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Articles 661 - 690 of 3676

Full-Text Articles in Physical Sciences and Mathematics

U/Pb Zircon Ages Of Felsic Veins In The Sawtooth Metamorphic Complex, Idaho, U.S.A: Implications For Magmatism And Vein Source, Kyle Tollefson Nov 2020

U/Pb Zircon Ages Of Felsic Veins In The Sawtooth Metamorphic Complex, Idaho, U.S.A: Implications For Magmatism And Vein Source, Kyle Tollefson

LSU Master's Theses

Veins associated with igneous activity provide numerous insights into the geologic history of an area. The Sawtooth Metamorphic Complex (SMC) in Idaho is a roof pendent of highgrade rocks cross-cut by numerous felsic veins of unknown age and source. Obtaining U/Pb zircon geochronology of these veins can facilitate understanding the ages of magmatism in the region, their source, when nearby batholiths were juxtaposed to the SMC, and provide additional insights into the geologic evolution of the area. Each potential source of these veins has a distinct age: the Sawtooth batholith (ca. 47 Ma), the Idaho batholith (98-53 Ma), an anatectic …


Adsorption And Reconfiguration Of Amphiphiles At Silica-Water Interfaces: Role Of Electrostatic Interactions, Van Der Waals Forces And Hydrogen Bonds, Yao Wu Nov 2020

Adsorption And Reconfiguration Of Amphiphiles At Silica-Water Interfaces: Role Of Electrostatic Interactions, Van Der Waals Forces And Hydrogen Bonds, Yao Wu

LSU Doctoral Dissertations

The ability to explore and predict metastable structures of hybrid self-assemblies is of central importance for the next generation of advanced materials with novel properties. As compared to their thermodynamically stable forms, the kinetically stabilized materials show improved functionality potentially over their stable counterparts. The self-assembly processes usually originate from weak intermolecular interactions, involving a dynamic competition between attractive and repulsive interactions. These weak forces, including van der Waals (vdW), electrostatic interaction and the hydrogen bonding (H-bonding), can be tuned by external stimuli, e.g., confinement, temperature and ionization, and consequently driving hybrid materials into different configurations. It is challenging to …


Methods For 1,2-Cis-Selective O-Glycosylation And Synthesis Of An A. Baumannii Lipooligosaccharide Core Disaccharide, Ashley Fulton Nov 2020

Methods For 1,2-Cis-Selective O-Glycosylation And Synthesis Of An A. Baumannii Lipooligosaccharide Core Disaccharide, Ashley Fulton

LSU Doctoral Dissertations

This dissertation focuses on the formation of organic thin films on gold surfaces and synthesis of oligosaccharides. Chapter one, is a brief introduction on the utility of thin films, as well as ways to characterize thin films, as well as, a report on the attempt to form organic thin films on Au(111) surfaces using photoredox catalysis.

Glycoconjugates on cell surfaces serve as important mediators of intercellular recognition, adhesion, and viral infection. Due to the significant role that glycoconjugates play on the surface of cells, oligosaccharide synthesis is of great interest. Chapter two, is an extensive review of oligosaccharide synthesis, its …


Synthesis And Investigation Of Amphiphilic Polypeptoids For Environmental And Biological Applications, Tianyi Yu Nov 2020

Synthesis And Investigation Of Amphiphilic Polypeptoids For Environmental And Biological Applications, Tianyi Yu

LSU Doctoral Dissertations

Polypeptoids are an emerging class of peptidomimetic polymers featuring N-substituted polyglycine backbones. Polypeptoids are cyto-compatible and backbone degradable, making them appealing to many biological applications. When the highly polar polyamide backbone is coupled with non-polar aliphatic side chains, polypeptoids can be considered as facial amphiphiles. Without extensive hydrogen bonding along the backbone, the conformation of polypeptoid is largely controlled by the N-substituent structures. The hydrophobicity-lipophilicity balance of polypeptoids can be readily tuned with the N-substituent structures as well as the molar ratio between the hydrophilic and hydrophobic segments in their copolymers. In view of these combined attributes, …


A Study Of 26al(P, Γ)27si With The Silicon Array For Branching Ratio Experiments (Sabre), Erin Courtney Good Nov 2020

A Study Of 26al(P, Γ)27si With The Silicon Array For Branching Ratio Experiments (Sabre), Erin Courtney Good

