Physical Sciences and Mathematics Commons^™

Library Synthesis Of Anticancer And Antibacterial Agents Via Azide Chemistry, Jianjun Zhang

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Various anticancer and antibacterial agents have been synthesized via azide chemistry by taking advantage of carbohydrate. Starting from the synthesis of 14 glycosyl azides, a library of carbohydrate-oxazolidinone conjugates and a library of carbohydrate-cyclopamine conjugates with biological interests were synthesized based on a highly efficient "click reaction" assisted by sonication. Some of the conjugates have improved solubility and enhanced anticancer activity.

A library of neomycin B derivatives with various modifications at the 5" position has been synthesized. Two leads exhibit prominent activity against both methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE). Antibacterial activities were measured when combined with other …

Evapotranspiration Of Kentucky Bluegrass, Lynda L. Fenton

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Rapid population growth in arid regions of the western US is placing increased demand on water resources. Variability in precipitation and common occurrence of drought have promoted scrutiny of water use in urban lawns and gardens. However, few reliable measurements of water use of these landscapes exist. Quantifying the amount of water used vs. required by landscapes such as turfgrass would allow significant water conservation. Evapotranspiration (ET) is affected by biophysical factors such as: available energy, turbulent mixing, saturation deficit, soil water, and stomatal conductance. In order to simulate the water use by turfgrass, the relative importance of these processes …

A Spatiotemporal Analysis Of Aspen Decline In Southern Utah’S Cedar Mountain, Using Remote Sensing And Geographic Information Systems, David M. Evans

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Widespread mortality of quaking aspen (Populus tremuloides Michx.) has occurred over large expanses of the Western US during the 20^th century. While much of this decline was due to conifer encroachment into seral aspen, significant aspen losses also occurred in areas of persistent aspen and may have been exasperated by drought conditions. Aspen decline has been especially notable at Cedar Mountain, Utah, an area of mostly private land and extensive persistent aspen coverage. The objectives of this study were to create a time series of live and dead aspen cover on the Cedar Mountain landscape, using remotely sensed …

Examination Of Deformation In Crystalline Rock From Strike-Slip Faults In Two Locations, Southern California, David H. Forand

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Damage zones adjacent to or associated with faults are important to the geologic community because of their implications to hazards and their ability to preserve evidence for, and show history of, slip, fluid flow, and deformation associated with large strike-slip faults. We examine two fault zones in southern California where fault zone damage is expressed. We revisit the drilled crystalline core from the Cajon Pass California drill hole, 4 km northeast of the San Andreas fault (SAF), and 1 km north of the Cleghorn fault, to perform a systematic structural analysis of deformation and alteration associated with strike-slip faulting at …

Dynamics Of Van Der Waals Clusters: Theoretical And Computational Studies, Jordan Aleksander Ramilowski

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The marriage of two very powerful techniques – cryogenic matrix isolation spectroscopy and seeded supersonic molecular beams – has led to the development of a novel type of cryogenic matrix isolation spectroscopy in ultracold, near 0 K, He droplets. The technique known as helium nanodroplet isolation (HENDI) has seen tremendeous experimental interest over the past 20 years; this in turn has resulted in the availability of spectroscopic data for many molecules and clusters embedded in He clusters. The experimental findings have motivated a large number of theoretical calculations. This dissertation focuses on theoretical and computational studies of the rotational dynamics …

Keeping Wetlands Wet: The Human Hydrology Of Wetlands In The Bear River Basin, Rebekah Downard

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

This research seeks to understand how wetlands maintain a water supply in the Bear River Basin, where water is generally scarce. Research was conducted through semi-structured interviews with wetland and water experts in the basin and archival research of historical documents and water rights.

