Physical Sciences and Mathematics Commons^™

Strategies For The Thermal And Photochemical Modification Of Gold Nanoparticles (Aunps) And The Fabrication Of Aunp Hybrid Materials, Hossein Ismaili

Electronic Thesis and Dissertation Repository

Among the existing approaches for the functionalization of the gold nanoparticle (AuNP), a direct interfacial organic reaction of terminal functional groups exposed on the surface of template nanoparticles with various reactants has been shown as a promising strategy to incorporate desired functionality onto the AuNP monolayer. In our own attempts to extend the types of reactions that can be utilized for efficient interfacial modifications of AuNPs, we examined uncatalyzed Huisgen 1,3-dipolar click-type cycloaddition of azide-modified AuNPs to terminal alkynes. These particular reactions were found to be generally too slow to be useful at ambient temperatures but it was shown that …

Double Helical Hydrogen-Bonded Aaa-Ddd Complexes And Supramolecular Polymers, Hong-Bo Wang

Electronic Thesis and Dissertation Repository

The design and characterization of linear oligomers that self-assemble into double helical structures has been a subject of interest to chemists since the elucidation of the double helix structure of DNA in 1953. Transition metal templates have been widely used in the construction of artificial double helical complexes from linear multidentate ligands. The use of other non-covalent interactions as the driving force in the self-assembly of these types of complexes is less common. Aromatic stacking interactions, anion templates, and salt-bridges have all been applied in this context. The great majority of these investigations have been concerned with the dimerization of …

Design And Syntheses Of Fluorescent Cytosine Analogues, David W. Dodd

Electronic Thesis and Dissertation Repository

The avid hybridization of peptide nucleic acid (PNA) to DNA and RNA along with the molecule’s biological stability has led it to be used in both antisense and antigene capacities. PNA acts against translation via a steric blockade mechanism. It is therefore reasonable to assume that increased heteroduplex stability could lead to increased potency. Two ways of doing this were explored. I) N-Terminal attachment of a platinous chloride chelating moiety to PNA complementary to Xenopus noggin was synthesized with the objective of selective, covalent platination of the target transcript in vivo. Phenotypes consistent with knockdown of the selected …

New Synthetic Methodologies Directed Toward Pharmacologically Active Compounds As Well As Silole Based Chromophores For Analytical And Optoelectronic Applications, Mahmoud M. Abd Rabo Moustafa

Electronic Thesis and Dissertation Repository

The development of new and efficient synthetic methodologies to prepare heterocyclic compounds has received great attention over the years due to their importance in the pharmaceuticals and fine chemicals industries. Described herein are several novel syntheses of a variety of heterocycles including siloles, azaindoles, piperideines, piperidines and tetrahydropyrans.

A one-pot, two-step methodology involving Tamao’s reductive cyclization followed by Negishi cross coupling was utilized to synthesize several new series of silole-based chromophores. The property studies revealed new electropolymerized poly(thienyl-silole)s with enhanced photoefficiency for all-polymer solar cells. In addition, a new procedure is developed for the synthesis of the first dissymmetric silole …