Physical Sciences and Mathematics Commons^™

New Synthetic Reactions Towards Global Chlorination And Enamides Functionalization, Mirza Ardella Saputra

LSU Doctoral Dissertations

This dissertation focuses on two main projects, global chlorination and enamide functionalization, which both encompass in cationic intermediates. Inspired by the desires to find a new chlorination method, global chlorination project is emphasized in chapter one and chapter two, in which chapter one details various known chlorine-containing natural products, including alkyl chlorides and vinyl chlorides. This chapter also describes the previously known protocols to synthesize alkyl chlorides in the attempts of chlorosulfolipids total syntheses, as well as several known reactions to synthesize vinyl chlorides that are both important functional groups in organic synthesis. Chapter two depicts our novel synthetic reaction …

Studying The Reaction 34ar(Alpha,P)37k And Its Impact On Xrb Nucleosynthesis And Observables, Amber C. Lauer

LSU Doctoral Dissertations

Type I X-Ray bursts (XRB’s) are a site of nucleosynthesis for some proton-rich elements up to A=100. These stellar explosions occur on the surface of a neutron star in a Low- Mass X-ray Binary accreting H- and He-rich material. During accretion nuclear burning occurs through stable processes such as the hot CNO (HCNO) cycles, but at some critical accretion condition the the HCNO cycles are bypassed through a breakout reaction. This triggers the thermonuclear runaway of the XRB. During the burst, nucleosynthesis on certain proton-rich nuclei, called (α, p) waiting points, can stall which could stall the energy generation and …

Hierarchical Fusion Based Deep Learning Framework For Lung Nodule Classification, Kazim Sekeroglu

LSU Doctoral Dissertations

Lung cancer is the leading cancer type that causes the mortality in both men and women. Computer aided detection (CAD) and diagnosis systems can play a very important role for helping the physicians in cancer treatments. This dissertation proposes a CAD framework that utilizes a hierarchical fusion based deep learning model for detection of nodules from the stacks of 2D images. In the proposed hierarchical approach, a decision is made at each level individually employing the decisions from the previous level. Further, individual decisions are computed for several perspectives of a volume of interest (VOI). This study explores three different …

Non-Centrosymmetric Superconductivity And Magnetism In The Presence Of Broken Symmetries, Mojammel Alam Khan

LSU Doctoral Dissertations

Non-centrosymmetric (NC) superconducting and magnetic compounds have been synthesized and investigated using magnetic, specific heat, and transport measurements, as well as by neutron scattering and quantum oscillations. The crystal structures of NC compounds are defined by the lack of an inversion center. In NC superconductors, a finite antisymmetric spin orbit coupling originating from broken inversion symmetry results in unconventional Cooper pairing. Instead of a single spin channel, the order parameter is a mixture of spin-singlet and spin-triplet states. For NC magnetic compounds, the antisymmetric and isotropic spin interactions compete, leading to a helical ground state.

We have studied the NC …

Energy-Constrained Quantum Communication And Digital Dynamical Decoupling, Haoyu Qi

LSU Doctoral Dissertations

This is a two-part thesis glued together by an everlasting theme in Quantum Information Science \-- to save the quantum state, or the information stored in it, from unavoidably environment-induced noise. The first part of this thesis studies the ultimate rate of reliably transmitting information, stored in quantum systems, through a noisy evolution. Specifically, we consider communication over optical links, upon which future inter-city quantum communication networks will be built. We show how to treat the infinite-dimensional bosonic system rigorously and establish the theory of energy-constrained private and quantum communication over quantum channels. Our result represents important progress in the …

Influences Of Hurricanes, Floods, And Organic Production On River-Delta Evolution Over Decadal To Centennial Time-Scales, Crawford M. White

LSU Doctoral Dissertations

Episodic overbank flooding and sediment resuspension events (such as cold front passages or tropical cyclones) are recognized as important natural components for wetlands maintaining vertical equilibrium with sea-level. However, the relative importance of these components to an anthropogenically unmodified delta complex remains unclear. This study uses sediment cores to describe the relative importance of these vertical accretion components the Lafourche and Balize Deltas of the Mississippi River. Existing wetlands of the abandoned lower Lafourche receive no direct fluvial sediment, but instead are supported by sediment resuspended by tropical cyclones and cold fronts that pass over them. Wetlands of the modern …