The U. S. Fish and Wildlife Service manages three refuges on the Bear River, and has obtained water rights portfolios for each. Holding water rights does not ensure that there will be water available for refuge wetlands. Instead, position in relation to other powerful water users is the most important factor in determining the security of …

Geometry And Electronic Structure Of Doped Clusters Via The Coalescence Kick Method, Boris Averkiev

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Developing chemical bonding models in clusters is one of the most challenging tasks of modern theoretical chemistry. There are two reasons for this. The first one is that clusters are relatively new objects in chemistry and have been extensively studied since the middle of the 20th century. The second reason is that clusters require high-level quantum-chemical calculations; while for many classical molecules their geometry and properties can be reasonably predicted by simpler methods.

The aim of this dissertation was to study doped clusters and explain their chemical bonding. The research was focused on three classes of compounds: aluminum clusters doped …

Alternative Sampling And Analysis Methods For Digital Soil Mapping In Southwestern Utah, Colby W. Brungard

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Digital soil mapping (DSM) relies on quantitative relationships between easily measured environmental covariates and field and laboratory data. We applied innovative sampling and inference techniques to predict the distribution of soil properties, soil attributes, taxonomic classes, and dominant vegetation across a 30,000-ha complex Great Basin landscape in southwestern Utah. This arid rangeland was characterized by rugged topography, diverse vegetation, and intricate geology. Environmental covariates calculated from digital elevation models (DEM) and spectral satellite data were used to represent factors controlling soil development and distribution. We investigated optimal sample size and sampled the environmental covariates using conditioned Latin Hypercube Sampling (cLHS). …

A Comparison Of Soil Moisture And Hillslope-Stream Connectivity Between Aspen And Conifer-Dominated Hillslopes Of A First Order Catchment In Northern Utah, Amy R. Burke

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Mountain headwater catchments in the semi-arid Intermountain West are important sources of surface water because these high elevations receive more precipitation than neighboring lowlands. The hydrology of these mountain catchments is especially important as the region faces water shortages and conflicts. Conifer encroachment on aspen stands has been observed across the western US and can result in a decline in water yield. The overall objective of this study was to further our understanding of hillslope-stream connectivity in a headwater catchment of Northern Utah and any observable differences in this connection between aspen and conifer hillslopes. Hillslopes are the fundamental unit …

Statistical Analysis Of Linear Analog Circuits Using Gaussian Message Passing In Factor Graphs, Miti Phadnis

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

This thesis introduces a novel application of factor graphs to the domain of analog circuits. It proposes a technique of leveraging factor graphs for performing statistical yield analysis of analog circuits that is much faster than the standard Monte Carlo/Simulation Program With Integrated Circuit Emphasis (SPICE) simulation techniques. We have designed a tool chain to model an analog circuit and its corresponding factor graph and then use a Gaussian message passing approach along the edges of the graph for yield calculation. The tool is also capable of estimating unknown parameters of the circuit given known output statistics through backward message …

Salinity Inventory And Tolerance Screening In Utah Agriculture, Austin Mccoy Hawks

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Soil salinity, a yield-limiting condition, has plagued crop production for centuries by reducing crop productivity. Research has introduced methods for successfully managing soil salinity. This research discusses the adaptation of established management methods to create new soil salinity management techniques.

One adapted technique is an automated crop screening apparatus. A new design was created and successfully used in rapidly screening two strawberry cultivars to determine their tolerance to salinity. Screening crops and determining their tolerance to yield-limiting conditions are essential in managing soil salinity.

Another salinity management tool used in this research was electromagnetic induction (EMI). EMI was used to …

Reconciling Holocene Alluvial Records In Buckskin Wash, Southern Utah, Jonathan E. Harvey

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Most approaches to interpreting alluvial records in drylands fall into one of two categories: (1) The "arroyo problem," wherein workers study cycles of streambed aggradation and degradation in broad, unconstricted alluvial valleys; and (2) paleoflood hydrology, where alluvial sequences in constricted bedrock canyons are interpreted as paleoflood deposits from streams with stable channel grade and geometry. Both approaches can be valid in their end-member settings, but there is confusion about how the two record types relate in a single drainage. We address this disconnect in Buckskin Wash, an ephemeral stream that consists of a broad alluvial reach draining into a …

Covert Botnet Design And Defense Analysis, Brandon Lyle Shirley

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Intrusion defense system (IDS) development has been largely reactionary in nature. This is especially troubling given that botnets are capable of compromising and controlling thousands of computers before security professionals develop a mitigation technique. As new exploits are created, new mitigation techniques are developed to detect infections and, where possible, remove them. This thesis breaks from this tradition of reacting to malware. Instead, it looks at possible malicious software models through analyzing existing defense systems for exploitable weaknesses.

