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Full-Text Articles in Physical Sciences and Mathematics

A P-Adic Spectral Triple, Sumedha Hemamalee Rathnayake Apr 2015

A P-Adic Spectral Triple, Sumedha Hemamalee Rathnayake

Open Access Dissertations

We construct a spectral triple for the C*-algebra of continuous functions on the space of p-adic integers. On the technical level we utilize a weighted rooted tree obtained from a coarse grained approximation of the space combined with the forward derivative D on the tree. Our spectral triple satisfies the properties of a compact spectral metric space and the metric on the space of p-adic integers induced by the spectral triple is equivalent to the usual p-adic metric. Furthermore, we show that the spectrum of the operator D*D is closely related to the roots of a certain …


Simulating Depth Of Field Using Per-Pixel Linked List Buffer, Yang Liu Apr 2015

Simulating Depth Of Field Using Per-Pixel Linked List Buffer, Yang Liu

Open Access Theses

In this thesis, I present a method for simulating three characteristics of depth of field image: partial occlusion, bokeh and blur. Retrieving color from occluded surfaces is achieved by constructing a per-pixel linked list buffer, which only requires two render passes. Additionally, per-pixel linked list buffer eliminates the memory overhead of empty pixels in depth layers. Bokeh and blur effect are accomplished by image-space point splatting (Lee 2008). I demonstrate how point splatting can be used to account for the effect of aperture shape and intensity distribution on bokeh. Spherical aberration and chromatic aberration can be approximated using a custom …


Framework For Functional Tree Simulation Applied To 'Golden Delicious' Apple Trees, Marek Fiser Apr 2015

Framework For Functional Tree Simulation Applied To 'Golden Delicious' Apple Trees, Marek Fiser

Open Access Theses

This research aims to develop a framework to model realistic and functional trees. Our modular framework is easily controllable and extensible by the user. The framework provides powerful features such as per-leaf light simulation and a source-sink based resources transport model. Our novel 3D reconstruction algorithm generates realistic tree models with a good 3D polygon topology. ^ The second part of this research is a functional model of a Golden Delicious apple tree. We use our simulation framework and data collected in Purdue Meigs farm over the year 2014 to create a realistic data-driven model. The model reacts on temperature …


Generalized Remote Preparation Of Arbitrary M-Qubit Entangled States Via Genuine Entanglements, Dong Wang, Ross D. Hoehn, Liu Ye, Sabre Kais Mar 2015

Generalized Remote Preparation Of Arbitrary M-Qubit Entangled States Via Genuine Entanglements, Dong Wang, Ross D. Hoehn, Liu Ye, Sabre Kais

Department of Chemistry Faculty Publications

Herein, we present a feasible, general protocol for quantum communication within a network via generalized remote preparation of an arbitrary m-qubit entangled state designed with genuine tripartite Greenberger–Horne–Zeilinger-type entangled resources. During the implementations, we construct novel collective unitary operations; these operations are tasked with performing the necessary phase transfers during remote state preparations. We have distilled our implementation methods into a five-step procedure, which can be used to faithfully recover the desired state during transfer. Compared to previous existing schemes, our methodology features a greatly increased success probability. After the consumption of auxiliary qubits and the performance of collective unitary …


Winter Weather Services And Forecasting Options For Local Agencies, Michael Baldwin Mar 2015

Winter Weather Services And Forecasting Options For Local Agencies, Michael Baldwin

Purdue Road School

Students majoring in atmospheric science at Purdue's Department of Earth, Atmospheric, and Planetary Sciences have organized a "forecasting club" to provide weather forecasting services to a wide range of customers. During the winter months, these students provide a detailed forecast of conditions across the state of Indiana that are expected to impact road maintenance operations. These forecasts are available via a web page as well as direct email. Other information regarding winter weather observations and predictions is rapidly increasing in availability. This presentation will discuss these freely available sources of winter weather information that can be used by local agencies …


A Contribution Toward Better Understanding Of Overbanking Tendency In Fixed-Wing Aircraft, Nihad E. Daidzic Feb 2015

A Contribution Toward Better Understanding Of Overbanking Tendency In Fixed-Wing Aircraft, Nihad E. Daidzic

