew Douglas Meyers

Theses and Dissertations

This thesis investigates cyanobacteria on two lakes in McLean County, Illinois from the months of August to October. Data was collected every other week.Cyanobacteria are prokaryotes that may be unicellular, colonial or filamentous in form. These cells can be known to be toxic or non-toxic. The factors that control the reproduction of cyanobacteria are the temperature and nutrients of nitrogen and phosphorus. These microorganisms are located in marine and terrestrial settings worldwide. The focus of this study was at two man-made lakes which are Lake Bloomington and Lake Evergreen. Sampling and collection of data was done on two lakes to …

Scalable Detection And Extraction Of Data In Lists In Ocred Text For Ontology Population Using Semi-Supervised And Unsupervised Active Wrapper Induction, Thomas L. Packer

Theses and Dissertations

Lists of records in machine-printed documents contain much useful information. As one example, the thousands of family history books scanned, OCRed, and placed on-line by FamilySearch.org probably contain hundreds of millions of fact assertions about people, places, family relationships, and life events. Data like this cannot be fully utilized until a person or process locates the data in the document text, extracts it, and structures it with respect to an ontology or database schema. Yet, in the family history industry and other industries, data in lists goes largely unused because no known approach adequately addresses all of the costs, challenges, …

Arimaa: Developing A Higher Ranked Fall Back Move Generator Using A Relational Database, Patrick Mckee

Theses and Dissertations

Our approach to playing the game of Arimaa understands that the game was created to showcase the limits of brute force computing power. Using a relational database, we will be able to view similar situations that have already been played out, inventory a number of suitable reactions and make the best move given a number of attributes. This results in us making a decision that can theoretically result in a win, and hopefully will. Measurable positive results have been procured specifically from the area of concentration component of the research. In the area of concentration component we target a specific …