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- HPLC (2)
- Acetaminophen (1)
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Articles 1 - 5 of 5
Full-Text Articles in Physical Sciences and Mathematics
Study Of Selectivity In Extraction, Separation, And Detection On Drugs Using Gas Chromatography, Anumeha P. Muthal
Study Of Selectivity In Extraction, Separation, And Detection On Drugs Using Gas Chromatography, Anumeha P. Muthal
Seton Hall University Dissertations and Theses (ETDs)
The selectivity of a method is defined by its ability to determine a particular analyte without interference in a complex mixture. Selectivity in gas chromatography (GC) can be obtained at different points in the analysis including the sample preparation, sample introduction, separation on column and detection. In GC, the first dimension of selectivity can be obtained in sample preparation; the second dimension in chromatographic separation and the third dimension in detection. This research focuses on the relationships between selectivity in these different dimensions, studied using some non-steroidal anti-inflammatory drugs, glucocorticoids, fatty acid methyl esters and polycyclic aromatic hydrocarbons. Recent methodologies …
Understanding The Dynamic Process Of Dissolution Using In-Situ Ft-Ir Spectroscopy, Vrushali M. Bhawtankar
Understanding The Dynamic Process Of Dissolution Using In-Situ Ft-Ir Spectroscopy, Vrushali M. Bhawtankar
Seton Hall University Dissertations and Theses (ETDs)
Dissolution studies provide valuable and critical drug release information (in vitro) that are important for quality control drug development. Using in-situ FT-IR spectroscopy methods has been developed for analyzing and monitoring dissolutions of pharmaceutical APIs. The accuracy of this technique was found to be ± 3% relative to HPLC and UV/Vis Spectroscopy. A dynamic analysis of the dissolution and subsequent hydrolysis of aspirin has been determined by in-situ FT-IR. This technique allows real-time analysis of the behavior of aspirin under simulated physiological conditions (pH 1.2, 4.5, 6.8) as aspirin (1205 cm-1) and salicylic acid (1388 cm-1) …
Synthesis Of Pyranobenzopyrans, Sumiea B. Eltayeb
Synthesis Of Pyranobenzopyrans, Sumiea B. Eltayeb
Seton Hall University Dissertations and Theses (ETDs)
Carbohydrates and their derivatives are involved in a wide array of biological processes and are crucial for the survival of living entities. As a result, sugar-based compounds have become attractive scaffolds for drug design. In addition, pyranobenzopyran derivatives have shown promise in the treatment of numerous health conditions such as anticoagulants, antifungal, and anti-inflammatory agents. They have also shown important properties as antibiotics anti-AIDS agents) and antitumor drugs. The main point of our research was to determine and develop a synthetic method for the preparation of pyranobenzopyrans and carbohydrate fused heterocyclic compounds. This was accomplished via a [4+2] cycloaddition reaction …
Apparent Retention Volume Variation With Flow Rate Change In High Performance Liquid Chromatography, Susanne Buntz Erz
Apparent Retention Volume Variation With Flow Rate Change In High Performance Liquid Chromatography, Susanne Buntz Erz
Seton Hall University Dissertations and Theses (ETDs)
Recent studies have demonstrated noticeable flow rate dependency of the chromatographic zone retention volume with respect to migration within the empty capillary. This appears to be the result of superposition of asymmetric lateral diffusion and of the laminar flow profile. Although these effects have been studied on empty capillaries, in the presence of the packed column, the retention shift may be insignificant relative to the adsorption-based retention of the analytes. In the case of fast and ultrafast HPLC with short capillary columns, the effect of extra-column caused variation in the analyte retention may constitute an increase of up to 120 …
Adsorption And Wetting In Model Mesoporous Silicas And In Complex Metal Oxide Catalysts, Karthik Jayaraman
Adsorption And Wetting In Model Mesoporous Silicas And In Complex Metal Oxide Catalysts, Karthik Jayaraman
Seton Hall University Dissertations and Theses (ETDs)
The surface of most metal oxides is covered by hydroxyl groups which influence many surface phenomena such as adsorption and wetting, catalysis and surface reactions. Surface chemistry of silica is a subject of exhaustive studies owing to a wide variety of practical applications of silica. In Chapter 1, a brief review of classification, synthesis and characterization of silica is provided. The hydroxylation of silica surface i.e the number of hydroxyl (-OH) groups on the surface is of utmost importance for its practical applications. In Chapter 2, a brief introduction to surface hydration of silica is provided followed by the gas …