Journal of Aviation Technology and Engineering

The phenomenon of overbanking tendency for a rigid-body, fixed-wing aircraft is investigated. Overbanking tendency is defined as a spontaneous, unbalanced rolling moment that keeps increasing an airplane’s bank angle in steep turns and must be arrested by opposite aileron action. As stated by the Federal Aviation Administration, the overbanking tendency may lead to a loss of control, especially in instrument meteorological conditions. It was found in this study that the speed differential over wing halves in horizontal turns indeed creates a rolling moment that achieves maximum values for bank angles between 45 and 55 degrees. However, this induced rolling moment …


The Integration Of Heat Resources In A Solar Thermal-Heat Pump Hydronic System, John Maxfield Degrove Jan 2015

The Integration Of Heat Resources In A Solar Thermal-Heat Pump Hydronic System, John Maxfield Degrove

Open Access Theses

According to the U.S. Department of Energy, roughly 41% of the energy consumed in the U.S. is used the power buildings. Within that number, almost half is used to heat or cool the building. Current technologies allow for consistent thermal management, but most utilize energy harvested from fossil fuels or convert electricity back into thermal energy. Background literature shows that the utilization of alternative heat resources such as heat pumps and solar thermal collectors can greatly reduce the energy used for heat delivery while producing adequate heating performance. A combined hydronic system using a bank of solar thermal collectors in …


Calculus For Decision Systems, Jorge Antonio Samayoa Ranero Jan 2015

Calculus For Decision Systems, Jorge Antonio Samayoa Ranero

Open Access Dissertations

The conceptualization of the term "system" has become highly dependent on the application domain. What a physicist means by the term system might be different than what a sociologist means by the same term. In 1956, Bertalanffy [1] defined a system as " a set of units with relationships among them". This and many other definitions of system share the idea of a system as a black box that has parts or elements interacting between each other. This means that at some level of abstraction all systems are similar, what eventually differentiates one system from another is the set of …


Genome-Wide Profiling Of Histone Modifications (H3k9me2 And H4k12ac) And Gene Expression In Rust (Uromyces Appendiculatus) Inoculated Common Bean (Phaseolus Vulgaris L), Vasudevan Ayyappan, Venu Kalavacharla, Jyothi Thimmapuram, Ketaki P. Bhide, Venkateswara R. Sripathi Jan 2015

Genome-Wide Profiling Of Histone Modifications (H3k9me2 And H4k12ac) And Gene Expression In Rust (Uromyces Appendiculatus) Inoculated Common Bean (Phaseolus Vulgaris L), Vasudevan Ayyappan, Venu Kalavacharla, Jyothi Thimmapuram, Ketaki P. Bhide, Venkateswara R. Sripathi

Cyber Center Publications

Histone modifications such as methylation and acetylation play a significant role in controlling gene expression in unstressed and stressed plants. Genome-wide analysis of such stress-responsive modifications and genes in non-model crops is limited. We report the genome-wide profiling of histone methylation (H3K9me2) and acetylation (H4K12ac) in common bean (Phaseolus vulgaris L.) under rust (Uromyces appendiculatus) stress using two high-throughput approaches, chromatin immunoprecipitation sequencing (ChIP-Seq) and RNA sequencing (RNA-Seq). ChIP-Seq analysis revealed 1,235 and 556 histone methylation and acetylation responsive genes from common bean leaves treated with the rust pathogen at 0, 12 and 84 hour-after-inoculation (hai), while …


Instrumentation And Development Of A Mass Spectrometry System For The Study Of Gas-Phase Biomolecular Ion Reactions, Ziqing Lin Jan 2015

Instrumentation And Development Of A Mass Spectrometry System For The Study Of Gas-Phase Biomolecular Ion Reactions, Ziqing Lin

Open Access Dissertations

Gas-phase reactions of biomolecular ions are highly relevant to the understanding of structures and functions of the biomolecules. Mass spectrometry is a powerful tool in investigating gas-phase ion chemistry. Various mass spectrometers have been developed to explore ion/molecule reactions, ion/ion reactions, ion/photon reactions, ion/radical reactions etc., both at atmospheric pressure and in vacuum. In-vacuum reactions have an advantage of involving pre-selecting the ions for the reactions using a mass analyzer. Over the decades, a variety of mass analyzers have been employed in the research of ion chemistry. Hybrid configurations, such as quadrupole ion trap with a time-of-flight and or a …