Information Theoretic Study Of Gaussian Graphical Models And Their Applications, Ali Moharrer

LSU Doctoral Dissertations

In many problems we are dealing with characterizing a behavior of a complex stochastic system or its response to a set of particular inputs. Such problems span over several topics such as machine learning, complex networks, e.g., social or communication networks; biology, etc. Probabilistic graphical models (PGMs) are powerful tools that offer a compact modeling of complex systems. They are designed to capture the random behavior, i.e., the joint distribution of the system to the best possible accuracy. Our goal is to study certain algebraic and topological properties of a special class of graphical models, known as Gaussian graphs. First, …

Hydroformylation And Aldehyde-Water Shift Catalysis By Dirhodium Tetraphosphine Complexes, Marshall Douglas Moulis

LSU Doctoral Dissertations

The use of a unique tetraphosphine ligand (et,ph-P4) allows for the chelating of two rhodium centers to perform bimetallic coopertivity in hydroformylation reactions to better the yields the linear aldehyde product. The proposed catalyst is [Rh₂(μ-H)₂(CO)₄(rac-et,ph-P4)]²⁺ and has been studied by in situ FT-IR and NMR. When tested in a polar phasic acetone/water (30 % by vol.), the catalyst forms a monocationic system [Rh₂(μ-H)₂(CO)₄(rac-et,ph-P4)]⁺ that has an initial TOF of 26 min^-1, selectivity of 27:1 L:B, and low byproducts of …

Nanoparticle-Based Drug-Delivery Systems Studied By Second Harmonic Generation, Raju Ram Kumal

LSU Doctoral Dissertations

Second harmonic generation (SHG) is used to study different types of colloidal nanoparticle drug-delivery systems. The surface charge density, electrostatic surface potentials, and ion adsorptions of 50 nm colloidal gold nanoparticle samples coated with mercaptosuccinic acid are determined using SHG measurements under varying NaCl and MgCl₂ concentrations in water. Numerical solutions to the spherical Poisson-Boltzmann equation are fit to the SHG results to account for the nanoparticle surface curvature and ion adsorption to the Stern layer interface, showing excellent agreement with electrophoretic mobility measurements. In another study, nanoparticles of gold, silver and polystyrene are functionalized with microRNA using a …

Application Of Grating-Based Interferometry To Additive Manufacturing, Lithium-Ion Batteries, And Crystals, Adam Joseph Brooks

LSU Doctoral Dissertations

X-ray and neutron imaging are convenient ways to non-destructively observe novel materials. X-rays provide advantages of low cost and high brilliance while neutrons show bulk and isotopic sensitivity. Imaging provides a way for observing chemical and physical properties of materials without the need for destruction. The way of the imaging future is utilizing imaging with grating-based interferometry. In comparison to traditional radiography and tomography, by using absorption and phase gratings in the beam path, the absorption, phase, and scattering of a sample can be detected. In essence, three image datasets can be obtained in one experiment, saving substantially on costs …

On Braids, Branched Covers And Transverse Invariants, Jose Hector Ceniceros

LSU Doctoral Dissertations

In this work, we present a brief survey of knot theory supported by contact 3-manifolds. We focus on transverse knots and explore different ways of studying transverse knots. We define a new family of transverse invariants, this is accomplished by considering $n$-fold cyclic branched covers branched along a transverse knot and we then extend the definition of the BRAID invariant $t$ defined in cite{BVV} to the lift of the transverse knot. We call the new invariant the lift of the BRAID invariant and denote it by $t_n$. We then go on to show that $t_n$ satisfies a comultiplication formula and …

Decentralized Scheduling For Many-Task Applications In The Hybrid Cloud, Brian Lyle Peterson

LSU Doctoral Dissertations

While Cloud Computing has transformed how we solve many computing tasks, some scientific and many-task applications are not efficiently executed on cloud resources. Decentralized scheduling, as studied in grid computing, can provide a scalable system to organize cloud resources and schedule a variety of work. By measuring simulations of two algorithms, the fully decentralized Organic Grid, and the partially decentralized Air Traffic Controller from IBM, we establish that decentralization is a workable approach, and that there are bottlenecks that can impact partially centralized algorithms. Through measurements in the cloud, we verify that our simulation approach is sound, and assess the …