First, this thesis presents a new specialized botnet that circumvents current network intrusion detection mechanisms. The proposed botnet coordinates external communication among …

A Comparison Theorem For The Topological And Algebraic Classification Of Quaternionic Toric 8-Manifolds, Piotr Runge

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

In order to discuss topological properties of quaternionic toric 8-manifolds, we introduce the notion of an algebraic morphism in the category of toric spaces. We show that the classification of quaternionic toric 8-manifolds with respect to an algebraic isomorphism is finer than the oriented topological classification. We construct infinite families of quaternionic toric 8-manifolds in the same oriented homeomorphism type but algebraically distinct. To prove that the elements within each family are of the same oriented homeomorphism type, and that we have representatives of all such types of a quaternionic toric 8-manifold, we present and use a method of evaluating …

Geologic Mapping, Alluvial Stratigraphy, And Optically Stimulated Luminescence Dating Of The Kanab Creek Area, Southern Utah, Michelle Carlene Summa

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

At the turn of the century, Kanab Creek incised 30-meters into its alluvium, leaving behind fluvial terraces and thick basin fill sediments exposed along arroyo walls. Research objectives were to determine the timing and causes of past valley-filling and arroyo-cutting episodes along a 20 km-long reach of Kanab Creek in southern Utah. Fluvial deposits were mapped at the 1:12,000 scale and sediments were described and dated using Optically Stimulated Luminescence (OSL) and radiocarbon dating.

The Kanab Creek valley can be divided into a narrow, upper terraced reach and a broad lower basin fill reach near Kanab, Utah. The most prominent …

A River Transformed: Historic Geomorphic Changes Of The Lower Rio Grande In The Big Bend Region Of Texas, Chihuahua, And Coahuila, David James Dean

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Over the last century, the construction and management of large dams and stream-flow diversions, and periodic drought have resulted in significant declines in stream flow of the lower Rio Grande in the Big Bend region. Reductions in mean annual flow and peak discharge have resulted in channel narrowing by the formation of vertically accreting inset floodplains. Narrowing has been temporarily interrupted by infrequent large dam releases greater than 1000 m³/s that have temporarily widened the channel; however, after each of these events, narrowing has resumed. Prior to 1942, floods of this magnitude occurred approximately once every 4 years …

Testing And Estimation For Functional Data With Applications To Magnetometer Records, Inga Maslova

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The functional linear model, Y_n = ψX_n + ε_n, with functional response and explanatory variables is considered. A simple test of the nullity of ψ based on the principal component decomposition is proposed. The test statistic has asymptotic chi-squared distribution, which is also an excellent approximation in finite samples. The methodology is applied to data from terrestrial magnetic observatories.

In recent years, the interaction of the auroral substorms with the equatorial and mid-latitude currents has been the subject of extensive research. We introduce a new statistical technique that allows us to test at a specified …

Watershed-Scale Analysis Of Riparian Buffer Function, Molly Van Appledorn

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The ability of riparian buffers to filter undesirable nutrients from upland sources has long been recognized as an important ecosystem service for maintaining or improving water quality, and as a result, many land management strategies have been built around the preservation or restoration of buffer zones. Newly derived flow-path metrics have shown great promise as a way to assess riparian buffer function at the watershed scale but a thorough investigation of metric performance was necessary. The goals of this study were to: 1) test the independence of flow-path metrics from traditional metrics using a spatially extensive, independent sample of watersheds, …

Synthetic Studies Of Laulimalide Analogues, Ian Addison Mcalexander

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Chapter 1 provides some background information on the disease area of cancer and current modes of treatment. Chemotherapy treatment is discussed with a focus on the major cellular targets for these drugs: DNA and microtubules. For each target, classes of active compounds are described along with their mode of action. The microtubule stabilizing agent laulimalide is introduced and a case is made for analogue synthesis.