Modeling, Optimization, And Sensitivity Analysis Of A Continuous Multi-Segment Crystallizer For Production Of Active Pharmaceutical Ingredients, Bradley James Ridder Jan 2015

Modeling, Optimization, And Sensitivity Analysis Of A Continuous Multi-Segment Crystallizer For Production Of Active Pharmaceutical Ingredients, Bradley James Ridder

Open Access Dissertations

We have investigated the simulation-based, steady-state optimization of a new type of crystallizer for the production of pharmaceuticals. The multi-segment, multi-addition plug-flow crystallizer (MSMA-PFC) offers better control over supersaturation in one dimension compared to a batch or stirred-tank crystallizer. Through use of a population balance framework, we have written the governing model equations of population balance and mass balance on the crystallizer segments. The solution of these equations was accomplished through either the method of moments or the finite volume method. The goal was to optimize the performance of the crystallizer with respect to certain quantities, such as maximizing the …


Synthetic Steganography: Methods For Generating And Detecting Covert Channels In Generated Media, Philip Carson Ritchey Jan 2015

Synthetic Steganography: Methods For Generating And Detecting Covert Channels In Generated Media, Philip Carson Ritchey

Open Access Dissertations

Issues of privacy in communication are becoming increasingly important. For many people and businesses, the use of strong cryptographic protocols is sufficient to protect their communications. However, the overt use of strong cryptography may be prohibited or individual entities may be prohibited from communicating directly. In these cases, a secure alternative to the overt use of strong cryptography is required. One promising alternative is to hide the use of cryptography by transforming ciphertext into innocuous-seeming messages to be transmitted in the clear. ^ In this dissertation, we consider the problem of synthetic steganography: generating and detecting covert channels in generated …


Structure-Activity Relationships For The Water-Gas Shift Reaction Over Supported Metal Catalysts, Kaiwalya D. Sabnis Jan 2015

Structure-Activity Relationships For The Water-Gas Shift Reaction Over Supported Metal Catalysts, Kaiwalya D. Sabnis

Open Access Dissertations

The Water-Gas Shift (WGS) reaction (CO + H2O → CO2 + H2) is an important chemical process for industrial hydrogen production. The overall goal of this project is to use kinetic experiments and in situ characterization techniques in tandem, in order to derive structure-activity relationships for various catalytic systems. These relationships facilitate the rational catalyst design by identification of catalyst descriptors. In order to establish such relationships, various studies were undertaken, such as (i) effect of transition admetals on the WGS catalysis by molybdenum carbide (ii) effect of residual oxygen content on the performance of …


Measurement Of The Drell--Yan Differential Cross Section With The Cms Detector At The Lhc, Alexey Svyatkovskiy Jan 2015

Measurement Of The Drell--Yan Differential Cross Section With The Cms Detector At The Lhc, Alexey Svyatkovskiy

Open Access Dissertations

This thesis describes precision measurements of electroweak interactions in a new energy regime and the application of these measurements to improve our understanding of the structure of the proton. The results are based on proton-proton collision data at √s = 7 and 8\TeV recorded with the Compact Muon Solenoid detector at the CERN Large Hadron Collider during the first years of operation. Measurements of the differential Drell–Yan cross section in the dimuon and dielectron channels covering the dilepton mass range of 15 to 2000\GeV and absolute dilepton rapidity from 0 to~2.4 are presented. The Drell–Yan cross section in proton-proton …


A 2-Categorical Extension Of The Reshetikhin--Turaev Theory, Yu Tsumara Jan 2015

A 2-Categorical Extension Of The Reshetikhin--Turaev Theory, Yu Tsumara

Open Access Dissertations

We concretely construct a 2-categorically extended topological quantum field theory that extends the Reshetikhin-Turaev TQFT to cobordisms with corners. The source category will be a well chosen 2-category of decorated cobordisms with corners and the target bicategory will be the Kapranov-Voevodsky 2-vector spaces.