Improved Protein Characterizations Using Ionic Liquids: Page And Maldi-Ms, Punprabhashi Vidanapathirana

LSU Doctoral Dissertations

Protein separation by polyacrylamide gel electrophoresis (PAGE) and identification by matrix assisted laser desorption ionization-mass spectrometry (MALDI-MS) are primary tools of protein analysis. In these techniques, surfactants are used in protein sample preparation in order to enhance the protein solubility. Conventional surfactants have shown limitations in protein analysis due to the structural complexity of proteomes, resulting in low resolution. The research goal of this dissertation is to address some of these limitations by applying novel cationic ionic liquid surfactants (ILS), N-alkyl-4-methyl pyridinium bromide (CnPBr where n=4, 8, 11). The ILS would be suitable candidates to be used in PAGE protein …

Manifestations Of Symmetry In Polynomial Link Invariants, Kyle Istvan

LSU Doctoral Dissertations

The use and detection of symmetry is ubiquitous throughout modern mathematics. In the realm of low-dimensional topology, symmetry plays an increasingly significant role due to the fact that many of the modern invariants being developed are computationally expensive to calculate. If information is known about the symmetries of a link, this can be incorporated to greatly reduce the computation time. This manuscript will consider graphical techniques that are amenable to such methods. First, we discuss an obstruction to links being periodic, developed jointly with Dr. Khaled Qazaqzeh at Kuwait University, using a model developed by Caprau and Tipton. We will …

Sediment Transport And Channel Morphology Dynamics Of Highly Regulated Alluvial Rivers - A Case Study Of The Lowermost Mississippi River., Sanjeev Joshi

LSU Doctoral Dissertations

The Mississippi River delta is facing severe land loss. An urgent need exists to examine sediment transport and channel morphology dynamics along this highly engineered alluvial river that has shaped and will continue to shape its delta. This dissertation research focuses on investigating channel morphology dynamics and sediment transport in the recent three decades along a 327-km reach (from about 492 to 167 km upstream from the river’s outlet in the Gulf of Mexico) of the Lowermost Mississippi River (LmMR). The specific objectives of this research were to: 1) analyze riverbed adjustment, i.e., channel-bed aggradation or channel erosion at seven …

Reduced Order Models For Beam-Wave Interaction In High Power Microwave Sources, Lokendra Singh Thakur

LSU Doctoral Dissertations

We apply an asymptotic analysis to show that corrugated waveguides can be represented as cylindrical waveguides with smooth metamaterial coatings when the corrugtions are subwavelength. Here the metamaterial delivers an effective anisotropic surface impedance, effective dielectric constant, and imparts novel dispersive effects on signals traveling inside the waveguide. These properties arise from the subwavelength resonances of the metamaterial. For sufficiently deep corrugations, the waveguide exhibits backward wave propagation, which can be understood in the present context as a multi-scale phenomenon resulting from local resonances inside the subwavelength geometry. Our approach is well suited to numerical computation and we provide a …

Human Gut Microbiota And Obesity: How Is Gut Microbiota Associated With Obesity Improvement Induced By Bariatric Surgeries Or Low-Calorie Diet Treatment?, Rui Zhang

LSU Doctoral Dissertations

An increasing number of studies suggest that the complex microbial community of the human gut may have an important role in human health and disease conditions such as obesity and diabetes. However, the causal relationship among gut microbiota, obesity, weight loss, and the influence of bariatric surgery remains largely unknown. This study investigated the correlation between human gut microbiota and obesity via determining how gut microbiota is associated with obesity improvement induced by bariatric surgeries (BRS) and low-calorie diet (LCD) treatment. Specifically, we investigated the effects of various bariatric surgery (BRS) procedures and a low-calorie diet (LCD) treatment on the …

Mining Social Media Data For Improved Understanding Of Disaster Resilience, Lei Zou

LSU Doctoral Dissertations

Disaster resilience is the capacity of a community to ‘bounce back’ from disastrous events, by effecting resilience building activities through the four phases of emergency management – preparedness, response, recovery, and mitigation. However, data describing a community’s behaviors in each phase are difficult to access in traditional databases. Social media data provide an innovative data source to better understand communities’ responses and behaviors in each phase of emergency management during disasters, and thus could ultimately monitor and enhance disaster resilience. This study analyzes the spatial-temporal patterns of Twitter activities during Hurricane Sandy, which struck the northeastern United States on October …

