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Articles 1 - 8 of 8
Full-Text Articles in Veterinary Pathology and Pathobiology
Sub-Typing Of Prrsv Isolates By Means Of Measurement Of Cross-Neutralization Reactions, Fernando A. Osorio
Sub-Typing Of Prrsv Isolates By Means Of Measurement Of Cross-Neutralization Reactions, Fernando A. Osorio
School of Veterinary and Biomedical Sciences: Faculty Publications
The degree of similitude or closeness between two different isolates or strains of PRRSV is very important for deciding which strains should be used for immunization, by either vaccinating with commercial vaccines or attempting to stabilize a herd with planned wt PRRSV infection. As previously known for certain important viral diseases, such as in Foot and Mouth Disease, the reciprocal (cross-) neutralization titers between two strains may be of utmost importance to establish the degree of similarity or difference between these. There is currently a void of methods that would allow distinguishing or grouping strains of PRRSV in a manner …
Visualization Of Intracellular Transport Of Vesicular Stomatitis Virus Nucleocapsids In Living Cells, Subash C. Das, Debasis Nayak, You Zhou, Asit K. Pattnaik
Visualization Of Intracellular Transport Of Vesicular Stomatitis Virus Nucleocapsids In Living Cells, Subash C. Das, Debasis Nayak, You Zhou, Asit K. Pattnaik
School of Veterinary and Biomedical Sciences: Faculty Publications
The phosphoprotein (P) of vesicular stomatitis virus (VSV) is a subunit of the viral RNA polymerase. In previous studies, we demonstrated that insertion of 19 amino acids in the hinge region of the protein had no significant effect on P protein function. In the present study, we inserted full-length enhanced green fluorescent protein (eGFP) in frame into the hinge region of P and show that the fusion protein (PeGFP) is functional in viral genome transcription and replication, albeit with reduced activity. A recombinant vesicular stomatitis virus encoding PeGFP in place of the P protein (VSV-PeGFP), which possessed reduced growth kinetics …
Transcriptome Signature Of Virulent And Attenuated Pseudorabies Virus-Infected Rodent Brain, Christina Paulus, Patricia J. Sollars, Gary E. Pickard, Lynn W. Enquist
Transcriptome Signature Of Virulent And Attenuated Pseudorabies Virus-Infected Rodent Brain, Christina Paulus, Patricia J. Sollars, Gary E. Pickard, Lynn W. Enquist
School of Veterinary and Biomedical Sciences: Faculty Publications
Mammalian alphaherpesviruses normally establish latent infections in ganglia of the peripheral nervous system in their natural hosts. Occasionally, however, these viruses spread to the central nervous system (CNS), where they cause damaging, often fatal, infections. Attenuated alphaherpesvirus derivatives have been used extensively as neuronal circuit tracers in a variety of animal models. Their circuit-specific spread provides a unique paradigm to study the local and global CNS response to infection. Thus, we systematically analyzed the host gene expression profile after acute pseudorabies virus (PRV) infection of the CNS using Affymetrix GeneChip technology. Rats were injected intraocularly with one of three selected …
The Epidemiology Of West Nile Virus In Louisiana, Karen Ruth Gruszynski
The Epidemiology Of West Nile Virus In Louisiana, Karen Ruth Gruszynski
LSU Doctoral Dissertations
West Nile virus (WNV), a member of the genus Flavivirus transmitted by mosquitoes, first appeared in the New York in 1999. Within five years WNV was detected throughout the contiguous 48 states causing disease in reservoirs and accidental hosts alike. In Louisiana, WNV was first detected in 2001 with one human case, ten equine cases, and six dead birds reported. The introduction of WNV into Louisiana presented an unique opportunity to observe an emerging disease unfold, so a study was launched to gain insight into the epidemiology of WNV in Louisiana. The first component, an environmental predictive model for West …
Brugia Phangi: Effects Of Third Stage Larvae Es Immunization On Early Migration And Parasite Establishment In Mongolian Gerbils (Meriones Unguiculatus), Ginger Ann Robertson
Brugia Phangi: Effects Of Third Stage Larvae Es Immunization On Early Migration And Parasite Establishment In Mongolian Gerbils (Meriones Unguiculatus), Ginger Ann Robertson
LSU Master's Theses
Brugia infections occur via the bite of an infected mosquito. Third stage infective larvae (L3) deposited on the skin during feeding migrate into the bite wound, through skin and into the lymphatic system. It is hypothesized that L3 excretory/secretory products (ES) are important in this initial phase of the infection. A model for these early migrations has been established by inoculating L3s into the dermis (ID) of the permissive gerbil host. In this model, most L3s injected ID in the louer hind limb travel to the popliteal lymph node by 3 days post infection. Adult parasites are located primarily in …
Effect Of Vaccination Of Goats With H-Gal-Gp And H11 Antigens From Intestinal Membrane Cells Of Haemonchus Contortus, Donya Dupree Olcott
Effect Of Vaccination Of Goats With H-Gal-Gp And H11 Antigens From Intestinal Membrane Cells Of Haemonchus Contortus, Donya Dupree Olcott
LSU Master's Theses
Extracts of adult Haemonchus contortus were purified and used as a vaccine against the blood feeding parasite in goats as previously studied in sheep. The proteins used were H11 and H-gal-GP, hidden gut antigens from the microvillar membrane of the gut of the worm and combined with Quil A as adjuvant, then administered to a group of goats kept on concrete then artificially infected with H. contortus. The control group received Quil A injections and also infected. This study was performed to analyze the effects of the H11/H-gal-GP vaccine when given to goats as compared to sheep. The trial showed …
Power Analysis For A Mixed Effects Logistic Regression Model, Yinmei Li
Power Analysis For A Mixed Effects Logistic Regression Model, Yinmei Li
LSU Doctoral Dissertations
In herd health studies, the mixed effects logistic regression model with random herd effects are commonly used for modeling clustered binary data. These models are well developed and widely used in the literature, among which is the logistic-normal regression model. In contrast to the rich literature in modeling methods, the sample size/power analysis methods for such mixed effects models are sparse. The sample size/power analysis method for the logistic-normal regression model is not readily available. This study is to develop a power analysis/sample size estimation method for the logistic-normal regression model. Extended from the sample size method for the likelihood …
Racial Disparities, Birth Outcomes, And Changing Demographics Of East Baton Rouge Parish, Louisiana, Misty D. Richard
Racial Disparities, Birth Outcomes, And Changing Demographics Of East Baton Rouge Parish, Louisiana, Misty D. Richard
LSU Doctoral Dissertations
Racial and socioeconomic disparities persist throughout the country regardless of which specific disparity is studied; however, some geographic regions experience more significant racial disparities. East Baton Rouge Parish, Louisiana has a large racial disparity among birth outcomes. Many factors impact the degree of racial disparities, some of which include racial segregation, isolation, or centralization, access to and quality of medical care, and factors of the neighborhood environment. EBRP has undergone dramatic shifts in the demographics of its residents. The purpose of this dissertation was to study the demographic changes in the population; as well as to study the disparities among …