LSU Doctoral Dissertations

The observation of the radioisotope 26Al is an indicator of ongoing nucleosynthesis in the Galaxy due to its short lifetime (t1/2 = 7.2 × 105 yr) on Galactic timescales. It is thought to be synthesized in several different environments in our Galaxy, one of which is in classical novae. Classical novae are stellar explosions that occur on the surface of a white dwarf in a binary system with a main sequence star. The isotopic production resulting from the nucleosynthesis that drives these explosions can be modeled with the input of nuclear reaction rates. In recent years, many …


Quantum Markov Chains Associated With Unitary Quantum Walks, Chul Ki Ko, Hyun Jae Yoo Nov 2020

Quantum Markov Chains Associated With Unitary Quantum Walks, Chul Ki Ko, Hyun Jae Yoo

Journal of Stochastic Analysis

No abstract provided.


Invariant Projections For Covariant Quantum Markov Semigroups, Franco Fagnola, Emanuela Sasso, Veronica Umanità Nov 2020

Invariant Projections For Covariant Quantum Markov Semigroups, Franco Fagnola, Emanuela Sasso, Veronica Umanità

Journal of Stochastic Analysis

No abstract provided.


Pauli Matrices: A Triple Of Accardi Complementary Observables, Stephen Bruce Sontz Nov 2020

Pauli Matrices: A Triple Of Accardi Complementary Observables, Stephen Bruce Sontz

Journal of Stochastic Analysis

No abstract provided.


Preface, Julius Esunge, Brian C. Hall, Ambar N. Sengupta, Aurel Stan Nov 2020

Preface, Julius Esunge, Brian C. Hall, Ambar N. Sengupta, Aurel Stan

Journal of Stochastic Analysis

No abstract provided.


A Modelling Study For Smart Pigging Technique For Pipeline Leak Detection, Caitlyn Judith Thiberville Nov 2020

A Modelling Study For Smart Pigging Technique For Pipeline Leak Detection, Caitlyn Judith Thiberville

LSU Master's Theses

Although leak incidents continue, a pipeline remains the most reliable mode of transportation within the oil and gas industry. It becomes even more important today because the projection for new pipelines is expected to increase by 1 billion BOE through 2035. In addition, increasing number and length of subsea tiebacks face new challenges in term of data acquisition, monitoring, analysis, and remedial actions. Passive leak-detection methods commonly used in the industry have been successful with some limitations in that they often cannot detect small leaks and seeps. In addition to a thorough review of related topics, this study investigates how …


Microbiological, Physicochemical, And Immunological Analysis Of A Commercial Cashew Nut-Based Yogurt, Christopher P. Mattison, Kayanush Aryana, Kristen Clermont, Eric Prestenburg, Steven W. Lloyd, Casey .. Grimm, Richard L. Wasserman Nov 2020

Microbiological, Physicochemical, And Immunological Analysis Of A Commercial Cashew Nut-Based Yogurt, Christopher P. Mattison, Kayanush Aryana, Kristen Clermont, Eric Prestenburg, Steven W. Lloyd, Casey .. Grimm, Richard L. Wasserman

Faculty Publications

Nut-based milks and yogurts are gaining popularity, but may not offer the same benefits as dairy yogurts to consumers. Cashew nuts often cause severe allergic reactions, and cashew nut allergens are stable to several types of processing. To compare its characteristics to dairy yogurt and characterize the effects of fermentation on the Ana o 1-3 cashew nut allergens, a commercial yogurt made from cashew nuts (Cashewgurt) was evaluated for microbiological, physiochemical, and immunological properties. Average counts for lactobacilli and Streptococcus thermophilus were greater than 10 million colony forming units per milliliter, indicating the capacity to provide a health benefit. Cashewgurt …


A Novel Mutation Of The Narrow Leaf 1 Gene Adversely Affects Plant Architecture In Rice (Oryza Sativa L.), Prasanta K. Subudhi, Richard S. Garcia, Sapphire Coronejo, Teresa B. De Leon Nov 2020

A Novel Mutation Of The Narrow Leaf 1 Gene Adversely Affects Plant Architecture In Rice (Oryza Sativa L.), Prasanta K. Subudhi, Richard S. Garcia, Sapphire Coronejo, Teresa B. De Leon

