Physical Sciences and Mathematics Commons^™

Understanding The Physics Of Magnetic Nanoparticles And Their Applications In The Biomedical Field, Suvra Santa Laha

Wayne State University Dissertations

The study of magnetic nanoparticles is of great interest because of their potential uses in magnetic-recording, medical diagnostic and therapeutic applications. Additionally, they also offer an opportunity to understand the physics underlying the complex behavior exhibited by these materials. Two of the most important relaxation phenomena occurring in magnetic nanoparticles are superparamagnetic blocking and spin-glass-like freezing. In addition to features attributed to superparamagnetism, these nanoparticles can also exhibit magnetic relaxation effects at very low temperatures (≲ 50 K). Our studies suggest that all structural defects, and not just surface spins, are responsible for the low-temperature glass-like relaxation observed in many …

Well-Posedness Properties In Variational Analysis And Its Applications, Wei Ouyang

Wayne State University Dissertations

This dissertation focuses on the study and applications of some significant properties in well-posedness and sensitivity analysis, among which the notions of uniform metric regularity , higher-order metric subregularity and its strong subregularity counterpart play an essential role in modern variational analysis. We derived verifiable sufficient conditions and necessary conditions for those notions in terms of appropriate generalized differential as well as geometric constructions of variational analysis. Concrete examples are provided to illustrate the behavior and compare the results. Optimality conditions of parametric variational systems (PVS) under equilibrium constraints are also investigated via the terms of coderivatives. We derived necessary …

Finite-Difference Approximations And Optimal Control Of Differential Inclusions, Yuan Tian

Wayne State University Dissertations

This dissertation concerns the study of the generalized Bolza type problem for dynamic systems governed by constrained differential inclusions. We develop finite-discrete approximations of differential inclusions by using the implicit Euler scheme and the Runge-Kutta scheme for approximating time derivatives, while an appropriate well-posedness of such approximations is justified. Our principal result establishes the uniform approximation of strong local minimizers for the continuous-time Bolza problem by optimal solutions to the corresponding discretized finite-difference systems by the strengthen $W^{1,2}$-norm approximation of this type in the case ``intermediate" (between strong and weak minimizers) local minimizers under additional assumptions. Especially the implicitly discrete …

Synthesis And Biological Evaluation Of Nitrile-Based Inhibitors Of Cysteine Proteases Caged With Ruthenium Complexes, Rajgopal Sharma

Wayne State University Dissertations

Light activated compounds can be used as tools for understanding and solving numerous biological problems. This dissertation focuses on developing ruthenium-based photocages for caging nitrile-based cysteine protease inhibitors. Four research areas pertaining to this dissertation, i) metals in medicine, ii) photocages in biological applications, iii) photodynamic therapy and iv) cysteine cathepsin proteases were briefly surveyed in the introductory chapter. Next, RuII(bpy)2 group was utilized for synthesizing nitrile-based caged CTSK and CTSB inhibitors. Light activated release of inhibitors, followed by toxicity and stability data were studied. Cathepsin enzyme activity inhibition in 2D and 3D assays were established. This work showcased the …

Building Computing-As-A-Service Mobile Cloud System, Kun Wang

Wayne State University Dissertations

The last five years have witnessed the proliferation of smart mobile devices, the explosion of various mobile applications and the rapid adoption of cloud computing in business, governmental and educational IT deployment. There is also a growing trends of combining mobile computing and cloud computing as a new popular computing paradigm nowadays. This thesis envisions the future of mobile computing which is primarily affected by following three trends: First, servers in cloud equipped with high speed multi-core technology have been the main stream today. Meanwhile, ARM processor powered servers is growingly became popular recently and the virtualization on ARM systems …

Novel Incorportation Of Biomedical Engineering Algorithms (Bispectral Index Guided Or Anesthetic Concentration Guided) In Real-Time Decision Support To Prevent Intraoperative Awareness Using An Electronic Anesthesia Information Mananagement System, Amy Melanie Shanks

Wayne State University Dissertations

Background: Intraoperative awareness with explicit recall (AWR) is a feared complication of surgery that can lead to significant psychological distress. Several large prospective trials have been completed comparing two methods of monitoring anesthetic depth [minimum alveolar concentration (MAC) or electroencephalography (EEG) monitoring using the bispectral index (BIS)] for the prevention of AWR. However, these trials were conducted in high risk populations, limiting generalizability.

Research Hypothesis: Real-time decision support with Anesthesia Information Management System alerts based on a novel anesthetic concentration algorithm (incorporating the use of intravenous anesthetics) or an EEG-guided algorithm will reduce the known incidence of AWR.

Methods: First, …