Novel Techniques For Quasi Three-Dimensional Nanofabrication Of Transformation Optics Devices, Paul R. West Jan 2015

Novel Techniques For Quasi Three-Dimensional Nanofabrication Of Transformation Optics Devices, Paul R. West

Open Access Dissertations

Current nanofabrication is almost exclusively limited to top-down, two-dimensional techniques. As technology moves more deeply into the nano-scale regime, fabrication of new devices with quasi three-dimensional geometries shows great potential. One excellent example of an emerging field that requires this type of non-conformal 3D fabrication technique is the field of Transformation Optics. This field involves transforming and manipulating the optical space through which light propagates. Arbitrarily manipulating the optical space requires advanced fabrication techniques, which are not possible with current two-dimensional fabrication technologies. One step toward quasi three-dimensional nanofabrication involves employing angled deposition allowing new growth mechanisms, and enabling a …


Advanced Wireless Communications Using Large Numbers Of Transmit Antennas And Receive Nodes, Junil Choi Jan 2015

Advanced Wireless Communications Using Large Numbers Of Transmit Antennas And Receive Nodes, Junil Choi

Open Access Dissertations

The concept of deploying a large number of antennas at the base station, often called massive multiple-input multiple-output (MIMO), has drawn considerable interest because of its potential ability to revolutionize current wireless communication systems. Most literature on massive MIMO systems assumes time division duplexing (TDD), although frequency division duplexing (FDD) dominates current cellular systems. Due to the large number of transmit antennas at the base station, currently standardized approaches would require a large percentage of the precious downlink and uplink resources in FDD massive MIMO be used for training signal transmissions and channel state information (CSI) feedback. First, we propose …


The Antitumorigenic Function Of Egfr In Metastatic Breast Cancer Is Regulated By Expression Of Mig6, Michael Wendt, Whitney K. Williams, Pete E. Pascuzzi, Nikolas G. Balanis, Barbara J. Schiemann, Cathleen R. Carlin, William P. Schiemann Jan 2015

The Antitumorigenic Function Of Egfr In Metastatic Breast Cancer Is Regulated By Expression Of Mig6, Michael Wendt, Whitney K. Williams, Pete E. Pascuzzi, Nikolas G. Balanis, Barbara J. Schiemann, Cathleen R. Carlin, William P. Schiemann

Borch Department of Medicinal Chemistry and Molecular Pharmacology Faculty Publications

Numerous studies by our lab and others demonstrate that epidermal growth factor receptor (EGFR) plays critical roles in primary breast cancer (BC) initiation, growth and dissemination. However, clinical trials targeting EGFR function in BC have lead to disappointing results. In the current study we sought to identify the mechanisms responsible for this disparity by investigating the function of EGFR across the continuum of the metastatic cascade. We previously established that overexpression of EGFR is sufficient for formation of in situ primary tumors by otherwise nontransformed murine mammary gland cells. Induction of epithelial-mesenchymal transition (EMT) is sufficient to drive the metastasis …


Intersection Of Art And Science, Petronio Bendito, Tim Korb Jan 2015

Intersection Of Art And Science, Petronio Bendito, Tim Korb

Lawson Building Exhibitions on the Intersection of Art and Science

The Intersection of Art and Science exhibition is an interdisciplinary educational project that examines a wide range of expressive approaches explored by international artists working at the intersection of art, mathematics, computer science, and technology. It is a joint collaboration between the Department of Computer Science and the Patti and Rusty Rueff School of Visual and Performing Arts at Purdue University. Featured artists: Sergio Albiac, Anne Burns, Conan Chadbourne, Hans Dehlinger, Brian Evans, Richard Hassell, Patrick Bingham-Hall, John Arden Hiigli, So Yoon Lym, Gabriel Meyer, and Robert M. Spann. The exhibition was curated by Dr. Petronio Bendito and Dr. Tim …


Natural Resources / Graduate Students / Wright & Andrews / Cornell University / 2013, Sarah J. Wright, Camille Andrews Jan 2015

Natural Resources / Graduate Students / Wright & Andrews / Cornell University / 2013, Sarah J. Wright, Camille Andrews

Data Information Literacy Case Study Directory

This case study describes a 6 week for credit Data Information Literacy course taught at Cornell University for students in Natural Resources. Subject covered include: data management, data organization, data analysis and visualization, data sharing, and data quality and documentation. Materials include a book chapter describing the case study, a rubric for developing a data management plan, a class exercise in finding and evaluating data repositories, and the evaluation form used for the course.