Faculty Publications

Plant architecture is critical for enhancing the adaptability and productivity of crop plants. Mutants with an altered plant architecture allow researchers to elucidate the genetic network and the underlying mechanisms. In this study, we characterized a novel nal1 rice mutant with short height, small panicle, and narrow and thick deep green leaves that was identified from a cross between a rice cultivar and a weedy rice accession. Bulked segregant analysis coupled with genome re-sequencing and cosegregation analysis revealed that the overall mutant phenotype was caused by a 1395-bp deletion spanning over the last two exons including the transcriptional end site …


Increasing The Bioavailability Of Poorly Soluble Anti-Cancer Prodrugs Through Encapsulation In Platinum Based Nanocages, Salim Cesar Lutfallah Nov 2020

Increasing The Bioavailability Of Poorly Soluble Anti-Cancer Prodrugs Through Encapsulation In Platinum Based Nanocages, Salim Cesar Lutfallah

Honors Capstones

No abstract provided.


Demographic Impacts Of Climate-Induced Migration And Environmental Shocks And Stressors In Cameron Parish, Louisiana, John Green Iii Nov 2020

Demographic Impacts Of Climate-Induced Migration And Environmental Shocks And Stressors In Cameron Parish, Louisiana, John Green Iii

Honors Capstones

No abstract provided.


A Coded Aperture Microscope For X-Ray Fluorescence Full-Field Imaging, D. P. Siddons, A. J. Kuczewski, A. K. Rumaiz, R. Tappero, M Idir, K. Nakhoda, J. Khanfri, V. Singh, E. R. Farquhar, M. Sullivan, D. Abel, D. J. Brady, X. Yuan Nov 2020

A Coded Aperture Microscope For X-Ray Fluorescence Full-Field Imaging, D. P. Siddons, A. J. Kuczewski, A. K. Rumaiz, R. Tappero, M Idir, K. Nakhoda, J. Khanfri, V. Singh, E. R. Farquhar, M. Sullivan, D. Abel, D. J. Brady, X. Yuan

Faculty Publications

The design and construction of an instrument for full-field imaging of the X-ray fluorescence emitted by a fully illuminated sample are presented. The aim is to produce an X-ray microscope with a few micrometers spatial resolution, which does not need to scan the sample. Since the fluorescence from a spatially inhomogeneous sample may contain many fluorescence lines, the optic which will provide the magnification of the emissions must be achromatic, i.e. its optical properties must be energy-independent. The only optics which fulfill this requirement in the X-ray regime are mirrors and pinholes. The throughput of a simple pinhole is very …


A Solution For Funding The Development Of Technology In Oilwell Drilling, Dalmo S. Amorim, Otto L. A. Santos, Ricardo C. Azevedo, Ana Carolina Chieregati Nov 2020

A Solution For Funding The Development Of Technology In Oilwell Drilling, Dalmo S. Amorim, Otto L. A. Santos, Ricardo C. Azevedo, Ana Carolina Chieregati

Faculty Publications

This article proposes a novel methodology to solve an existing gap in benchmark definition by the adoption of statistically defined benchmarks as references to test products or technical procedures. In a win-win partnership, remuneration is made upon realistic bases of comparison being proportional to existing risks. However, establishing values for benchmarks is rarely unanimous if asked to different persons involved in drilling analysis. Conventional benchmarking, which enhances few results and leaves aside poor operational performances, produces references that do not properly represent the geological environment. Nonetheless, when testing new products, it serves as reference to remunerate suppliers. The review of …


Potential Link Between Compromised Air Quality And Transmission Of The Novel Corona Virus (Sars-Cov-2) In Affected Areas, M. G. Manoj, M. K. Satheesh Kumar, K. T. Valsaraj, C. Sivan, Soumya K. Vijayan Nov 2020

Potential Link Between Compromised Air Quality And Transmission Of The Novel Corona Virus (Sars-Cov-2) In Affected Areas, M. G. Manoj, M. K. Satheesh Kumar, K. T. Valsaraj, C. Sivan, Soumya K. Vijayan