Chapter 2 describes our first generation efforts toward synthesis of des-methyl laulimalide. The target compound is divided into a northern and southern fragment with the synthesis of each fragment described. The preparation of landmark intermediates …

Measurement And Modeling Of Reduced-Gravity Fluid Distribution And Transport In Unsaturated Porous Plant-Growth Media, Robert Heinse

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The effect of reduced gravity on the balanced management of liquid, gaseous and ionic fluxes in unsaturated porous media remains a central challenge for plant-based bio-regenerative life support systems needed for long-duration space missions. This research investigated how shifting capillary and gravitational forces alter the sample-scale transport and distribution of fluids in mm-sized porous ceramic aggregates. Measurements in variably saturated media conducted on the International Space Station in microgravity (~1⋅10^-3 g_earth) and measurements during parabolic flight in variable gravity encompassing microgravity, terrestrial gravity and hypergravity (~1.8g_earth) were supported by numerical modeling based on fundamental, …

Sonication Assisted Synthesis Of Oligomannosides, Christabel Tomla Tanifum

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Oligomannosides prevalently exist as cell surface antigens. They play important roles in diseases such as viral infection and cancer, and they have been shown to be useful as candidates for vaccines. HIV, one of the most devastating modern diseases, has a high content of mannose sugars on its envelope glycoprotein gp120. Oligomannosides of the HIV virus, also called Man9, which are found on the glycoprotein gp120, have been shown to play a protective role for the HIV virus, shielding highly conserved protein domains of gp120 from proteolytic attacks. Thus gp120 plays an important role in HIV infection of cells, being …

A Geologic And Hydrochemical Investigation Of The Suitability Of Central Utah's Navajo Sandstone For The Disposal Of Saline Process Water And Co2, Kevin L. Randall

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Salt water is produced from the Ferron Sandstone Member of the Mancos Shale in central Utah as part of the production of coalbed methane (CBM) and is disposed of by injection predominantly into the Navajo Sandstone between 4,500 feet to 7,300 feet and is considered to be a hazardous waste. Local government agencies are concerned about the potential impacts on shallow groundwater because of this disposal method.

Water samples were gathered from four shallow water-supply wells, and nine salt water disposal (SWD) wells to compare hydrochemistries as an indicator of potential mixing. Shallow water-supply wells are likely recharged by local …

Investigations Of Variable Importance Measures Within Random Forests, Andrew C. Merrill

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Random Forests (RF) (Breiman 2001; Breiman and Cutler 2004) is a completely nonparametric statistical learning procedure that may be used for regression analysis and. A feature of RF that is drawing a lot of attention is the novel algorithm that is used to evaluate the relative importance of the predictor/explanatory variables. Other machine learning algorithms for regression and classification, such as support vector machines and artificial neural networks (Hastie et al. 2009), exhibit high predictive accuracy but provide little insight into predictive power of individual variables. In contrast, the permutation algorithm of RF has already established a track record for …

Predicting Rna Secondary Structures By Folding Simulation: Software And Experiments, Joel Omni Gillespie

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

We present a new method for predicting the secondary structure of RNA sequences. Using our method, each RNA nucleotide of an RNA Sequence is represented as a point on a 3D triangular lattice. Using the Simulated Annealing technique, we manipulate the location of the points on the lattice. We explore various scoring functions for judging the relative quality of the structures created by these manipulations. After near optimal configurations on the lattice have been found, we describe how the lattice locations of the nucleotides can be used to predict a secondary structure for the sequence. This prediction can be further …