Applying Hierarchical Task Analysis Method To Discovery Layer Evaluation, Marlen Promann, Tao Zhang Jan 2015

Applying Hierarchical Task Analysis Method To Discovery Layer Evaluation, Marlen Promann, Tao Zhang

Libraries Faculty and Staff Scholarship and Research

While usability tests have been helpful in evaluating the success or failure of implementing discovery layers in the library context, the focus of usability tests has remained on the search interface rather than the discovery process for users. The informal site-­‐ and context specific usability tests have offered little to test the rigor of the discovery layers against the user goals, motivations and workflow they have been designed to support. This study proposes hierarchical task analysis (HTA) as an important complementary evaluation method to usability testing of discovery layers. Relevant literature is reviewed for the discovery layers and the HTA …


On The Origin Of Protein Superfamilies And Superfolds, Abram Magner, Wojciech Szpankowski, Daisuke Kihara Jan 2015

On The Origin Of Protein Superfamilies And Superfolds, Abram Magner, Wojciech Szpankowski, Daisuke Kihara

Department of Biological Sciences Faculty Publications

Distributions of protein families and folds in genomes are highly skewed, having a small number of prevalent superfamiles/superfolds and a large number of families/folds of a small size. Why are the distributions of protein families and folds skewed? Why are there only a limited number of protein families? Here, we employ an information theoretic approach to investigate the protein sequence-structure relationship that leads to the skewed distributions. We consider that protein sequences and folds constitute an information theoretic channel and computed the most efficient distribution of sequences that code all protein folds. The identified distributions of sequences and folds are …


What Do Experienced Water Managers Think Of Water Resources Of Our Nation And Its Management Infrastructure?, Faisal Hossain, Jeffrey R. Arnold, Edward Beighley, Casey M. Brown, Steven J. Burian, Ji Chen, Anindita Mitra, Dev Dutta S Niyogi, Roger A. Pielke, Vincent C. Tidwell, Dave Wegner Jan 2015

What Do Experienced Water Managers Think Of Water Resources Of Our Nation And Its Management Infrastructure?, Faisal Hossain, Jeffrey R. Arnold, Edward Beighley, Casey M. Brown, Steven J. Burian, Ji Chen, Anindita Mitra, Dev Dutta S Niyogi, Roger A. Pielke, Vincent C. Tidwell, Dave Wegner

Department of Earth, Atmospheric, and Planetary Sciences Faculty Publications

This article represents the second report by an ASCE Task Committee "Infrastructure Impacts of Landscape-driven Weather Change" under the ASCE Watershed Management Technical Committee and the ASCE Hydroclimate Technical Committee. Herein, the 'infrastructure impacts" are referred to as infrastructure-sensitive changes in weather and climate patterns (extremes and non-extremes) that are modulated, among other factors, by changes in landscape, land use and land cover change. In this first report, the article argued for explicitly considering the well-established feedbacks triggered by infrastructure systems to the land-atmosphere system via landscape change. In this report by the ASCE Task Committee (TC), we present the …


Ontogenetic Scaling Patterns And Functional Anatomy Of The Pelvic Limb Musculature In Emus (Dromaius Novaehollandiae), Luis P. Lamas, Russell P. Main, John R. Hutchinson Dec 2014

Ontogenetic Scaling Patterns And Functional Anatomy Of The Pelvic Limb Musculature In Emus (Dromaius Novaehollandiae), Luis P. Lamas, Russell P. Main, John R. Hutchinson

Department of Basic Medical Sciences Faculty Publications

Emus (Dromaius novaehollandiae) are exclusively terrestrial, bipedal and cursorial ratites with some similar biomechanical characteristics to humans. Their growth rates are impressive, as their body mass increases eighty-fold from hatching to adulthood whilst maintaining the same mode of locomotion throughout life. These ontogenetic characteristics stimulate biomechanical questions about the strategies that allow emus to cope with their rapid growth and locomotion, which can be partly addressed via scaling (allometric) analysis of morphology. In this study we have collected pelvic limb anatomical data (muscle architecture, tendon length, tendon mass and bone lengths) and calculated muscle physiological cross sectional area …


Privacy-Preserving And Outsourced Multi-User K-Means Clustering, Bharath Samanthula, Fang-Yu Rao, Elisa Bertino, Xun Yi, Dangxi Liu Dec 2014

Privacy-Preserving And Outsourced Multi-User K-Means Clustering, Bharath Samanthula, Fang-Yu Rao, Elisa Bertino, Xun Yi, Dangxi Liu