Faculty Publications

The emergence of a novel human corona virus disease (COVID-19) has been declared as a pandemic by the World Health Organization. One of the mechanisms of airborne transmission of the severe acute respiratory syndrome corona virus (SARS-CoV-2) amid humans is through direct ejection of droplets via sneezing, coughing and vocalizing. Nevertheless, there are ample evidences of the persistence of infectious viruses on inanimate surfaces for several hours to a few days. Through a critical review of the current literature and a preliminary analysis of the link between SARS-CoV-2 transmission and air pollution in the affected regions, we offer a perspective …


Correlation Analysis Of Precipitation And River Flow With The Injection And Discharge Of The Three Gorges Dam And Reservoir, Lirong Yin Oct 2020

Correlation Analysis Of Precipitation And River Flow With The Injection And Discharge Of The Three Gorges Dam And Reservoir, Lirong Yin

LSU Master's Theses

The Yangtze River has been the primary support of the resources and transportation of China. Its basin covers an area of 1.8 million square kilometers. The Three Gorges Dam and Reservoir on the Yangtze River is one of the world's largest dams. After the dam construction in 1997, the reservoir started injecting the reservoir to a size of over 600 km2. The influence caused by the dam and reservoir on the river system has been overwhelming and destructive. The possible influence of this vast water body and the operation to maintain this waterbody's size and water level on …


A Phase-Field Approach To Diffusion-Driven Fracture, Friedrich Wilhelm Alexander Dunkel Oct 2020

A Phase-Field Approach To Diffusion-Driven Fracture, Friedrich Wilhelm Alexander Dunkel

LSU Doctoral Dissertations

In recent years applied mathematicians have used modern analysis to develop variational phase-field models of fracture based on Griffith's theory. These variational phase-field models of fracture have gained popularity due to their ability to predict the crack path and handle crack nucleation and branching.

In this work, we are interested in coupled problems where a diffusion process drives the crack propagation. We extend the variational phase-field model of fracture to account for diffusion-driving fracture and study the convergence of minimizers using gamma-convergence. We will introduce Newton's method for the constrained optimization problem and present an algorithm to solve the diffusion-driven …


Demonstration Of Dynamic Thermal Compensation For Parametric Instability Suppression In Advanced Ligo, T. Hardwick, V. J. Hamedan, C. Blair, A. C. Green, D. Vander-Hyde Oct 2020

Demonstration Of Dynamic Thermal Compensation For Parametric Instability Suppression In Advanced Ligo, T. Hardwick, V. J. Hamedan, C. Blair, A. C. Green, D. Vander-Hyde

Faculty Publications

Advanced LIGO and other ground-based interferometric gravitational-wave detectors use high laser power to minimize shot noise and suspended optics to reduce seismic noise coupling. This can result in an opto-mechanical coupling which can become unstable and saturate the interferometer control systems. The severity of these parametric instabilities scales with circulating laser power and first hindered LIGO operations in 2014. Static thermal tuning and active electrostatic damping have previously been used to control parametric instabilities at lower powers but are insufficient as power is increased. Here we report the first demonstration of dynamic thermal compensation to avoid parametric instability in an …


The Role Of Sediment-Induced Light Attenuation On Primary Production During Hurricane Gustav (2008), Zhengchen Zang, Z. George Xue, Kehui Xu, Samuel J. Bentley, Qin Chen, Eurico J. D'Sa, Le Zhang, Yanda Ou Oct 2020

The Role Of Sediment-Induced Light Attenuation On Primary Production During Hurricane Gustav (2008), Zhengchen Zang, Z. George Xue, Kehui Xu, Samuel J. Bentley, Qin Chen, Eurico J. D'Sa, Le Zhang, Yanda Ou

Faculty Publications

We introduced a sediment-induced light attenuation algorithm into a biogeochemical model of the Coupled Ocean-Atmosphere-Wave-Sediment Transport (COAWST) modeling system. A fully coupled ocean-atmospheric-sediment-biogeochemical simulation was carried out to assess the impact of sediment-induced light attenuation on primary production in the northern Gulf of Mexico during the passage of Hurricane Gustav in 2008. When compared with model results without sediment-induced light attenuation, our new model showed a better agreement with satellite data on both the magnitude of nearshore chlorophyll concentration and the spatial distribution of offshore bloom. When Hurricane Gustav approached, resuspended sediment shifted the inner shelf ecosystem from a nutrient-limited …


Adaptive Data Migration In Load-Imbalanced Hpc Applications, Parsa Amini Oct 2020

Adaptive Data Migration In Load-Imbalanced Hpc Applications, Parsa Amini

LSU Doctoral Dissertations

Distributed parallel applications need to maximize and maintain computer resource utilization and be portable across different machines. Balanced execution of some applications requires more effort than others because their data distribution changes over time. Data re-distribution at runtime requires elaborate schemes that are expensive and may benefit particular applications.