Manipulating Physical Properties Of Complex Materials By Processing, Mohammad Saghayezhian

LSU Doctoral Dissertations

Transition metal oxides (TMOs) are a class of materials in which charge, orbital, spin and lattice strongly interact with each other. In the present thesis, a special attention is paid to the physical properties of TMOs as a function of processing. First, TMOs are studied as substrates, where the surface is of prime importance. Second, the thin films are fabricated and their physical properties are presented. The SrTiO3 (001) and (111) surfaces are weakly and strongly polar and the free energy of intact surfaces should diverge. It is shown that in TiO2 terminated SrTiO3(001) the top most layer shows rumpling …

Sediment Transport And Slope Stability In The Northern Gulf Of Mexico, Jeffrey Blake Obelcz

LSU Doctoral Dissertations

Sediment transport and slope stability are fundamental organizing agents of the geological record. These processes have been extensively studied along the northern margin of the Gulf of Mexico basin for both basic and applied purposes, but our knowledge of them is limited by the spatial and temporal sampling capabilities of traditional geologic oceanographic surveying tools such as coring, single-beam echosounders, and sidescan sonar. This dissertation seeks to update the state of knowledge regarding northern Gulf of Mexico sediment transport and slope stability from annual to millennial timescales, primarily using relatively high-resolution acoustic geophysical tools such as swath bathymetric echosounders and …

Symbolic And Deep Learning Based Data Representation Methods For Activity Recognition And Image Understanding At Pixel Level, Manohar Karki

LSU Doctoral Dissertations

Efficient representation of large amount of data particularly images and video helps in the analysis, processing and overall understanding of the data. In this work, we present two frameworks that encapsulate the information present in such data. At first, we present an automated symbolic framework to recognize particular activities in real time from videos. The framework uses regular expressions for symbolically representing (possibly infinite) sets of motion characteristics obtained from a video. It is a uniform framework that handles trajectory-based and periodic articulated activities and provides polynomial time graph algorithms for fast recognition. The regular expressions representing motion characteristics can …

Nanoscale Studies Of Proteins And Thin Films Using Scanning Probe Microscopy, Zachary Lane Highland

LSU Doctoral Dissertations

Nanostructures of organosilanes, thin metal films, and protein nanopatterns were prepared and analyzed with atomic force microscopy (AFM). Organosilanes with designed functional groups were used to selectively pattern green fluorescent protein at the nanoscale using protocols developed with particle lithography. Mesospheres are deposited onto a substrate to produce a surface mask. Organosilanes are deposited to form a matrix film surrounding nanopores for depositing proteins. The nanopatterns were characterized using AFM, after steps of particle lithography for directly visualizing surface changes. Studies with AFM also provide a compelling tool for teaching undergraduates to introduce concepts of nanoscience. An undergraduate laboratory was …

The Role Of Defects In The Metal-Nonmetal Transition In Metallic Oxide Films, Gaomin Wang

LSU Doctoral Dissertations

Metal-nonmetal transition, or more specifically, metal-insulator transition (MIT) has been one of the most intriguing topics in condensed matter physics. Two theories describing fundamental driving mechanisms of MIT has been well-established over time: Mott-Hubbard theory and Anderson localization theory. The former mainly deals with contribution of electron interactions/correlations to the MIT, and the latter focuses on the role of disorder. However, it is an open topic how a system behaves when both effects exist in a system. This study mostly takes interest in a type of MIT induced by dimensionality-crossover in the transition metal oxides (TMOs) systems. TMO system is …

On The Skein Theory Of 0-Framed Surgery Along The Trefoil Knot, Andrew Robert Holmes

LSU Doctoral Dissertations

In this dissertation, we will give a generating set of the Kauffman bracket skein module over the field Q(A) of 0-framed surgery along the trefoil knot. This generating set is described as a certain subset of a known basis for the skein module over Z[A^±1] of the trefoil exterior.