Cyber Center Publications

Many techniques for privacy-preserving data mining (PPDM) have been investigated over the past decade. Often, the entities involved in the data mining process are end-users or organizations with limited computing and storage resources. As a result, such entities may want to refrain from participating in the PPDM process. To overcome this issue and to take many other benefits of cloud computing, outsourcing PPDM tasks to the cloud environment has recently gained special attention. We consider the scenario where n entities outsource their databases (in encrypted format) to the cloud and ask the cloud to perform the clustering task on their …


Misalignments: Challenges In Cultivating Science Faculty With Education Specialties In Your Department, Seth D. Bush, Nancy Pelaez, James A. Rudd Ii, Michael T. Stevens, Kimberly D. Tanner, Kathy S. Williams Dec 2014

Misalignments: Challenges In Cultivating Science Faculty With Education Specialties In Your Department, Seth D. Bush, Nancy Pelaez, James A. Rudd Ii, Michael T. Stevens, Kimberly D. Tanner, Kathy S. Williams

PIBERG Publications

Science Faculty with Education Specialties (SFES) are increasingly being hired across the United States. However, little is known about the motivations for SFES hiring or the potential or actual impact of SFES. In the context of a recent national survey of US SFES, we investigated SFES perceptions about these issues. Strikingly, perceptions about reasons for hiring SFES were poorly aligned with perceptions about potential and actual contributions reported by SFES themselves, and the advice they extended to beginning SFES was varied. While preparation of future teachers and departmental teaching needs were common reasons offered for SFES hiring, the potential and …


Poster: Protecting Against Data Exfiltration Insider Attacks Through Application Programs, Asmaa Mohamed Sallama, Elisa Bertino Nov 2014

Poster: Protecting Against Data Exfiltration Insider Attacks Through Application Programs, Asmaa Mohamed Sallama, Elisa Bertino

Cyber Center Publications

In this paper, we describe a system that distinguishes be- tween legitimate and malicious database transactions per- formed by application programs. Our system is particularly useful for protecting against code-modification attacks performed by insiders who have access to and can change the programs' source code to make them execute different queries than those they are expected to execute. Our system works with any type of DBMS and requires minimum modification to application programs.


Particle Swarms In Confining Geometries, Eric Robert Boomsma Oct 2014

Particle Swarms In Confining Geometries, Eric Robert Boomsma

Open Access Dissertations

The transport of micro- and nano-particles in subsurface fluid deposits is an area of increasing interest due to the rising use of these particles for consumer and industrial purposes. Subsurface particle transport is complicated by the presence of fractures and fracture networks which govern the paths that particles will be able to take. In this thesis, subsurface particle transport will be investigated using particle swarms; collections of hydro-dynamically interacting particles which exhibit group behavior. The effects of fluid viscosity, particle properties, fracture geometry, and fracture aperture on swarm behavior were experimentally investigated. ^ Swarm parameters were examined in time with …


New Experimental And Theoretical Tools For Studying Protein Systems With Elements Of Structural Disorder, Tairan Yuwen Oct 2014

New Experimental And Theoretical Tools For Studying Protein Systems With Elements Of Structural Disorder, Tairan Yuwen

Open Access Dissertations

Disordered proteins are one class of proteins which do not possess well-folded three-dimensional structures as their native conformations. Many eukaryotic proteins have been found to be fully disordered or contain certain disordered regions. Disordered proteins usually display several characteristic properties, such as increased motional freedom and the conformational heterogeneity caused by that. The elements of structural disorder are commonly involved in many important biological functions and are implicated in many diseases. Therefore, the study of disordered proteins has become one of the most important research topics in recent years. This thesis presents results from three different research projects; the common …


Indoor Acoustic Mapping And Geolocation, Thomas Shyy Oct 2014

Indoor Acoustic Mapping And Geolocation, Thomas Shyy

Open Access Theses

The Global Positioning System (GPS) is widely used in navigations of flights, vehicles and travelers nowadays. However, the signals are not always available and there are some cases where the receptions of the GPS signal can be lost because of the presence of urban canyons, buildings, tunnels and forests. Another down side for the GPS is that indoor positioning can be really difficult because of the greater signal interference from the indoor.

On the other hand, the concept of echolocation has also been used for positioning purposes. Echolocation offers a promising approach to improve the quality of life of people …