This dissertation discusses a solution for HPX applications to monitor application execution with APEX and use AGAS migration to adaptively redistribute data and load balance applications at runtime to improve application performance and scaling behavior. This dissertation provides evidence for the practicality of using the Active Global Address Space as is …


Using Spatial Analysis And Machine Learning Techniques To Develop A Comprehensive Highway-Rail Grade Crossing Consolidation Model, Samira Soleimani Oct 2020

Using Spatial Analysis And Machine Learning Techniques To Develop A Comprehensive Highway-Rail Grade Crossing Consolidation Model, Samira Soleimani

LSU Doctoral Dissertations

The safety of highway-railroad grade crossings (HRGC) is still an issue in the United States of America (USA). The grade crossing is where a railroad crosses a road at the same level without any over or underpass. To improve the safety of crossings, the crossings’ condition should be explored from several aspects such as engineering design (speed limit, warning signs, etc.), road condition (number of lanes, surface markings, etc.), rail design (the type of track, ballast, etc.), temporal variables (weather, visibility, time of day, lightning, etc.), social variables (population, race, etc.), and last but not least, spatial variables (the type …


The Life History And Population Dynamics Of Southern Flounder, Kenneth A. Erickson Oct 2020

The Life History And Population Dynamics Of Southern Flounder, Kenneth A. Erickson

LSU Master's Theses

Southern Flounder, Paralichthys lethostigma, are a coastal, estuarine-dependent flatfish species that inhabits the Southeastern US Atlantic Ocean and Gulf of Mexico. Throughout their range, Southern Flounder are exploited by both commercial and recreational fisheries. Recently, numerous sources have expressed concerns about Southern Flounder populations, with stock assessments indicating declines in spawning stock biomass and recruitment. To estimate life history traits needed for informed management, such as age, growth, and maturity, I collected 327 Southern Flounder from Louisiana and obtained 14,184 historical records from the Louisiana Department of Wildlife and Fisheries. Using a von Bertalanffy growth equation in a Bayesian …


Preface For Article Collection "Evolution And Variability Of Asian Monsoon And Its Linkage With Cenozoic Global Cooling", Ryuji Tada, Christian Betzler, Peter D. Clift Oct 2020

Preface For Article Collection "Evolution And Variability Of Asian Monsoon And Its Linkage With Cenozoic Global Cooling", Ryuji Tada, Christian Betzler, Peter D. Clift

Faculty Publications

No abstract provided.


Ideas And Perspectives: The Same Carbon Behaves Like Different Elements - An Insight Into Position-Specific Isotope Distributions, Yuyang He, Xiaobin Cao, Huiming Bao Oct 2020

Ideas And Perspectives: The Same Carbon Behaves Like Different Elements - An Insight Into Position-Specific Isotope Distributions, Yuyang He, Xiaobin Cao, Huiming Bao

Faculty Publications

It is expected that information on the source, reaction pathway, and reaction kinetics of an organic compound can be obtained from its position-specific isotope compositions or intramolecular isotope distribution (Intra-ID). To retrieve the information, we could use its predicted equilibrium Intra-ID as a reference for understanding the observed Intra-IDs. Historically, observed, apparently close-to-equilibrium carbon Intra-ID has prompted an open debate on the nature of biosystems and specifically the pervasiveness of reversible biochemical reactions. Much of the debate remains unresolved, and the discussion has not clearly distinguished between two states of equilibrium: (1) the equilibrium among the corresponding bond-breaking and bond-forming …


The Dynamic Trophic Niche Of An Island Bird Of Prey, Ulises Balza, Nicolas A. Lois, Michael J. Polito, Klemens Puetz, Amira Saalom, Andrea Raya Rey Oct 2020

The Dynamic Trophic Niche Of An Island Bird Of Prey, Ulises Balza, Nicolas A. Lois, Michael J. Polito, Klemens Puetz, Amira Saalom, Andrea Raya Rey