Correlation, Paleogeography, And Provenance Of The Neoproterozoic Eastern Uinta Mountain Group, Goslin Mountain Area, Northeastern Utah, Daniel J. Rybczynski

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Geologic mapping, facies analysis, sedimentary petrography, and detrital zircon analyses of undivided eastern Uinta Mountain Group stratigraphy are presented to better understand the depositional environments and tectonic setting of the Uinta Mountain Group basin. Subdivided units have been modified and correlated from previous work and include the Red Pine Shale, Hades Pass, Crouse Canyon, Outlaw Trail, and Diamond Breaks formations. Three lower-order maximum flooding surfaces associated with the lower Outlaw Trail formation, lower Hades Pass formation, and Red Pine Shale are interpreted. The relative magnitude of each lower-order transgression increases up section along with increasing diversity of palynomorph assemblages found …

Optimal Candidate Generation In Spatial Co-Location Mining, Zhongshan Lin

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Existing spatial co-location algorithms based on levels suffer from generating extra, nonclique candidate instances. Thus, they require cliqueness checking at every level. In this thesis, a novel, spatial co-location mining algorithm that automatically generates co-located spatial features without generating any nonclique candidates at any level is proposed. Subsequently, this algorithm generates fewer candidates than other existing level-wise, co-location algorithms without losing any pertinent information. The benefits of this algorithm have been clearly observed at early stages in the mining process.

Detecting Organic Molecules On The Surface Of Inorganic Dust Particles Using Aerosol Mass Spectrometry, Sileola B. Akinsiku

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Detection of organic molecules present on the surface of dust particles is important in homeland security, agriculture, and several other applications. The research presented reports the ability of the aerosol mass spectrometer (AMS) to detect molecules on the surface of dust particles without detecting the particle core.

Experiments were carried out to detect semi-volatile organic compounds adsorbed onto the surface of particulates without interference from the dust particle core. Methyl salicylate, oleic acid, and organophosphorus pesticides such as Malathion were detected on the surface of particles representative of dust-type materials. Zeolite powders were used as aerosol support, representative of a …

Simulation, Kriging, And Visualization Of Circular-Spatial Data, William James Morphet

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The circular dataimage is defined by displaying direction as the color at the same direction in a color wheel composed of a sequence of two-color gradients with color continuity between gradients. The resulting image of circular-spatial data is continuous with high resolution. Examples include ocean wind direction, Earth's main magnetic field, and rocket nozzle internal combustion flow. The cosineogram is defined as the mean cosine of the angle between random components of direction as a function of distance between observation locations. It expresses the spatial correlation of circular-spatial data. A circular kriging solution is developed based on a model fitted …

Covert Botnet Implementation And Defense Against Covert Botnets, Lokesh Babu Ramesh Babu

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The advent of the Internet and its benevolent use has benefited mankind in private and business use alike. However, like any other technology, the Internet is often used for malevolent purposes. One such malevolent purpose is to attack computers using botnets. Botnets are stealthy, and the victims are typically unaware of the malicious activities and the resultant havoc they can cause. Computer security experts seek to combat the botnet menace. However, attackers come up with new botnet designs that exploit the weaknesses in existing defense mechanisms and, thus, continue to evade detection.

Therefore, it is necessary to analyze the weaknesses …

Modeling The Evolution Of Insect Phenology With Particular Reference To Mountain Pine Beetle, Brian P. Yurk

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Climate change is likely to disrupt the timing of developmental events (phenology) in insect populations in which development time is largely determined by temperature. Shifting phenology puts insects at risk of being exposed to seasonal weather extremes during sensitive life stages and losing synchrony with biotic resources. Additionally, warming may result in loss of developmental synchronization within a population, making it difficult to find mates or mount mass attacks against well-defended resources at low population densities. It is unknown whether genetic evolution of development time can occur rapidly enough to moderate these effects.

The work presented here is largely motivated …