Chemical Synthesis: New Methods For O-Glycosylation And The Preparation Of Organic Thin Films, Rashanique Deondria Quarels

LSU Doctoral Dissertations

This dissertation focuses on the diverse use of chemical synthesis. Herein, I will discuss the use of synthetic organic chemistry for the modification surfaces and the synthesis of small molecules. Chapter One is an introduction to the realm of surface chemistry. I have highlighted some key methods for surface modification. Additionally, methods to characterize the as-formed thin films are also outlined. In Chapter Two, I discuss the use of visible-light photoredox catalysis in the nanoscale lithography of Au(111) surfaces. Blue LED irradiation of solutions of NBDT in the presence of Ru(bpy)32+ results in the formation of p-nitrophenyl radicals that graft …

Numerical Simulations Of Mass Transfer In Close And Contact Binaries Using Bipolytropes, Kundan Vaman Kadam

LSU Doctoral Dissertations

We present the first self-consistent, three dimensional study of hydrodynamic simulations of mass transfer in close and contact binary systems, with both stars represented as bipolytropes (composite polytopes). The project is motivated by the recent eruption of V1309 Scorpii which was proved to be the merger of a contact binary system. The final eruption is assumed to be the disruption of the core of the secondary inside the more massive star. The initial, equilibrium binary models are rotating synchronously in circular orbits and are obtained using the Bipolytropic Self Consistent Field (BSCF) technique, which is a modi cation of Hachisu's …

Design, Synthesis, And Evaluation Of Innovative Bodipy-Peptidic Conjugates For Biological Application, Tyrslai Menyaee Williams

LSU Doctoral Dissertations

Abstract Chapter 1 provides a brief introduction to colorectal cancer (CRC), methods of detection, photodynamic therapy (PDT), and EGFR as an attractive targeting strategy for imaging CRC. Chapter 2 details the synthesis of ten peptide sequences for targeting EGFR receptors at the site of CRC, as a collaborative work with Dr. Seetharama Jois. This chapter also investigates the efficacy of these peptides for EGFR. Chapter 3 offers the first synthetic strategy for developing BODIPY-peptide conjugates via amide linkages. All conjugates were optimized for the best reaction conditions and good yields were observed. Each conjugate was subjected to photophysical, SPR, and …

A Palynostratigraphic Investigation Of Holocene Coastal Texas Bays: Implications For Future Coastal Change, Shannon Marie Ferguson

LSU Doctoral Dissertations

Although the Gulf of Mexico is one of the most studied basins in the world, a majority of the focus has been driven by petroleum exploration and/or on seismic and sedimentological facies models. Rarely has the intent of previous studies been to characterize the Holocene climatic record of coastal Texas. Of those studies that discuss Holocene vegetation change, the majority focus on the Mississippi River Delta, the Edwards Plateau or central Florida, leaving an absence of insight to western Gulf of Mexico climate changes. The Texas coastline stretches 595 km across almost 4° of latitude and the strong northwestern precipitation …

Effect Of Metal Speciation In Fly Ash On Environmentally Persistent Free Radical Formation, Elisabeth Eileen Cook

LSU Doctoral Dissertations

Waste incineration and Superfund sites lead to the formation of pollutants harmful to both the environment and human health. Environmentally Persistent Free Radicals (EPFRs) are a class of newly discovered radical pollutants known to form on combustion by-products such as fly ash and particulate matter. EPFRs are rapidly gaining attention for their harmful effects on the environment and human health. Previous research has shown the formation of EPFRs through surface-mediated reactions with transition metal-oxides on particulates. The work presented in this dissertation explores the relationship between fly ash composition and EPFR formation. Fly ash production occurs from combustion systems, namely …

The Effects Of Instrumental Noise On Searches For Generic Transient Gravitational Waves In Advanced Ligo, Marissa Walker

LSU Doctoral Dissertations

One hundred years after Albert Einstein predicted the existence of gravitational waves as a result of his theory of general relativity, the Laser Interferometer Gravitational-Wave Observatory (LIGO), made the first direct detection of a gravitational-wave signal from a binary black hole merger, GW150914. GW150914 was found not only by search methods specifically developed to find the distinctive waveform produced by coalescing binaries, but also by generic searches designed to find any arbitrary short-duration signal in the LIGO data. The impact of noise on the searches must be carefully investigated in order to reduce the search background and enable confident gravitational-wave …