Faculty Publications

Optimal foraging theory predicts an inverse relationship between the availability of preferred prey and niche width in animals. Moreover, when individuals within a population have identical prey preferences and preferred prey is scarce, a nested pattern of trophic niche is expected if opportunistic and selective individuals can be identified. Here, we examined intraspecific variation in the trophic niche of a resident population of striated caracara (Phalcoboenus australis) on Isla de los Estados (Staten Island), Argentina, using pellet and stable isotope analyses. While this raptor specializes on seabird prey, we assessed this population's potential to forage on terrestrial prey, especially invasive …


Fish Assemblages Associated With Artificial Reefs Assessed Using Multiple Gear Types In The Northwest Gulf Of Mexico, Jeffrey D. Plumlee, Kaylan M. Dance, Michael A. Dance, Hay R. Rooker, Thomas C. Tinhan, J. Brooke Shipley, R. J. David Wells Oct 2020

Fish Assemblages Associated With Artificial Reefs Assessed Using Multiple Gear Types In The Northwest Gulf Of Mexico, Jeffrey D. Plumlee, Kaylan M. Dance, Michael A. Dance, Hay R. Rooker, Thomas C. Tinhan, J. Brooke Shipley, R. J. David Wells

Faculty Publications

Quantitative surveys of fishes associated with artificial reefs in the northwest Gulf of Mexico were conducted over a 4-yr period (2014-2017). Artificial reefs surveyed were comprised of three types: concrete structures, rig jackets, and decommissioned ships. All reefs were surveyed using vertical long line ( VLL), fish traps, and Adaptive Resolution Imaging Sonar (ARIS 1800). Mean fish abundance did not significantly differ using VLL [1.7 ind set(-1) (SD 2.2)] among the three reef types. However, relative abundance among all fishes collected was significantly highest on rig reefs using traps [6.2 ind soak(-1) (SD 3.8)], while results from sonar surveys indicated …


Tidal And Storm Impacts On Hydrodynamics And Sediment Dynamics In An Energetic Ebb Tidal Delta, Kehui Xu, P. Ansley Wren, Yanxia Ma Oct 2020

Tidal And Storm Impacts On Hydrodynamics And Sediment Dynamics In An Energetic Ebb Tidal Delta, Kehui Xu, P. Ansley Wren, Yanxia Ma

Faculty Publications

Bottom-mounted instrumentation was deployed at two sites on a large sandy shoal of an ebb tidal delta offshore of the Port Royal Sound of South Carolina of USA to collect hydrodynamics and sediment dynamics data. One site ("borrow site") was 2 km offshore in a dredge pit for nearby beach nourishment and the other site ("reference site") was 10 km offshore. In situ time-series data were collected during two periods after the dredging: 15 March-12 June (spring) and 18 August-18 November (fall) of 2012. Data at the reference site indicated active migrating bedforms from centimeters to decimeters tall, and sediment …


All-Atomic Molecular Dynamic Studies Of Human And Drosophila Cdk8: Insights Into Their Kinase Domains, The Lxxll Motifs, And Drug Binding Site, Wu Xu, Xiao-Jun Xie, Ali K. Faust, Mengmeng Liu, Xiao Li, Feng Chen, Ashlin A. Naquin, Avery C. Walton, Peter W. Kishbaugh, Jun-Yuan Ji Oct 2020

All-Atomic Molecular Dynamic Studies Of Human And Drosophila Cdk8: Insights Into Their Kinase Domains, The Lxxll Motifs, And Drug Binding Site, Wu Xu, Xiao-Jun Xie, Ali K. Faust, Mengmeng Liu, Xiao Li, Feng Chen, Ashlin A. Naquin, Avery C. Walton, Peter W. Kishbaugh, Jun-Yuan Ji

Faculty Publications

Cyclin-dependent kinase 8 (CDK8) and its regulatory partner Cyclin C (CycC) play conserved roles in modulating RNA polymerase II (Pol II)-dependent gene expression. To understand the structure and function relations of CDK8, we analyzed the structures of human and Drosophila CDK8 proteins using molecular dynamics simulations, combined with functional analyses in Drosophila. Specifically, we evaluated the structural differences between hCDK8 and dCDK8 to predict the effects of the LXXLL motif mutation (AQKAA), the P154L mutations, and drug binding on local structures of the CDK8 proteins. First, we have observed that both the LXXLL motif and the kinase activity of CDK8 …